• In the kidney, the loop of Henle (English: /ˈhɛnli/) (or Henle's loop, Henle loop, nephron loop or its Latin counterpart ansa nephroni) is the portion of a nephron that leads from the proximal convoluted tubule to the distal convoluted tubule. (wikipedia.org)
  • The Bowman's capsule produces filtrate, which travels down the proximal convoluted tubule, descending loop of Henle, the ascending loop of Henle and the distal convoluted tubule. (flashcardmachine.com)
  • The loop is also sometimes called the nephron loop. (wikipedia.org)
  • The structure and transport properties of the loop of Henle in the nephron. (howstuffworks.com)
  • The site of action appears to be the cortical diluting segment of the ascending limb of Henle's loop of the nephron. (nih.gov)
  • We conclude that glibenclamide impairs sodium reabsorption in one or more of the nephron segments that comprise the loop of Henle. (aspetjournals.org)
  • 3. A pharmacologic action in the functional area of the nephron, i.e., proximal and distal tubules and the ascending limb of the loop of Henle. (drugs.com)
  • The therapeutic efficacy of Furosemide Syrup 1% is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule, but also in the ascending limb of the loop of Henle. (drugs.com)
  • The nephron has the following vital parts: Bowman's capsule, tubule-like region, the loop of Henle. (vedantu.com)
  • The loop of Henle can be divided into four parts: Thin descending limb of loop of Henle The thin descending limb has low permeability to ions and urea while being highly permeable to water. (wikipedia.org)
  • The ascending limb of the loop of Henle receives an even lower volume of fluid and has different characteristics compared to the descending limb. (wikipedia.org)
  • The loop of Henle has a descending limb and an ascending limb. (howstuffworks.com)
  • citation needed] The descending loop of Henle receives isotonic (300 mOsm/L) fluid from the proximal convoluted tubule (PCT). (wikipedia.org)
  • As in the proximal tubule, the reabsorption of other solutes in the thick segment of the ascending loop of Henle is closely linked to the reabsorptive capability of the sodium-potassium ATPase pump, which maintains a low intracellular sodium concentra-tion. (brainkart.com)
  • My work suggests that proximal delivery of calcium to the loops of Henle is important in the pathogenesis of nephrocalcinosis and kidney stone formation. (ku.edu)
  • These data indicate that AP-III has a unique natriuretic effect different from frusemide, and that the main site of natriuretic action by AP-III is proximal to the ascending loop of Henle. (portlandpress.com)
  • Named after its discoverer, the German anatomist Friedrich Gustav Jakob Henle, the loop of Henle's main function is to create a concentration gradient in the medulla of the kidney. (wikipedia.org)
  • This video explains why desert mammals have longer Henle's loops. (topperlearning.com)
  • These results are consistent with the hypothesis that the natriuresis resulting from glibenclamide administration is a consequence of blockade of potassium channels in the apical membrane of the thick ascending limb of Henle's loop. (aspetjournals.org)
  • The loop has a sharp bend in the renal medulla going from descending to ascending thin limb. (wikipedia.org)
  • Urine next passes through the loop of Henle, a long straight tubule that carries urine into the renal medulla before making a hairpin turn and returning to the renal cortex. (innerbody.com)
  • Of these 3 types of diuretics, loop diuretics have a greater effect on renal magnesium wasting because of their site of action. (medscape.com)
  • this, in turn, inhibits sodium and chloride reabsorption in the ascending loop of Henle and distal renal tubule. (medscape.com)
  • By means of a countercurrent multiplier system, which uses electrolyte pumps, the loop of Henle creates an area of high urea concentration deep in the medulla, near the papillary duct in the collecting duct system. (wikipedia.org)
  • The interstitium of the kidney increases in osmolarity outside as the loop of Henle descends from 600 mOsm/L in the outer medulla of the kidney to 1200 mOsm/L in the inner medulla. (wikipedia.org)
  • The loop of Henle can then concentrate NaCl in the medulla. (howstuffworks.com)
  • Which type of nephrons are long loops of Henle that deeply invade the medulla? (freezingblue.com)
  • Most pharmaceutical drugs are detrimental to the kidneys, and "loop diuretics" are especially so. (oneradionetwork.com)
  • The loop of Henle consists of three functionally distinct segments: the thin descending segment, the thinascending segment, and the thick ascending segment. (brainkart.com)
  • The thick segment of the loop of Henle, which begins about halfway up the ascending limb, has thick epithelial cells that have high metabolic activity and are capable of active reabsorption of sodium, chloride, and potassium (see Figure 27-8). (brainkart.com)
  • About 25 per cent of the filtered loads of sodium, chloride, and potassium are reabsorbed in the loop of Henle, mostly in the thick ascending limb. (brainkart.com)
  • Considerable amounts of other ions, such as calcium, bicarbonate, and magnesium, are also reabsorbed in the thick ascending loop of Henle. (brainkart.com)
