• At a median follow-up of 23.5 months, the median overall survival and median disease-free survival had not yet been reached. (urologytimes.com)
  • When comparing partial nephrectomy, radical nephrectomy, ablative therapies, and active surveillance through a large registry, cancer-specific survival was comparable in all groups when adjusting for age and comorbidities. (urologytimes.com)
  • In patients with locoregional renal cell carcinoma (RCC) who were at high risk of tumor recurrence after nephrectomy, adjuvant sunitinib (Sutent) showed a 2-year advantage in median survival versus placebo. (urologytimes.com)
  • The drug appears to have a 3-month longer median progression-free survival than temsirolimus (Torisel). (urologytimes.com)
  • The median overall survival (OS) and progression-free survival (PFS) were calculated using Kaplan-Meier and Cox regression methods, respectively. (cancerindex.org)
  • The median progression-free and overall survival periods were 11.8 and 38.7 months, respectively, and sustained stable disease was obtained in some selected patients. (cancerindex.org)
  • Studies have shown that radical nephrectomy and inferior vena cava TT removal for patients with locally advanced renal cancer can effectively improve the prognosis, and the 5-year tumor-specific survival rate is 40-65% [ 2 ]. (biomedcentral.com)
  • Survival data are similar between groups, but follow-up times were inconsistent and patient selection was clearly biased, with only small tumors being selected for MIS. (northwestern.edu)
  • Median survival is only approximately 1 year. (e-urol-sci.com)
  • Purpose The study evaluated whether preoperative measures of the C-reactive protein-based systemic inflammatory response may predict cancer survival independent of tumor stage in patients with upper urinary tract urothelial carcinoma (UTUC). (scielo.org)
  • Variables and outcomes analyzed in each group included the percent of patients with metastatic disease at presentation, lymph node involvement, Eastern Cooperative Oncology Group score, response to immunotherapy, and median and overall survival using Kaplan-Meier curves. (nih.gov)
  • Median survival for patients with pT3a disease and perinephric or renal sinus fat involvement was 36 months with a 36% 5-year cancer specific survival rate. (nih.gov)
  • 0.001), which was similar to median survival of those with stage pT4 disease (11 months). (nih.gov)
  • Upper pole tumors with direct extension into the adrenal gland predict significantly worse survival than similarly staged tumors with fat invasion and they have a prognosis similar to that of stage pT4 disease. (nih.gov)
  • The median overall survival was not reached. (actionkidneycancer.org)
  • In univariate analysis, there was a statistically significant correlation between p53 and mdm2 overexpression in the same tumor and poor survival( P = 0.00179). (aacrjournals.org)
  • Median overall survival was not reached in either group. (ascopost.com)
  • Median progression-free survival was 16.6 months vs 8.3 months. (ascopost.com)
  • The median disease-free survival was not reached in either the pembrolizumab or the placebo arm. (dana-farber.org)
  • Therefore, in the present investigation the expression of protein within different tissue areas obtained from renal cell carcinomas, their invasion front and corresponding histologically benign renal parenchyma was determined and statistically correlated with several tumor and patient characteristics including the disease-specific long-term survival following surgical treatment. (uni-luebeck.de)
  • Kaplan-Meier method and log-rank test were used to compare the differences of median progression free survival (PFS) and overall survival (OS) under different HER2 expression status.Results:All the 77 patients received a median of 11 (range: 2 - 45) doses of anti-PD-1 treatment with a median duration of treatment of 6.4 (range: 1.5 - 47.8) months and the ORR was 33.8% (26/77). (bvsalud.org)
  • Some factors such as individual treatment strategy, according to the histology of the primary tumor, plan of treatment strategies carried out in a multidisciplinary manner, risk-benefit of radiotherapy, assessment of the degree of spinal instability, improvement in communication and referral between specialists in oncology showed an increase in the survival of these patients. (bvsalud.org)
  • Unadjusted median survival time was 388, 542 and 1473 days for the ALS, no ALS and possible ALS groups, respectively. (cdc.gov)
