Membrane binds multiple calcium calcium binding proteins. Medical search. Frequent questions

Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)
Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)
The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)
Mammalian host cells have also evolved an array of pattern recognition receptors for microbes or microbial factors, such as the Toll-like receptors (TLRs), which when bound, trigger intracellular signalling cascade(s) with antimicrobial effects. (immunology.org)
These results identify potential roles for AS in multiple aspects of postnatal heart maturation including vesicular trafficking and intracellular membrane dynamics. (abt-888.net)
Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. (embl.de)
It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin . (wikidoc.org)
The intracellular domain contains a highly- phosphorylated region vital to beta-catenin binding and therefore to E-cadherin function. (wikidoc.org)
Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs (Olsen et al. (beauty104.com.tw)
Activation of protein serine/threonine kinases and pathways coupled to small G proteins, and elevation of intracellular calcium, are examples of the events that follow. (nih.gov)

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. (nih.gov)
May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. (assaygenie.com)
Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. (assaygenie.com)
The ABCB4 gene (also known as MDR3 ) provides instructions for making a protein that helps move certain fats called phospholipids across the membranes of liver cells and release the phospholipids into a digestive fluid called bile. (medlineplus.gov)
Outside the liver cells, phospholipids attach (bind) to bile acids, which are a component of bile that digest fats. (medlineplus.gov)
when they are bound to phospholipids, bile acids are less toxic. (medlineplus.gov)
ABCB4 gene mutations that cause PFIC3 impair the movement of phospholipids across cell membranes, leading to a lack of phospholipids available to bind to bile acids. (medlineplus.gov)
Under most circumstances, though, enough protein is available to move an adequate amount of phospholipids out of liver cells to bind to bile acids. (medlineplus.gov)
Although the mechanism is unclear, the function of the remaining ABCB4 protein appears to be impaired during pregnancy, which may further reduce the movement of phospholipids into bile. (medlineplus.gov)
The lack of phospholipids available to bind to bile acids leads to a buildup of toxic bile acids that can impair liver function, including the regulation of bile flow. (medlineplus.gov)
After phosphorylation these residues provide binding sites for other critical linkers, listed above, and enzymes that activate Ras and hydrolyze phospholipids. (nih.gov)
It can bind to phospholipids such as phosphatidylserine and phosphatidylinositol, which are important for its membrane association. (creativebiomart.net)
In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)

It binds two calcium ions with high affinity. (nih.gov)
Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. (thermofisher.com)
Likely to bind calcium ions. (embl.de)
Likely calcium ions. (embl.de)
C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. (embl.de)
They are dependent on calcium (Ca 2+ ) ions to function, hence their name. (wikidoc.org)
1988). The resulting damage leads to loss of membrane permeability, reduced ion uptake, loss of plasma ions, and changes in blood parameters relating to respiration. (canada.ca)
Specialized cells that surround and nourish egg cells release progesterone, which makes calcium ions rush into human sperm. (acs.org)

Thus to protect itself from such virulence mechanisms, the host cell fights back by synthesising siderocalin receptors which competitively bind iron. (immunology.org)
Another serious human pathogen, Bacillus anthracis, causative of anthrax , has well-developed virulence mechanisms involving the secretion of three proteins, one of which, protective antigen (PA), binds host cell receptors to effect entry of either lethal factor (LF) or edema factor (EF). (immunology.org)
Animal steroid hormones initiate signaling by passive diffusion into cells and binding to their nuclear receptors to regulate gene expression. (biologists.com)
Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. (string-db.org)
The first step of virus infection requires the interaction between virus attachment proteins (VAPs) and cellular receptors, which is known to contribute to host range, tissue tropism and viral pathogenesis. (biomedcentral.com)
Following binding of the antigen-HLA complex to the TCR, receptors aggregate, associated protein tyrosine kinases (PTK) are activated, and TCR subunits and a number of linker or adapter molecules are phosphorylated on tyrosine residues. (nih.gov)
The pheromone receptors have seven hydrophobic segments and are coupled to a heterotrimeric G protein. (berkeley.edu)
Receptors of this type are ubiquitous and transduce binding of a wide variety of extracellular ligands (peptide hormones, neurotransmitters and other bioactive compounds) into a physiological signal. (berkeley.edu)
The 3' replication has freely activated by RNase Z surface, a mature binding in receptors( reviewed in Maraia and Lamichhane 2011). (evakoch.com)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

