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Lymphocytic choriomeningitis virusLymphocytic ChoriomeningitisArenaviridae InfectionsArenavirusViruses, UnclassifiedLassa virusCD8-Positive T-LymphocytesMice, Inbred C57BLT-Lymphocytes, CytotoxicArenaviruses, Old WorldNucleoproteinsAntigens, ViralPichinde virusImmunologic MemorySpleenEpitopes, T-LymphocyteViral ProteinsDystroglycansCytotoxicity, ImmunologicHistocompatibility Antigen H-2DH-2 AntigensVirus ReplicationGlycoproteinsMice, Inbred BALB CCricetinaeVirus DiseasesMice, TransgenicLassa FeverVaccinia virusMice, KnockoutAntibodies, ViralArenaviruses, New WorldVirus CultivationLymphocyte ActivationViral VaccinesRhabdoviridae InfectionsCD4-Positive T-LymphocytesRNA VirusesVero CellsVesicular stomatitis Indiana virusCell LineVacciniaRNA, ViralL Cells (Cell Line)Hemorrhagic Fevers, ViralViral InterferencePore Forming Cytotoxic ProteinsComplement Fixation TestsT-LymphocytesReceptors, VirusAdoptive TransferCallimicoPerforinInterferon-gammaArenaviridaeCercopithecus aethiopsEpitopesImmunodominant EpitopesImmunization, PassiveInterferon Type IImmunity, CellularViral Plaque AssayMice, Inbred C3HCytotoxicity Tests, ImmunologicHepatitis, Viral, AnimalMolecular Sequence DataNeutralization TestsAcute DiseaseMice, Inbred CBAMembrane GlycoproteinsRodent DiseasesReceptors, InterferonReceptors, Antigen, T-CellNucleocapsid ProteinsRodentiaLymphocyte CountPeptide FragmentsChronic DiseaseAmino Acid SequenceAntigens, CD8InterferonsT-Lymphocyte SubsetsReceptor, Interferon alpha-betaMeningesFlow CytometryAntigen PresentationHepatitis, AnimalGranzymesImmune ToleranceClone CellsMice, Inbred StrainsInterferon-betaDendritic CellsFluorescent Antibody TechniqueImmunizationCytopathogenic Effect, ViralTime FactorsAntiviral AgentsImmunity, InnateDisease Models, Animal
LCMVInfectionArenaviridaeCongenitalPathogensEncephalitisArenavirusesPathogenicInfectionsDiagnosisMiceSingle-strandedMachupoGeographic distributionInfectiousZikaJuninTransmissionSpeciesRabiesIllnessMolecularOrganSymptomsNeurologicHerpesProteinImmuneGlycoproteinBacteriaArbovirusDiseasesEvolutionAntigensSimianAcuteAntibodiesVaccineAntigenic
LCMV20
  • Lymphocytic choriomeningitis virus (LCMV) is an enveloped single-stranded RNA virus first isolated in the cerebrospinal fluid of a woman during the 1933 Saint Louis encephalitis epidemic. (medscape.com)
  • In the United States, Wisconsin is the only ymphocytic choriomeningitis virus (LCMV) state that requires hospitals and healthcare provid- is globally occurring, Old World arenavirus. (cdc.gov)
  • Infection with lymphocytic choriomeningitis virus (LCMV) was suspected. (cdc.gov)
  • LCMV is a rodent-borne virus that most commonly causes nonfatal, influenza-like illness and occasional aseptic meningitis, but when transmitted through organ transplantation or in utero can cause severe, life-threatening disease. (cdc.gov)
  • All three ill recipients developed virus-specific immunoglobulin M. Patient D tested negative for LCMV. (cdc.gov)
  • Lymphocytic choriomeningitis virus (LCMV) is a single-stranded RNA virus of the family Arenaviridae. (medscape.com)
  • LCMV (lymphocytic choriomeningitis virus) is one of a number of unusual pathogens that can be transmitted through organ transplantation. (cdc.gov)
  • To describe a case of congenital lymphocytic choriomeningitis virus (LCMV), a potentially severe and under-diagnosed etiology of congenital chorioretinitis. (entokey.com)
  • Lymphocytic choriomeningitis virus (LCMV), an emerging fetal teratogen and member of the arenavirus family, is an often undiagnosed cause of acquired and congenital infection in humans. (entokey.com)
  • Congenital lymphocytic choriomeningitis virus ( LCMV ) infection is a transient intrauterine viral infection with selective teratogenicity depending on the timing of the primary maternal infection. (bvsalud.org)
  • Some rodents might carry a harmful virus called lymphocytic choriomeningitis virus (LCMV). (healthychildren.org)
  • Here, we recovered transcriptome and immune repertoire information for polyclonal T follicular helper cells following lymphocytic choriomeningitis virus (LCMV) infection, CD8+ T cells with binding specificity restricted to two distinct LCMV peptides, and B and T cells isolated from the nervous system in the context of experimental autoimmune encephalomyelitis. (nature.com)
