Mscs lymphocytes cell proliferation. Medical search. Frequent questions

Adipose-derived MSCs, in particular, pose an attractive option for cell-based therapy due to their relatively decreased morbidity during isolation and potential for expansion and differentiation [ 12 ]. (hindawi.com)
Multipotential differentiation of MSCs into adipogenic, osteogenic, and chondrogenic cell lineages. (hindawi.com)
Furthermore, MSCs can undergo osteogenic, adipogenic and chondrogenic differentiation ex vivo. (wikipedia.org)
The standard test to confirm multipotency is differentiation of the cells into osteoblasts, adipocytes and chondrocytes as well as myocytes. (wikipedia.org)
Different groups have established several protocols to induce the differentiation of MSCs into HLCs in vitro . (springer.com)
BACKGROUND: Gene regulation by microRNA (miRNA) is central in T lymphocytes differentiation processes. (bvsalud.org)
Here, we investigate miRNA-29b (miR-29b) roles in the reprogramming of T cell differentiation, which can be a promising therapeutic avenue for various types of inflammatory disorders such as rheumatoid arthritis and multiple sclerosis. (bvsalud.org)
This study indicates that the transfection of miR-29b mimics into T lymphocytes through AMSC-Exo can alter the CD4+ T cells' differentiation into other types of T cells. (bvsalud.org)
CONCLUSIONS: In conclusion, AMSC-Exo-based delivery of miR-29b can be considered as a new fascinating avenue for T cell differentiation inhibition and the future treatment of several inflammatory disorders. (bvsalud.org)
Until recently, differentiation was thought to be the primary function of regenerative cells. (vetstem.com)
We studied cell surface marker expression, doubling time, lineage differentiation potential and immunosuppressive function of the MSCs. (terraintherapy.com)
E-MSCs were characterized for the colony formation capacity, proliferative potential and multilineage differentiation. (preprints.org)
We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
We developed techniques to isolate mouse OMSCs derived from mandibles and verified their MSC characteristics by single colony formation, multi-lineage differentiation, and in vivo tissue regeneration. (ca.gov)
2016). Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells. (springer.com)
Especially Mesenchymal Stem cells have been focused in a plethora of preclinical and clinical experiments over the five decades due to extraordinary capacity in differentiation to multiple lineages, immunomodulation and angigenic properties. (samploon.com)
Monthly cyclical endometrial growth, differentiation, and regression are governed by a fine tuned inter play between ovarian sex steroid hormones and numerous cell types. (samploon.com)
13) Like other sources, endometrial MSCs have recently been emerged as a promising alternative source of therapeutic MSCs due to its unique ability to undergo smooth muscle differentiation, migratory, angiogenic. (samploon.com)
EMSCs also have the high capacity proliferation, multidirectional differentiation that is indicative for the potentiality for tissue regeneration. (samploon.com)
Large body of data of experiment concludes that EMSCs have the ability to differentiation in multiple lineages such as osteoblast, cartilage, adipose, smooth muscle cell(1/18), hepatocytes, cardiomyocyte, neural cells. (samploon.com)
Inside a concentration dependent manner, such treatment improved the proliferation, migration, and differentiation of cardiac lineage marker-negative/stem cell antigen-1-positive human being mesenchymal stem cells. (fsu93.org)
These beneficial effects are consecutive to the upregulation of proteins involved in oxidative stress safety, cell-cell adhesion, and commitment to differentiation[32]. (fsu93.org)
MSC-biomaterial constructs maintain MSCs tradition with the accompanying risks Dienogest of contamination and cell differentiation. (fsu93.org)
Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
and (iii) MSCs maintains the differentiation potentials of adipocytes, osteoblasts, and chondroblasts in vitro [14]. (researchsquare.com)
In spite of tissue origin, many other elements such as culture method and further modulations also influence the heterogeneity of MSCs, leading to differential gene expression profiles, growth phenotype, and differentiation potentials [15-17]. (researchsquare.com)
However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. (techscience.com)
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
The focus of this review is to highlight the role of statins in modulating the function and differentiation of various blood cells. (archivesofmedicalscience.com)
As opposed to old em in vivo /em research that feature higher bone relative density to decreased bone tissue turnover, newer research show the potential of bisphosphonates to improve osteoblast proliferation and differentiation in bone tissue marrow-derived mesenchymal stem cells (MSC) and osteoblasts [13-15]. (healthyconnectionsinc.com)

