Maternal mice inbred c57bl. Medical search. Frequent questions

Families of recombinant inbred strains numbering from 25 to 5000 are often used to map the locations of DNA sequence differences (quantitative trait loci) that contributed to differences in phenotype in model organisms. (wikipedia.org)
It is possible to accumulate extensive genetic and phenotype data for each member of a family of recombinant inbred strains under several different conditions (e.g., baseline environment versus stressful environment). (wikipedia.org)
To further evaluate the role of CRTC1 in the brain, we generated a knockout mouse line and analyzed its behavioral and molecular phenotype. (nih.gov)
Right here, we report the phenotype of mice bred to hold two copies of the BAC, which extra utterly recapitulate the phenotypic options of HGPS in pores and skin, adipose, skeletal, and vascular tissues. (eumorphia.org)
The tumor phenotype in mice takes eight weeks to develop from the H-Ras and shp53 model. (genengnews.com)
The tumor phenotype is revealed when mice appear lethargic and have an enlarged head. (genengnews.com)
A very recent work shows that ENU-generated DISC1 L100P mice have multiple ENU-induced mutations which sum up to produce the phenotype [ 14 ]. (biomedcentral.com)
Surgical removal of interscapular BAT did not impact the behavioural phenotype of USF1 KO mice. (researchsquare.com)

Recombinant inbred strains or lines were first developed using inbred strains of mice but are now used to study a wide range of organisms - Saccharomyces cerevisiae (yeast), Zea mays (maize), barley, Drosophila melanogaster, C. elegans and rat. (wikipedia.org)
Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
Differences in hepatic fibrosis and granuloma size in several strains of mice infected with Schistosoma japonicum. (rsbmt.org.br)

The origins and history of recombinant inbred strains are described by Crow. (wikipedia.org)
While the potential utility of recombinant inbred strains in mapping analysis of complex polygenic traits was obvious from the outset, the small number of strains only made it feasible to map quantitative traits with very large effects (quasi-Mendelian loci). (wikipedia.org)
One of the initial motivations to use recombinant inbred strains is that expensive genotype data can be accumulated and reused - greatly simplifying mapping studies. (wikipedia.org)
As genotyping became progressively less expensive and more accurate the main advantage of using recombinant inbred strains and other genetic reference panels shifted to the ability to assemble massive and coherent databases on phenotypes (e.g., the GeneNetwork web service), and to use these coherent open-source data sets for large-scale collaborative research projects in predictive medicine and plant and animal research. (wikipedia.org)
Recombinant inbred strains are now widely used in systems genetics and to study gene-environment interactions. (wikipedia.org)
Chromosomes of recombinant inbred strains typically consist of alternating haplotypes of highly variable length that are inherited intact from the parental strains. (wikipedia.org)
All else being equal, the larger the family of recombinant inbred strains, the greater the power and resolution with which phenotypes can be mapped to chromosomal locations. (wikipedia.org)
Somewhat larger families of recombinant inbred strains were generated concurrently by Benjamin Taylor to map Mendelian and other major effect loci. (wikipedia.org)
In the 1990s the utility of recombinant inbred strains for mapping was significantly improved thanks to higher density genotypes made possible by the use of microsatellite markers. (wikipedia.org)

In order to understand the causal relationship between maternal UBE3A mutations and AS, we have constructed a mouse model with targeted inactivation of Ube3a. (nih.gov)
N -ethyl- N -nitrosourea (ENU)-induced inheritable missense point mutations in exon 2 of the mouse DISC1 gene have been of particular interest since Q31L mutant mice showed depression-like behaviors while L100P mutants showed schizophrenia-like phenotypes [ 4 ]. (biomedcentral.com)
Furthermore, a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513 (p.R250W) or Kif3c (p.R412H) alone do not led to clear phenotypes with gingival fibromatosis, whereas the double mutations led to gingival hyperplasia phenotypes. (nature.com)

