• The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
  • Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
  • In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
  • Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)
  • Phylogeny of major intrinsic proteins. (lu.se)
  • In eukaryotic cells, chromatin comprises a complex consisting of DNA, RNA, and proteins where covalent modifications correlate with regulation of gene expression [ 1 ]. (biomedcentral.com)
  • Regulation of gene expression by proteins and small RNAs. (otago.ac.nz)
  • My work spans two important areas of biochemistry: enzyme catalysis and regulation of gene expression by DNA-binding proteins. (uwm.edu)
  • Degradations of proteins to amino acids and regulation. (unizg.hr)
  • These thermosensors are part of a regulatory network, such as the production of heat shock proteins mediated by sigma factor 32 (RpoH) in Escherichia coli or the transcriptional repressor of heat-shock genes HrcA in Bacillus subtilis (Hecker et al. (springer.com)
  • This has provided insights into mechanisms of microaerobic gene regulation, and has enabled the development of oxygen-dependent expression systems for high-level synthesis of recombinant proteins. (caltech.edu)
  • Protocols were developed for the use of ORE-based expression systems for regulated, high level synthesis of recombinant proteins in high cell density fermentations. (caltech.edu)
  • Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
  • A flavin-dependent monoxygenase (OppA1), one of the most up-regulated proteins in the OPP-growing cells, was isolated via heterologous expression and its catabolic activity was verified in vitro . (nature.com)
  • BioID screen for bacterial virulence proteins: new tools for… The discovery of penicillin in the 1920s revolutionized our ability to treat bacterial infection. (atlasofscience.org)
  • The course comprises molecular biology of genes, proteins, multicomponent protein complexes, and other biomolecules that provide structure and perform the organism's functions. (lu.se)
  • Fe addition elicited varying responses by different diatom genera, with more prevalent diatoms experiencing more differential regulation of Fe-responsive pathways and proteins. (uri.edu)
  • Below is a non-exhaustive list of in-house infrastructures that are categorized into three overarching themes: bio-imaging, proteins, genes & cells and other resources. (lu.se)
  • Within genetics, post-genomic research has rendered bacterial small non-coding RNAs (sRNAs) as major players in post-transcriptional regulation of gene expression in response to environmental stimuli. (wikipedia.org)
  • By coupling advances in the basic science of bacterial physiology with new tools in deep learning, cell simulation, and bacterial genetics, we aim to transform the process of cellular engineering. (utsouthwestern.edu)
  • Research opportunities in the department are in the areas of protein structure and function, enzyme reaction mechanisms, regulation of gene expression, mechanism of hormone action and cell signaling, enzymology and mechanisms of DNA replication and repair, cell cycle regulation, control of cell growth, molecular biology of the cancer process, molecular neurobiology, and the genetics and biochemistry of bacterial and viral pathogens. (nymc.edu)
  • Appropriate for students majoring in Microbiology, Genetics, Biochemistry or Molecular Biotechnology. (otago.ac.nz)
  • Reverse genetics: NS1 genes will be altered through site mutagenesis and mutated viruses will be generated through co-transfection of macropahges with a reverse genetics system to determine which part of the NS1 genes is responsible for the observed differences in cytopathogenic effect (apoptosis) and the modulation of the immnue genes detected by microarray analysis. (usda.gov)
  • The creation and isolation of specific mutants is a cornerstone of bacterial genetics. (lu.se)
  • An important factor of bacterial virulence is the formation of biofilms which are aggregates of microorganisms incorporated into an extracellular matrix that protects bacteria from hostile environments. (usp.br)
  • It induces both local effects in the gut, as well as alterations in distant organs through stimuli generated by bacteria, structural bacterial components, and microbial metabolites [ 7 ]. (biomedcentral.com)
  • Bacterial genomics, regulation, and resistance - Bacteria are a powerful unicellular model system to investigate the fundamental relation between genomic sequence, gene and protein expression, dynamics of molecular pathways, and resultant phenotypes. (utsouthwestern.edu)
  • MICR 335 will provide a fundamental knowledge of the mechanisms that bacteria use to sense their environment and adapt their gene expression to optimise their growth and survival. (otago.ac.nz)