Although the mechanism remains elusive, the interest in exploring the therapeutic potential of MSC-Exo has greatly increased after the first report of MSC-Exo ameliorating myocardial ischemia/reperfusion injury in a mouse model 10 . (nature.com)
Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
Hence, a therapeutic approach was designed whereby mesenchymal stem cells (MSCs) capable of immunomodulation and significant regenerative capacity were administered systemically to cats that did not respond to extraction therapy. (bsavalibrary.com)
This lecture focuses on recent discoveries and current understandings in both etiopathogenesis and therapeutic options including stem cell therapy and immune modulation. (bsavalibrary.com)
Despite initial therapeutic outcomes, conventional stem cells face key limitations. (biomedcentral.com)
therefore, there has been growing therapeutic interest of MSCs as an option for many incurable diseases [ 11 ]. (biomedcentral.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Although there is a great deal of preclinical and clinical research about MSCs in the treatment of ALF, the exact mechanism underlying the therapeutic role of MSCs remains unclear [ 6 ]. (springer.com)
During these efforts, mesenchymal stem cells (MSCs) have shown potential as the next generation of therapeutic methods with wide application for diseases that have successfully controlled "cytokine storm" following the virus infection. (drramon.com)
The source of MSC-derived exosomes is a determining factor in its therapeutic effect. (drramon.com)
In particular, exosomes derived from mesenchymal stem cells (MSCs) are used as cell-free therapeutic agents. (drramon.com)
This ability of MSCs to adopt a different phenotype in response to sensing an inflammatory environment is not captured in assays that are commonly used to characterize these cells, but it is crucial for understanding their therapeutic potential in immune-mediated disorders. (pdffox.com)
According to current research, MSC-derived extracellular vesicles (EVs) contribute to MSC-exerted therapeutic benefits. (benitonovas.com)
As well as their remarkable therapeutic effects, MSC-EVs derived from diverse sources also possess a variety of physiological functions that may affect their therapeutic application. (benitonovas.com)
To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
The heterogeneity of MSCs discussed above hampers the comparison of the therapeutic among different MSC products when applied to clinic use. (researchsquare.com)
MSCs, if considered as a CTP in therapeutic use, have a huge challenge to achieve stable and uniform biological characteristics for ensuring safety and effectiveness in patients received MSCs treatment. (researchsquare.com)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
In this article, we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives. (techscience.com)
Many studies related to MSCs therapeutic potential in which MSCs derived extracellular vesicles accomplished a vital role. (techscience.com)
Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)

In this study, we wanted to examine the efficacy of periocular injection of human umbilical cord-derived MSC-Exo in a rat EAU model. (nature.com)
MSCs have also been derived from embryonic tissues, such as Wharton's jelly and umbilical cord blood [ 13 , 14 ]. (hindawi.com)
The term encompasses multipotent cells derived from other non-marrow tissues, such as placenta, umbilical cord blood, adipose tissue, adult muscle, corneal stroma, or the dental pulp of deciduous (baby) teeth. (wikipedia.org)
The youngest and most primitive MSCs may be obtained from umbilical cord tissue, namely Wharton's jelly and the umbilical cord blood. (wikipedia.org)
In many studies, bone marrow has been the primary source of MSC-derived exosomes, while umbilical cord MSCs have been used for exosome extraction in a study. (drramon.com)
1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)
A variety of human tissues can be used as a source of mesenchymal stem/stromal cells (MSCs), ranging from bone marrow (BM) to umbilical cord (UC). (benitonovas.com)
MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)

