Mast dendritic cells. Medical search. Frequent questions

White blood cells, particularly monocytes and macrophages, express complement receptors on their surface. (wikipedia.org)
CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and mast cells. (biolegend.com)
Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. (bdbiosciences.com)
These neuropeptides are released not only from nerve endings but also from inflammatory immune cells such as monocytes, dendritic cells, eosinophils and mast cells. (eur.nl)
These cells are closely related to neutrophils and monocytes. (aacrjournals.org)
Mononuclear myeloid cells include terminally differentiated macrophages and dendritic cells (DC), as well as monocytes, which under inflammatory conditions differentiate in tissues to macrophages and DCs. (aacrjournals.org)
Myeloid cells generated under these conditions, although similar to neutrophils and monocytes in morphology and phenotype, have different genomic and biochemical profiles and functional activity. (aacrjournals.org)
The field started changing in the late 1990s when the Gr1 + CD11b + cellular phenotype was suggested as defining the immune-suppressive myeloid cells in spleens of mice and when these cells were shown to be phenotypically similar but functionally distinct from monocytes and neutrophils ( 2, 3 ). (aacrjournals.org)
Lymphocyte - These cells have a rounded nucleus, no prominent granules, and are smaller than monocytes. (pearson.com)
Based on this definition, all granulocytes and monocytes are myeloid cells. (rsscience.com)
However, the Hu-SGM3 model consistently generated higher numbers of human T cells, monocytes, dendritic cells, mast cells, and megakaryocytes, and a low number of circulating platelets showing an activated profile when compared with the other murine strains. (bvsalud.org)

Corticosteroids reduce airway inflammation and hyperresponsiveness by altering the production of mediators associated with inflammatory cells in the airways, such as macrophages, eosinophils, lymphocytes, mast cells and dendritic cells 7 . (ersjournals.com)
Granulocytic myeloid cells include populations of terminally differentiated polymorphonuclear neutrophils, eosinophils, basophils, and mast cells. (aacrjournals.org)
The histamine receptor H4 has been shown to have a role in chemotaxis and mediator release in a variety of immune cells, such as mast cells, eosinophils, dendritic cells, and T cells. (multispaninc.com)

Upon treatment, MHC-II signal intensity per positive cell and TNF alpha signal in mast cells increased, as well as the numbers of CD68 positive/CD163 positive cells (M2 macrophages), BDCA2 positive (plasmacytoid dendritic) cells and CD4 positive/CD25 positive (Treg) lymphocytes number. (fupress.net)

The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
Monocyte - These large cells have a U-shaped nucleus and no prominent granules. (pearson.com)

Cluster of Differentiation-200 receptor 1 (CD200R1), also known as OX-2 receptor, is a transmembrane protein in the immunoglobulin superfamily expressed on the surface of myeloid cells and important in the regulation of myeloid cell activity (1-3). (rndsystems.com)
Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. (bdbiosciences.com)
Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. (nih.gov)
Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)
1 Activation of DCs through toll-like receptors (TLRs) for "infectious nonself" or other "danger" signals normally initiates a process of cellular differentiation resulting in "mature" DCs capable of stimulating T-cell and natural killer (NK)-cell responses. (ashpublications.org)
Objective: To explore the effect of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and the combination of bFGF and EGF in the neural differentiation of human bone marrow mesenchymal stem cells (hBMSCs), and the role of Wnt/ß-catenin signaling pathway in this process. (bvsalud.org)

Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)

In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)

Thereafter, we identified significant difference of infiltrated immune cells (effector memory CD8 T cell, activated B cell, memory B cell, natural killer cell, CD56 bright natural killer cell, natural killer T cell, plasmacytoid dendritic cell, and neutrophil) between AD and control samples. (nature.com)

Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. (bdbiosciences.com)
Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. (biomedcentral.com)

Complement receptor (CR) 1, 3, and 4 function as opsonins which stimulate phagocytosis, whereas CR2 is expressed only on B cells as a co-receptor. (wikipedia.org)
G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)
This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. (cancerindex.org)
SHPS1 Immunoglobulin-like cell surface receptor for CD47. (affbiotech.com)
Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. (affbiotech.com)
3-5 LILRs are encoded by a set of genes within the leukocyte receptor cluster on chromosome 19q13.4, adjacent to the killer Ig-like receptor ( KIR ) genes that are responsible for controlling NK- and CD8 T-cell survival and effector functions. (ashpublications.org)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. (affbiotech.com)