We used a 4 h whole-body hyperthermia (WBH) protocol and, separately, systemic inflammation induced by bacterial endotoxin (LPS) at 250 µg/kg, to dissociate temperature and inflammatory elements of fever in two ASD animal models: C58/J and Shank3B- mice. (beds.ac.uk)
Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. (colorado.edu)
Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)

A recombinant inbred strain or recombinant inbred line (RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. (wikipedia.org)
The only exception is that the Y chromosome and the mitochondrial genome, both of which are inherited intact from the paternal and maternal strain, respectively. (wikipedia.org)
To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. (ox.ac.uk)
The immune response of nine inbred and one outbred strain of mice to the streptococcal group A polysaccharide was investigated with respect to magnitude and restriction. (silverchair.com)
the immune sera of these mice had their own, rather uniform isoelectric focusing spectra whereby structural genes of the low responder strain were expressed to predominant levels in 81% of the hybrids. (silverchair.com)
In this study we have increased the density of microsatellite markers 2- to 5-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH, and CXB). (nervenet.org)
Here, we add to the literature on the cerebellum in mouse models of autism with the characterization of the cerebellum in the idiopathic BTBR T + Itpr3 tf /J (BTBR) inbred mouse strain, which has behavioral phenotypes that are reminiscent of ASD in patients. (mdpi.com)
C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. (mmpc.org)

In a previous study, we characterized behavioral phenotypes of a mouse model generated by a sequential process of early-life social stress imitating child abuse or maltreatment composed of maternal separation (MS), social defeat (SD), and social isolation (SI). (encephalitisjournal.org)
The MS/SD/SI mice exhibited hyper-phenotypes of social interaction and offensive aggressiveness and hypo-phenotypes of predator fear and empathy-related behavior. (encephalitisjournal.org)
Prenatal immune activation interacted with mhDISC1 to produce the neurobehavioral phenotypes that were not seen in untreated mhDISC1 mice and that resemble aspects of major mental illnesses. (researchgate.net)
Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. (genenetwork.org)

Maternal, but not paternal, transmission of the targeted allele leads to beta-galactosidase activity in hippocampal and cerebellar neurons. (nih.gov)

High-affinity zinc uptake system protein mutant ( znuA mutant) showed reduced growth in zinc chelated medium, and failed to replicate in HeLa cells and mouse bone marrow-derived macrophages. (go.jp)
Mouse Disabled-2 (Dab2) was isolated as a 96 kDa phosphoprotein involved in CSF-1 signaling in macrophages, and was initially referred to as p96 [ 1 ]. (biomedcentral.com)

In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)

CONCLUSIONS AND RELEVANCE: In this study, results of a novel telehealth-adapted observational neurodevelopmental assessment extended a previous finding of no association between prenatal exposure to maternal SARS-CoV-2 infection and infant neurodevelopment. (cdc.gov)

We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)

UBE3A encodes UBE3A/E6-AP, a ubiquitin-protein ligase, and shows brain-specific imprinting, with brain expression predominantly from the maternal allele. (nih.gov)
As predicted from the dependence of UBE3A-mediated ubiquitination of p53 on HPV E6 protein, our maternal-deficient mice show normal brain p53 levels. (nih.gov)
Congenital Zika syndrome is associated with maternal protein malnutrition. (ox.ac.uk)
These results suggest that maternal protein malnutrition increases susceptibility to CZS. (ox.ac.uk)
The high starch diet (corn) provides the greatest amount of glucose, whereas the distillers product provides both high protein and high fat, both of which stimulated greater maternal insulin production in the circulation but did not result in differences in maternal glucose circulation. (genengnews.com)
expression of mhDISC1, endogenous DISC1, lissencephaly type 1, nuclear distribution protein nudE-like 1, glycoprotein 130, growth factor receptor-bound protein 2, and glycogen synthase kinase-3beta were assessed in cortical samples of newborn mice. (researchgate.net)

