Mmps matrix metalloproteinase 9. Medical search. Frequent questions

LTP-associated MMP proteolysis is probably then terminated by an increase in the activity of endogenous inhibitors called tissue inhibitors of metalloproteinases. (nature.com)
Matrix metalloproteinases (MMPs), a multi-gene category of structurally and functionally homogeneous proteolytic enzymes in stability with their tissues inhibitors (TIMPs), regulate ECM turnover and so are proposed to truly have a determinant function in atrial structural redecorating mixed up in advancement and perpetuation of AF [10-15]. (californiaehealth.org)
Excessive proteolytic activity, which relates to an imbalance of the elastase/alpha1-antitrypsin system or metalloprotease (MMPs) and their inhibitors (tissue inhibitors of metalloproteases [TIMPs]), may be important in lung destruction and formation of cysts. (medscape.com)
Development of Matrix Metalloproteinase inhibitors as anti-cancer therapeutics has been a major consideration in the drug development arena for the past few decades, the reason being elevated levels of Matrix Metalloproteinases (MMPs) observed in several cancers. (amrita.edu)
We examined the effect of cytokines, mitogens, inducers and inhibitors on MMP-2 and MMP-9 expression in cervical and ovarian cancer cell lines. (drrathresearch.org)
Defining the cells and proteinases responsible for destruction of lung extracellular matrix associated with cigarette smoking will be required for development of appropriate proteinase inhibitors for application in COPD. (atsjournals.org)
The expression and regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) in neuroectodermal precursor cells is undocumented. (uea.ac.uk)
Measurement of 30 cytokines, five MMPs and four tissue inhibitors of metalloproteinases was carried out using Luminex® technology on a well-characterised population of AS patients (n = 157). (bath.ac.uk)
Remodeling of atrial extracellular matrix (ECM) in atrial fibrillation (AF) involves changes in the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). (unboundmedicine.com)
TY - JOUR T1 - Upregulation of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases in rapid atrial pacing-induced atrial fibrillation. (unboundmedicine.com)
Modulation of plasma matrix metalloproteinase 9 and its inhibitors by vitamin D. (qmul.ac.uk)
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are upregulated in a variety of diseases. (qmul.ac.uk)
Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM). (medscape.com)
Further studies are needed to establish the relationship between the initial process of resorption of the blood clot, and the involvement of MMPs 2 and 9 and its regulators/tissue inhibitors. (bvsalud.org)

Matrix metalloproteinases (MMPs) are a large family of mostly secreted, extracellularly acting proteolytic enzymes. (nature.com)

Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
however, in the corneal stroma, excessive infiltration of monocytes/macrophages is considered to be unfavorable because they secrete matrix metalloproteinases (MMPs) and other proteins undesirable for tissue healing. (medscape.com)
Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (cancerindex.org)
Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
For example, matrix metalloproteinases (MMPs), such as MMP-2 and −9, have been shown to be typical NF-κB target proteins that are responsible for extracellular matrix breakdown and cell invasion ( 7 ). (spandidos-publications.com)
Matrix metalloproteinases (MMPs) are a large family of extracellular enzymes, which function to remodel the pericellular environment, primarily through the cleavage of extracellular matrix proteins [ 16 , 17 , 18 ]. (biomedcentral.com)
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. (anaspec.com)
A critical step in this process is degradation of the basement membrane, which contains extracellular matrix (ECM) proteins and functions as a barrier to surrounding tissues. (aacrjournals.org)
Aortic atherosclerotic lesion size, plaque matrix proteins, and EMMPRIN and other inflammatory factors were measured using Oil Red O Staining, Masson's trichromestaining and immunohistochemical staining and real-time PCR. (biomedcentral.com)

Zymography assay demonstrated that KLF6 inhibited the activities of matrix metalloproteinase 9 (MMP-9) and weakened the expression of mesenchymal markers, such as snail, slug, and vimentin. (medsci.org)
The activities of matrix metalloproteinase (MMP)-2 and−9 were further inhibited and TIMP-1 and−2, and NM23-H1, the MMPs negative modulators, were further activated in the combined treatment. (frontiersin.org)