Although the expression of MHC class I and II molecules can be upregulated by MSC exposure to inflammatory cytokines interferon-gamma (IFN- γ ) and tumor necrosis factor-alpha (TNF- α ), they are still unable to induce an immunological response [ 18 ]. (hindawi.com)
Research has shown that exosomes are as effective as MSCs in the management of "cytokine storm" so that in a pattern similar to MSCs, exosomes downregulate T-cells proliferation, induce auto-reactive lymphocytes for the apoptosis of activated T cells, and secrete anti-inflammatory cytokines such as IL-10 and TGF-β. (drramon.com)
Cytokine analyses of cocultures of MSCs and macrophages showed that both adult and young MSCs suppress tumor necrosis factor alpha (TNF-a) and induce interleukin-10 (IL-10) production in macrophage co-culture assay in a similar manner. (terraintherapy.com)
The consensus of researchers studying RILI is that ionizing radiation could induce damage to epithelial cells and endothelial cells, dysfunction of the blood-air barrier, and increase vascular permeability. (biomedcentral.com)
Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
To induce in vitro chondrogenesis, MSCs were seeded into MC solution retained within a porous polyurethane (PU) matrix. (nature.com)
By supporting mitochondrial transfer, MSC-exosomes can suppress inflammatory cytokine production and induce phenotype 2 alveolar macrophages (M2), leading to acute lung injury (ALI) rescue. (benitonovas.com)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
Oncolytic viruses (OVs) specifically induce cancer cells death by infection of and spreading on tumor cells through different mechanisms such as direct lysis effect or adjacent cells fusion. (biomedcentral.com)

In the mixed lymphocyte reaction assay, MSCs from infants produced similar levels of suppression at all three MSC/T-cell ratios, but adult MSCs only inhibited T-cell proliferation at a 1:3 ratio. (terraintherapy.com)

These MSCs may prove to be a useful source of MSCs for clinical applications, due to their primitive properties and fast growth rate. (wikipedia.org)
Stem cell therapy in particular is an innovative new field of scientific investigation and clinical application that holds promise for a variety of diseases in veterinary medicine as well as human medicine. (vin.com)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
The efficacy of MSCs for the treatment of non-responsive FCGS has been an ongoing study, for the past 9 years, tested in several clinical trials. (bsavalibrary.com)
This lecture discusses the general concept of MSC immunomodulation therapy as well as the clinical outcome of MSC therapy for cats with FCGS and future directions. (bsavalibrary.com)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Stem cell-based immunotherapy has been recognized as a crucial immunoregulatory regimen in various preclinical and clinical studies. (biomedcentral.com)
Success in numerous animal models of disease and emerging success in human clinical trials for Crohn's fistulas 1 and stroke, 2 along with hundreds of ongoing clinical trials (see sidebar) support the rationale for stem cell use, and now success, in veterinary medicine. (vetstem.com)
VetStem Regenerative Cell Therapy is based on a clinical technology licensed from Artecel Inc. Original patents are from the University of Pittsburgh and Duke University. (vetstem.com)
Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Therapy, Preclinical and Clinical Evidence. (drramon.com)
Cell proliferation is a very important physiological effect for low power laser irradiation (LPLI) used in clinical practice. (biomedcentral.com)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Herein, we shed light on the current understanding of MSC-based therapy for RILI, including the feasibility, molecular mechanisms, animal studies, and clinical research of MSC-based therapy for RILI. (biomedcentral.com)
For their clinical use Mesenchymal Stromal Cells (MSCs), isolated from bone marrow (BM-MSCs) are considered Advanced Therapy Medicinal Products (ATMP) and need to be produced according to Good Manufacturing Practice (GMP). (preprints.org)
In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treating immune-based disorders. (pdffox.com)
An informed view of the scope of this clinical potential will require a clear understanding of the dynamic interplay between MSCs and the innate and adaptive immune systems. (pdffox.com)
Finally, we discuss progress toward clinical application of MSCs, focusing on GvHD as a case study. (pdffox.com)
1999). Historically, a challenge that has faced the field has been the lack of uniform criteria to define MSCs, which has hindered efforts to compare results obtained from different experimental and clinical studies. (pdffox.com)
On the basis of these highly promising results, the Aldo e Cele Daccò Clinical Research Centre of the Mario Negri Institutehas begun pilot cellular therapy studies using MSCs in kidney and liver transplant patients. (persico.com)
Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
Tissue regeneration approach using stem cells in different clinical settings is a medical sensation now-a-days. (samploon.com)

These cells have several advantages over bone-marrow-derived MSCs. (wikipedia.org)
Adipose-tissue-derived MSCs (AdMSCs), in addition to being easier and safer to isolate than bone-marrow-derived MSCs, can be obtained in larger quantities. (wikipedia.org)
2-5 The majority of these studies provide evidence that systemic administration of bone marrow-derived or adipose-tissue derived MSC can help preserve renal function in the face of acute insults and can also help reduce tubular injury and fibrosis. (vin.com)
Bone marrow - derived stromal cells or mesenchymal stromal cells (BMSCs or MSCs, as we will call them in this work) are multipotent progenitor cells that can differentiate into osteoblasts, adipocytes and chondrocytes. (terraintherapy.com)
Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)

Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
The stromal fraction that is harvested from adipose tissue is a heterogeneous mixture of regenerative cells (see below). (vetstem.com)

The in vitro effects of MSC-Exo on immune cell migration and responder T cell proliferation were examined by chemotactic assays and lymphocyte proliferation assays, respectively. (nature.com)
In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells. (hindawi.com)
These stem cells are capable of differentiating into chondrocytes, cardiomyocytes, melanocytes, and hepatocyte‐like cells in vitro. (wikipedia.org)
Mesenchymal stem cells clearly modulate immune responses, as demonstrated by both in vitro and in vivo studies. (vin.com)
Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
MSCs can be isolated based on their ability to adhere to plastic culture dishes, and they are capable of significant expansion by consecutive in vitro passaging (Pittenger et al. (pdffox.com)
Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
The present study had aimed to evaluate the effect of a feeder layer of irradiated MSCs in the in vitro expansion of NK cells. (springer.com)
The objective of this em in vitro /em study was to illuminate the impact of bisphosphonates on osteoblast proliferation and extracellular matrix production over a period of 14 days. (healthyconnectionsinc.com)

Our group recently reported that CD73 on the cell membrane also contributes to the immunomodulatory capacity of MSCs 3 , suggesting that MSCs exert their immunomodulatory properties in a multifactorial manner. (nature.com)
Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. (mendeley.com)

However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)

The presence of MSCs in culture or in vivo appears to either suppress or promote tumour growth. (edu.au)
Further studies, particularly in vivo, are needed to provide consistent results of how the doxorubicin-induced changes to MSCs affect treatment and patient health. (edu.au)
In vivo experiments confirmed mitochondrial abundance and mitochondrial oxygen consumption rates were elevated in host tissues following MSC treatment. (frontiersin.org)
GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
Our study suggests that both OMSCs and host cells contribute to bone formation in vivo. (ca.gov)
There have been reports showing the usefulness of MSCs-exosomes for treating a variety of ailments, such as lung, kidney, liver, neurodegenerative, cardiac, and musculoskeletal diseases, as well as skin wounds in vivo. (benitonovas.com)
Shaping of natural killer cell antitumor activity by ex vivo cultivation. (springer.com)
Purified B cells were cultured ex lover vivo in the absence or presence of stimuli of NB-598 hydrochloride B cell survival, proliferation, and activation. (mingsheng88.org)

Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)

MSCs were initially isolated from bone marrow but are now known to exist in a wide range of tissues in the human adult, including brain, thymus, lung, liver, spleen, kidney, and dental pulp [ 11 , 12 ]. (hindawi.com)
Recent years have brought increased interest in the potential for adult stem cells to help in the treatment of many diseases through both their regenerative properties as well as their apparent ability to alter the environment in injured and diseased tissues. (vin.com)
Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
In part, the lack of definitive markers probably reflects the diverse lineage of MSC and the fact that each MSC population reflects to some degree the characteristics of tissues from which they were derived. (vin.com)
MSC reside in most organs and tissues such as bone marrow, adipose, and periodontal ligament. (bsavalibrary.com)
The light must be absorbed by the endogenous chromophores of cells or tissues for actions. (biomedcentral.com)
Since mesenchymal stem cells (MSCs) have effective immune-modulatory features, inhibit T-lymphocyte proliferation, and have a high regenerative capacity, they can play a vital role in the reconstruction of injured tissues, including bronchioles, in pulmonary diseases. (biomedcentral.com)
Among the affected cells are mesenchymal stem cells (MSCs), which are involved in the maintenance and repair of tissues in the body. (edu.au)
Introduction Mesenchymal stromal cells (MSCs) are adult, fibroblast-like multipotent cells characterized by the ability to differentiate into tissues of mesodermal origin, such as adipocytes, chondroblasts, and osteoblasts (Friedenstein et al. (pdffox.com)
In the present study, we examine the specific impacts of MSCs on mitochondrial morphology and function in host tissues. (frontiersin.org)
Inflammatory preconditioning The function from the cytokine environment: Tissues injury is normally associated with irritation, cell-damage items discharge and subsequent infiltration of macrophages and neutrophils. (fsu93.org)
These MSCs derived different tissues do not have uniform characteristics, differing in expression profiles of surface markers and biological functions after certain stimulation such as pro-inflammatory mediators [5, 13]. (researchsquare.com)
Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
Polyploidization is a hallmark of cancer cells but also occurs during normal development in several tissues, e.g. in the liver. (villungerlab.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)

