• Mucins, the main constituents of the mucus layer, are glycoproteins synthesized by goblet cells. (scielo.br)
  • Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. (nih.gov)
  • Mucus comprises water, glycoproteins (mucins), and ions. (bmj.com)
  • Mucin-like molecules are a new family of glycoproteins present in tissues of the hematopoietic system. (bdbiosciences.com)
  • Mucins are high molecular-weight glycoproteins (120-1000 kDa) with sialylated oligosaccharides. (romj.org)
  • The role of mucins, high molecular weight glycoproteins that comprise the mucus, in the pathophysiology of cystic fibrosis is currently being investigated. (healthdrugpdf.com)
  • The effects of serum on mucin (MUC-1) expression were observed in cultured conjunctival epithelial cells in vitro. (bmj.com)
  • The additive effect of human serum for cultured conjunctival epithelial cells showed significant MUC-1 upregulation on the cell surface. (bmj.com)
  • Muc in animals ) is a transmembrane mucin glycoprotein expressed in mucosal epithelial cells and hematopoietic cells . (bvsalud.org)
  • The MUC1 protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
  • Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)
  • In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
  • namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
  • The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
  • Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
  • 3) In asthma, continuous epithelial shedding and a restitution process characterize the airway disease (4) and are responsible for the airway hyperresponsiveness. (indexarticles.com)
  • However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
  • Mucin glycoprotein expression in IMPN epithelial cells within the cyst lining is routinely used to help characterize these IPMN subtypes by immunohistochemistry [ 12 ]. (gastrores.org)
  • 9: Sirviö E, Mikkonen JJW, Koistinen AP, Miinalainen I, Kullaa AM. Localization of transmembrane mucin MUC1 on the apical surface of oral mucosal cells. (moleculardepot.com)
  • MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. (oncotarget.com)
  • The transmembrane mucin MUC1 co- localizes with CFTR. (healthdrugpdf.com)
  • BACKGROUND: Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. (koreamed.org)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • Simultaneously, increased gene expression of physiologically essential molecules such as mucin (MUC1 and MUC3) and brain-derived neurotrophic factor (BDNF) was also observed in this group. (biomedcentral.com)
  • Aquaporin 3 and 4 are expressed in the basolateral plasmamembrane and their role hydration of mucus is not established. (researchtoactionforum.org)
  • 1, 2 This review approaches the role of mucin degrading enzymes from the potential interaction of micro-organisms with the cervical mucus barrier, and discusses the contribution that mucin degrading enzymes may make to microbial colonisation of the reproductive tract. (bmj.com)
  • 4 The proteins that occur in the mucus, including lactoferrin, lysozyme, and secretory IgA, are part of this defence system. (bmj.com)
  • As tumor cells shed this MUC-1 antigen into the bloodstream, it is recognized by 2 monoclonal antibodies in a radioimmunoassay. (medscape.com)
  • In a study of lung adenocarcinoma [ 4 ] , EMT markers were associated with enhanced tumor infiltration of CD4 + Foxp3 + Tregs and upregulation of inhibitory immune checkpoint molecules such as programmed cell death (PD)-ligand (L) 1, PD-L2, TIM-3, B7-H3, and CTLA-4. (encyclopedia.pub)
  • Histologically a circumscribed tumor with lakes of mucin, neoplastic cells arranged in strands and nests, and apocrine secretion is frequently observed ( Fig-1 ) [4]. (asploro.com)
  • Influence of the application of enemas with oily extract of curcumin ( Curcuma longa ) on the tissue content of neutral and acidic mucins in the colonic mucosa without fecal stream ☆ ☆ Study conducted at Universidade São Francisco (USF), Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Investigação Médica (LIM), Bragança Paulista, SP, Brazil. (scielo.br)
  • To verify if the application of enemas containing oily extracts of curcumin preserves the tissue content of mucins in the glands of the colonic mucosa without fecal stream. (scielo.br)
  • Tissue quantification of neutral and acid mucins in the mucosa of the colon with and without fecal stream in rats. (scielo.br)
  • Thus, the mucin-coated CP has the potential to contribute to gallstone-associated cholecystitis via oxidative damage of mucosa and epithelium. (romj.org)
  • Mucin, a major component of mucosa, is not only absorbed by these particles but is also actively incorporated [2, 4]. (romj.org)