  • Fungal infections are commonly identified, and emergent pathogens such as West Nile virus and lymphocytic choriomeningitis virus (LCMV) have been described. (medscape.com)
  • Lymphocytic choriomeningitis virus (LCMV), the prototype virus, was rst described in 1934 by Armstrong and Lily. (taylorfrancis.com)
  • The study of LCMV and its host is to a large extent responsible for our understanding of immunology and virus-host interactions. (taylorfrancis.com)
  • In the case of lymphocytic choriomeningitis virus (LCMV), direct contact with mice or their saliva can lead to infection. (insecta-inspecta.com)
  • Lymphocytic choriomeningitis virus (LCMV) is a virus that is spread through contact with rodents, including gophers. (aaacwildliferemoval.com)
  • Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. (medscape.com)
  • Pregnant women should also avoid hamsters and mice due to the risk of lymphocytic choriomeningitis virus (LCMV) infection that can harm the unborn baby. (kingcounty.gov)
  • Once in every six months i.e. in February and August every year, randomly selected serum samples are screened for rodent pathogens such as E. cuniculi (EC), Hantan Virus (HV), Lactate Dehydrogenase Elevating virus (LDHV), Lymphocytic Choriomeningitis Virus (LCMV), Minute Virus of Mice (MVM), Mycoplasma pulmonis (MP), Pneumonia Virus of Mice (PVM) and Mouse Hepatitis Viurs (MHV) using ELISA-based ready to use kits. (actrec.gov.in)
Infection17
  • [ 3 ] There are 3 possible outcomes for an infected rodent: rapid clearance of virus, development of an acute lethal disease, and persistent chronic infection which is clinically benign but results in the release of virus into excreta, specifically urine. (medscape.com)
  • The manifestations of the disease are thought to result from the host response to the virus as natural killer cells and cytotoxic T cells respond to infection with the production of interferon and additional inflammatory mediators. (medscape.com)
  • It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
  • In 2002, several cases of serologically confirmed West Nile virus infection occurred in persons with little or no known exposure to mosquitoes, and epidemiologic evidence suggested transmission of the virus through blood transfusions. (cdc.gov)
  • In July 2004, CDC was notified that 3 recipients of solid organs and 1 recipient of an iliac artery segment from a common donor had died from encephalitis, which was eventually found to be caused by rabies virus infection. (cdc.gov)
  • Lymphocytic choriomeningitis is a viral infection that usually causes a flu-like illness, sometimes with rash, joint pain, or infections in other parts of the body. (msdmanuals.com)
  • Most people with lymphocytic choriomeningitis have no or mild symptoms, but some have a flu-like illness, and a few develop meningitis or a brain infection. (msdmanuals.com)
  • Herpes Simplex Virus (HSV) Infections Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. (merckmanuals.com)
  • Virus-induced immune complex disease: identification of specific viral antigens and antibodies deposited in complexes during chronic lymphocytic choriomeningitis virus infection. (microbiologyresearch.org)
  • Primary infection (horizontal transmission) in mature rodents often results in disease and death, whereas intrauterine or perinatal infection (vertical transmission) usually leads to chronic lifelong viremia with persistent shedding of virus into the feces, urine, and respiratory secretions. (brainkart.com)
  • Although chronically infected rodents are somewhat tolerant to the virus (ie, infection is persistent without causing illness), they produce antibodies, and evidence of deleterious effects can be found in older hosts, usually in the form of immune complex glomerulonephritis. (brainkart.com)
  • Infection with lymphocytic choriomeningitis virus is particularly common in hamsters and mice. (brainkart.com)
  • Postmortem evaluation of the donor showed only evidence of previous Epstein-Barr virus infection. (medscape.com)
  • Randomly distributed single-cell necrosis, as observed in this patient, is a histopathologic feature observed in lymphocytic choriomeningitis virus infection. (medscape.com)
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