A number of mechanisms are involved in phenotypic alterations, including prevention of apoptosis, cell proliferation, immunomodulatory reactions, attenuation of oxidative stress, and improving oxygen supply to recipient cells. (benitonovas.com)
Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
Lead-induced apoptosis in PC 12 cells: involvement of p53, Bcl-2 family and caspase-3. (who.int)

Additionally cell surface marker characterization via flow cytometry differentiates them from hematopoetic cells, though no truly unique MSC molecule has been identified. (vin.com)
Moreover, flow cytometry and Enzyme-linked Immunosorbent Assay were respectively used to measure the frequency of T regulatory cells and the levels of cytokines production (Interleukin 17, Interleukin 4, Interferon-gamma, and transforming growth factor beta. (bvsalud.org)
Flow cytometry analysis was used to obtain the percentage of division (PD) of T cells. (mendeley.com)
B7-H1 expression on BM- and WJ-MSCs was detected by flow cytometry. (korea.ac.kr)

MSC = multipotent mesenchymal stromal cell. (hindawi.com)
While the terms mesenchymal stem cell (MSC) and marrow stromal cell have been used interchangeably for many years, neither term is sufficiently descriptive: Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. (wikipedia.org)
For most studies, the adult stem cell in question is actually a mesenchymal stem cell or mesenchymal stromal cell. (vin.com)

Among their other immunological properties, MSC inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function and alter DC cytokine production, and decrease IFN-g production by NK cells. (vin.com)
At a 1:30 ratio, however, MSCs from adults did not, but MSCs from infants did suppress T-cell proliferation. (terraintherapy.com)

The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
In this study, we evaluated the ability of MSCs derived from very young children and adults on T-cell suppression and cytokine secretion by monocytes/macrophages. (terraintherapy.com)
Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
Of importance, match bound to MSC enhanced their phagocytosis by classical and intermediate monocytes which may clarify, at least in part, why MSCs are not found in the blood circulation after infusion[40]. (fsu93.org)

As defined by the International Society for Extracellular Vesicles (ISEV), EVs are lipid bilayer particles secreted by cells that do not replicate. (benitonovas.com)

Tumor cells-derived exosomes (called texosomes) were isolated and characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, high-performance liquid chromatography, Fourier transform infrared, and Western blot assays. (bvsalud.org)
The inhibitory effect of MSCs on T lymphocytes was observed using PHA-induced T cell proliferation assays. (korea.ac.kr)

Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)

MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
Methods Cell culture Human hip bone osteoblasts (HOB-c, Promo Cell, Heidelberg, Germany) between passages 5-9 were cultured at a density of 200 000 cells per well using 6-well plates. (healthyconnectionsinc.com)

Studies have shown that exosomes play an important role in cell-to-cell communication as well as several physiological and pathological processes. (benitonovas.com)

In addition, it is also important to keep the immune modulatory properties of MSC in mind when interpreting the results of many stem cell therapy studies. (vin.com)
MSCs immune modulatory properties include decreased T-cell and B cell proliferation and function and altered lymphocytes phenotypes. (bsavalibrary.com)

In fact, some argue that MSCs and fibroblasts are functionally identical. (wikipedia.org)
VetStem Regenerative Cell (VSRC™) therapy delivers a functionally diverse cell population able to communicate with other cells in their local environment. (vetstem.com)

MSCs can not only differentiate into lung alveolar epithelial cells and secrete anti-inflammatory factors, but they also deliver some vehicles for gene therapy in repairing the injured lung, which provides new ideas for managing RILI. (biomedcentral.com)
Then, the MVB's can either fuse with lysosomes resulting in degradation of intra-luminal contents or they can secrete their content as exosomes outside the donor cells. (bbrc.in)

They also form more and dense colonies of fibroblasts (colony forming unit!fibroblast [CFU-F]). MSCs from both young and adult subjects suppressed T-cell proliferation in a mitogen-induced assay at 1:3 and 1:30 ratios. (terraintherapy.com)
MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission state to a more fused appearance indicating an effect of MSC co-culture on host cell mitochondrial network formation. (frontiersin.org)