  • After 2.7 years median follow-up, 3 of the 12 patients with pT3bN0 disease had metastases, but there were no local recurrences. (nih.gov)
  • She found a mass in my abdomen, X-ray, MRI and CT confirmed an 8cm tumour in my left kidney, no metastases. (cancer.org)
  • Case 1 imaging examination revealed a left kidney tumor with venous TT (Mayo stage 1) and multiple lung metastases. (biomedcentral.com)
  • The imaging examination of case 3 showed left kidney tumor with retroperitoneal lymphadenopathy, left renal vein TT (Mayo grade 0) and multiple lung metastases. (biomedcentral.com)
  • They developed metastases in the colon, pancreas, and duodenum, respectively 12-168 months (median time 156 months) following primary tumor resection. (aku.edu)
  • Whereas p53 and mdm2 positivity correlated significantly ( P = 0.00004), no correlation could be found between mdm2 protein overexpression and tumor stage, lymph node involvement, and presence of distant metastases. (aacrjournals.org)
  • Multivariate analysis revealed that coincident mdm2/p53 overexpression, the presence of distant metastases,and tumor grade were independent predictors for tumor progression. (aacrjournals.org)
  • This risk level was defined as tumor stage 2 with nuclear grade 4 or sarcomatoid differentiation, tumor stage 3 or higher, regional lymph node metastasis, or stage M1 (metastases that had been surgically removed) with no evidence of disease. (dana-farber.org)
  • No metastases attributable to LOT were identified (median follow-up 9.6 years). (elsevierpure.com)
  • Our outcomes compare favorably to published data on open surgical radical nephrectomy in this setting, and HALN should be considered in centers with experience with this technique. (nih.gov)
  • Secondary outcomes included change in tumor diameter, RENAL nephrometry score, renal function based on eGFR, tumor response, and surgical complications. (medpagetoday.com)
  • Six of the 26 patients had Clavien grade III-IV surgical complications after partial nephrectomy, including urine leaks in four patients. (medpagetoday.com)
  • If it is a high-risk Mayo grade 0 TT or even grade 1 TT, traditionally two steps were utilized including management of the inferior vena cava and removement of the TT, and then nephrectomy after changing the surgical position. (biomedcentral.com)
  • The aim of the study was to explore the feasibility of single position transperitoneal laparoscopic radical nephrectomy (LRN) and high-risk Mayo 0 and 1 tumor thrombectomy and the surgical techniques were described in detail. (biomedcentral.com)
  • Surgical resection is performed and pathologic evaluation shows completely resected Wilms tumor with focal penetration of the renal capsule. (pedsurglibrary.com)
  • Conclusions: Each scoring system outperformed tumor size and location, and may be useful when describing the surgical complexity of renal tumors treated with partial nephrectomy. (uky.edu)
  • Conclusions: The results of this study suggest that both TP and RP are feasible approaches when performing MI-PN, irrespectively from tumor location or surgical complexity. (unipg.it)
  • A sufficient follow-up after surgical therapy was available in 251 cases In total, 88 out of 251 patients (35%) had died from tumor progression after a median follow-up of 138 (36-240) months. (uni-luebeck.de)
  • The study found that certain chemotherapy medications - including ifosfamide , cisplatin , carboplatin, high-dose methotrexate and high-dose cyclophosphamide - as well as radiation aimed at the kidney region and nephrectomy (surgical removal of part or all of the kidney) increased the risks of later kidney damage. (rxwiki.com)
  • Nephrectomy or surgical removal of a kidney is the best treatment for a kidney tumor, providing that the patient is not in kidney failure. (animalsurgicalcenter.com)
  • The excision of the tumor with a minimal margin of healthy parenchyma surrounding the neoplasm is currently considered the standard technique for NSS, in order to minimize the risk of positive surgical margins (PSMs) and achieve optimal local cancer control. (unifi.it)
  • UroToday - Positive Surgical Parenchymal Margin After Laparoscopic Partial Nephrectomy for Renal Cella: Oncological Outcomes Carcinom Thursday, 15 March 2007 BERKELEY, CA (UroToday.com) - Positive margins following supposedly curative surgery can be devastating for patient and surgeon alike. (theroboticsurgeon.com)
  • Minimally invasive nephrectomy is performed routinely for adult renal tumors and for many benign pediatric conditions. (northwestern.edu)