Our study suggests Myr insertion is involved in the sorting of membrane lipids around the protein binding site to prepare it for viral assembly. (elifesciences.org)
Our realistic membrane models confirm interactions with PIP 2 and PS lipids are highly favored around the HBR, and are strong enough to keep the protein bound even without Myr insertion. (elifesciences.org)
The tail domain of vinculin binds to membrane lipids and to actin filaments. (wikidoc.org)
Yes, ANXA4 has been shown to interact with several proteins and lipids. (creativebiomart.net)

Altered membrane events induced selective inhibition of TCR-induced phosphorylation of regulatory P85 subunit of PI3K and AKT as well as abrogated calcium influx. (nature.com)
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. (string-db.org)
In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)
Disturbances in mitochondrial dynamics may influence many cellular and molecular pathways, as calcium-dependent immune activation, transcription factors phosphorylation, cytokine secretion, organelle transference and even cell death. (frontiersin.org)
Engagement of the TCR by antigenic peptide bound to a histocompatibility molecule (in humans, an HLA molecule) leads to a complex set of biochemical events in which the initial activation of protein phosphorylation is critical. (nih.gov)
These complexes contain enzymes that are regulated by protein phosphorylation and whose substrates are located at the membrane. (nih.gov)
Initial studies focused on characterization of the multiple TCR subunits and discovery of TCR tyrosine phosphorylation. (nih.gov)
The tyrosine phosphorylation of some of these molecules creates binding sites for additional molecules. (nih.gov)
We have shown that Ypk1, a member of the AGC class of protein kinases conserved from yeast to humans, is the essential target of and activated via phosphorylation by the plasma membrane-associated TORC2 complex. (berkeley.edu)
Ypk1, in turn, regulates (via its phosphorylation of multiple substrates) maintenance of sphingolipid and glycerolipid homeostasis and bilayer lipid organization in the plasma membrane. (berkeley.edu)
These two levels serve degraded by a phosphorylation including at least 6 membranes in a such tail that both leaves the 2' disorder ubiquitination and adducts the 3' heart to the 5' cell. (evakoch.com)

Taxonomy and function of C1 protein kinase C homology domains. (embl.de)
These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl.de)
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. (embl.de)
The atypical protein kinase C (PKC) member PKC-zeta has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. (embl.de)
May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. (string-db.org)
Protein serine kinase H2. (string-db.org)
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. (string-db.org)
The Wee1 class of protein-tyrosine kinase has an important role in cell cycle control. (berkeley.edu)
We investigated control mechanisms that regulate the activity, localization, and stability of Wee1, especially the bud neck-localized protein kinase Hsl1 and its more distant paralogs (Gin4 and Kcc4), in particular their recruitment to septin filaments, which assemble at the presumptive site of cell division. (berkeley.edu)
Activation of the pheromone receptor-coupled G protein initiates a four-tiered cascade of protein kinases, ultimately resulting in stimulation of a messenger-activated protein kinase or MAPK (Fus3) that translocates into the nucleus. (berkeley.edu)

The noted discrepancy of membrane proteins included calcium binding proteins (annexin A1, annexin A2), and voltage-dependent anion channels proteins (VDAC 1, VDAC 2), suggesting that these molecules may affect JEV attachment to and/or entry into BHK-21 cells and worthy of further investigation. (biomedcentral.com)
ANXA4 can also interact with other annexin proteins or cytoskeletal proteins, potentially contributing to its diverse cellular functions. (creativebiomart.net)

Actin filaments are linked to α-actinin and to membrane through vinculin. (wikidoc.org)
Binds to actin filaments (F-actin) and shows cross- linking activity. (string-db.org)

Finally, the protein interaction network analysis revealed that VGLL3 is likely involved in the Hippo signaling pathway. (researchgate.net)
The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. (degruyter.com)
May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. (string-db.org)
This download is the types and cells led from a human assembly target content soccer methylated alongside the set of two interaction localizing enzyme proteins in New Zealand. (evakoch.com)
Does ANXA4 have any interaction partners or binding proteins? (creativebiomart.net)

Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. (nih.gov)
There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. (thermofisher.com)
Previously we showed that genes that undergo AS regulation during heart development produce transitions from GSK1324726A embryonic to adult protein isoforms GSK1324726A largely without changes in overall transcript levels presenting a new paradigm for understanding developmentally regulated gene expression in heart3. (abt-888.net)

Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)
We have recently shown that this same pathway modulates the content of integral membrane proteins and, in collaborative studies, that it is also involved in maintenance of the sterol composition of the plasma membrane. (berkeley.edu)
RESULTS: A total of 28 main components were identified in WGLWE, and these compounds can directly bind to the inflammatory pathway proteins such as JAK2, NFκB and STAT3. (bvsalud.org)

In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. (embl.de)
Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl.de)

Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein. (embl.de)
Tunicamycin treatment experiments, biochemical fractionation and extraction experiments, and proteinase K protection experiments collectively indicate that Axl2p is an integral membrane glycoprotein at the plasma membrane. (embl.de)
Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)

Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. (nih.gov)
Please note that proteins can be included in multiple pathways, ie. (embl.de)
Seems to act as a scaffold protein in multiple signaling pathways. (string-db.org)

The C2 domain is thought to be involved in calcium-dependent phospholipid binding [ ( PUBMED:8253763 ) ] and in membrane targetting processes such as subcellular localisation. (embl.de)

ANXA2 is part of the putative cell surface vitamin D binding protein binding site complex and functions to mediate the chemotactic cofactor effect. (assaygenie.com)

One of the most convincing methods to verify a putative virus receptor is to transfer the receptor gene into a cell line that cannot bind virus and later demonstrate that the receptor-negative cell acquires the ability to bind virus and permit virus to replicate within it after the receptor gene is regained [ 13 ]. (biomedcentral.com)

Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
CM and CF TCF7L3 communicate through multiple signaling mechanisms and through extracellular-matrix (ECM)11. (abt-888.net)
In structure, they share cadherin repeats , which are the extracellular Ca 2+ - binding domains . (wikidoc.org)

A recent paper also indicated that several proteins on the surface of C6/36 cells with masses ranging from 35-80 kDa and 150-200 kDa may bind to JEV, but failed to identify specific proteins by mass spectroscopic fingerprint analysis [ 11 ]. (biomedcentral.com)

Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred calmodulin binding proteins. (biomedcentral.com)
The Calcium Hypothesis was thus extended as the Calmodulin Hypothesis since CaM not only binds to and regulates CaMBPs critical to learning and memory but also proteins involved in the formation of amyloid plaques and tangles, hallmarks of AD [ 41 ]. (biomedcentral.com)

This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. (wikidoc.org)

Alternative splicing results in many transcript variants encoding different proteins. (thermofisher.com)
We present a comprehensive list of 54 C1 domains occurring singly or doubly in 34 different proteins. (embl.de)

2003). FGF molecules bind to a family of receptor molecules consisting of 4 members (FGFR1, FGFR2, FGFR3, and FGFR4). (beauty104.com.tw)
Such broad tropism of JEV rationally suggests that most possibly there exists more than one cellular receptor responsible for virus binding and entry into susceptible cells above mentioned. (biomedcentral.com)
The ZAP-70 PTK binds to phosphorylated TCR subunits upon receptor activation. (nih.gov)
ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)

Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. (embl.de)
Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins. (embl.de)
Principal interactions of structural proteins at cadherin-based adherens junction. (wikidoc.org)
There are multiple classes of cadherin molecule, each designated with a one-letter prefix (generally noting the type of tissue with which it is associated). (wikidoc.org)
For example, an N-cadherin will bind only to another N-cadherin molecule. (wikidoc.org)

By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
The C2 domain is a Ca 2+ -dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. (embl.de)
Additionally, it can be influenced by environmental factors, such as changes in calcium levels and cellular stress. (creativebiomart.net)

C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes, including phosphatidylserine and phosphatidylcholine. (embl.de)

LAT, initially characterized by this laboratory, is an integral membrane protein with multiple tyrosine residues. (nih.gov)

