Localization tumor suppressor proteins. Medical search. Frequent questions

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. (wikipedia.org)
BAP1 is also known as: UniProt name: Ubiquitin carboxyl-terminal hydrolase BAP1 ubiquitin carboxyl-terminal hydrolase like-2 (UCHL2) human cerebral protein 6 (hucep 6) human cerebral protein-13 (hucep-13) In humans, BAP1 is encoded by the BAP1 gene located on the short arm of chromosome 3 (3p21.31-p21.2). (wikipedia.org)
Mutations in the tumor suppressor gene BAP1 occur in approximately 15% of clear cell renal cell carcinoma (CCRCC) cases. (wikipedia.org)
Multiple endocrine neoplasia syndrome type 1 (MEN-1), loss-of-function germline mutations in the tumor suppressor gene MEN1 increase the risk of developing pituitary, parathyroid and pancreatic islet tumors, and less commonly thymic carcinoids, lipomas and benign adrenocortical tumors. (intechopen.com)
The CDKN1B gene provides instructions for making a protein called p27. (medlineplus.gov)
Most of the CDKN1B gene mutations that cause multiple endocrine neoplasia type 4 change single protein building blocks (amino acids) in the p27 protein. (medlineplus.gov)
Mutations in the CDKN1B gene have also been found to cause tumors in single endocrine glands, such as the pituitary gland or the parathyroid glands. (medlineplus.gov)
Somatic CDKN1B gene mutations have been identified in sporadic (nonfamilial) pituitary adenomas and in sporadic parathyroid adenomas, which are noncancerous tumors of the parathyroid glands. (medlineplus.gov)
Apart from multiple endocrine neoplasia, the CDKN1B gene is rarely mutated in cancerous tumors. (medlineplus.gov)
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions. (amedeo.com)
To assess the role of an individual HDAC isoenzyme in physiology and tumor development, HDAC2-mutant mice were generated from a gene trap embryonic stem cell clone. (aacrjournals.org)
Complex patterns of posttranslational modifications of chromatin including acetylation of histones establish combinatorial signals that are apparently interpreted by chromatin-binding proteins and the gene expression machinery to control transcriptional activity of individual genes. (aacrjournals.org)
Although the tumor protein 53 (TP53) gene is intensively studied, there are few data on TP53 mutations in Romanian CRC. (bvsalud.org)
The breast and ovarian cancer susceptibility gene BRCAl has been recently cloned and revealed an open reading frame of 1863 amino acids, but a lack of significant homology to any known protein in the database has led to few clues about its functions. (um.es)
Mutational analyses of the exon3 of the β-catenin gene and Axin gene were performed on tumors with nuclear β-catenin expression. (biomedcentral.com)
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. (caslab.com)
Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. (caslab.com)
Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family]. (nih.gov)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. (rupress.org)
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins. (rupress.org)
The gene encodes a phosphoprotein of 522 amino acids made of three domains: a central hydrophobic domain of eight repeats of 42-44 amino acids each, displaying similarity to the arm motif found in junctional and nucleopore complex proteins, and flanked by two hydrophilic NH2- and COOH-terminal domains. (rupress.org)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (ayassbioscience.com)
This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (ayassbioscience.com)
The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
Using the ONCOMINE and Gene Expression Omnibus (GEO) databases, we compared the gene expression of 24 importins and exportins in 20 cancer microarray datasets and then analyzed the survival of the candidate genes, CSE1L (Chromosome Segregation Like 1 protein/CAS) was finally selected. (researchsquare.com)
Chatterjee, TK & Fisher, RA 2000, ' Novel alternative splicing and nuclear localization of human RGS12 gene products ', Journal of Biological Chemistry , vol. 275, no. 38, pp. 29660-29671. (elsevierpure.com)
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. (idrblab.net)
As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). (embl.de)
STK11 is a tumor suppressor gene, in that its overexpression can induce a growth arrest of a cell at the G1 phase of the cell cycle and that somatic inactivation of the unaffected allele of STK11 is often observed in polyps and cancers from patients with Peutz-Jeghers syndrome. (medscape.com)
Desmoid tumors occur at a rate of 10-15% in patients with FAP, an autosomal inherited disease caused by germline mutations in the APC gene. (medscape.com)
[ 11 ] Desmoid tumors show biallelic APC mutation, with one change usually occurring distal to the second beta-catenin binding/degradation repeat of the gene (3' to codon 1399). (medscape.com)
In desmoid tumors, one of the two mutations usually occurs distal to the second beta-catenin binding/degradation repeat of the gene (3' to codon 1399). (medscape.com)
In desmoid tumors, 1 of the 2 mutations usually occurs distal to the second beta-catenin binding/degradation repeat of the gene (3' to codon 1399). (medscape.com)
This process is an example of the Knudsen "two hit" hypothesis, in which a tumor suppressor gene, such as APC , must be biallelically mutated in order for a specific type of tumor to occur. (medscape.com)
In genetically normal individuals, with normal germline genes, this necessitates a rare combination of events, such that at least 2 somatic mutations must occur in both alleles of a single tumor suppressor gene, in this case the APC gene. (medscape.com)
In FAP syndrome patients, one APC germline gene is already mutated in every cell in the body (barring a rare reverse somatic mutation in some cells), and, therefore, only one new somatic mutation is required in the opposite APC gene for the tumor to develop. (medscape.com)