When we examined both male and female BTBR mice in comparison to C57BL/6J (C57) controls, we noted that both sexes of BTBR mice showed motor coordination deficits characteristic of cerebellar dysfunction, but only the male mice showed differences in delay eyeblink conditioning, a cerebellum-dependent learning task that is known to be disrupted in ASD patients. (mdpi.com)
Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)

Genetic attenuation of maternal platelet aggregation is similarly ineffective. (mcw.edu)
A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. (colorado.edu)

OBJECTIVE: To assess whether mild or asymptomatic maternal SARS-CoV-2 infection vs no infection during pregnancy is associated with infant neurodevelopmental differences at ages 5 to 11 months. (cdc.gov)
Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)

Maternal inheritance of the Ube3a mutant allele also causes impaired performance in tests of motor function and spatial learning, as well as abnormal hippocampal EEG recordings. (nih.gov)
Our findings suggest that the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice. (biomedcentral.com)
Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)

Crtc1(-/-) mice exhibit impulsive aggressiveness, social withdrawal, and decreased sexual motivation, together with increased behavioral despair, anhedonia, and anxiety-related behavior in the novelty-induced hypophagia test. (nih.gov)
Crtc1(-/-) mice have a blunted response to the antidepressant fluoxetine in behavioral despair paradigms, whereas fluoxetine normalizes their aggressiveness and their behavioral response in the novelty-induced hypophagia test. (nih.gov)
On the behavioral stage, solely restricted and gentle alterations have been reported, with a big a part of analyzed behaviors being unaffected in GAMT KO as in contrast with wild-type mice. (eumorphia.org)
We tested whether modulation of inhibition or excitation in the auditory cortex of male mice could evoke such a variety of effects in tone-evoked responses and in behavioral frequency discrimination acuity. (jneurosci.org)
Nevertheless, it suggests that further studies are needed to elucidate the cause of behavioral variance associated with DISC1 L100P or Q31L mutants and to determine whether these mice strains are suitable animal models to study schizophrenia and depression. (biomedcentral.com)

The first set of eight strains, the CXB family, were generated by Donald Bailey at the Jackson Laboratory from an intercross between a female BALB/cBy mouse (abbreviated C) and a male C57BL/6By mouse in the 1960s. (wikipedia.org)
For example, immune sera of BALB/c mice, restricted high responders, and of C57BL/6 mice, heterogeneous low responders, had distinct focusing properties. (silverchair.com)
Responsiveness in C57BL/6 x BALB/c F 2 progeny segregated into 79% high and 21% low responders, and showed no genetic linkage to the following characteristics: hair color, sex, H-2 type, and Ig allotype of the heavy chain. (silverchair.com)

We evaluated interaction between mutant human disrupted-in-schizophrenia 1 (mhDISC1) and maternal immune activation implicated in schizophrenia and mood disorders. (researchgate.net)
However, during fever, such as that brought about by infection, there is significant production of inflammatory mediators and it is plausible that these mediators, rather than temperature change per se, may be the drivers of altered function in the central nervous system, as has been shown in a recent study implicating IL-17a in improving social behaviour in a maternal immune activation (MIA) model in the absence of significant hyperthermia. (beds.ac.uk)

Differences in hepatic fibrosis in ICR, C3H, and C57 BL/6 mice infected with Schistosoma manson . (rsbmt.org.br)
This discrepancy may be explained by differences in the genetic background of the mice, the laboratory environment, experimental design and more. (biomedcentral.com)

Here, we developed an assay system to evaluate conspecific maltreatment behavior in the mouse. (encephalitisjournal.org)
MS/SD/SI mice exhibited more sustained nose-poking behavior during the experiment, resulting in increased foot shocks to the mouse in the opposite chamber. (encephalitisjournal.org)
Tissue content of monoamines, volumetric brain abnormalities, dendritic spine density in the hippocampus, and various domains of the mouse behavior repertoire were evaluated in adult male mice. (researchgate.net)