  • In 1964, Yanofsky and colleagues established that gene sequences and protein sequences are colinear in bacteria. (pharmaceuticalintelligence.com)
  • Small regulatory RNAs (sRNAs) are often employed in bacterial mechanisms of stress adaptation, and there are precedents in and related bacteria for regulation by sRNAs of the expression of genes involved in carbon metabolism (11, 26, 29, 43, 50). (bassresearch.com)
  • Research suggests that SCFAs produced by intestinal bacteria activate key players in the regulation of energy metabolism in the gut as well as regulate healthy gene expression for mucin production, supporting tight-junction assembly, healthy mucous production, and a healthy intestinal barrier. (pureprescriptions.com)
  • I am interested in the study of Bacterial Physiology and Metabolism to better understand mechanisms of adaptation of bacteria to their environment and to engineer bacteria for applications in biotechnology. (toulouse-biotechnology-institute.fr)
  • My major area of study is RNA dynamics in bacteria to better understand genome-wide post-transcriptional regulations, their role in the regulation of gene expression and their potential for engineering bacteria. (toulouse-biotechnology-institute.fr)
  • More recently, I have also initiated studies on bacterial diversity and heterogeneity, working on various bacteria strains alone, in consortia or in interaction with non-equivalent monoclonal subpopulations. (toulouse-biotechnology-institute.fr)
  • My research concerns predominantly two model bacteria, Lactococcus lactis and Escherichia coli , using a systems biology approach to elucidate the different levels of metabolic regulation and notably genome wide omic regulations. (toulouse-biotechnology-institute.fr)
  • Using gene specific primers, tissue-specific and developmental-specific expression as well as its immune role against bacteria, fungus and P. berghei was studied. (biomedcentral.com)
  • Bacteria with variant cagY alleles that reduced T4SS function showed comparable reduction in binding to a5ß1 integrin, although CagY was still expressed on the bacterial surface. (pacb.com)
  • Light-regulated gene expression in Bacteria: Fundamentals, advances, and perspectives. (optobase.org)
  • Numerous photoreceptors and genetic circuits emerged over the past two decades and now enable the light-dependent i.e., optogenetic, regulation of gene expression in bacteria. (optobase.org)
  • Here, we survey the underlying principles, available options, and prominent examples of optogenetically regulated gene expression in bacteria. (optobase.org)
  • These applications jointly testify to the maturity of the optogenetic approach and serve as blueprints bound to inspire and template innovative use cases of light-regulated gene expression in bacteria. (optobase.org)
  • Given these advantages, pREDusk and pREDawn enable red-light-regulated expression for diverse use cases in bacteria. (optobase.org)
  • Consequently, bacteria have developed different systems to sense changes in environmental conditions such as temperature and induce an adaptation of metabolism and gene expression. (springer.com)
  • The realization of the vastness of bacterial diversity and the development of novel experimental techniques have propelled molecular microbiology into a new era of investigation This course provides insights into how genes are organized and regulated in bacteria and in their viruses. (lu.se)
  • In Chapter 3, metatranscriptomic sequencing was used to examine the gene expression response of a SO diatom community and their associated bacteria to Fe-amendment incubations during the 2016 WAP cruise. (uri.edu)
  • BPSE changed the gene expressions mainly responsible for central carbon metabolism and the cellular oxidative stress. (bvsalud.org)
  • Topics covered will include cell membrane structure and function, metabolism, cell motility and division, genome structure and replication, the regulation of gene expression and protein production, genotype to phenotype relationship, and basic principles of inheritance. (middlebury.edu)
  • Transcription analysis of all putative catabolic genes established their role in the metabolism of OPP. (nature.com)
  • With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
  • A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
  • Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)
  • Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)
  • Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (nature.com)
  • The second involves post-transcriptional regulation through an upstream inverted repeat sequence, effectively suppressing expression of the sigH gene. (hal.science)
  • CyAbrB2 contributes to the transcriptional regulation of low CO2 acclimation in Synechocystis sp. (cyanolab.de)
  • Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
  • Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
  • Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
  • INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
  • It is the body's first-line defense against many bacterial pathogens. (medscape.com)
  • In particular, we have investigated the activation of phage T4 promoters during T4 infection and the regulation of promoters that express virulence gene products in the pathogens Bordetella pertussis and Vibrio cholerae . (nih.gov)
  • Understanding this process is fundamental to the development of anti-bacterial strategies because biofilms shield pathogens from environmental stresses, nutrient loss, and most, importantly antibiotics. (nih.gov)
  • Streptococcal pathogens continue to evade concerted efforts to decipher clear-cut virulence mechanisms, although numerous genes have been implicated in pathogenesis. (cdc.gov)
  • Cancer Metastasis - Current cancer therapies lack major insight into non-genetic mechanisms of metastasis and drug resistance that are governed by autonomous cellular signaling programs and complex interactions with the environment. (utsouthwestern.edu)
  • Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. (nature.com)
  • My lab focuses on elucidating these mechanisms of transcription initiation and regulation. (nih.gov)
  • Here, we have uncovered two distinct mechanisms allowing activation of SigH production in a minor fraction of the bacterial cell population. (hal.science)
  • Understanding mechanisms underlying human gene expression variation with RNA sequencing. (uchicago.edu)
  • Although the genes that encode carotenogenesis and flavonoids enzymes are well characterized, the transcriptional regulatory mechanisms that are related to the pathway genes remain to be investigated. (researchsquare.com)
  • Mechanisms responsible for oxygen-dependent regulation act at the level of transcription initiation from two overlapping promoters within the region upstream of the VHb gene. (caltech.edu)
  • Given the important roles of the gut microbiome in regulating host physiology and gene expression, a better understanding of the relationship between the host and the symbiont microbiota should provide new insights into human health and disease risk. (biomedcentral.com)
  • Butyrate plays a major role in intestinal physiology, supporting both physical and biochemical protective barrier function, bowel motility, nutrient absorption, and immune activity of intestinal cells. (pureprescriptions.com)
  • I initiated collaborations with mathematicians to rationalise the use of large-scale genomic data-sets to investigate bacterial physiology. (toulouse-biotechnology-institute.fr)
  • The major H. pylori virulence factor that determines whether infection causes disease or asymptomatic colonization is the type IV secretion system (T4SS), a sort of molecular syringe that injects bacterial products into gastric epithelial cells and alters host cell physiology. (pacb.com)
  • We will study the phylogeny, anatomy, physiology, and ecology of the major extinct and extant taxa of vertebrates and discuss how each group solves the problems of finding food, finding mates, and avoiding predators. (middlebury.edu)
  • Four of the Center's eight faculty research labs ( Kim , Lin , Reynolds , and Toprak ) are collectively working to elucidate and eventually program this molecular circuitry in the context of metabolic regulation and antibiotic resistance. (utsouthwestern.edu)
  • Carbon atoms of degraded amino acids as major metabolic intermediates. (unizg.hr)
  • Adaptations to climate in candidate genes for common metabolic disorders. (uchicago.edu)
  • 6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
  • The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
  • A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)
  • The PEP enzyme recognizes the -10 and -35 cis -elements, similar to those found in bacterial promoters whereas the NEP enzyme recognizes the YRTA-motif, which can also be found upstream of several genes with PEP promoters indicating that these genes can be transcribed by both polymerases ( Pfannschmidt and Liere, 2005 ). (frontiersin.org)
  • Enzyme kinetics including its regulation and inhibition, Vitamins and Coenzymes. (entrance-exam.net)
  • Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical. (cipsm.de)
  • For this, the upstream regions of the gacA, gacS, ladS, retS, rsmA, rsmZ and PA1611 genes were cloned separately into a miniTn7 vector and inserted into the PAO1 chromosome. (usp.br)
  • We then evaluated the growth and activity of the upstream regions by lux expression under different carbon sources and iron deprivation. (usp.br)
  • In our findings, mvaT has a negative influence on regulating rsmA, since its inactivation leads to a higher expression of the upstream region of rsmA. (usp.br)