The main function of metalloproteinases is to degrade extracellular matrix and basement membrane components. (medscape.com)
The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)
Cancer cells form protrusive invadopodia, which produce and release matrix metalloproteinases (MMPs) to degrade the basement membrane thereby enabling metastasis. (oncotarget.com)
Colorectal, pancreatic and hepatic carcinomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the ECM and basement membrane, allowing cancer cells to spread to distal organs. (drrathresearch.org)
Aims Matrix metalloproteinases (MMPs) play a significant function in wound recovery: they are able to degrade all the different parts of the extracellular matrix. (researchensemble.com)

Accumulating evidence suggests that the activation of MMPs and TIMPs through integrin signaling plays an important role in cancer invasion and metastasis ( 5, 6 ). (aacrjournals.org)
We report the presence of MMP-2, but no MMP-9, and of all the four known TIMPs in neuroepithelial stem cells isolated from the human CNS. (uea.ac.uk)
Hence, regulation of selective MMPs and TIMPs occurs during differentiation of human neural precursors suggesting that MMP-2 and TIMP-4 in particular may perform regulatory roles in the developing CNS. (uea.ac.uk)
The contributions of MMPs and TIMPs to the pathogenesis of AF development have not been clearly defined. (unboundmedicine.com)

The MMPs of all samples were visualised by zymography and tear samples were assayed using nitrophenol acetate and an MMP-9 susceptible quenched fluorescent peptide as substrate. (bmj.com)
Duodenal biopsies from untreated, treated celiac patients and controls were used to quantify the expression of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12, MMP-14, their inhibitor TIMP-1, IFN-gamma and TNF-alpha by using real-time reverse transcription-polymerase chain reaction and the gelatin/casein/elastin activities by gel zymography, and to isolate lamina propria mononuclear cells (LPMCs). (nih.gov)
Zymography assays and Western blot analysis revealed an additional promotion of MMP secretion into the extracellular matrix by LASP1, thus, most likely, altering the microenvironment during cancer progression. (oncotarget.com)
After 24h the media were removed and analyzed for MMP-2 and MMP-9 by gelatinase zymography and quantitated by densitometry. (drrathresearch.org)
The known degrees of MMP-2 and -9 were measured using zymography [20]. (researchensemble.com)
In addition, nuclear factor (NF)‑κB and matrix metalloproteinase (MMP) expression was examined by western blotting, and MMP‑2/‑9 activities were determined by gelatin zymography. (spandidos-publications.com)
After extraction, the animals were euthanized at 7, 14, 21 and 30 days and the hemi-maxillae were collected for microscopic analysis (Hematoxylin and Eosin and immunohistochemistry for MMP-9) and zymography (MMP-2 and 9). (bvsalud.org)

Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas. (cancerindex.org)
Relative gene expression of matrix metalloproteinases (MMPs), interleukin (IL)-6, and IL-8 was determined via the comparative cycle threshold method. (avma.org)

By comparing the zymographic activity profiles of the gelatinases present in the samples obtained, it was deduced that the main source of these MMPs was granulocytes. (bmj.com)
The gelatinases MMP-2 and MMP-9 are enzymes that will hydrolyse type IV collagen, the major component of basement membranes. (bmj.com)
Among the several isoforms of MMPs, Gelatinases (MMP-2 and MMP-9) and MT1-MMP, a membrane bound activator of MMP-2/9, play a prominent role in metastasis by cleaving the major components of the extracellular matrix. (amrita.edu)
This study evaluated the in situ activity and expression of gelatinases (MMP-2 and MMP-9) and their relationship with TIMP-1 or TIMP-3 in atria undergoing rapid atrial pacing for the induction of AF (4 weeks' pacing followed by 2 weeks of maintained AF) in pigs. (unboundmedicine.com)
We analysed the involvement of gelatinases, MMP-2 and MMP-9, in the pathogenesis of myofibrillar myopathy (MFM). (bvsalud.org)
While similar levels of matrix metalloproteinase (MMP-2 and MMP-9, two gelatinases) was found for coated and noncoated needle stabs during the first week, markedly increased levels of both MMPs was seen for gelatin-coated but not non-coated needle stabs after 2. (lu.se)