  • Thus, a high expression of inhibitory immune checkpoint molecules such as PD-1, PD-L1, CTLA-4, OX40L, and PD-L2 was observed in tumors with the most mesenchymal EMT scores. (encyclopedia.pub)
  • Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
  • Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
  • The most overexpressed genes included Fc Fragment of IgG Binding Protein ( FCGBP , logFC = 3.01, pFDR = 0.015), Mucin 2 ( MUC2 , logFC = 2.78, pFDR = 0.015), and Alpha 1B Defensin ( DEFA1B , logFC = 2.73, pFDR = 0.024). (biomedcentral.com)
  • ASL is made up of two layers an upper viscoelastic layer of mucins secreted by the goblet cells and submucosal glands and a lower periciliary layer made up of large membrane-bound glyocproteins as well as tethered mucins (muc-1 muc-4 and muc-16) [13 14 The periciliary layer is relatively less viscous and acts as a lubricating layer for cilia to beat. (researchtoactionforum.org)
  • The crystal structure of the mucin monoclonal antibody SM3 complexed with a 13 amino acid MUC1 mucin peptide was determined. (wisconsin.edu)
  • He discovered that the mucins MUC1 and MUC-X, which are transferred to the milk fat globule upon secretion, have greater size in human milk and therefore may carry greater protection against infections and injurious environmental agents. (wikipedia.org)
  • The CA 15-3 antigen (also known as MUC1, from which it is derived) represents sequences of mucins that are often overexpressed in malignant glandular cells, such as breast cancer. (medscape.com)
  • A hallmark of the predominant asthma subtype is the stimulation of the adaptive immune system [ 2 ], specifically a Th2-type response, with involvement of interleukin (IL)-4 and IL-13, as well as antigen-specific immunoglobulin (Ig) type E. Type 2 innate immunity typically involves type 2 innate lymphoid cells, especially in older patients. (biomedcentral.com)
  • MUC1 mucin in urological malignancy. (moleculardepot.com)
  • In addition to clinical manifestations of the primary malignancy, patients may complain of abdominal pain , swelling [4], bloating, and increase in abdominal girth (due to ascites ) [5]. (symptoma.com)
  • Am J Respir Cell Mol Biol;54(4): 515-23, 2016 Apr. (bvsalud.org)
  • The molecular structure of mucin is like a bottle brush flower with its stem representing the mucin protein and the red flowers representing the dense array of sugars attached to the protein (see illustration). (milkgenomics.org)
  • CD164 is a 80-90 kDa, mucin-like molecule present on CD34+ cells during the early stages of B cell, erythroid cell and myelomonocytic cell development. (bdbiosciences.com)
  • The content of both mucin subtypes was measured by computerized morphometry. (scielo.br)
  • Gene ontology implicated the immune system, including interleukins 4 and 13, as well as antimicrobial peptides in this overexpression. (biomedcentral.com)
  • In fact, our preliminary studies using trinitrophenyl (TNP) as a hapten model, suggested that K b -restricted peptides haptenated in position 4 in 8 mers or position 5 in 9 mers induced a TNP-specific CTL repertoire whose TcR was poorly dependent on MHC class I contacts and highly degenerate ( 9 ). (silverchair.com)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • Transcriptional regulation of the 11p15 mucin genes. (imrpress.com)
  • Sando and colleagues demonstrated that a principal milk fat globule membrane protein is the milk mucin named MUC-1, which is densely decorated with a variety of sugars that also resemble the sugar structures on proteins present on the surface of gut cells [10]. (milkgenomics.org)
  • 3, 4 Several tumour vaccines directed against MUC1 core protein, oligosaccharides, or MUC1 cDNAs have been shown to stimulate immune reactions in basic clinical trials to confer antitumour activity. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • 7) nuclear protein reflecting the level of proliferative activity (Ki-67) [4, 5]. (cttjournal.com)
  • 4] It has been suggested that the MUC1 protein and its overexpression may be causally related to cancer invasion and metastasis. (medscape.com)
  • Mucins are characterized by a core protein heavily decorated by many sugar structures [5, 9, 10]. (milkgenomics.org)
  • Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages. (bvsalud.org)
  • Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
  • MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
  • Capable of bringing about the hydrolysis (splitting of a compound into fragments by the addition of water) of mucin, as by a mucinase (an enzyme that acts upon mucin). (wordinfo.info)
  • 2 2 Gaudier E, Hoebler C. Physiological role of mucins in the colonic barrier integrity. (scielo.br)