  • Although open radical nephroureterectomy remains the standard of care for Wilms tumor and most pediatric renal malignancies, there are an increasing number of reports of minimally invasive surgery (MIS) for those operations as well. (northwestern.edu)
  • The remaining studies reported only on minimally invasive nephrectomy. (northwestern.edu)
  • Intraoperative ultrasonography has facilitated the management of these tumors during minimally invasive partial nephrectomy. (johnshopkins.edu)
  • To summarize the available evidence on renorrhaphy techniques and to assess their impact on peri‐operative outcomes after minimally invasive partial nephrectomy (MIPN). (bjuinternational.com)
  • Integrated overview of evidence‐based technical principles for renal reconstruction during minimally invasive partial nephrectomy and suggested standardized reporting of key renorrhaphy features in clinical studies on this topic. (bjuinternational.com)
  • Background: Aim of this study was to evaluate and compare perioperative outcomes of transperitoneal (TP) and retroperitoneal (TR) approaches in a multi-institutional cohort of minimally invasive partial nephrectomy (MI-PN). (unipg.it)
  • RFA is a good alternative to partial or radical nephrectomy for SRMs, although randomized trials comparing surgery to minimally invasive thermal ablation techniques are missing. (regionh.dk)
  • For the nivolumab/cabozantinib group vs the sunitinib group, median patient age was 62 years (range = 29-90 years, 40.9% ≥ 65 years) vs 61 years (range = 28-86 years, 36.0% ≥ 65 years), and 77% vs 71% of patients were male. (ascopost.com)
  • Conclusions: RPN is feasible, safe, and effective in the treatment of select intrarenal kidney tumors with outcomes similar to those of partially exophytic tumors. (johnshopkins.edu)
  • Completely intrarenal kidney tumors should not be automatically relegated to radical nephrectomy or open surgery. (johnshopkins.edu)
  • Two types of kidney tumors exist: ones that originate from within the kidney and ones that have spread to the kidney from another tumor within the body. (animalsurgicalcenter.com)
  • No patients had progression of their primary tumor. (urologytimes.com)
  • The objective was to compare time-to-tumor progression (TTP) in patients receiving SUTENT plus best supportive care versus patients receiving placebo plus best supportive care. (pfizermedicalinformation.com)
  • TTP=time-to-tumor progression. (pfizermedicalinformation.com)
  • BACKGROUND: Acid retention associated with reduced GFR exacerbates nephropathy progression in partial nephrectomy models of CKD and might be reflected in CKD patients with reduced eGFR by increased anion gap (AG). (cdc.gov)
  • Liver metastasis, high-grade tumor, absence of CN, non-clear cell histology, and MSKCC (Memorial Sloan-Kettering Cancer Center) poor prognosis status were associated with adverse treatment outcomes. (muni.cz)
  • In the study, 167 cases were followed up for 12 months (1-62 months), including 1 case with recurrence and metastasis , 4 cases with metastasis , and 2 cases with other tumors (1 case died). (bvsalud.org)
  • Urinary tract ultrasound, enhanced MRI, MRA, chest CT and bone scan were performed before surgery to determine the location, size and metastasis of the tumor. (biomedcentral.com)
  • The imaging examinations of case 2 showed a left kidney tumor with venous TT (Mayo grade 1), accompanied by left adrenal gland metastasis. (biomedcentral.com)
  • Note that presence of tumor within the adrenal gland is not interpreted as metastasis. (pedsurglibrary.com)
  • The 2002 pTNM (for pathologic Tumor Lymph Node and Metastasis ) classification system was used for pathologic staging [ 4 ]. (journalmc.org)
  • Advanced imaging such as abdominal MRI or CT scan can be used to define the extent of the kidney tumor, but also may be used to determine if metastasis is also present. (animalsurgicalcenter.com)
  • von Hippel-Lindau (VHL) disease, or von Hippel-Lindau syndrome, is a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems that have subsequent potential for malignant change. (medscape.com)
  • As you know, at around the time, almost 10 years ago, some of these neoadjuvant trials had not mandated biopsy, so we had patients with benign tumors or different types of histologies. (medscape.com)
  • Twenty-eight patients had benign tumors or underwent treatment for recurrence of prior RCC. (regionh.dk)
  • What are my chances that my kidney tumor is benign? (theroboticsurgeon.com)