  • In our study, we hypothesized that both have a role in the activation of the upstream region of the retS in LB media and MOPS glucose since their mutation led to higher expression of the upstream region. (usp.br)
  • Para isso, as regiões upstream dos genes gacA, gacS, ladS, retS, rsmA, rsmZ e PA1611 foram clonadas separadamente em um vetor repórter miniTn7 e inseridas no cromossomo de PAO1. (usp.br)
  • Genetic studies demonstrated the presence of an oxygen-responsive element (ORE) upstream of the VHb gene. (caltech.edu)
  • nbsp;provides a balanced, comprehensive introduction to all major areas of microbiology. (mheducation.com)
  • nbsp;is appropriate for microbiology majors and mixed majors courses. (mheducation.com)
  • I am a scientist in the " Microbiology and Food Chain " division of the French National Institute for Agricultural, Food and Environmental Research, currently working at the Toulouse Biotechnology Institute as head of the research group BLADE (Bacterial Adaptation Diversity and Engineering). (toulouse-biotechnology-institute.fr)
  • Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)
  • a plastid-encoded bacterial-type RNA polymerase (PEP) and a nuclear-encoded phage-type RNA polymerase (NEP), which recognize distinct types of promoters. (frontiersin.org)
  • This technique, not previously used for metatranscriptomics, is powerful for the simultaneous identification of transcriptional start sites (i.e., the suite of active promoters) and the analysis of gene expression at community-wide scale. (cyanolab.de)
  • The transcripts of five carotenogenesis genes were highly correlated with lycopene contents, and 16, 40, 48, 24 and 18 transcription factors (TFs) were predicted to potentially bind their promoters, respectively. (researchsquare.com)
  • To conduct our work on virulence gene regulation, we collaborate with the laboratory of Dr. Scott Stibitz at the U.S. Food and Drug Administration. (nih.gov)
  • Our work has revealed a unique architecture for the interaction of the Bordetella pertussis response regulator (BvgA) with a particular virulence gene promoter. (nih.gov)
  • Regulation of bacterial virulence gene expression by the host environment. (jci.org)
  • The 3.9-kb operon comprises three genes, organized as homolog (25). (bassresearch.com)
  • The second ben/cat operon was located in a 92-kb scaffold along with (i) an operon ( opp ) comprising genes for the transformation of OPP to BA and 2-hydroxypenta-2,4-dienoate (and genes for its transformation) and (ii) an incomplete biphenyl catabolic operon ( bph ). (nature.com)
  • In the case of the lac operon of E. coli, a well-studied system for whether a gene is regulated. (lu.se)
  • Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)
  • We also observed from in vivo analysis that Velo knock-down flies exhibit significant upregulation of the AMP expression and reduced bacterial load. (cnrs.fr)
  • In the bacterial metatranscriptome, upregulation of Fe-siderophore uptake genes was observed, possibly indicating increased competition for Fe among the stimulated diatom-associated bacterial community. (uri.edu)
  • In particular, exposure to CAS resulted in the upregulation of hypha-specific genes known to play a role in biofilm formation, such as ALS3 and HWP1. (who.int)
  • In all of our systems, we combine classic protein and nucleic acids biochemistry with state-of-the-art structural and molecular modeling techniques to understand the protein-protein and protein-DNA contacts that are needed for regulation. (nih.gov)
  • Interestingly, FLU-exposed biofilms showed no significant changes in gene expression over the course of the experiment. (who.int)
  • In AMB-exposed biofilms, 2.7% of the genes showed altered expression, while in CAS-exposed biofilms, 13.0% of the genes had their expression modified. (who.int)
  • There was little overlap between AMB- or CAS-responsive genes in biofilms and those that have been identified as AMB, FLU, or CAS responsive in C. albicans planktonic cultures. (who.int)
  • In this regard, our study led us to observe that AMB physically bound C. albicans biofilms and beta-glucans, which have been proposed to be major constituents of the biofilm extracellular matrix and to prevent azoles from reaching biofilm cells. (who.int)
  • Biochemical regulation of gene expression. (entrance-exam.net)
  • Biochemical and structural studies reveal significant functional similarities among bacterial, archaeal, and eukaryotic RNA polymerases. (nih.gov)
  • Laboratories that perform biochemical genetic testing are required by CLIA regulations to meet the general quality systems requirements for nonwaived testing and the personnel requirements for high-complexity testing. (cdc.gov)