The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
Notably, Debcl modulates Drp1 mitochondrial localization during apoptosis. (sdbonline.org)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. (nih.gov)
Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits. (nih.gov)
To evaluate the function of CSE1L in vitro and in vivo , CCK-8, colony formation, cell apoptosis and subcutaneous tumor model were performed. (researchsquare.com)
Export and import of mRNA and specific proteins from the nucleus is a key step in intracellular signaling and can lead to cell proliferation or apoptosis. (researchsquare.com)
The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. (ijbs.com)

Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)

Protein transport between the nuclear and the cytoplasmic compartment is a key factor for cell viability and proliferation. (massgeneral.org)
Oddly enough BRCA1 was uncovered as nuclear phosphoprotein in regular cells and PTZ-343 in tumor cell lines from tissue other than breasts and ovary whereas predominant cytoplasmic area of BRCA1 continues to be seen in the breasts and ovarian cancers cells (54). (healthy-nutrition-plan.com)
Furthermore BRAP2 (BRCA1 binding proteins 2) binds BRCA1 NLSs to facilitate cytoplasmic retention by disrupting relationship with. (healthy-nutrition-plan.com)
Furthermore overexpression of XPO1 correlates with an unhealthy prognosis in lots of human malignancies indicating that adjustments in nuclear-cytoplasmic trafficking leading to aberrant localization of essential proteins can donate to cancers development and development. (tech-strategy.org)

The level of free β-catenin is low in normal cells, since the protein is sequestered in a complex, which includes the adenomatous polyposis coli (APC) protein, a serine threonine glycogen kinase (GSK-3β) and conductin or Axin, leading to degradation of β-catenin by proteasome. (biomedcentral.com)
The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)

This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1. (univ-paris5.fr)
[5-10] These small noncoding molecules, measuring on average 22 nucleotides, have been demonstrated to play an important role in the multi-step process of carcinogenesis either by taking on oncogenic or tumour suppressor functions. (ysjournal.com)
Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)

This protein is found in cells and tissues throughout the body. (medlineplus.gov)
MMR IHC of formalin-fixed paraffin-embedded tissues from tumor areas obtained from 651 patients with CRC who underwent surgical resection at Hamamatsu University Hospital (Hamamatsu, Japan) between August 2016 and March 2022 were used to evaluate MMR status, which was determined by staining for the expression of 4 MMR proteins (MLH1, MSH2, PMS2, and MSH6). (bvsalud.org)
MAGEH1 expression was downregulated in HCC tumor tissues compared with adjacent normal liver tissues and in samples from patients with tumor recurrence. (nih.gov)
Thereafter, the OHO31 protein is predominantly expressed, albeit at reduced levels, in proliferating tissues. (rupress.org)
Increased expression of CSE1L in tumor tissues associated with shorter survival times and advanced pathological stage of patients with cancer. (researchsquare.com)
[ 12 , 13 ] The relationship between extracolonic manifestations and the site of the APC mutation suggests a specific role of the APC protein in different tissues. (medscape.com)
Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)

To date, 5 years after surgery, the patient remains without evidence of tumor recurrence. (mdpi.com)
This course and the tendency for recurrence make the treatment of these relatively rare fibrous tumors challenging. (medscape.com)

Many tumor cell lines and experimental tumors respond to HDAC inhibition. (aacrjournals.org)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
Inhibition of CKα using siRNA or small-molecule inhibitors (TBBz, CX-4945) reduced cell growth, decreased tumor size, and increased survival rates in GBM xenograft mouse models. (stanford.edu)

In cancer, BAP1 can function both as a tumor suppressor and as a metastasis suppressor. (wikipedia.org)
This study also identified a germline mutation in one of the uveal melanoma patients, suggesting that, besides being a metastasis suppressor, BAP1 could predispose certain people to more aggressive uveal melanoma tumors. (wikipedia.org)
No relationship was observed between the expression pattern of β-catenin and cyclin D1 and age, sex, tumor size, stage, differentiation grade, lymph node metastasis, response to chemotherapy, or survival. (biomedcentral.com)