  • UroToday - Incidence of Benign Pathologic Findings at Partial Nephrectomy for Solitary Renal Mass Presumed to be Renal Cell Carcinoma on Preoperative Imaging The authors conclude that there is no reliable indicator of benign pathology preoperatively in solitary renal masses, as all of these were considered to be renal cell carcinoma on preoperative imaging. (theroboticsurgeon.com)
  • All the cases of CDC which were diagnosed at our center following a radical or partial nephrectomy in the past 15 years were included. (e-urol-sci.com)
  • A retrospective review of the hospital's electronic database was conducted to identify the cases of CDC of the kidney from among those patients who underwent either radical or partial nephrectomy between June 2005 and January 2020. (e-urol-sci.com)
  • [ 7 ] including radical or partial nephrectomy or nephron-sparing surgery. (medscape.com)
  • This review demonstrates that lymph node harvest has been inadequate for MIS pediatric nephrectomy and there appears to be an increased risk for intraoperative spill. (northwestern.edu)
  • Stewart also mentioned the phase 3 PROSPER trial, which compared perioperative nivolumab with observation in patients with high-risk, localized RCC scheduled to undergo nephrectomy. (urologytimes.com)
  • CONCLUSION: In the hands of an experienced laparoscopist, LPN can safely be performed for hilar tumors, with preservation of perioperative outcomes and durable renal functional and oncologic outcomes. (hofstra.edu)
  • To clarify these issues we evaluated the association of tumor size, location, R.E.N.A.L. (Radius/Exophytic/Nearness to collecting system/Anterior/Location), PADUA (Preoperative Aspects and Dimensions Used for an Anatomical classification) and centrality index scores with perioperative outcomes. (uky.edu)
  • Patient demographics, tumor characteristics, and perioperative outcomes were compared for patients with intrarenal tumors and tumors with any exophytic component. (johnshopkins.edu)
  • The KEYNOTE-564 trial was designed to evaluate adjuvant immunotherapy following partial or radical nephrectomy (removal of the cancerous kidney) within 12 weeks prior to randomization. (dana-farber.org)
  • Twenty-four cases of LOT were identified among 574 consecutive tumors diagnosed as oncocytoma and treated with partial or radical nephrectomy, corresponding to an incidence of 4.18% of tumors historically diagnosed as oncocytomas, and 0.35% of 6944 nephrectomies performed between 1970 and 2012. (elsevierpure.com)
  • Irreversible electroporation is a predominantly nonthermal and adjacent structure-sparring ablation method that has been proven safe and efficient in the treatment of tumors in the liver, pancreas, and prostate. (rsna.org)
  • Radical nephrectomy is commonly preferred for treatment of tumors that extend into the inferior vena cava. (medscape.com)
  • Thirteen patients underwent HALN for radiologic T3b disease (tumor thrombus confined to the renal vein on preoperative computed tomography) under the care of three surgeons at two centers between 1997 and 2006. (nih.gov)
  • Median preoperative global GFR was comparable for TE and SPN (75mL/min/1.73m 2 versus 78mL/min/1.73m 2 , p=0.6). (auanet.org)
  • Hilar lesions were defined as renal cortical tumors in direct physical contact with the renal artery, vein, or both, as identified on preoperative imaging and confirmed intraoperatively. (hofstra.edu)
  • Materials and Methods: Patients undergoing partial nephrectomy with available preoperative imaging were identified from 2005 to 2011. (uky.edu)
  • Study subjects were grouped by PN or RN, then matched by age, sex, comorbidities, body mass index, tumor size and depth, histologic type, and preoperative estimated glomerular filtration rate (eGFR) using propensities score. (korea.ac.kr)
  • Tumor enucleation (TE) optimizes parenchymal preservation and could yield better function than standard partial nephrectomy (SPN). (auanet.org)
  • Standard partial nephrectomy (PN) has been defined as the excision of the tumor comprising a minimal margin of healthy peritumoral renal parenchyma. (unifi.it)
  • There was 1 recurrence detected in the hilar group, with a median follow-up of 41.6 months. (hofstra.edu)
  • At a median follow-up of 26 months (24, 32), there was no local recurrence and only 1 distant recurrence was detected. (ewha.ac.kr)
  • For inclusion in the trial, patients were required to have a clear-cell component of their tumor and be at intermediate-high or high risk of recurrence. (dana-farber.org)