To better understand the pathophysiological role of the cerebellum in ASD, it is necessary to have a variety of mouse models that have face validity for cerebellar disruption in humans. (mdpi.com)

Crtc1(-/-) mice strikingly show, in addition to a reduced dopamine and serotonin turnover in the prefrontal cortex, a concomitant decreased expression of several susceptibility genes involved in neuroplasticity, including Bdnf, its receptor TrkB, the nuclear receptors Nr4a1-3, and several other CREB-regulated genes. (nih.gov)
Genetic-linked variation in susceptibility of mice to Schistosomiasis mansoni . (rsbmt.org.br)

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway. (colorado.edu)

pairs of the F2 progeny are then mated to establish inbred strains through long-term inbreeding. (wikipedia.org)

The mouse model was sequentially subjected to maternal separation (MS), social defeat (SD), and social isolation (SI) in that order (MS/SD/SI model). (encephalitisjournal.org)
Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. (biomedcentral.com)
In the inbred non-obese diabetic (NOD) mouse model of T1D, susceptible NOD mice were shown to harbor a distinct gut microbiota to a variety of T1D-protected inbred strains [ 8 ]. (biomedcentral.com)
Our DISC1 mouse model is a valuable system to study GEI relevant to mental illnesses. (researchgate.net)
We used upstream stimulatory factor 1 (USF1) knock-out mice as a genetic model of constitutively activated BAT and positive cardiometabolic traits, and we found a reduction of depression-like and anxiety-like behaviours associated with USF1 deficiency. (researchsquare.com)
Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. (colorado.edu)
An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia. (bouxseinlab.org)
More research is needed to determine the biochemical mechanisms and treatment efficacy of this technique.OBJECTIVE: We aimed to determine if forebrain repetitive transcranial magnetic stimulation can improve cortical BDNF gene expression and cholinergic signaling in the 3xTgAD mouse model of AD.METHODS: Both B6 wild type mice and 3xTgAD mice aged 12 months were given daily treatment sessions for 14 days or twice weekly for 6 weeks. (stanford.edu)
The B6 mice only had an increase in BDNF gene expression for the 6-week group.CONCLUSION: Brain stimulation is a possible non-invasive and nonpharmaceutical treatment option for AD as it improves both plasticity markers and cholinergic signaling in an AD mouse model. (stanford.edu)
Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer's Disease. (stanford.edu)
pubMedId':'35068462','pubMedUrl':'https://www.ncbi.nlm.nih.gov/pubmed/35068462','publicationId':'837933','title':'Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer's Disease. (stanford.edu)

The transformed cells are, however, all oncogenic in the host animal and in immunocompetent mice. (microbiologyresearch.org)

The working hypothesis going into the experiment was that the primary impact on the fetal growth in previous studies was the result of the amount of glucose in the maternal diet. (genengnews.com)
The conclusion from this study where maternal nutrient supply was measured is that glucose supply to the fetus was not impacted by maternal glucose intake. (genengnews.com)

In contrast, even a partial loss of thrombin sensitivity of maternal platelets protects pregnancies. (mcw.edu)
Baseline prepulse inhibition of the startle reflex predicts the sensitivity to the conditioned rewarding effects of cocaine in male and female mice. (psych.ac.cn)

We now have been utilizing the Inbred Lengthy- and Quick-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to research the genetic underpinnings of acute ethanol tolerance which is taken into account to be a threat issue for alcohol use issues (AUDs). (eumorphia.org)

High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)
Increased T1D disease risk from IL-2 pathway loci in the TwinsUK cohort of human subjects resulted in some similar microbiota changes to those observed in the NOD mouse. (biomedcentral.com)
These studies indicate that in the steady state, NOD mice harbor a "diabetes-permissive" microbiota, and major perturbations in the microbiota can both reduce and accelerate disease. (biomedcentral.com)
Joint mouse-human phenome-wide association to test gene function and disease risk. (genenetwork.org)

Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. (researchsquare.com)