  • 6: Dhar P, McAuley J. The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation. (moleculardepot.com)
  • Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
  • Earlier it was shown that crystals coated with plasma proteins can stimulate greater chemiluminescent response of polymorphonuclear leukocytes than untreated particles [7], but little is known about effects of adsorbed mucin. (romj.org)
  • There was an increase in the tissue content of neutral mucins in animals treated with curcumin at a concentration of 50 mg/kg/day for four weeks, whereas in the group treated with 200 mg/kg/day there was an increase independent of the time of intervention. (scielo.br)
  • Therefore, strategies to use conditional oncolytic virus, or the so-called attenuated replication-competent viruses, to specifically target prostate tissue have been developed [ 2 - 4 ]. (hindawi.com)
  • A cDNA encoding Tc-MUC-5, a mucin from Toxocara canis larvae identified by expression screening. (expasy.org)
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • While working in John O'Brien's lab in the Department of Neurosciences, School of Medicine, UCSD, with funding support from NIH, Patton began extensive work analyzing the nature of human milk, with special emphasis on its mucins. (wikipedia.org)
  • Many scientists report that large populations of different bacterial species are present in the human gut where they aid digestion of food [3, 4]. (milkgenomics.org)
  • CP were incubated in mucin or human serum albumin (HSA) giving CP-Muc and CP-HSA. (romj.org)
  • Their hemolytic activity towards human erythrocytes was assayed, and neutrophil lucigenin- and luminol- chemiluminescence (Luc-CL and Lum-CL) response to CP, CP-HSA and CP-Muc was measured. (romj.org)
  • METHODS The stability of essential components (EGF, vitamin A, and TGF-β) in preserved serum were examined following preservation at 4°C and −20°C. In a primary clinical trial, 12 patients with Sjögren's syndrome were treated with autologous serum (diluted to 20% with sterile saline) for 4 weeks, and vital staining of the ocular surface was compared before and after treatment. (bmj.com)
  • The stability of the serum was assessed by measuring the concentration of EGF, TGF-β, and vitamin A in fresh serum samples, and after preservation in the freezer (−20°C) and refrigerator (4°C) for up to 3 months. (bmj.com)
  • The proinflammatory effect of mucin-coated particles is still unclear, and our aim was to study the role of mucin sorption in activation of neutrophil respiratory burst. (romj.org)
  • The probe did not contain any cells or mucin and was D-PAS unfavorable. (giknet.org)
  • McGuckin and colleagues concluded that the sugar structures on gut mucins often resemble the sugar structures present on the surface of gut cells [5]. (milkgenomics.org)
  • These investigators concluded that one of the functions of MUC-1 is to bind pathogenic bacteria, thereby diverting these bacteria from binding to gut cells [9]. (milkgenomics.org)
  • Toxocara canis family of secreted mucins Tc-MUC-1 to -5, which are implicated in immune evasion. (expasy.org)
  • A recent study has shown that, despite the high intrinsic mutability of subexonic repeats, the vast majority of thousands of subexonic repeats remain strongly conserved among mammals 4 . (nature.com)
  • The incidence and subsequent resection of IPMN have increased over the last 20 years, partially explained by the increased utilization of high-resolution diagnostic imaging [ 4 ]. (gastrores.org)
  • The lethal nature of pancreatic cancer is mainly correlated with its late diagnosis, high metastatic capacity to nearby organs, and resistance to therapeutic agents [ 4 ]. (oncotarget.com)
  • Well Nacific Triple Cica Natural Mucin Series ini adalah rangakain skincare terbaru dari Nacific yang cocok untuk kulit sensitif, berjerawat dan juga terdapat bekas jerawat. (daniaku.com)
  • Jadi ingridients utama dari Nacific Triple Cica Natural Mucin Series ini adalah Wild Yam Root Extrac t yang terkenal akan keampuhanya untuk melembabkan kulit yang kasar, mencerahkan kulit yang kusam, menambah kekenyalan kulit dan menutrisi kulit sensitif. (daniaku.com)
  • Nah untuk seru dari Triple Cica Natural Mucin ini bahan utamanya adalah Fructan yang membantu mengembalikan elastisitas kulit, Triple Cica yang sangat baik untuk menenangkan kulit juga sebagai antibacterial yang memperbaiki kulit rusak dan juga Hyaluronic Acid yang membantu memberikan kelembaban pada kulit. (daniaku.com)
  • The possible contribution of mucin degrading enzymes to the pathogenesis of infection is, therefore, not to be underestimated. (bmj.com)