  • While off-clamp and clamped robotic partial nephrectomy were equally safe, a relevant number of off-clamp partial nephrectomy cases were not feasible due to later bleeding. (urologytimes.com)
  • Objective To assess the functional and oncologic outcomes of robotic laparoendoscopic single site surgery (LESS) partial nephrectomy with a minimum of 2-year follow-up. (ewha.ac.kr)
  • Materials and Methods Thirty-nine consecutive patients who had undergone robotic LESS partial nephrectomy were identified with a minimum of 2-year follow-up. (ewha.ac.kr)
  • Conclusion This study appears to be the first to report on intermediate term functional and oncologic outcomes after robotic LESS partial nephrectomy. (ewha.ac.kr)
  • Source: Journal of Robotic Surgery, Volume 2, Number 3 / September, 2008 Conclusions We report a large, multi-institutional series of RPN for renal tumors, confirming safety and feasibility reported in previous small, single-institution studies. (theroboticsurgeon.com)
  • Source: Washington University Website "Robotic surgery is more efficient and precise than either open or laparoscopic surgery for tumors confined to the kidney," says Bhayani, assistant professor of surgery and a leader in the field of robotic surgery. (theroboticsurgeon.com)
  • Additionally, performance status (PS) and resection of the primary tumor were observed to influence mOS. (cancerindex.org)
  • 27 patients with bladder UC received surgery on the primary tumors including radical cystectomy (n = 18), partial cystectomy (n = 4) and transurethral resection (n = 5). (bvsalud.org)
  • 43 patients with renal pelvis or ureteral UC received surgery on the primary tumors including radical nephroureterectomy (n = 38), local resection (n = 3) and palliative resection (n = 2). (bvsalud.org)
  • These data helped inform the launch of the phase 2 NAXIVA trial, a single-arm, multi-center trial that included 20 patients with RCC with venous tumor thrombus. (urologytimes.com)
  • These data demonstrate that HALN for renal cell cancer with tumor thrombus limited to the renal vein is feasible. (nih.gov)
  • SAN DIEGO -- Use of neoadjuvant axitinib (Inlyta) resulted in significant reductions in tumor size and complexity, enabling partial nephrectomy in a cohort of patients with highly complex renal masses in whom the procedure would ordinarily not be feasible, according to an interim analysis from a small phase II trial. (medpagetoday.com)
  • It is feasible to control left renal vein and partial inferior vena cava through descending colon mesentery in a single position during LRN and tumor thrombectomy for the treatment of high-risk Mayo grade 0 and 1 TT. (biomedcentral.com)
  • In contrast, expression of p27 Kip1 within the primary tumors was not identified to reveal any prognostically important information. (uni-luebeck.de)
  • Immunohistochemical (IHC) staining was used to detect the expression level of HER2 protein in the tumor tissues (74 cases from primary tumors and 3 cases from metastatic tumors) obtained from the initial diagnosis. (bvsalud.org)
  • The median resected tumor size was 3 cm (2, 3.7), and the median operative time was 185 minutes (135, 237). (ewha.ac.kr)
  • Results Multivariate analyses showed that tumor location, pathologic T stage, lymphovascular invasion, margin status, and albumin level were independent contributors. (scielo.org)
  • In a case series with pathologically proven renal cell carcinomas, 32% of tumors with a diameter ≤3 cm were echogenic. (medscape.com)
  • To assess outcomes after hand-assisted laparoscopic nephrectomy (HALN) for renal cell cancer tumor thrombus confined to the renal vein and to compare outcomes with published series in this setting. (nih.gov)
  • The aim of this study was to analyze the feasibility and the safety of laparoscopic nephrectomy in the treatment of pathologies of the upper urinary tract through the experience of the Urology B department. (springeropen.com)
  • We have retrospectively and monocentrally selected patients who underwent laparoscopic nephrectomy from January 2017 to December 2019. (springeropen.com)
  • Laparoscopic nephrectomy appears to be an efficient and reliable technique. (springeropen.com)
  • When it comes to urology, it all started when Ralph Clayman performed the first laparoscopic nephrectomy in 1991 [ 1 ]. (springeropen.com)
  • In 1993, Gaur proposed the retro-peritoneal (RP) approach to perform laparoscopic nephrectomy [ 4 ]. (springeropen.com)
  • Since then, laparoscopic nephrectomy has undergone significant development, whether performed trans or retroperitoneally, with or without robot assistance. (springeropen.com)