Specific protein-lipid interactions are critical for viral assembly. (elifesciences.org)
The matrix (MA) domain drives Gag onto the plasma membrane through electrostatic interactions at its highly-basic-region (HBR), located near the myristoylated (Myr) N-terminus of the protein. (elifesciences.org)
The FGFs are heparin -binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans has been shown to be essential for FGF signal transduction. (beauty104.com.tw)

May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. (string-db.org)

Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. (arigobio.com)

The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. (thermofisher.com)
The communication in subunit: enabling lymphoid GT-domains preventing membrane as a subunits addition: A ATM identified to the Faculty of Graduate Studies and Research in isolated pore of the heterotrimers for the use of Master of Nursing. (evakoch.com)

Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
A single mutation in the ABCB4 gene leads to a mild reduction of the ABCB4 protein. (medlineplus.gov)
Here, in order to discover those membrane proteins that may be involved in JEV attachment to or entry into virus permissive BHK-21 cells, a chemically mutated cell line (designated 3A10-3F) that became less susceptible to JEV infection was preliminarily established and selected by repeated low moi JEV challenges and RT-PCR detection for viral RNA E gene fragment. (biomedcentral.com)
The RPA gene is the structural excretion loss-of-function, However Binding it from the corresponding growth( De Laat et al. (evakoch.com)

In this regard, we have recently shown that efficient activation of Ypk1 by TORC2 requires stimulation of TORC2 by the GTP-bound state of a Rab5 GTPase (Vps21/Ypt51) and that, in turn, Rab5-dependent endocytosis may be a mechanism to down-regulate TORC2 signaling after it has been activated. (berkeley.edu)

Insertion events only occur with one of the membrane models, showing a combination of surface charge and internal membrane structure modulate this process. (elifesciences.org)

As a consequence, TCR-induced LAT, PLC-γ, and AKT microcluster formation from aggregation of smaller nanocluster units, PI3K-AKT signaling axis, and calcium influx were potently inhibited by GML treatment. (nature.com)

2. According to the recommended primary antibody dilution ratio, use the TBST Buffer containing 5% Skim Milk Powder to dilute the CD38 Antibody at , soak the PVDF Membrane in the primary antibody working solution, incubate overnight at 4 ℃, and gently shake. (elabscience.com)
Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). (creativebiomart.net)

Axl2p is predicted to be a type I transmembrane protein. (embl.de)
Soak the PVDF Membrane in methanol for 1 min to activate it, and then soak the PVDF Membrane in the Transmembrane Buffer (Cat# E-BC-R333 ), the filter paper and fiber mat must be soaked in the Transmembrane Buffer for use too. (elabscience.com)
Cadherins are a class of type-1 transmembrane proteins . (wikidoc.org)

The new research suggests that progesterone works by opening a pH-sensitive calcium channel called CatSper, which resides on sperm tail membranes. (acs.org)

We characterized Myr insertion events from microsecond trajectories, and examined the membrane response upon initial membrane targeting by MA. (elifesciences.org)
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. (string-db.org)
These initial events lead to the generation of multiple protein complexes that localize at the TCR and the plasma membrane. (nih.gov)

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. (thermofisher.com)

We suggest that Axl2p acts as an anchor in the plasma membrane that helps direct new growth components and/or polarity establishment components to the cortical axial budding site. (embl.de)
We found that GML potently altered order and disorder dynamics in the plasma membrane that resulted in reduced formation of LAT, PLC-γ, and AKT microclusters. (nature.com)
T-cadherins have no cytoplasmic domains and must be tethered to the plasma membrane. (wikidoc.org)

causative of melioidosis or glanders ) have multiple secretion processes through which they deliver virulence factors into the host cell. (immunology.org)

This imbalance in calcium metabolism occurs because calcium mobilization from bone into the serum pool is insufficient to compensate for the efflux of calcium via the mammary glands during lactation. (merckvetmanual.com)

We also studied the roles of other classes of protein kinases (Cla4) and additional post-translational modifications (SUMOylation) in septin complex assembly, formation of different septin-based supramolecular ensembles, disassembly of septin-containing structures, and the function of septin organization in the events required for cell division and membrane septation during cytokinesis. (berkeley.edu)
Are there any known post-translational modifications of the ANXA4 protein? (creativebiomart.net)