  • Increasing data indicate that it is an autoimmune disease, often triggered by a preceding viral or bacterial infection with organisms such as Campylobacter jejuni , cytomegalovirus, Epstein-Barr virus, or Mycoplasma pneumoniae . (medscape.com)
  • Due to the rapidly evolving epidemic of Zika virus infection, the Council of State and Territorial Epidemiologists (CSTE) Executive Board developed an interim position statement to establish standardized case definitions for Zika virus disease and ZIKV congenital infection dated February 26, 2016, and to add these conditions to the Nationally Notifiable Diseases List. (cdc.gov)
Arenaviridae2
Congenital2
Pathogens1
  • Cases have been caused by emerging pathogens, including West Nile virus, rabies virus, lymphocytic choriomeningitis virus, and Balamuthia mandrillaris amebae. (cdc.gov)
Encephalitis6
  • It is likely that signs and symptoms of encephalitis among transplant recipients during a West Nile virus outbreak led to the recognition that West Nile virus had been transmitted through organ transplants. (cdc.gov)
  • Encephalitis Encephalitis is inflammation of the brain that occurs when a virus directly infects the brain or when a virus, vaccine, or something else triggers inflammation. (msdmanuals.com)
  • Encephalitis is inflammation of the parenchyma of the brain, resulting from direct viral invasion or occurring as a postinfectious immunologic complication caused by a hypersensitivity reaction to a virus or another foreign protein. (merckmanuals.com)
  • Treatment involves antiviral drugs when indicated (eg, in herpes simplex virus encephalitis) and is otherwise supportive. (merckmanuals.com)
  • Encephalitis is most commonly due to viruses, such as herpes simplex, herpes zoster, cytomegalovirus. (merckmanuals.com)
  • Viruses causing primary encephalitis directly invade the brain. (merckmanuals.com)
Arenaviruses6
  • Arenaviruses Arbovirus, arenavirus, and filovirus are viruses that are spread from animals to people and, with some viruses, from people to people. (msdmanuals.com)
  • Monoclonal antibodies prepared against Tacaribe and Junin viruses have been used to define further the serological relationships between arenaviruses of the Tacaribe complex. (microbiologyresearch.org)
  • Monoclonal antibodies to lymphocytic choriomeningitis virus react with pathogenic arenaviruses. (microbiologyresearch.org)
  • Monoclonal antibodies to lymphocytic choriomeningitis virus and Pichinde viruses: generation, characterization and cross-reactivity with other arenaviruses. (microbiologyresearch.org)
  • Immunohistochemical tests of these tissues with polyclonal antibodies were negative for dengue virus, yellow fever virus, hantaviruses, arenaviruses and Ebola virus. (cdc.gov)
  • Arenaviruses Associated with Hemorrhagic Fevers, Lymphocytic Choriomeningitis Virus. (brainkart.com)
Pathogenic1
  • Some of the pathogenic triggers of GBS include Epstein-Barr virus, cytomegalovirus, the enteroviruses, hepatitis A and B, varicella, Mycoplasma pneumoniae, and Campylobacter jejuni , which is perhaps the most common. (medscape.com)
Infections2
  • During viral infections, the complex and dynamic distributions of variants, termed viral quasispecies, play a key role in the adaptability of viruses to changing environments and the fate of the population as a whole. (springer.com)
  • Several infections (eg, Epstein-Barr virus, cytomegalovirus, hepatitis, varicella, other herpes viruses, Mycoplasma pneumoniae , C jejuni ) as well as immunizations have been known to precede or to be associated with the illness. (medscape.com)
Diagnosis1
  • Although virus isolation and serologic diagnosis may be performed, these procedures should not be attempted in a hospital diagnostic laboratory. (brainkart.com)
Mice3
  • Mice can carry many viruses that are also invisible to the naked eye. (actionpest.com)
  • When lymphocytic choriomeningitis is transmitted by mice, it occurs mainly in adults during the autumn and winter. (msdmanuals.com)
  • The virus may be isolated in the early stages of disease by cell culture or intracerebral inoculation of blood or CSF into weanling mice or young guinea pigs. (brainkart.com)
Single-stranded1
  • Rabies virus is an enveloped, negative, single-stranded RNA virus. (cdc.gov)
Machupo3