  • The aim of this study is to evaluate the feasibility of laparoscopic nephrectomy, its advantages and especially its complications through the experience of the urology B department of the Ibn Sina hospital. (springeropen.com)
  • Patients managed with partial nephrectomy (PN) with necessary data for analysis of preservation of ipsilateral parenchymal mass and global GFR from two centers were included. (auanet.org)
  • Why and how it is replacing past approaches in the management of solid tumors is the subject of this two-part overview. (cancernetwork.com)
  • The situation with solid tumors is considerably more complex, and the evolution of targeted therapies for these cancers is still in its infancy. (cancernetwork.com)
  • At present, and for some years to come, the treatment of most solid tumors will continue to rely on a patchwork of empirically derived and newly introduced molecularly targeted agents. (cancernetwork.com)
  • This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). (rsna.org)
  • We had, I believe, 11 out of 24 patients with a partial response - about 46% of patients who had a partial response by the response evaluation criteria in solid tumors (RECIST) criteria - which was quite encouraging, with a relatively short duration of therapy. (medscape.com)
  • The adult survivors also had been treated for brain, bone, kidney, soft tissue or liver tumors, among other types of cancers. (rxwiki.com)
  • In making the overall evaluation, the Working Group considered the following evidence: (i) although the hypothesis linking the formation of mouse liver tumors with peroxisome proliferation is plausible, trichloroethylene also induced tumors at other sites in mice and rats. (who.int)
  • Diagnosis of RCC with rhabdoid features was confirmed in both primary and metastatic tumors. (aku.edu)
  • So we showed that in this complex cohort of patients, axitinib can be used to cytoreduce masses and enable partial nephrectomy in a highly specific cohort of patients with imperative indications for the procedure," Hakimi concluded, adding that accrual for the trial is ongoing, with a targeted enrollment of 5o patients. (medpagetoday.com)
  • The present paper analyses a large cohort of patients, and the results indicate that primary tumor removal should still be strongly considered in patients who are treated with targeted therapies. (muni.cz)
  • To explore the feasibility of single-position laparoscopic radical nephrectomy (LRN) and tumor thrombectomy for left renal cell carcinoma with high-risk Mayo 0 and 1 tumor thrombus (TT). (biomedcentral.com)
  • Mucinous tubular and spindle cell carcinoma of the kidney is a rare and a recently described tumor with a favorable prognosis. (journalmc.org)
  • LOT is an uncommon eosinophilic renal neoplasm with an indolent prognosis that constitutes ∼4% of tumors historically diagnosed as oncocytoma. (elsevierpure.com)
  • We conducted a comprehensive evaluation of clinical and histologic parameters in PRCC in nephrectomies and their impact on prognosis, with an emphasis on World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grade, tumor architecture (solid, micropapillary, and hobnail), and PRCC type. (lab.equipment)
  • Treatment outcome of laparoscopic partial nephrectomy in patients with renal tumors of moderate to high complexity]. (bvsalud.org)
  • To investigate the treatment outcome of laparoscopic partial nephrectomy in the patients with renal tumors of moderate to high complexity (R.E.N.A.L. score 7-10). (bvsalud.org)
  • Based on the complexity of the tumor , with the increase of difficulty, the warm ischemia time and operation time tend to increase gradually, while "the trifecta" rate gradually decreases. (bvsalud.org)
  • Specific tumour features (i.e. size, hilar location, anatomical complexity, nearness to renal sinus and/or urinary collecting system), surgeon's experience, robot‐assisted technology, as well as the aim of reducing warm ischaemia time and the amount of devascularized renal parenchyma preserved represented the key factors driving the evolution of the renorrhaphy techniques during MIPN over the past decade. (bjuinternational.com)
  • Median postoperative stay was 3 days. (nih.gov)
  • Stage II (without anaplasia) tumors receive postoperative vincristine (VCR) and dactinomycin (AMD) for 18 weeks. (pedsurglibrary.com)
  • Material and methods: All consecutive patients undergone MI-PN for clinical T1 renal tumors at 26 Italian centers (RECORd2 project) between 01/2013 and 12/2016 were evaluated, collecting the pre-, intra-, and postoperative data. (unipg.it)
