For historical reasons, the scientific literature may also refer to this protein as Prostate secretory protein 94 (PSP94), microseminoprotein (MSP), microseminoprotein-beta (MSMB), beta-inhibitin, prostatic inhibin peptide (PIP), and inhibitin like material (ILM). (wikipedia.org)
A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. (ox.ac.uk)
BACKGROUND: Recent genome-wide association studies have shown an association of a SNP two base pairs upstream of the 5' UTR of the microseminoprotein-beta (MSMB) gene with an increased risk of developing the prostate cancer, re-igniting interest in its protein product, MSMB. (ox.ac.uk)
Beta-microseminoprotein2
Beta-microseminoprotein is a protein that in humans is encoded by the MSMB gene. (wikipedia.org)
Beta microseminoprotein is not a prostate-specific protein. (wikipedia.org)
Prostate9
The protein inhibits growth of cancer cells in an experimental model of prostate cancer, though this property is cell line-specific. (wikipedia.org)
Two large genome-wide association studies showed that decreased expression of the MSMB protein caused by the rs10993994 single nucleotide polymorphism is associated with an increased risk of developing prostate cancer (odds ratio for CT allele pair ~1.2x, and for TT allele pair ~1.6x, when compared to the low risk CC allele pair). (wikipedia.org)
The expression of MSMB is found to be decreased in prostate cancer, so it may be usable as a biomarker for prostate cancer. (wikipedia.org)
Urinary MSMB has been found to be superior to urinary PSA at differentiating men with prostate cancer, at all Gleason grades. (wikipedia.org)
BACKGROUND: β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. (ox.ac.uk)
A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. (ox.ac.uk)
RESULTS: It has been consistently shown that MSMB expression is high in normal and benign prostate tissue and lowered or lost in prostate cancer suggesting that it might be a useful tissue biomarker for prostate cancer diagnosis and its levels in serum may be useful as a marker for prognosis. (ox.ac.uk)
Thus, in the benign prostate, MSMB regulates cell growth, but when MSMB is lost during tumourigenesis, cells are able to grow in a more uncontrolled manner. (ox.ac.uk)
CONCLUSIONS: MSMB has potential as a biomarker of prostate cancer development, progression and recurrence and potentially as a target for therapeutic intervention. (ox.ac.uk)
Benign1
A 2003 study proposed using a truncated form of the MSMB protein called PSP61 as a biomarker for benign prostatic hyperplasia (BPH). (wikipedia.org)
Humans1
Both full length MSMB and a short peptide comprised of amino acids 31-45 have been tested for potential therapeutic benefit in mouse models and humans. (ox.ac.uk)
Peptide1
This truncated form of the MSMB protein lacks the fungicidal peptide identified in 2012. (wikipedia.org)
Amino acids1
Solution structures of human and porcine MSMB show remarkable similarity despite having only 51% of amino acids in common. (wikipedia.org)
Family1
Members of the cysteine-rich secretory protein family and laminin receptors have been shown to bind MSMB at the cell surface and in serum thereby regulating apoptosis. (ox.ac.uk)
Prostate cancer9
β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. (nih.gov)
A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. (nih.gov)
The protein inhibits growth of cancer cells in an experimental model of prostate cancer, though this property is cell line-specific. (wikipedia.org)
Two large genome-wide association studies showed that decreased expression of the MSMB protein caused by the rs10993994 single nucleotide polymorphism is associated with an increased risk of developing prostate cancer (odds ratio for CT allele pair ~1.2x, and for TT allele pair ~1.6x, when compared to the low risk CC allele pair). (wikipedia.org)
The expression of MSMB is found to be decreased in prostate cancer, so it may be usable as a biomarker for prostate cancer. (wikipedia.org)
Urinary MSMB has been found to be superior to urinary PSA at differentiating men with prostate cancer, at all Gleason grades. (wikipedia.org)
6. Evaluation of the prognostic significance of MSMB and CRISP3 in prostate cancer using automated image analysis. (nih.gov)
8. Effect of androgen deprivation therapy on the expression of prostate cancer biomarkers MSMB and MSMB-binding protein CRISP3. (nih.gov)
14. Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression. (nih.gov)
Secretion1
This study found PSP61 in the expressed prostatic secretion of 10 out of 10 men suffering from BPH, while not finding it in 10 out of 10 age-matched BPH-free men. (wikipedia.org)
Tumors2
Markers can also be useful for studying angiogenesis within tumors, examining proteins with a potential impact on tumor growth and survival such as CD31, CD34 and VEGFA. (stratech.co.uk)
Another useful IHC marker for TNBC is the ΔNp63 isoform of transcription factor TP63, a protein involved in regulating cell adhesion that is regularly overexpressed in triple negative tumors (Nekulova, 2016). (stratech.co.uk)
Variants1
The progression of their disease is similar to those with germline variants in these proteins, but the mechanisms of selective inactivation and somatic mutation are less clear and have been described as the BRCAness phenotype. (stratech.co.uk)