The immunosuppressive effect of BM- and WJ-MSCs on phytohemagglutinin (PHA)-induced T cell proliferation was compared using direct and indirect co-culture systems. (korea.ac.kr)
induced immunosuppressive properties of B7-H1 in human BM- and WJ-MSCs were mediated by STAT-1 signaling, and not by PI3K/RAC-a serine/threonine-protein kinase signaling. (korea.ac.kr)
GLUT has been reported to enhance the immunosuppressive properties of MSCs. (fsu93.org)

For example, MSC are poor antigen presenting cells and do not express MHC class II or co-stimulatory molecules and only low levels of MHC class I molecules. (vin.com)
NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)

The mechanism of immunologic tolerance lies in the fact that T lymphocytes take on the work of regulatory T cells (Treg cells), which inhibit the proliferation of the T lymphocytes implicated in the rejection. (persico.com)

MSCs have been seen to even differentiate into neuron-like cells, but doubt remains about whether the MSC-derived neurons are functional. (wikipedia.org)
while cell viability decreased in a dose dependent manner across PbTx concentrations of 100-2000 nM, the LC50 was significantly higher than is seen in mammalian neurons. (vin.com)

In addition, MSCs have been shown to modulate the function of a variety of immune cells. (terraintherapy.com)
These results highlight the potential of MSCs to modulate mitochondria in both inherited and pathological disease states. (frontiersin.org)

Exosomes, which are 30- to 120-nm vesicles, are released by most types of cells, including tumor cells. (bbrc.in)
EVs are medium-sized vesicles, ranging from 30 to 120 nm and are secreted by different cell types under both physiological and pathological conditions. (bbrc.in)

Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
Young MSCs double more quickly and differentiate into bone and fat cells more efficiently than those from older donors. (terraintherapy.com)

During embryonic development mesodermal differentiate into endothelial cells, hemangioblast and hematopoietic progenitors give rise to blood vessel, the vasculogenesis. (samploon.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)

Here, we demonstrated the impact of iPSC-derived human MSCs on the development of immune tolerance and long-term graft survival in mouse orthotopic airway allografts. (biomedcentral.com)
The preconditioning of MSCs by glutathione-allylsulfur conjugates can enhance their survival after post-ischaemic myocardial implantation. (fsu93.org)
We next investigated the potential involvement of Sox5 up-regulation in the survival, proliferation and activation of B lymphocytes. (mingsheng88.org)
This slow degradation of MCL1 is usually assumed to act as a timer defining cell survival. (villungerlab.com)
We now identified the E3 Ubiquitin ligase MARCH5 as a factor that controls the stability of the MCL1/NOXA complexes during mitotic arrest with dramatic effects on the survival of the cells during and after mitotic arrest. (villungerlab.com)
In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. (archivesofmedicalscience.com)

Stem cells are generally divided into two groups, embryonic stem cells and adult stem cells. (vin.com)
Embryonic stem cells isolation primarily requires the consent of donors and can include the killing of fertilized eggs. (techscience.com)