Fibrinolytic system may participate directly in tumor progression by plasmin activity, or indirectly via metalloproteinases regulation as well. (czytelniamedyczna.pl)
Metalloproteinases in hypertension and cardiac disease: Differential expression and mutual regulation. (ualberta.ca)

We excluded gentle tissue infections, because bacteria may secrete MMPs. (researchensemble.com)

paroxysmal AF and long lasting AF differ regarding serum MMPs. (californiaehealth.org)
Plasma and serum samples were collected 2 days prior to surgery and tested for MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, high-density lipoprotein, low-density lipoprotein, high-sensitivity C-reactive protein and erythrocyte sedimentation rate. (unav.edu)
Serum levels of some cytokines and MMPs have been found to be elevated in active disease, but there is a general lack of information about biomarker profiles in AS and how these are related to disease activity and function. (bath.ac.uk)
Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis: higher MMP-9 levels are associated with plaque vulnerability. (cdc.gov)

Here, we aimed to determine whether matrix metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9 and MMP-10), tissue inhibitor of MMPs (TIMP-1) and in vivo inflammation studied by F-18-FDG-PET/CT predict recurrent cardiovascular events in patients with carotid stenosis who underwent endarterectomy. (unav.edu)

In the past, numerous studies investigating WAT inflammation have shown that the release of pro-inflammatory cytokines, such as TNFα, IL-6 or gp130 cytokines, are implicated in insulin-resistance [ 9 , 10 ]. (springer.com)
The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. (bath.ac.uk)
The purpose of this study was to investigate whether clinical measures of disease activity and function in AS are associated with particular profiles of circulating cytokines and MMPs. (bath.ac.uk)
Principal component analysis identified eight clusters consisting of various combinations of cytokines and MMPs. (bath.ac.uk)

Using fibroblasts recovered from wild-type or gene-deleted mice, invasion of three-dimensional fibrin gels proceeded in a matrix metalloproteinase (MMP)-dependent fashion. (silverchair.com)
The process of tumor invasion requires degradation of extracellular matrix by proteolytic enzymes. (oncotarget.com)
Matrix metalloproteinases (MMPs) secreted by cervical and ovarian cancer, especially MMP-2 and MMP-9, play crucial roles in tumor invasion and metastasis. (drrathresearch.org)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
The importance of MMPs in tumor development and invasion and other diseases is well known. (anaspec.com)
It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
The enhanced levels of MMP-7 and -9 mRNA expressions and increased cell invasion into matrigel were observed in colon cancer cells upon stimulation with TAM-conditioned medium. (lu.se)

Matrix metalloproteinases (MMPs) play an important role in cancer progression by degrading extracellular matrix components, promoting tumor cell migration, and thus enhancing tumor metastasis. (suny.edu)
Strong clinical and experimental evidence demonstrates association of elevated levels of uPA and MMPs with cancer progression, metastasis and shortened patient survival. (drrathresearch.org)
MMPs have been implicated in these processes and a previous study has suggested that the plasma level of MMP-2 and MMP-9 may be viewed as a non-invasive indicator of invasiveness and metastasis in colon cancer ( 3 ). (spandidos-publications.com)

95,7% and 100% samples showed MMP-2 and MMP-9 upregulation ICC, respectively. (bvsalud.org)

Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
Materials and Methods: We employed immunohistochemical staining of RANKL and MMP7 in the lesional skin from five patients with PCAC, and microarray analysis of MMPs using human monocyte-derived macrophages. (iiarjournals.org)
The ruptured fibrous cap is known to be rich in macrophages that produce MMPs, thus digesting extracellular matrix and weakening the fibrous cap. (biomedcentral.com)

Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence. (cdc.gov)

The significant increase of MMP-9 in its pro-form and mRNA level, but not MMP-2, was shown to be responsible for the increased gelatinase activity in atria with AF. (unboundmedicine.com)

Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. (cancerindex.org)
BACKGROUND/AIMS Matrix metalloproteinases (MMPs) accumulate in the tears of patients with active peripheral ulcerative keratitis (PUK) but it is unknown whether these enzymes have a central role in disease progression. (bmj.com)
13 The suggestion that these MMPs may be involved in PUK is based on the observation that MMP-2 production is upregulated in keratocytes cultured from perforated corneas of patients with PUK, and the finding that the quantity of MMP-9 in tear samples taken from eyes of patients with rheumatoid arthritis is correlated with the extent of PUK progression in the corresponding corneas. (bmj.com)

The results showed that formononetin downregulated the expression of the key pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and matrix metalloproteinases. (spandidos-publications.com)
We previously demonstrated that acute MWCNT exposure led to impaired vascular reactivity that was dependent on MMP-9 activation and CD36 signaling. (cdc.gov)
To assess whether TIMP-1 was a marker of vascular disease insulin, sCRP, fibrinogen, homocysteine, PAI-1 were measured in Bangladeshis pre supplementation with vitamin D. TIMP-1, MMP2, 9 and 25 hydroxyvitamin D 25(OH)vitD were also measured pre and post supplementation. (qmul.ac.uk)
Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. (ualberta.ca)
dhBBR and Di-MeBBR reduced expression of EMMPRIN, CD68, and NFκB p65, and Di-MeBBR also reduced expression of matrix metalloproteinase-9, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in aortic plaques. (biomedcentral.com)

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene. (wikipedia.org)
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). (cancerindex.org)
KLF6 downregulation enhances MDM2 gene expression that deregulates the p53 pathway [ 9 ]. (medsci.org)
We have also confirmed that non-steroidal anti-inflammatory drug activated gene (NAG-1) is a major molecular target of AST during its antitumorigenic action, which has a strong correlation with the PI3K-Akt signaling pathway during its action ( 9 ). (spandidos-publications.com)
Our data establish new functions for G9a-mediated H3K27me1 in MMP-9-dependent H3NT proteolysis and demonstrate how histone modification can be exploited to regulate osteoclastogenic gene expression at the molecular level. (biomedcentral.com)
There are few reports suggesting that gene expression and activation of various matrix metalloproteinases (MMPs) are deregulated. (bvsalud.org)

For example proteoglycans sequester biomolecules such as growth factors (TGF-β, VEGF, FGF etc.) and MMPs (Matrix Metalloproteinases). (springer.com)

The role of matrix metalloproteinases in multiwalled carbon nanotube (MWCNT)-induced inflammation in C57BL/6 mice. (cdc.gov)
Matrix metalloproteinases (MMPs) are ubiquitously expressed extracellular matrix (ECM) proteases that are activated in inflammation and injury and play varied roles in cellular homeostasis, adaptation, tissue remodeling and immunity. (cdc.gov)
Identification of a novel heart/liver axis: Matrix metalloproteinases-2 negatively regulates cardiac secreted phospholipase a2 to modulate lipid metabolism and inflammation in the liver. (ualberta.ca)

In physiological condition, myofibroblasts represent the main source of MMP-2, whereas LPMCs produce almost all MMPs only after cytokine stimulation. (nih.gov)
Conversely, cells isolated from active patients constitutively express MMPs without any increase after cytokine stimulation, while those from treated patients are in a resting condition. (nih.gov)

RESULTS The major MMPs that accumulate in the tears of patients with rheumatoid arthritis with active ocular disease are MMP-9 and a species of M r 116 000. (bmj.com)