Their discovery, published online in the Journal of Allergy and Clinical Immunology , shows that administering nicotinamide adenine dinucleotide (NAD+), a natural molecule found in all living cells, shuts off the capacity of dendritic cells and macrophages to dictate CD4+ T fate. (eurekalert.org)

The granules in granulocytes carry distinct chemicals based upon cell type. (ishinobu.com)

Morphine has been shown to negatively impact macrophage function by impairing the proliferation of macrophage progenitor cells, inhibiting cytokine secretion leading to decreased chemotaxis, hindering the ability of macrophages to directly phagocytize pathogens, and inhibiting nitric oxide production. (uspharmacist.com)
This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)

Interleukin-3Rα+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3. (bdbiosciences.com)
The cells of the immune system originate in the bone marrow. (pearson.com)
All types of leukocytes are made in bone marrow, derived from stem cells. (ishinobu.com)
[In this image] The family of the hematopoietic (meaning blood) system is originated from the hematopoietic stem cells in our bone marrow. (rsscience.com)

Eosinophil - These cells have a bi-lobed nucleus and prominent red-staining cytoplasmic granules containing enzymes. (pearson.com)

For blocking of Fc receptors in flow cytometric analysis, pre-incubate the cells with purified anti-CD16/CD32 antibody (=1.0 µg per 10 6 cells in 100 µL volume) for 5-10 minutes on ice prior to immunostaining. (biolegend.com)
a partial map of receptors on human mast cells cultured in vitro. (bdbiosciences.com)
Immunoglobulin-like transcripts are a family of inhibitory and stimulatory cell surface immune receptors. (rupress.org)
Specifically, the mechanism of action of corticosteroids is believed to begin with diffusion across the cell membrane and subsequent binding to glucocorticoid receptors residing in the cytoplasm of target cells 5 . (ersjournals.com)
The key function of apoE is to mediate the binding of lipoproteins or lipid complexes in the plasma or interstitial fluids to specific cell-surface receptors. (randox.com)
These receptors internalise apoE-containing lipoprotein particles and so apoE participates in the distribution or redistribution of lipids among various tissues and bodily cells. (randox.com)
2 Previous studies have evaluated the opioid receptors on a wide array of immune cells. (uspharmacist.com)
Recent studies have suggested a role for human leukocyte Ig-like receptors (LILRs, also known as ILT, LIR, or CD85) in regulating the function of myeloid cells, potentially implicating these molecules in the control of immune responses. (ashpublications.org)
In innate immunity, immune cells are activated by their pattern recognition receptors (PRRs), which bind to pattern molecules of invading pathogens. (fortunejournals.com)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

CD4+ T helper cells and dendritic cells play a central role in immunity. (eurekalert.org)
All vertebrates have natural killer cells and acquired immunity. (ishinobu.com)
Natural killer (NK) cells, players in innate immunity, are relatively big. (ishinobu.com)
NK's smaller cousins work in the department of acquired immunity: B and T cells. (ishinobu.com)
Dendritic cells (DCs) link innate and adaptive immunity, initiating and regulating effector cell responses. (ashpublications.org)

FDC: follicular dendritic cell. (wikipedia.org)

Therefore treatment apparently led to the activation of cells and of intercellular communication pathways possibly down-regulating the inflammatory response. (fupress.net)

Endo: endothelial cell. (wikipedia.org)

Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)

For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)
TotalSeq™ reagents are designed to profile protein levels at a single cell level following an optimized protocol similar to the CITE-seq workflow. (biolegend.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
IGSF4A is a 75 kDa immunoglobulin superfamily protein that mediates calcium-independent adhesive interactions, either homophilic or heterophilic with CRTAM (class I-restricted T cell-associated molecule), Necl-1 (SynCAM3) or Nectin-3 (1 - 4). (rndsystems.com)
Since it was recognized that interstitial cells of Cajal express the gene product of c-kit, we performed immunohistochemistry for c-kit protein in ciliary muscle specimens of monkeys' eyes. (scielo.br)
13 Morphine has been shown to decrease IL-23 production in murine models, decreasing dendritic cell antimicrobial protein production. (uspharmacist.com)
This protein, once produced, is exported from the cell and is then presented to the cells that make up the immune system. (educatetruth.com)
The cells that produce this foreign protein are not attacked because they do not express this viral protein on their own surfaces. (educatetruth.com)
The worry has been that if antibodies are generated to this viral "spike protein" after it has had a chance to bind to human cells (post-fusion conformation), that this would give a better chance for non-neutralizing antibodies to arise (and thus provide a better chance for unwanted inflammation of ADE to develop). (educatetruth.com)