These results suggest that MSC-Exo effectively ameliorate EAU by inhibiting the migration of inflammatory cells, indicating a potential novel therapy of MSC-Exo for uveitis. (nature.com)
Mesenchymal stem cell (MSC)-based therapy for the treatment of autoimmune diseases has demonstrated a particular promise after its successful applications in both animal models and patients. (nature.com)
Cell-based therapy utilizing mesenchymal stromal cells (MSCs) is an attractive option for augmenting the fracture repair process. (hindawi.com)
The International Society for Cellular Therapy (ISCT) has proposed a set of standards to define MSCs. (wikipedia.org)
There are numerous studies of MSC therapy in rodent models of renal failure, though most studies have focused on models of short-term protection from acute renal disease. (vin.com)
Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
Moreover, with the emerging field of regenerative medicine, this lecture informs practitioners on the practicability of stem cell therapy for FCGS. (bsavalibrary.com)
Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
Conclusion: Based on these findings, CAAR T cells are promising for curing or modulating autoimmunity and can be served as a new approach for clone-specific B cell depletion therapy in multiple sclerosis. (bvsalud.org)
3-6 The first peer-reviewed double-blinded multicenter study for adipose-derived stem cell therapy use in canine osteoarthritis of the hip showed significant improvement in all post treatment evaluation times for lameness, pain, and range of motion. (vetstem.com)
induced expression of B7-H1 in MSCs may ultimately lead to an improved understanding of MSCs and provide insight into their use as cell therapy agents. (korea.ac.kr)
Thus, many scientists have attempted to manage RILI using MSC-based therapy. (biomedcentral.com)
However, as a novel therapy MSCs still face various limitations. (biomedcentral.com)
In response to this challenge, the International Society for Cellular Therapy formulated minimal criteria for defining MSCs in order to create a broader consensus for more uniform characterization of these cells (Dominici et al. (pdffox.com)
To that end, it needs to be verified whether or not MCS cellular therapy has induced an increase in the level of Treg lymphocytes, and whether the Treg levels are maintained constant over time. (persico.com)
Collectively, our data indicate that MSC therapy rescues impaired mitochondrial morphology, enhances host metabolic capacity, and induces widespread host gene shifting. (frontiersin.org)
At present, little is known about the impact of MSC therapy on mitochondrial function and morphology. (frontiersin.org)
In a wide range of human disorders, MSC-exosomes are considered an effective alternative to whole-cell therapy because of their low immunogenicity and improved safety profile. (benitonovas.com)
Understanding of molecular mechanisms in natural killer cell therapy. (springer.com)
2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)
EMSCs also expressed high levels of CD73, CD90, CD105, and CD166, but they lacked CD14, CD34, and CD45 expression that is very similar with the minimum characteristics of MSCs defined by the Committee of the International Society for Cellular Therapy. (samploon.com)
As a result, this novel type of cell-free therapy may be safer and more efficient than the whole cell product. (fsu93.org)
The inhibition of match activation has been proposed for improving the outcome of MSC-based therapy. (fsu93.org)
Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. (techscience.com)
The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)

Stem cells are present in amniotic fluid. (wikipedia.org)

The cytotoxicity, proliferation, and cytokine production of the MBP-CAAR T cells were investigated in co-culture with B cells. (bvsalud.org)

However, no inhibitory effect of MSC-Exo on IRBP-specific T cell proliferation was observed. (nature.com)
Inhibitory effect of mesenchymal stem cells on lymphocyte proliferation. (edu.au)
Leukemia inhibitory factor (LIF), Hepatocyte growth factor (HGF) and stem-cell factor (SCF) have the essential contribution in endometrial regeneration. (samploon.com)
In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)

Scientists have observed that the primary mechanism of stem cell efficacy for COVID-19 treatment is managing the cytokine storm through their paracrine effects. (drramon.com)

This regenerative capacity is due to presence of EnSCs that were demonstrated to be immuno-privileged in comparison with other cell types, shedding a new light for cell-based therapies and rendering these cells as a promising resource in regenerative medicine. (samploon.com)

On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)

MSCs exert its angiogenic properties by not only paracrine signaling but also direct cellular involvement. (samploon.com)

In particular, adult stem cells called mesenchymal stem cells can migrate to affected areas and may be able to support the growth of other stem cells as well as moderate the response of the immune system. (vin.com)
Obtaining adult stem cells also does not raise ethical concerns. (vin.com)
uses a concentrated form of autologous adipose-derived adult stem cells to treat traumatic and degenerative diseases, including bowed tendons, ligament injuries, osteoarthritis, and osteochondral defects in horses, dogs, and cats. (vetstem.com)
MSCs are adult staminal cells obtained from bone marrow, which possess very promising immunosuppressant properties. (persico.com)

The precise spatial and temporal impact of immune cells and their cytokines on fracture healing remains obscure. (hindawi.com)
We demonstrated that iPSC-derived MSC treatment leads to significant increases in hTSG-6 protein, followed by an upregulation of mouse Tregs and IL-5, IL-10, and IL-15 cytokines, which augments graft microvascular blood flow and oxygenation, and thereby maintained a healthy airway epithelium and prevented the subepithelial deposition of collagen at d90 post transplantation. (biomedcentral.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)

Basis of treatment based dendritic cells to combat coronavirus infections is summarized. (medsci.org)