Primers used to assess INF-γ, TNF-α, MMP-2, MMP-9 and GAPDH levels were from SuperArray (SABiosciences). (bmj.com)
The strongest association with the BASDAI was found with a component consisting of MMP-8, MMP-9, hepatocyte growth factor and CXCL8, and was independent of C-reactive protein levels. (bath.ac.uk)
A profile consisting of high levels of MMP-8, MMP-9, hepatocyte growth factor and CXCL8 is associated with increased disease activity in AS. (bath.ac.uk)

Together with the survey of several MMPs transcripts and the level of transforming growth factor-beta1 (TGF-beta1), we proposed that the increased activity of gelatinase (i.e. (unboundmedicine.com)

By analyzing microarray data of in-house generated control and LASP1-depleted MDA-MB-231 breast cancer cells, we observed downregulation of MMP1, -3 and -9 upon LASP1 depletion. (oncotarget.com)

Although H3 acetylation at K18 has been shown to stimulate MMP-9 enzymatic activity toward H3NT, nothing is known about the influence of other H3NT modifications on this epigenetic reaction. (biomedcentral.com)
The fibrinolytic system cooperating with the extracellular matrix metalloproteinases constitutes a very complex enzymatic system, with a wide range of proteolytic activity. (czytelniamedyczna.pl)

Matrix metalloproteinases (MMPs) are a group of structurally related endopeptidases that require a metal cofactor. (medscape.com)

Barely detected in an unwounded cornea, MMPs are strongly induced during wound healing. (medscape.com)

A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ40) aggregation, were evaluated for the inhibition of tau protein aggregation. (ibecbarcelona.eu)

Atrial structural redecorating is strongly linked to the fibrotic procedure and the next disruptions in extracellular matrix (ECM) turnover. (californiaehealth.org)
MMP-9), TIMP-1 and TIMP-3 and their interaction may contribute to atrial ECM remodeling of AF. (unboundmedicine.com)

Matrix metalloproteinase ( MMP ) is known to be involved in the initial and progressive stages of cancer development, and in the aggressive phenotypes of cancer. (biomedcentral.com)

We investigated the effect of LASP1, a newly identified protein in invadopodia, on expression, secretion and activation of MMPs in invasive breast tumor cell lines. (oncotarget.com)
Total protein extracts from tissue biopsies were analyzed for elastases MMP-2, -9, -12 and collagenases MMP-1, -3, -8, 13 using a multiplex profiling kit (R&D Systems, Minneapolis, MN). (sages.org)
For example, TAMs suppress effector T-cells through immune checkpoint molecules, such as those of the programmed cell death 1 (PD-1) ( 7 ) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) ( 8 , 9 ) pathways. (iiarjournals.org)

Conclusions Our study confirms the pivotal role of MMPs in the development of tissue damage. (bmj.com)
Matrix metalloproteinases (MMPs) are a family of endopeptidases playing a key role in tissue remodelling in both physiological and pathological conditions. (nih.gov)
The newly identified role of LASP1 in regulating matrix degradation by affecting MMP transcription and secretion elucidated the migratory potential of LASP1 overexpressing aggressive tumor cells in earlier studies. (oncotarget.com)
An inhibitor of matrix metalloproteinases (MMPs) decreased the transmigration of microglia in our system, indicating that MMPs play a role in microglial chemotaxis. (portlandpress.com)
MMP-9 plays a direct role in the activation of pro-osteoclastogenic genes by cleaving histone H3N-terminal tail (H3NT) and altering chromatin architecture. (biomedcentral.com)

This study focused on the hemopexin domain of MMP-9, a nonproteolytic domain, which is essential for MMP-9 regulated tumor cell migration. (suny.edu)
Fibrinolytic enzymes and metalloproteinases are involved in various physiological and pathological processes that require tissue remodeling and cell migration. (czytelniamedyczna.pl)