  • Across all studies, there were a total of 151 patients, 126 of which had Wilms tumor and 10 patients had RCC. (northwestern.edu)
  • Many noncomparison studies reported the harvest of 2 of fewer lymph nodes for Wilms tumor. (northwestern.edu)
  • A three-year old child presents with a large renal mass suspected to be a Wilms tumor. (pedsurglibrary.com)
  • staging for Wilms tumor on Childrens Oncology Group (COG) protocols is shown below. (pedsurglibrary.com)
  • Children with which of the following conditions should receive screening renal ultrasounds for nephroblastoma (Wilms tumor)? (pedsurglibrary.com)
  • Wilms tumor usually presents as an asymptomatic abdominal mass in an otherwise healthy child. (pedsurglibrary.com)
  • Nephrogenic rests are also present in the predisposition syndromes of WAGR (Wilms tumor- aniridia - genital anomalies - retardation), Denys-Drash (nephropathy, intersex disorders), Beckwith-Wiedemann (hemihypertrophy, macroglossia, hypoglycemia) and isolated hemihypertrophy. (pedsurglibrary.com)
  • Dome JS, Huff V. Wilms' Tumor Overview, in Pagon RA, Bird TD, Dolan CR, Stephens K (eds) GeneReviews [Internet] University of Washington, Seattle, www.ncbi.nlm.nih.gov NCBI Literature updated 2011. (pedsurglibrary.com)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • To determine whether the clinical behavior of pT3a adrenal tumors differs from that of tumors with perinephric fat invasion (also stage pT3a) a retrospective analysis was performed. (nih.gov)
  • The present study was designed to analyze the expression of p53 and mdm2 in clear cell renal cell carcinoma with special emphasis on their association with tumor grade and clinical outcome. (aacrjournals.org)
  • No statistically significant differences were found among patients with positive and negative margins in terms of gender, BMI, indication to NSS (elective/relative vs. imperative), symptoms at the time of diagnosis, ECOG performance status, number of lesions, clinical stage and tumor side. (unifi.it)
  • observation remains the standard of care after nephrectomy or clinical-trial enrollment. (medscape.com)
  • Objective:To explore the effect of different HER2 expression levels and gene amplification on the efficacy of immunotherapy in metastatic urothelial carcinoma (UC).Methods:The clinical data of 77 patients with metastatic UC who received immunotherapy from June 2017 to April 2021 after failure to the previous chemotherapy were analyzed retrospectively, including 49 males and 28 females with the median age of 62 years. (bvsalud.org)
  • Also new in the guideline: The guideline prioritizes partial nephrectomy in the management of cT1a renal masses and nephron-sparing approaches for patients with solitary kidneys, bilateral tumors, known familial RCC, pre-existing chronic kidney disease (CKD), or proteinuria. (urologytimes.com)
  • Note the multiple echogenic tumors of varying sizes in both kidneys. (medscape.com)
  • Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive subtype of renal cancer arising from the collecting duct epithelium of the kidney with an incidence of 0.4%-1.8% of all renal tumors. (e-urol-sci.com)
  • Methods: The search focused on MIS for renal tumors in children and followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist. (northwestern.edu)
  • Patients and Methods: For analysis of p27 Kip1 expression in 420 tumor nephrectomy specimens obtained from 420 consecutively included patients, tissue microarrays were used comprising 1260 tissue samples each obtained from the tumor itself, the invasive front as well as the non-malignant surrounding parenchyma. (uni-luebeck.de)
  • Materials and Methods We reviewed our prospectively maintained database for RN and PN in T1b renal tumors surgically treated between 1999 and 2011 at five institutions in Korea. (korea.ac.kr)
  • The PROSPER-RCC trial took the unique approach of giving immunotherapy before surgery when the tumor was in place, and all of the immune cells had close interaction with the agent, such that it could potentially stimulate a response," said ECOG-ACRIN Genitourinary Committee Co-Chair Naomi B. Haas, MD , a medical oncologist at Penn Medicine's Abramson Cancer Center in Philadelphia. (eurekalert.org)
  • Simple Summary: The treatment of metastatic renal cell carcinoma is traditionally initiated with the removal of the diseased kidney with the tumor in many patients. (muni.cz)