MSCs are able to evade the host cell immune system due to their low expression of major histocompatibility complex (MHC) class I molecules and complete lack MHC class II molecules and other costimulatory molecules (CD40, CD40L, CD80, and CD86) required for immune cell stimulation [ 15 - 17 ]. (hindawi.com)
They also carry biological membrane proteins, cytosolic proteins, transcription factors, messenger RNA (mRNA), and cell adhesion molecules to help bind to target cells. (drramon.com)
The identification of the Treg population among all the T lymphocytes present in the human blood is a very complex process requiring the simultaneous detection of several cellular parameters (relating to molecules located on the surface of the cell or inside the cytoplasm), which has previously been impossible. (persico.com)
By transmitting their molecules, such as proteins, messenger RNA (mRNA), and microRNAs (miRNAs), MSC exosomes stimulate phenotypic changes and subsequently modify regenerative programs of target organs. (benitonovas.com)
Upon the stage of tumorigenesis, down-regulation of the major histocompatibility complex class-I (MHC-I) molecules and also the overexpression of the stress-induced ligands on the surface of malignant cells to avoid recognition by cytotoxic T-lymphocytes (CTLs), make them more sensitive to NK cell-mediated death. (biomedcentral.com)

Over the last few decades numerous studies have reported the beneficial effects of mesenchymal stem cells (MSCs) on tissue repair and regeneration. (biomedcentral.com)
The cyclic regeneration of human endometrium is guaranteed by the proliferative capacity of Endometrial Mesenchymal Stromal Cells (E-MSCs). (preprints.org)
E2Fs to restrict proliferation of polyploid hepatocytes during liver development and regeneration. (villungerlab.com)
Here, we identified the PIDDosome as essential player under transcriptional control by E2Fs to restrict proliferation of proliferation of polyploid hepatocytes during liver development and regeneration. (villungerlab.com)

In this study, we tested the effect of local administration of human MSC-Exo on established EAU in the same species. (nature.com)
MSCs are found throughout the human body. (wikipedia.org)
The novel Cymerus™ manufacturing facilitates production of a virtually limitless supply of consistent human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells, which could play a key role in selective immunosuppression and graft repair during rejection. (biomedcentral.com)
By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
Human BM- and WJ-MSCs were isolated and cultured. (korea.ac.kr)
induced B7-H1 expression on human BM- and WJ-MSCs increased in a time-dependent manner. (korea.ac.kr)
Key findings: Doxorubicin has the potential to lead to significant and irreversible damage to the human bone marrow environment, including MSCs. (edu.au)
Human platelet lysate (HPL) represents a good GMP-compliant alternative to animal serum and after pathogen inactivation with Psoralen was more efficient and safer to produce MSCs in GMP. (preprints.org)
We aimed to compare two different endometrial sampling methods, the surgical curettage and the Vacuum Aspiration Biopsy Random Assay, and to validate a novel xeno-free method to culture human E-MSCs. (preprints.org)
Six E-MSCs cell lines were isolated after a mechanical tissue homogenization and cultured using human platelet lysate. (preprints.org)
Human endometrial tissue composed of epithelial stem cells (0.22%), mesenchymal stem cells (1.25%) and side population stem cells. (samploon.com)
Recently, treatment of human being decidua basalis MSCs with a high level of glucose was shown to enhance the engraftment and restorative potential of MSCs. (fsu93.org)
Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)

Anatomy50

Organisms16

Diseases11

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes58

Disciplines and Occupations1

Information Science3

Differentiation32

Therapeutic22

Umbilical9

Induce9

Mixed lymphocyte reaction assay1

Clinical23

Bone-marrow-derived5

Adipose tissue3

Vitro11

Immunomodulatory properties2

Progenitor cells3

Vivo8

Chondrocytes1

Tissues15

Apoptosis3

Flow cytometry4

Stromal cell3

Suppress2

Monocytes4

Extracellular Vesicles1

Assays2

Tumor necro1

Osteoblasts2

Shown that exosomes1

Immune modulatory properties2

Functionally2

Secrete2

Fibroblasts2

Immunosuppressive3

Antigen prese3

Inhibit the proliferation1

Neurons2

Modulate2

Vesicles2

Differentiate into bone2

Endothelial cells2

Survival6

Embryonic2

Therapy28

Amniotic fluid1

Cytokine production1

Inhibitory4

Efficacy1

Regenerative capacity1

Innate and adaptive immune1

Exert1

Adult4

Cytokines3

Dendritic cells1

Molecules5

Regeneration4

Human13