  • The thick ascending limb of the loop of Henle is the site of action of the powerful " loop " diureticsfurosemide, ethacrynic acid , and bumetanide , all ofwhich inhibit the action of the sodium 2-chloride, potassium co-transporter. (brainkart.com)
  • Conversely, the kidney retains a strong capacity to resorb magnesium, and the main site for reabsorption is the thick ascending loop of Henle. (medscape.com)
  • A) Magnesium reabsorption in the thick ascending limb of the loop of Henle. (medscape.com)
  • A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. (bvsalud.org)
  • UMOD codes for uromodulin (also known as Tamm-Horsfall protein), which is expressed exclusively in the thick ascending limb of the loop of Henle and is the most common protein in normal urine. (medscape.com)
  • Ascending limb of loop of Henle Sodium (Na+), potassium (K+) and chloride (Cl−) ions are reabsorbed from the urine by secondary active transport by a Na-K-Cl cotransporter (NKCC2). (wikipedia.org)
  • In thethick ascending loop , movement of sodium across the luminal membrane is mediated primarily by a 1-sodium , 2-chloride , 1-potassium co-transporter (Figure 27-9). (brainkart.com)
  • Thin ascending limb of loop of Henle The thin ascending limb is impermeable to water, but it is permeable to ions. (wikipedia.org)
  • The descending portion of the loop of Henle is extremely permeable to water and is less permeable to ions, therefore water is easily reabsorbed here and solutes are not readily reabsorbed. (wikipedia.org)
  • As filtrate moves down the loop of Henle, water is reabsorbed, but ions (Na,Cl) aren't. (howstuffworks.com)
  • In the loop of Henle mostly Na + and Cl - ions and water are reabsorbed. (trc-p.nl)
  • This efficient process is possible because of the anatomy of the loop of Henle with a descending and an ascending limb in each other's close vicinity. (trc-p.nl)
  • citation needed] The main function of the loop of Henle is to set up a concentration gradient. (wikipedia.org)
  • The longer the loop, the bigger the concentration gradient. (howstuffworks.com)
  • About 20 per cent of the filtered water is reabsorbed in the loop of Henle, and almost all of this occurs in the thin descend-ing limb. (brainkart.com)
  • Are the ascending or descending Loop of Henle usually thin segements? (freezingblue.com)
  • What these two transport properties do is set up a concentration difference in NaCl along the length of the loop, with the highest concentration at the bottom and lowest concentration at the top. (howstuffworks.com)
  • Since water is also reabsorbed the volume of fluid in the loop of Henle is less than the PCT, approximately one-third of the original volume. (wikipedia.org)
  • The 300 mOsm/L fluid from the loop loses water to the higher concentration outside the loop and increases in tonicity until it reaches its maximum at the bottom of the loop. (wikipedia.org)
  • Are the ascending or descending Loop of Henle freely permeable to water? (freezingblue.com)
  • The tissue type of the loop is simple squamous epithelium. (wikipedia.org)
  • citation needed] The loop of Henle is supplied by blood in a series of straight capillaries descending from the cortical efferent arterioles. (wikipedia.org)
  • The functional relevance of NKCC2 in human is illustrated by the many abnormalities that result from the inactivation of this transport system through the use of loop diuretics or in the setting of inherited disorders. (nih.gov)
  • Durisef increases toxicity of polymixines and aminoglycosides, diuretics affecting loop of Henle in kidneys. (umc-cares.org)
  • Loop diuretics. (freezingblue.com)
  • ROMK is an apical K(+) channel expressed in the thick ascending limb of Henle (TALH) and throughout the distal nephron of the kidney. (nih.gov)
  • occurs in the loop of henle, 2 tubules running in the opposite direction to one another - one thin descending, one thick ascending. (brainscape.com)
  • Completely dysfunctional mutations in the receptors and ion channels in the thick ascending limb of the loop of Henle (TALH) are probably not compatible with life. (medscape.com)
  • SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na + , K + , and Cl - ions through the apical membrane of the thick ascending loop of Henle (TALH). (nih.gov)
  • citation needed] The loop of Henle is supplied by blood in a series of straight capillaries descending from the cortical efferent arterioles. (wikipedia.org)
  • These capillaries have a hairpin configuration similar to that of the loops of Henle. (medscape.com)
  • 20. Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors. (nih.gov)
  • Since water is also reabsorbed the volume of fluid in the loop of Henle is less than the PCT, approximately one-third of the original volume. (wikipedia.org)
  • The 300 mOsm/L fluid from the loop loses water to the higher concentration outside the loop and increases in tonicity until it reaches its maximum at the bottom of the loop. (wikipedia.org)
  • It must also usually be given with a diuretic, frequently one acting in the ascending limb of the loop of Henle, to prevent serious fluid accumulation. (nih.gov)
  • Bumetanide is a loop diuretic with a rapid onset and short duration of action. (nih.gov)
  • As flow increases, the ability of the loop to maintain its osmolar gradient is reduced. (wikipedia.org)
  • The tissue type of the loop is simple squamous epithelium. (wikipedia.org)
  • Loop of Henle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)