  • Likewise, this supposed paradox of "genomic equivalence" is not discussed as a major problem in developmental biology courses since it has been solved by the last 40 years of research in developmental biology. (ncse.ngo)
  • This consensus view of development has been overwhelmingly supported by the discovery of genes such as Ultrabithorax which regulate other genes involved in developmental pathways. (ncse.ngo)
  • 2022. Synergistic regulation of transcription and translation in Escherichia coli revealed by co-directional increases in mRNA concentration and translation efficiency. (toulouse-biotechnology-institute.fr)
  • Silencing of Velo led to constitutive expression of the IMD pathway dependent antimicrobial peptides (AMPs), and Escherichia coli stimulation further enhanced the AMP expression. (cnrs.fr)
  • It is inducing against bacterial and fungal elicitors. (biomedcentral.com)
  • The Drosophila Toll pathway is required in the host defenses against several Gram-positive bacterial infections as well as against fungal infections. (cnrs.fr)
  • Taken together, we propose a unique model for staphylococcal competence regulation by SigH that could help explain the acquisition of antibiotic resistance genes through horizontal gene transfer in this important pathogen. (hal.science)
  • Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. (jci.org)
  • mvaT is a major regulator, exerting negative control in many genes described. (usp.br)
  • We are interested in elucidating the details of gene regulation by the B. pertussis global response regulator, BvgA, which regulates all the known pertussis virulence genes. (nih.gov)
  • The major events in the regulation of the host response on a transcriptional level occur within the first 3 days after infection. (biomedcentral.com)
  • Whereas in the acute phase of the disease immunoregulatory processes prevail in the hippocampus and the cortex, we observed a strong activation of neurogenic processes in the hippocampal dentate gyrus, both by gene expression and immunohistology starting as early as 3 days after infection. (biomedcentral.com)
  • While 2'-5'-oligoadenylate synthetase (OAS)-like gene was upregulated at the 6th hour post infection up to 3.3 fold, Mx protein was downregulated marginally. (usda.gov)
  • Expression of IFN-inducible protein IP-30 was suppressed up to 2.4 fold but that of interferon-inducible 58 kDa with tetratricopeptide repeats 5 (IFIT-5) was increased up to 20.1 fold in the early stage of infection (6 hrs post infection). (usda.gov)
  • While the IFN beta expression was increased up to 1.7 fold 12 hrs post infection, interferon gamma expression did not change. (usda.gov)
  • Major immune response pathways control the expression of hundreds of genes that represent potential effectors of the immune response. (cnrs.fr)
  • amino acid synthesis from intermediates of citric acid cycle and other major pathways. (unizg.hr)
  • On the other hand, mRNA is expressed in similar levels of the carbon supply useful for bacterial development regardless. (bassresearch.com)
  • Etienne T., Cocaign-Bousquet M. , Ropers D. (2020) Competitive effects in bacterial mRNA decay. (toulouse-biotechnology-institute.fr)
  • To investigate further the function of the RGL genes, we examined the expression profiles of all 5 DELLA protein genes by real-time PCR. (nih.gov)
  • Using the newly isolated rgl1, rgl2, and rgl3 T-DNA insertion mutants, we demonstrated that RGL2 is the major repressor in seed germination. (nih.gov)
  • Operons regulation by repressor. (unizg.hr)
  • Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. (elifesciences.org)
  • Students tailor the major to meet their needs by choosing one of the specializations as their focus of study: environmental and microbial biotechnology, plant biotechnology, insect and pathogen biotechnology, general biotechnology, or aquaculture and bioreactor biotechnology. (hawaii.edu)
  • First, light-dependent expression underpins novel concepts and strategies for enhanced yields in microbial production processes. (optobase.org)
  • The BTK gene is large and consists of 19 exons that encode the 659 amino acids that form the Btk cytosolic tyrosine kinase. (medscape.com)
  • For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain damage, i.e. the cortex and the hippocampus, at four different stages of the disease in an infant rat model. (biomedcentral.com)
  • The optogenetic control of bacterial expression predominantly employs but three fundamental strategies: light-sensitive two-component systems, oligomerization reactions, and second-messenger signaling. (optobase.org)
  • Portions of this work were in Regulation of Drug Metabolizing Enzymes in Inflammation: Role of the Toll-Like Receptor 4 Signaling Pathway (R. Ghose, D. White, J. Vallejo, and S. J. Karpen), which was presented at Experimental Biology 2007 in Washington, DC, April 28-May 2, 2007. (aspetjournals.org)