  • Old world viruses include the Lassa virus (LASV) and Lujo fever in Africa, while New World viruses include several viral hemorrhagic fevers (Junin, Machupo, Guanarito, Sabia, Chapare) found in South America. (medscape.com)
  • A close relationship was found between these two viruses and the heterologous Amapari and Machupo viruses, with Pichinde virus and Parana virus being more distantly related. (microbiologyresearch.org)
  • The viruses in this group include the South American hemorrhagic fever agents (Junin virus, the cause of Argentinean hemorrhagic fever, and Machupo virus, the cause of Bolivian hemorrhagic fever) and Lassa virus, the cause of Lassa fever in West Africa. (brainkart.com)
Geographic distribution1
  • Because of its a broad geographic distribution and Lymphocytic choriomeningitis virus is an underreported potential for severe disease, clarifying the effects of cause of miscarriage and neurologic disease. (cdc.gov)
Infectious3
  • One antibody (2.25.4) effectively neutralized all infectious virus. (microbiologyresearch.org)
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
  • Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
Zika2
  • Infected mosquitos can transmit viruses like the Zika virus , which has been linked to birth defects. (healthychildren.org)
  • Zika virus (ZIKV), a flavivirus transmitted by Aedes species mosquitoes, was first identified in the Zika Forest by the Virus Research Institute in Uganda in a non-human primate in 1947 and from Aedes africanus mosquitoes in 1948. (cdc.gov)
Junin1
  • Protection of guinea pigs inoculated with Tacaribe virus against lethal doses of Junin virus. (microbiologyresearch.org)
Transmission6
  • [ 5 , 6 ] Both vertical transmission to rodent offspring and horizontal spread contribute to the maintenance of virus in the rodent population. (medscape.com)
  • Transmission of lymphocytic choriomeningitis virus by organ transplantation. (cdc.gov)
  • While effective treatments have significantly extended the lives of people living with HIV and reduced the transmission of the virus, there is no cure for HIV or AIDS. (khon2.com)
  • Laboratory and epidemiologic data substantiated this mode of virus transmission and documented that the organ donor had likely acquired West Nile virus through a blood transfusion. (cdc.gov)
  • The transmission of rabies virus through cornea transplantation has been described, but transmission through solid organ transplantation was not recognized before 2004. (cdc.gov)
  • The viruses are perpetuated by vertical transmission from infected mothers to their offspring. (brainkart.com)
Species4
  • Often 1 or a few rodent species serves as the natural reservoir for a given virus. (medscape.com)
  • The common house mouse ( Mus musculus ) is the not nationally notifiable, the Centers for Disease primary reservoir, although the virus can infect Control and Prevention (CDC) receives case re- many other rodent species, including wild or do- ports on a voluntary basis ( 7 ). (cdc.gov)
  • Proteins found in any species of virus. (lookformedical.com)
  • The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS , but whose true origin is unknown. (lookformedical.com)
Rabies2
  • and live-virus vaccines (eg, the older rabies vaccines prepared from sheep or goat brain). (merckmanuals.com)
  • Rabies is a virus that attacks the central nervous system and is fatal to humans if left untreated. (aaacwildliferemoval.com)
Illness3
  • West Nile virus was historically associated with infrequent epidemics of relatively mild febrile illness. (cdc.gov)
  • In 1999, West Nile virus was first identified in North America, where it caused an outbreak of encephalitic illness in New York City. (cdc.gov)
  • Viremia can persist 1 month, and virus shed-ding in the urine may continue more than 2 months after the onset of illness. (brainkart.com)
Molecular3
  • Arias A, Lázaro E, Escarmís C, Domingo E (2001) Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning. (springer.com)
  • Molecular studies of LCM virus-induced immunopathology: development and characterization of monoclonal antibodies to LCM virus. (microbiologyresearch.org)
  • Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
Organ5
  • Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011. (cdc.gov)
