• Mechlorethamine also known as mustine, brand name MUSTARGEN administered intravenously is the prototype anticancer chemotherapeutic drug, is indicated for the palliative treatment of Hodgkin's disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. (ncats.io)
  • Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard sold under the brand name Mustargen among others. (wikipedia.org)
  • Mechlorethamine injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
  • In 2009, a shortage of mechlorethamine (a standard component of chemotherapy regimens for childhood leukemia) forced oncologists to treat patients with an alternative agent, cyclophosphamide (which was thought to be equally effective). (ahrq.gov)
  • A group of 243 patients with mycosis fungoides (MF) received treatment with topical applications of dilute acqueous solutions of mechlorethamine and/or systemic chemotherapy over the past 10 years. (johnshopkins.edu)
  • MUSTARGEN® MSD Mechlorethamine HCl Alkylating Agent Action And Clinical Pharmacology: Mechlorethamine, a biologic alkylating agent, has a cytotoxic action which inhibits rapidly proliferating cells. (rxmed.com)
  • The particular nitrogen mustard chlormethine (mechlorethamine) was first synthesized. (wikipedia.org)
  • Bendamustine is a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring. (centerwatch.com)
  • Mechlorethamine (maybe bendamustine, its deriv? (freezingblue.com)
  • In 2013 was approved orphan drug Valchlor (mechlorethamine) gel for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. (ncats.io)
  • Mechlorethamine gel is FDA approved for the treatment of Stage 1A and 1B mycosis fungoides-type cutaneous T-cell lymphoma in patients who have received prior skin-directed therapy. (lls.org)
  • There have been studies demonstrating that topical administration of mechlorethamine has efficacy in mycosis fungoides-type cutaneous T cell lymphoma. (wikipedia.org)
  • Historically, some uses of mechlorethamine have included lymphoid malignancies such as Hodgkin's disease, lymphosarcoma, chronic myelocytic leukemia, polycythemia vera, and bronchogenic carcinoma Mechlorethamine is often administered intravenously, but when compounded into a topical formulation it can also be used to treat skin diseases. (wikipedia.org)
  • By having the commercial rights of VALCHLOR ® (mechlorethamine) in China, Kyowa Kirin has shown that it is serious about meeting patients' unmet needs in the rare disease therapeutic areas" added Kazunobu Mikawa, General Manager in China (KKCN) , "VALCHLOR ® will be one of our strategic products for our dermatology and hemato-oncology franchise. (pharmiweb.com)
  • VALCHLOR ® is contraindicated in patients with known severe hypersensitivity to mechlorethamine. (pharmiweb.com)
  • Mechlorethamine is also used to treat polycythemia vera (a disease in which too many red blood cells are made in the bone marrow). (medlineplus.gov)
  • Mechlorethamine comes as powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Though ingestion is uncommon, if mechlorethamine is swallowed it causes severe chemical burns to the gastrointestinal tract and concomitant nausea, vomiting, diarrhea, abdominal pain, and hemorrhage. (wikipedia.org)
  • Mechlorethamine is a highly toxic medication, especially for women who are pregnant, breastfeeding, or of childbearing age. (wikipedia.org)
  • The impact of drug shortages on children with cancer-the example of mechlorethamine. (ahrq.gov)
  • Mechlorethamine and its derivatives form electrophilic alkyl groups. (centerwatch.com)
  • Topical mechlorethamine has not been associated with liver injury, although the possibility of systemic absorption continues to make hepatic adverse events mentioned as a concern. (nih.gov)
  • 1] Because of the potential for serious adverse reactions in the breastfed infant, breastfeeding from mechlorethamine mothers should not breastfed during therapy with mechlorethamine therapy, including topical application. (nih.gov)
  • Vallerand AHA, Sanoski CAC, Quiring CC. Mechlorethamine (topical). (unboundmedicine.com)
  • Historically, some uses of mechlorethamine have included lymphoid malignancies such as Hodgkin's disease, lymphosarcoma, chronic myelocytic leukemia, polycythemia vera, and bronchogenic carcinoma Mechlorethamine is often administered intravenously, but when compounded into a topical formulation it can also be used to treat skin diseases. (wikipedia.org)
  • There have been studies demonstrating that topical administration of mechlorethamine has efficacy in mycosis fungoides-type cutaneous T cell lymphoma. (wikipedia.org)
  • 1. Long-term efficacy, curative potential, and carcinogenicity of topical mechlorethamine chemotherapy in cutaneous T cell lymphoma. (nih.gov)
  • 2. A prospective study of cutaneous intolerance to topical mechlorethamine therapy in patients with cutaneous T-cell lymphomas. (nih.gov)
  • 3. Mechlorethamine gel for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma. (nih.gov)
  • 4. Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. (nih.gov)
  • 16. Topical mechlorethamine therapy for early stage mycosis fungoides. (nih.gov)