  • Here we found that these recombination events produce parallel changes in specific binding to a5ß1 integrin, a host cell receptor that is essential for T4SS-dependent translocation of bacterial effectors. (pacb.com)
  • Butyrate is one of the three most abundant short-chain fatty acids (SCFAs) produced by anaerobic bacterial fermentation of polysaccharides/fiber in the colon, where it serves as an energy source for epithelial cells. (pureprescriptions.com)
  • In particular, soluble fiber may be important in and 48 mo from 3358 children from the United States and Germany this respect, because it is converted to the short-chain fatty acids prospectively followed in the TEDDY (The Environmental Deter- acetate, propionate, and butyrate by bacterial fermentation in the minants of Diabetes in the Young) study. (lu.se)
  • Rhizobial adaptations to soil and plant cell environments require the coordinate expression of complex gene networks in which sRNAs are expected to participate. (wikipedia.org)
  • The response of a plant to drought stress is positively related to physiological traits and gene expression. (ac.ir)
  • Verification of eQRNA/RNAz predictions by Northern hybridization and RACE mapping led to the identification of eight previously unknown genes, with recognizable promoter and termination signatures, expressing small transcripts. (wikipedia.org)
  • fusion gene was constructed, with the clpQ + Y + promoter fused to a lacZ reporter gene. (openmicrobiologyjournal.com)
  • The nucleotide sequence of the gene and its flanking regions was determined and analyzed. (caltech.edu)
  • Early work suggested that the process and regulation of transcription initiation fundamentally differed between bacterial polymerase and higher organisms. (nih.gov)
  • In many cases, these factors interact with only a small surface of RNA polymerase, yet they impose a major specificity change through this contact. (nih.gov)
  • Beyond this time, no differences in global gene expression in infected and control animals were detectable by microarray analysis. (biomedcentral.com)
  • Cultures will be grown in triplicate and realtime RT-PCR will be used on individual cultures to confirm the microarray findings on selected genes, which will initially include: MHC class I, MHC class II, MHC B-G, IL-1b, IL-4, and CCL5. (usda.gov)
  • We anticipate that NS1 mediates the effects of AIV on macrophages and would like to test viruses with different NS1 alleles to determine if it mediates the downregulation of immune function genes as we described in the Prelimiary Results. (usda.gov)
  • 1. Extensive Regulations of immune genes in chicken macrophages and lungs infected with influenza virus H9N2. (usda.gov)
  • These products have several anti-inflammatory properties of any/multiple islet autoantibodies (242 and 151 events, respec- such as regulation of immune-related gene expression and cy- tively) and T1D (71 events) by soluble fiber intake were calculated tokine release (8). (lu.se)
  • In 1952, Colonel Ogden Bruton noted the absence of immunoglobulins (Ig) in a boy with a history of pneumonia and other bacterial sinopulmonary infections. (medscape.com)
  • As Bruton originally described, XLA manifests as pneumonia and other bacterial sinopulmonary infections in 80% of cases. (medscape.com)
  • Bacterial RNA maturation. (otago.ac.nz)
  • Our study reveals a novel pathway of small guide RNA maturation and the first example of a host factor (RNase III) required for bacterial RNA-mediated immunity against invaders. (nature.com)
  • tracrRNA-mediated crRNA maturation is conserved among different bacterial species. (nature.com)
  • The gene encoding the VHb polypeptide was isolated from a Vitreoscilla genomic library. (caltech.edu)
  • and his early discovery of colinearity, the linear relationship between the structures of genes and their protein products, considered an essential element in revealing the details of the genetic code. (pharmaceuticalintelligence.com)
  • DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. (uchicago.edu)
  • Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. (jci.org)
  • A bacterial protein from Pseudomonas, Bordetella, or Alcaligenes which operates as an electron transfer unit associated with the cytochrome chain. (lookformedical.com)
  • This shows that although TIRAP mediates inflammatory responses induced by LPS, it is not essential in regulating LPS-mediated alterations of gene expression in liver. (aspetjournals.org)
  • Moreover, resveratrol appears to attenuate spinal microglia activation, regulate primary receptors in dorsal root sensory neurons, inhibit pertinent voltage-gated ion channels, and curb the expression of inflammatory mediators and oxidative stress responses. (bvsalud.org)