To sustain their virulence mechanisms, many bacteria can sequester free iron in the mammalian host, through the elaboration of iron-binding siderophores. (immunology.org)

The expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot, respectively. (researchgate.net)
Alternate mRNA splicing gives rise to two distinct forms (b and c) of FGFRs1-3 which differ significantly in their ligand-binding profiles. (beauty104.com.tw)

Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). (embl.de)
Protein tyrosine kinases of the Src family, Fyn and Lck, are associated with the TCR and TCR coreceptors, respectively. (nih.gov)

ANXA2 protein functions as an autocrine factor which increases osteoclast formation and bone resorption. (assaygenie.com)

They play important roles in cell adhesion , ensuring that cells within tissues are bound together. (wikidoc.org)
Proteins that act both at the cell surface and intracellularly will be discussed in this thesis, with particular emphasis on the fibroblast growth factors. (beauty104.com.tw)
loop kappa p21 D cell 4( ABCD4) is shown to reduce the CD127 performance of cobalamin( Cbl membrane parking B12) into the mitochondrion, interacting it ED for the composition of Cbl lives. (evakoch.com)

and membrane organization These AS transitions are enriched among targets of two RNA-binding proteins Celf1 and Mbnl1 which undergo developmentally regulated changes in expression. (abt-888.net)
At higher doses, cells undergo mitochondrial destabilization due to calcium release from the endoplasmic reticulum, and die. (hindawi.com)

These AS changes are enriched as targets of the CUGBP ELAV-Like family GSK1324726A (Celf) and Muscleblind-like (Mbnl) RNA-binding protein families both of which are involved in AS and are regulated during postnatal heart development3 23 In the heart vesicular trafficking-related AS transitions likely impact ligand/growth factor uptake ion channels GSK1324726A dynamics and/or postnatal. (abt-888.net)
We present a molecular dynamics simulation study on the binding mechanism of the membrane targeting domain of HIV-1 Gag protein. (elifesciences.org)

Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). (nih.gov)

We are currently using a multidisciplinary approach to study LAT as well as the multi-protein complexes that form at phosphorylated LAT. (nih.gov)

1. According to the molecular weight of the target protein, prepare 0% separation gel. (elabscience.com)
Add the test sample to each well, and add 5 μL of Pre-stained Protein Marker ( Cat# E-BC-R273 )to a reserved well in order to verify the target molecular weight and the extent of membrane transfer. (elabscience.com)
1. Choose the PVDF Membrane (Cat# E-BC-R266 ) with a pore size of μm according to the molecular weight of the target protein. (elabscience.com)

Short-term Celf1 induction in adult animals results in disrupted transverse tubule organization and calcium handling. (abt-888.net)
Interestingly we found that genes involved in vesicular trafficking and membrane organization are regulated by AS during postnatal CM development. (abt-888.net)

Regions with significant homology [ ( PUBMED:7559667 ) ] to the C2-domain have been found in many proteins. (embl.de)

Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca 2+ -binding loops are located at the end of an 8 stranded antiparallel beta sandwich. (embl.de)

Anatomy31

Organisms14

Diseases2

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture5

Information Science3

Health Care1

Intracellular10

Phospholipids13

Ions8

Receptors10

Lipids4

Phosphorylation11

Kinase10

Annexin2

Actin filaments2

Interaction5

Isoforms3

Pathway3

Domain-containi2

Glycoprotein3

Pathways3

Phospholipid1

Mediate1

Putative1

Extracellular3

Several proteins1

Regulates2

Basement membrane1

Different proteins2

Receptor4

Cadherin5

Cellular3

Phosphatidylserine1

Integral1

Interactions3

Synaptic1

Variants1

Subunits2

Gene4

Endocytosis1

Modulate1

Influx1

Incubate2

Transmembrane3

Tail1

Initial3

Subunit1

Plasma3

Secretion1

Metabolism1

Post-translational2

Virulence1

MRNA2

Kinases2

ANXA21

Cell3

Undergo2

Dynamics2

Mechanism1

Complexes1

Molecular3

Organization2

PUBMED1

Structural1