  • 17. Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data. (nih.gov)
  • 18. Response of mycosis fungoides to topical chemotherapy with mechlorethamine. (nih.gov)
  • 19. Treatment of early-stage mycosis fungoides with twice-weekly applications of mechlorethamine and topical corticosteroids: a prospective study. (nih.gov)
  • Mechlorethamine is currently available as a topic gel for treatment of cutaneous T-cell lymphomas and mycosis fungoides, but requires special handling. (nih.gov)
  • 14. Frequent low doses of intravenous mechlorethamine for late-stage mycosis fungoides lymphoma. (nih.gov)
  • Currently, the FDA-approved drugs available in the CTCL market for the treatment of mycosis fungoides or Sézary syndrome include Istodax (romidepsin), Valchlor (mechlorethamine), Uvadex (methoxsalen), Targretin (bexarotene), Adcetris (brentuximab vedotin) and Zolinza (vorinostat) . (delveinsight.com)
  • Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate. (researchwithnj.com)
  • You must check to make sure that it is safe for you to take mechlorethamine with all of your drugs and health problems. (medicine.com)
  • Because it is irritating to local tissues and causes gastrointestinal intolerance, mechlorethamine is administered intravenously. (nih.gov)
  • The impact of drug shortages on children with cancer-the example of mechlorethamine. (ahrq.gov)
  • The mechlorethamine portion of Emcyt (Estramustine) prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells. (pocketpills.com)
  • Mechlorethamine is in a class of medications called alkylating agents. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to mechlorethamine, any other medications, or any of the ingredients in mechlorethamine injection. (medlineplus.gov)
  • It is made up of 2 different types of medications joined together: Mechlorethamine and estrogen. (pocketpills.com)
  • The adverse effects of mechlorethamine depend on the formulation. (wikipedia.org)
  • Mechlorethamine is used to treat a type of lymphoma that affects the skin. (medicine.com)
  • The potential mechanism of hepatotoxicity from mechlorethamine is probably similar to that of other alkylating agents, a direct cytotoxic injury which is most specific to rapidly dividing cells, but in high doses can injury other cell types such as sinusoidal lining cells or hepatocytes. (nih.gov)
  • Though ingestion is uncommon, if mechlorethamine is swallowed it causes severe chemical burns to the gastrointestinal tract and concomitant nausea, vomiting, diarrhea, abdominal pain, and hemorrhage. (wikipedia.org)
  • Check with the doctor or pharmacist to see how to handle mechlorethamine. (medicine.com)
  • you should know that mechlorethamine may interfere with the normal menstrual cycle (period) in women, may stop sperm production in men, and may cause infertility (difficulty becoming pregnant). (medlineplus.gov)
  • You should not become pregnant or breast-feed while you are receiving mechlorethamine injection. (medlineplus.gov)
  • If you are pregnant or you get pregnant while taking mechlorethamine, call your doctor right away. (medicine.com)
  • Mechlorethamine is a highly toxic medication, especially for women who are pregnant, breastfeeding, or of childbearing age. (wikipedia.org)
  • Modifications of the chemical structure of mechlorethamine has led to similarly effective, but safer and better tolerated forms of alkylating agents, such as cyclophosphamide, ifosfamide, chlorambucil and melphalan. (nih.gov)
  • In recent years, mechlorethamine has been replaced by more stable alkylating agents such as cyclophosphamide (COPP). (nih.gov)
  • Most sources consider that mothers receiving antineoplastic therapy should not breastfeed, especially with alkylating agents such as mechlorethamine. (nih.gov)
  • The disease-free survival rate was 88 percent for the 181 patients whose treatment included mechlorethamine. (wgbh.org)
  • Given parenterally in combination with other antineoplastic agents it was associated with low rates of serum enzyme elevations during therapy, but mechlorethamine has not been implicated specifically in cases of acute, clinically apparent injury. (nih.gov)
  • You will need to take special care when handling mechlorethamine. (medicine.com)
  • Caregivers need to wear special gloves when putting on mechlorethamine and wash hands after use. (medicine.com)
  • Do not breast-feed while you take mechlorethamine. (medicine.com)
  • mechlorethamine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
  • If you get mechlorethamine in your eyes, it may cause eye problems like eye pain, burns, swelling, or blurred eyesight. (medicine.com)
  • Do not touch your eyes while using mechlorethamine. (medicine.com)
  • If you get mechlorethamine in your eyes, flush with water for at least 15 minutes and call your doctor. (medicine.com)
  • Your doctor may not want you to receive mechlorethamine. (medlineplus.gov)
  • Use mechlorethamine as ordered by your doctor. (medicine.com)
  • What are the side effects of mechlorethamine that I need to call my doctor about immediately? (medicine.com)