  • Furthermore, 15/15 candidate TFs might regulate at least three key genes and contribute to carotenoids/flavonoids accumulation in CNO fruit. (researchsquare.com)
  • These labs are joined by our UTSW Distinguished Fellow, Scott Saunders , who develops revolutionary technology for editing bacterial genomes with unprecedented efficiency to accelerate experimentation. (utsouthwestern.edu)
  • During the past decade, biotechnology has brought about major changes in agricultural sciences and society. (hawaii.edu)
  • The results have wide-ranging implications for the understanding of bacterial persistence and cellular aging. (cyanolab.de)
  • Because transcription initiation proceeds through multiple steps, this process provides multiple points for regulation. (nih.gov)
  • DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
  • Similarly, expression of CagY in the absence of other T4SS genes was necessary and sufficient for whole bacterial cell binding to a5ß1 integrin. (pacb.com)
  • Yet with a few exceptions, all these cell types contain same genes as the fertilized egg. (ncse.ngo)
  • There, he chose to tackle what was, at the time, a little-known form of translational control: the regulation of ribosomal protein synthesis by the nascent polypeptide. (u-bordeaux.fr)
  • Breakdown and synthesis, regulation. (unizg.hr)
  • Interestingly, the 2-MIB synthesis gene was consistently expressed, regardless of the water temperature. (mdpi.com)
  • Synthesis of active VHb was shown to occur in E. coli from the natural expression signals of the VHb gene. (caltech.edu)
  • op or pr) fusion gene was each crossed into lambda phage. (openmicrobiologyjournal.com)
  • Both tracrRNA and pre-crRNA confer immunity against acquisition of a protospacer gene derived from a lysogenic phage. (nature.com)
  • So now we can start to study the regulatory elements that may be driving expression of these genes. (scitechdaily.com)
  • This presents an interesting situation: genes are put into new locations in the genome, with new regulatory elements driving the genes' expression. (scitechdaily.com)
  • High-resolution mapping of expression-QTLs yields insight into human gene regulation. (uchicago.edu)
  • By understanding the cephalopod genome, we can gain insight into the genes that are important in setting up the nervous system, as well as into neuronal function. (scitechdaily.com)
  • Here, we apply this insight to reprogram two widely used setups for bacterial gene expression from blue-light to red-light control. (optobase.org)
  • In this study in order to investigate the sunTIP7 gene expression and its relation with relative water content (RWC), stomatal conductance, shoot fresh and dry weight, root area, chlorophyll index (SPAD) and electrolyte leakage (EL), six selected sunflower (Helianthus annuus L.) inbred lines were planted in a greenhouse under normal irrigation and water deficit conditions. (ac.ir)
  • Here, we profile the gut microbiome and chromatin characteristics in colon epithelium from mice fed either an obesogenic or control diet, followed by an analysis of the resultant changes in gene expression. (biomedcentral.com)
  • The obesogenic diet shapes the microbiome prior to the development of obesity, leading to altered bacterial metabolite production which predisposes the host to obesity. (biomedcentral.com)
  • The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)
  • In silico analysis of available array data showed that a large number of genes traditionally classified as PEP dependent genes are transcribed during early embryo development from the pre-globular stage to the mature-green-stage. (frontiersin.org)
  • Phylogenetic analysis reveals that HPX15, AsP-15 and AcP-15 are unique to Anophelines and this may be due to the involvement of this peroxidase in regulation of Plasmodium development. (biomedcentral.com)
  • Controlling the process of transcription is fundamental to gene expression, gene regulation, and development. (nih.gov)
  • If genes control development, and the genes in every are the same, why are the cells so different? (ncse.ngo)
  • We previously showed that a novel staphylococcal secondary sigma factor, SigH, was a likely key component for competence development, but the corresponding gene appeared to be cryptic as its expression could not be detected during growth under standard laboratory conditions. (hal.science)
  • In this study, Cara cara navel orange fruit at four development stages were used to identify the key genes and TFs for carotenoids and flavonoids accumulation. (researchsquare.com)
  • The major goal of pharmacogenomics research is the development of genotype or transcriptome-based predictive tests of drug efficacy or toxicity. (bvsalud.org)
  • Current estimates of the number of bacterial species range from 1 to 1000 million. (lu.se)