During the last decades, research has focused on the cell-type-specific properties of these cells in culture, which then led to an immunocentric view of their role in disease like if they were primed like T cells to infiltrate target organs to cause tissue damage and drive progressive scaring [ 2 , 3 ]. (hindawi.com)
Fiber alterations consisting in loss of acidophilia and disappearance of nuclei and intercalar disks were found only in acute MI, while a cell infiltrate was found both in acute and previous MI. (fupress.net)

The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
The best characterized ligand for αEβ7 is E-cadherin on epithelial cells, though there is evidence of a second ligand in the human system. (nih.gov)

Alpha E beta 7 (αEβ7) is an α-I domain-containing integrin that is highly expressed by a variety of leukocyte populations at mucosal sites including intraepithelial T cells, dendritic cells, mast cells, and T regulatory cells (Treg). (nih.gov)

Myocardial infarction (MI) consists in myocardial cell death due to prolonged ischemia. (fupress.net)
The behaviour of DC and mast cells in myocardial infarction is still to be studied. (fupress.net)

Another cell type involved in acute reaction to tissue injury are mast cells. (fupress.net)
Massive infiltration of DC was found only in acute MI, while mast cells were similar to controls. (fupress.net)
The predominant cells of pus, neutrophils are the hallmark of acute inflammation. (ishinobu.com)
Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. (nih.gov)

TotalSeq™-A antibodies are compatible with 10x Genomics Single Cell Gene Expression Solutions . (biolegend.com)
Expression on mast cells allows attachment to neurites and fibroblasts (9, 10). (rndsystems.com)
As SgIGSF (spermatogenic IgSF), expression on developing sperm allows adhesion to an unknown partner on Sertoli cells that is critical for normal development (11, 12). (rndsystems.com)
It was demonstrated that expression of interleukin‑8 (IL‑8) mRNA was significantly upregulated in Gem‑R PaCa cells by cDNA microarray and RT‑qPCR analyses. (cancerindex.org)
The same treatment had been shown to increase mast cell expression of basic fibroblast growth factor and fibroblast number (1), potentially responsible for increased production of extracellular matrix. (fupress.net)
CD84 expression increases following activation of T cells, B cells, and dendritic cells. (reactome.org)

A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
Furthermore, we discuss how published data supports the view that changing tissue environments induce the well-known different phenotypes of mononuclear phagocytes, a process that not only enforces each of the different environments but also explains the contribution of these cells to the different tissue pathologies. (hindawi.com)
Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Recently, next-generation sequencing, especially single-cell RNA sequencing is a possible option for the analysis of detailed cell population subtypes of LUAD from bulk tissue samples at single cell level [ 10 , 11 ]. (aging-us.com)
Recently, scientists found that even in a sterile wound (like stroke or heart attack), tissue repair and regeneration also require certain types of white blood cells. (rsscience.com)

Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. (peprotech.com)

The enigmatic plasmocytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. (bdbiosciences.com)
Ligated DCs exhibited poor stimulatory activity for primary and memory T-cell proliferative responses, but this was substantially reversed by blockade of CD80 or its preferred ligand CTLA-4, or by depleting CD4 + CD25 + CD127 lo regulatory T cells. (ashpublications.org)

Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. (iospress.com)
From a physiological standpoint, MDSC can be thought of as effectors of a homeostatic mechanism that regulate T cell-mediated inflammatory responses to pathogens [ 5 ]. (iospress.com)
This may allow evasion of antitumor responses, since TSLC-1 interaction with CRTAM on activated NK and CD8 + T cells stimulates cytotoxicity and upregulates IFN-gamma production (3, 6). (rndsystems.com)
Alterations or aberrant dendritic cells and T cell responses can lead to many health conditions including autoimmune diseases, infections, allergy, primary immunodeficiencies and cancer. (eurekalert.org)
The main functional characteristic of these cells is their potent ability to suppress various types of immune responses. (aacrjournals.org)
Dendritic cells (DC) are involved in the regulation of immune responses and in the organization of inflammatory cell infiltrates in vascular wall, even independent of immune reactions. (fupress.net)
This results in differing cytotoxic responses that are influenced by the nature of target cells, assay types and concentrations of ATZ. (frontiersin.org)
This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
NK cells are themselves adaptive: remembering their encounters and mounting pattern-sensitive (antigen-aware) secondary responses. (ishinobu.com)
Dendritic cells (DCs) play pivotal roles in the initiation, regulation, and maintenance of immune responses. (ashpublications.org)

Opioids have considerable effects on cellular function across many immune cell lineages, affecting both the innate and adaptive immune systems. (uspharmacist.com)