This Review focuses on recent studies that indicate that MMPs have important roles in driving such synapse plasticity under non-pathological conditions that are distinct from their roles in neuropathophysiology. (nature.com)
Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in brain injury and disease. (nature.com)
In view of the important roles of MMP-9 and EMMPRIN in vulnerability of atherosclerotic plaques, MMP-9 and EMMPRIN are potential targets for therapeutic inventions to inhibit plaque rupture and acute medical conditions. (biomedcentral.com)

Metalloproteinases: Key and common mediators of multiple gpcrs and candidate therapeutic targets in models of hypertensive cardiac disease. (ualberta.ca)

We show that H3 monomethylation at lysine 27 (H3K27me1) is essential for MMP-9-dependent H3NT proteolysis during RANKL-induced osteoclast differentiation. (biomedcentral.com)
Through the recognition of H3K27me1 mark, MMP-9 localizes and generates H3NT proteolysis at the genes encoding osteoclast differentiation factors. (biomedcentral.com)
By using RNAi and small molecule inhibitor approaches, we also confirmed that G9a is the major methyltransferase to catalyze H3K27me1 for MMP-9-dependent H3NT proteolysis and trigger the expression of osteoclast-specific genes. (biomedcentral.com)

Exposure to diethyl nitrosamine can induce more hepatic tumors in KLF6-/+ mouse than in wild-type animals [ 9 ]. (medsci.org)

Osteoblasts are mononucleated mesenchymal stem cells that form bone matrix, whereas osteoclasts are bone-resorbing multinucleated cells that differentiate from hematopoietic progenitors of the myeloid lineage [ 3 , 4 , 5 ]. (biomedcentral.com)
The aim of this study was to evaluate comparatively the effect of fluoride (F) on the activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) involved in process of alveolar bone repair. (bvsalud.org)
Microscopically the process of bone repair was similar in all groups, being noted only a delay of the blood clot resorption and bone formation in the group of 50 ppm F. The expression for MMP-9 showed differences betweengroups only during the initial repair (7 days). (bvsalud.org)
Ours results suggest an effect of fluoride on the activity of MMPs 2 and 9 at the initial period of alveolar repair which could be associated to the process of blood clot remission and delay in bone repair. (bvsalud.org)

Matrix metalloproteinase content and activity in low-platelet, low-leukocyte and high-platelet, high-leukocyte platelet rich plasma (PRP) and the biologic response to PRP by human ligament fibroblasts. (anaspec.com)

All animals received medroxyprogesterone acetate 9 and 2 days prior the infection. (bmj.com)

MMPs are proteolytic enzymes highly specialized in the degradation of ECM component [ 15 , 16 ] and each member of the MMP family is specifically involved in degradation of one or several ECM components. (springer.com)

To date, polymorphisms of the promoter domain have been described in MMP-1, -3, -9, -12 to influence the expression level of the genes [ 10 ]. (biomedcentral.com)

Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)

Anatomy37

Organisms11

Diseases17

Chemicals and Drugs117

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Health Care1

Inhibitors14

Acting proteolytic enzymes1

Proteins9

Activities of matrix metalloproteinase2

Degrade5

TIMPs4

Zymography7

Expression of Matrix Metalloproteinases2

Gelatinases6

Regulation2

Secrete1

Serum4

Tissue Inhibitor1

Cytokines4

Invasion7

Metastasis3

Upregulation1

Macrophages3

Carotid1

MRNA1

Progression3

Vascular5

Gene6

VEGF1

Inflammation3

Cytokine2

Rheumatoid arthritis1

Levels3

Gelatinase1

Downregulation1

Enzymatic2

Structurally1

Cornea1

Inhibition1

Atrial2

Cancer1

Protein3

Role5

Migration2

Roles3

Mediators1

Proteolysis3

Induce1

Bone4

Activity1

Acetate1

Degradation1

Promoter1

Accumulation of extracellular1