We found that L100P mice show normal affective behaviors but obvious deficits in object recognition which is prevented by clozapine, but not haloperidol. (biomedcentral.com)
Collectively these data suggest that the metabolic regulator USF1 is involved in the control of affective behaviour in mice and that this modulation of mood states is unrelated to USF1-dependent BAT activation, but instead reflected in structural changes in the brain. (researchsquare.com)

We found that mice lacking CRTC1 associate neurobehavioral endophenotypes related to mood disorders. (nih.gov)
We found that mice with an MHC class II-peptide repertoire reduced to a single complex demonstrated various autoimmune reactions. (umass.edu)

Supportively, both CA1 region and DG of L100P mice hippocampus shows suppression of intracellular [Ca 2+ ] elevation after glutamate challenge. (biomedcentral.com)

Prenatal interaction modulated secretion of inflammatory cytokines in fetal brains, levels of mhDISC1, endogenous mouse DISC1, and glycogen synthase kinase-3beta. (researchgate.net)

Rabbits and mice vaccinated with the live recombinant virus produced antibodies that recognized 48K, 57K and 61K mol. (microbiologyresearch.org)

Dentate gyrus (DG) granule cells carrying homozygous mutation of L100P exhibit decreased synaptic excitation and intact synaptic inhibition, meanwhile Schaffer collateral-CA1 synapses of L100P mice display impaired synaptic plasticity. (biomedcentral.com)

Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility. (biomedcentral.com)

Following treatment, brain tissue was extracted for immunological stains for plaque load, as well as biochemical analysis for BDNF gene expression and cholinergic signaling via acetylcholinesterase and choline acetyltransferase ELISA assays.RESULTS: For the 3xTgAD mice, both 14 days and 6 weeks treatment regimens resulted in an increase in BDNF gene expression relative to sham treatment, with a larger increase in the 6-week group. (stanford.edu)

WBH reduced repetitive behaviours and improved social interaction in C58/J mice and significantly reduced compulsive grooming in Shank3B- mice. (beds.ac.uk)

Lack of a functional maternal allele of UBE3A causes AS. (nih.gov)

MT-Exendin mice generate antibodies directed against Ex-4, exendin NH 2 -terminal peptide (ENTP), and proexendin-4 as well as antibodies that cross-react with native GLP-1. (diabetesjournals.org)

The GAMT knockout (KO) mouse mannequin presents biochemical alterations in bodily fluids, the mind, and muscle tissue, together with elevated GAA and decreased Cr and creatinine (Crn) ranges, that are just like these noticed in people. (eumorphia.org)
We now report that MT-Exendin mice develop extensive tissue lymphocytic infiltration with increased numbers of CD4 + and CD8a + cells in the liver and/or kidney and increased numbers of B220 + cells present in the pancreas and liver. (diabetesjournals.org)

We additional present that genetic discount of the mechanistic goal of rapamycin (mTOR) considerably extends lifespan in these mice, offering a rationale for pharmacologic inhibition of the mTOR pathway within the therapy of HGPS. (eumorphia.org)

Pregnant mice were treated with saline or polyinosinic:polycytidylic acid at gestation day 9. (researchgate.net)

Organisms3

Phenomena and Processes1

Phenotype8

Strains of mice3

Recombinant inbred strains9

Mutations3

Inflammation3

Strain8

Phenotypes4

Paternal1

Macrophages2

Genetics1

Prenatal exposure1

Developmental1

Protein6

Sexes2

Attenuation2

Pregnancy2

Hippocampal3

Behavioral5

BALB3

Immune activation2

Differences2

Behavior3

Cerebellar1

Susceptibility2

Hepatic fibrosis1

Progeny1

Model11

Immunocompetent1

Glucose2

Sensitivity2

Tolerance1

Disease4

Genes2

Affective2

Found that mice2

Hippocampus1

DISC11

Rabbits1

Synaptic1

Animal1

Gene expression1

Significantly1

Lack1

Antibodies1

Tissue2

Inhibition1

Pregnant1