The peripheral blood mononuclear cells (PBMCs) have a round nucleus ( Delves, 2016 ). (frontiersin.org)

An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)
Then, multivariate analysis was performed to demonstrate that the signature was an independent prognostic factor and highly correlated with immune-cell infiltrations and immune-suppressive states. (aging-us.com)
The inflammatory arthritides, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA), comprise autoimmune disorders characterised by chronic joint inflammation, immune cell infiltration to the synovium, fibroblast-like synoviocyte expansion and destruction of cartilage and bone. (biomedcentral.com)
In conclusion, our findings highlight the importance of selecting the appropriate humanized mouse model for specific research questions, considering the strengths and limitations of each model and the immune cell populations of interest. (bvsalud.org)

Red blood cells (RBCs) also express CR1, which enables RBCs to carry complement-bound antigen-antibody complexes to the liver and spleen for degradation. (wikipedia.org)
Dendritic cells (DCs), which are the most important antigen-presenting cells (APCs) that send signals to the T cells, mainly participate in the pathogenesis of many diseases with immunoregulatory mechanisms, such as AR. (frontiersin.org)
Of importance, both pathways require antigen presenting cells (APCs) in particular dendritic cells (DCs) or macrophages (Mφ). (eurekalert.org)
An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
On release they can exert both direct stimulatory and inhibitory effects on T cell activation and also indirect effects through their influence on the recruitment and activation of professional antigen-presenting dendritic cells. (eur.nl)
and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)

The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells, and platelets . (rsscience.com)
Buffy coat contains a mixture of various white blood cells and platelets. (rsscience.com)
The hu-NOG-EXL model had a similar cell development profile but a higher number of circulating platelets with an inactivated state, and the hu-NSG and hu-NCG developed low frequencies of immune cells compared with the other models. (bvsalud.org)

Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)

The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found 16 significant regulated pathways in imDCs and 10 significant regulated pathways in mDCs, including the phagosome, cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. (frontiersin.org)
As of today, two major pathways have been described to regulate CD4+ T cell response. (eurekalert.org)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
To detect and destroy microbial invaders, an immune system covers 2 territories: cells and the extracellular pathways of the body, including the circulatory system. (ishinobu.com)

Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells. (bdbiosciences.com)
Isolation and characterization of human tonsil dendritic cells. (bdbiosciences.com)
Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. (bdbiosciences.com)
Transcripts for one member of this family, ILT7, are selectively expressed in human plasmacytoid dendritic cells (pDCs). (rupress.org)
The number of these cells in a human body runs to the billions. (ishinobu.com)
Our results showed that all murine strains sustained human immune cells within a proinflammatory environment induced by GvHD. (bvsalud.org)

Two distinct immune-related periodontitis subtypes were identified and one is characterized by B cell reaction and the other is IL-6 cytokine reactions. (researchsquare.com)

The observations of the accumulation in spleens and tumors of large numbers of these cells with potent immune-suppressive activity were readily reproducible in most murine tumor models. (aacrjournals.org)

A constant feedback system between the command chains and effector cells ensures an appropriate response that ends when the threat is extinguished. (ishinobu.com)

This process is epitomized by myeloid-derived suppressor cells (MDSC). (aacrjournals.org)

In this commentary, the contribution of various neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide and somatostatin to the regulation of T cell activation is discussed. (eur.nl)
Neuropeptides should therefore be included in the conceptual framework of the immune regulation of T cell function by dendritic cells. (eur.nl)

Relevant information has now been established on solid tumors and their micro-environments, which include immune, endothelial and mesenchymal cells. (fortunejournals.com)

Anatomy48

Organisms11

Diseases14

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes44

Disciplines and Occupations1

Information Science2

Health Care1

Monocytes11

Eosinophils3

Lymphocytes1

Monocyte2

Differentiation6

Macrophage and dendritic cell1

Macrophages and dendritic cells1

Plasmacytoid dend1

Subsets2

Receptor8

Phagocytosis1

Immunology1

Granulocytes1

Chemotaxis2

Bone marrow4

Eosinophil1

Receptors10

Immunity5

Follicular1

Inflammatory response1

Endothelial cell1

Airway1

Protein9

Infiltrate2

Epithelial cells2

Mucosal1

Myocardial infarction2

Acute4

Expression6

Tissue5

Inhibits1

Ligand2

Responses10

Adaptive1

20161

Immune cell4

Antigen6

Platelets3

Mononuclear2

Pathways4

Human6

Cytokine1

Murine1

Effector1

Myeloid Derived Suppressor Cells1

Regulation2

Tumors1