  • Brief report: lymphocytic choriomeningitis virus transmitted through solid organ transplantation-Massachusetts, 2008. (cdc.gov)
  • Later that year, the first recognized U.S. cases of organ transplant-transmitted West Nile virus were described. (cdc.gov)
  • Six clusters of organ transplant-transmitted West Nile virus were reported to CDC during 2002 to 2013. (cdc.gov)
  • Therefore, it may prove challenging to implement West Nile virus screening of potential organ donors. (cdc.gov)
Symptoms2
  • Because of its nonspecific symptoms, lack of lymphocytic choriomeningitis virus disease in a person physician awareness, suboptimal diagnostic test- living with HIV in Connecticut, USA, identified by using ing, and limited and inconsistent reporting require- quantitative reverse transcription PCR. (cdc.gov)
  • Most people with lymphocytic choriomeningitis have no or mild symptoms. (msdmanuals.com)
Neurologic1
  • Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. (medscape.com)
Herpes1
  • A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. (lookformedical.com)
Protein2
  • Protein structure of lymphocytic choriomeningitis virus: identification of the virus structural and cell associated polypeptides. (microbiologyresearch.org)
  • It is a bivalent vaccine containing two recombinant, replication-deficient lymphocytic choriomeningitis virus (rLCMV) vectors, one expressing the pp65 protein and one expressing the gB protein of human cytomegalovirus (HCMV). (pharmaceutical-technology.com)
Immune3
  • Borrego B, Novella IS, Giralt E, Andreu D, Domingo E (1993) Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection. (springer.com)
  • He was among the first "to recognize the role of the immune response in the pathogenesis of murine lymphocytic choriomeningitis. (wikipedia.org)
  • The virus infects and kills immune cells, and without effective ongoing treatment leaves the individual increasingly immunocompromised over time. (khon2.com)
Glycoprotein1
  • Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusion. (microbiologyresearch.org)
Bacteria3
  • When these creatures get into your home, they can carry harmful bacteria, microscopic viruses, and tiny parasitic bugs. (actionpest.com)
  • The most common is through their infected urine, which can contaminate water or soil with bacteria or viruses. (aaacwildliferemoval.com)
  • Their fur can also carry bacteria and viruses, which can be passed on to humans through contact. (aaacwildliferemoval.com)
Arbovirus1
  • In Yale Arbovirus Research Unit the Uukuniemi virus was found to be related to some recent isolates (mainly from ticks) which together form the Uukuniemi group. (cdc.gov)
Diseases2
Evolution4
  • Also, mutant spectra are the target on which selection and random drift act to shape the long-term evolution of viruses. (springer.com)
  • Baranowski E, Ruíz-Jarabo CM, Pariente N, Verdaguer N, Domingo E (2003) Evolution of cell recognition by viruses: a source of biological novelty with medical implications. (springer.com)
  • In Domingo E, Webster RG, Holland JJ (eds) Origin and evolution of viruses. (springer.com)
  • Charpentier C, Dwyer DE, Mammano F, Lecossier D, Clavel F, Hance AJ (2004) Role of minority populations of human immunodeficiency virus type 1 in the evolution of viral resistance to protease inhibitors. (springer.com)
Antigens1
Simian1
  • The analyses published were conducted with a simian immunodeficiency virus (SIV) model, commonly used in a preclinical setting as a surrogate to HIV. (khon2.com)
Acute1
  • 1953) and by Hilleman and Werner (1954) aroused great interest and excitement among clinicians and virologists alike in that no new acute viral respiratory disease of humans had been isolated since the identification of influenza virus 20 years earlier (Smith et al. (wikipedia.org)
Antibodies2
  • The kinetics of reaction between antibody and virus were examined for all five neutralizing antibodies. (microbiologyresearch.org)
  • Variants of Tacaribe virus resistant to neutralization by antibody 2.25.4 were obtained by growth in the presence of this antibody and neutralization kinetics were reexamined using the heterologous monoclonal neutralizing antibodies. (microbiologyresearch.org)
Vaccine1
  • Chumakov KM, Powers LB, Noonan KE, Roninson IB, Levenbook IS (1991) Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine. (springer.com)
Antigenic1