  • The role of cytoreductive nephrectomy (CN) in treatment of locally advanced or metastatic renal cell carcinoma (mRCC) in the era of targeted therapies (TT) is still not clearly defined. (muni.cz)
  • All patients with left renal cell carcinoma and venous TT (high-risk Mayo grade 0 and 1) who were performed single-position LRN and tumor thrombectomy were involved. (biomedcentral.com)
  • Mucinous tubular and spindle cell carcinoma of the kidney is a rare and a distinctive renal tumor with a relatively indolent behavior. (journalmc.org)
  • Commentary on "Detailed analysis of morbidity following nephrectomy for renal cell carcinoma in octogenarians. (elsevierpure.com)
  • Dive into the research topics of 'Commentary on "Detailed analysis of morbidity following nephrectomy for renal cell carcinoma in octogenarians. (elsevierpure.com)
  • Histological examination of the nephrectomies carried out in our department revealed mainly chronic non-specific pyelonephritis in 24 (35.3%) patients, followed by renal cell carcinoma in 23 (33.82%) patients and urothelial carcinoma in 9 (13.2%) patients. (springeropen.com)
  • Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
  • Tumors that originate within the kidney include renal carcinoma, renal adenocarcinomas, transitional cell carcinoma, sarcomas of varying types and a tumor that originates from embryonic cells called a nephroblastoma. (animalsurgicalcenter.com)
  • Purpose The study was to compare the oncologic and functional outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for pathologically proven T1b renal cell carcinoma using pair-matched groups. (korea.ac.kr)
  • Sarcomatoid renal cell carcinoma (SRCC) is currently defined in the 2004 World Health Organization (WHO) classification of renal tumors as any histologic type of renal cell carcinoma (RCC) containing foci of high-grade malignant spindle cells. (medscape.com)
  • Tumor biopsy was performed in 94% of cases, of which 56% were confirmed renal cell carcinoma (RCCs). (regionh.dk)
  • The therapeutic approach for renal cell carcinoma is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
  • Tumor enucleation can be considered specifically for patients with familial RCC, multifocal disease, or severe CKD, although more research is needed to conclude whether this is oncologically safe. (urologytimes.com)
  • Simple tumor enucleation (SE) has been defined as the blunt tumor excision without removing a visible rim of parenchymal tissue around the pseudocapsule. (unifi.it)
  • For patients that have large masses that have imperative indications for partial nephrectomy -- such as a decreased eGFR [estimated glomerular filtration rate] or some other indication that would make them dialysis dependent if they underwent a radical nephrectomy -- using a neoadjuvant approach can make them amenable to a partial nephrectomy and allow them to conserve more renal function and avoid dialysis dependence or some other complication from chronic kidney disease. (medpagetoday.com)
  • Only two patients had a greater than 50% reduction in their eGFR, and only one patient was dialysis dependent, and that patient underwent a radical nephrectomy. (medpagetoday.com)
  • Axitinib (Inlyta) appears to be well tolerated and effective for the treatment of patients with metastatic RCC who were unsuitable for nephrectomy. (urologytimes.com)
  • In an evaluation of circulating "cell-free" tumor DNA (liquid biopsy) and known mutations found in RCC, researchers determined that 67% of their cohort had detectable DNA mutations versus 3% of control patients. (urologytimes.com)
  • We sought to evaluate the safety, feasibility, and comparative effectiveness of robot-Assisted partial nephrectomy (RPN) in the management of completely intrarenal tumors. (johnshopkins.edu)
  • abstract = "Purpose: Multiple scoring systems have been proposed to standardize the description of anatomical features of renal tumors. (uky.edu)
  • abstract = "Introduction: Intrarenal tumors pose a unique challenge to surgeons due to the lack of visual cues on the kidney surface. (johnshopkins.edu)
  • Radical nephrectomy should be considered when there is increased oncologic potential. (urologytimes.com)
  • Laparoscopic partial nephrectomy for hilar tumors: oncologic and renal" by A. K. George, A. S. Herati et al. (hofstra.edu)
  • OBJECTIVE: To present our experience with laparoscopic partial nephrectomy (LPN) for hilar tumors and evaluate intermediate oncologic and renal functional outcomes. (hofstra.edu)
  • Young age, SE, middle or lower tumor location and low grade tumor are all independent predictors of NSMs. (unifi.it)