Recent studies have shown that BAP1 and its fruit fly homolog, Calypso, are members of the polycomb-group proteins (PcG) of highly conserved transcriptional repressors required for long-term silencing of genes that regulate cell fate determination, stem cell pluripotency, and other developmental processes. (wikipedia.org)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
Mutations in β-catenin or axin genes are not responsible for this abnormal localization of β-catenin. (biomedcentral.com)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

My goal is to expand on this initial finding and determine if casein kinase 2 could be a therapeutically relevant drug target in adult brain tumors and whether this protein plays a role in pediatric brain tumors. (stanford.edu)

In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki) . (sdbonline.org)
This study shows that Schip1 , a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. (sdbonline.org)
Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
The availability of a sophisticated genetic tool box makes Drosophila an excellent genetic model well suited to studying the biology of Lunasin and its effect on tumor progression in an in vivo model organism. (weeksmd.com)

Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. (cusabio.com)
Following extensive washing, a Phospho-AMPKα (Thr172) Mouse Detection Antibody is added to detect the captured phospho-AMPKα (Thr172) protein. (cellsignal.com)

Desmoid tumors are cytologically bland fibrous neoplasms originating from the musculoaponeurotic structures throughout the body. (medscape.com)
Desmoid tumors often appear as infiltrative, usually well-differentiated, firm overgrowths of fibrous tissue, and they are locally aggressive. (medscape.com)
Although desmoid tumors can arise in any skeletal muscle, they most commonly develop in the anterior abdominal wall and shoulder girdle. (medscape.com)
[ 4 ] . Implant-associated breast desmoid tumors may occur. (medscape.com)
Immunostaining with vimentin, alpha smooth muscle actin, muscle actin, and desmin are helpful in distinguishing the tumors in the differential diagnosis of desmoid tumors. (medscape.com)
Primary surgery with negative surgical margins is the most successful primary treatment modality for desmoid tumors. (medscape.com)
[ 7 ] Since desmoid tumors do not metastasize, many approaches are nonoperative in nature. (medscape.com)
[ 8 ] Since desmoid tumors may stabilize and regress, active observation is an option. (medscape.com)
Although desmoid tumors most commonly arise from the rectus abdominis muscle in postpartum women and in scars due to abdominal surgery, they may arise in any skeletal muscle. (medscape.com)
Desmoid tumors tend to infiltrate adjacent muscle bundles, frequently entrapping them and causing their degeneration. (medscape.com)
The myofibroblast is the cell considered to be responsible for the development of desmoid tumors (see Procedures). (medscape.com)
Additionally, evidence also exists for a genetic predisposition to desmoid tumors in FAP, independent of the APC mutation. (medscape.com)
However, unknown genetic factors independent of APC may be important in the susceptibility to desmoid tumors in patients with FAP. (medscape.com)
Independent predictors of increased desmoid risk in one study were said to be (1) germline mutation distal to codon 1399, (2) any family history of gastrointestinal disease, and (3) a strong family history of desmoid tumors. (medscape.com)
Desmoid tumors are associated with a biallelic APC mutation in the affected tissue. (medscape.com)

Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. (ox.ac.uk)
In this study, we have examined the subcellular localisation of Cdc2, cyclin B and p21(WAF1/CIP1) by immunohistochemistry in a well characterised series of primary breast cancers. (ox.ac.uk)
We conclude that breast tumorigenesis may be characterised by abnormalities in pathways determining not only levels of expression of key regulatory molecules, but also their subcellular localisation. (ox.ac.uk)

Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations. (amedeo.com)
Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)
Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)
The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. (nih.gov)
Casein kinase 2a regulates glioblastoma brain tumor-initiating cell growth through the ß-catenin pathway. (stanford.edu)
An alternative solution pathway of BRCA1 nuclear localization is certainly mediated through BARD1 as binding partner via the relationship through RING area (72) and recommended feasible system of nuclear localization from the additionally spliced variations of BRCA1 with spliced out exon 11 (73). (healthy-nutrition-plan.com)
Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations. (univ-paris5.fr)
We show that the flavin-dependent halogenase from the jamaicamide biosynthetic pathway, JamD, is not only capable of terminal alkyne halogenation on a late-stage intermediate en route to the final natural product but also has broad substrate tolerance for simple to complex alkynes. (escholarship.org)
A database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. (idrblab.net)

The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
It really is a member from the karyopherin β category of transportation receptors that binds over 200 focus on protein through a hydrophobic leucine-rich nuclear export indication (NES) within the cargo [20]. (tech-strategy.org)
The E6 protein of HPV-6 and HPV-11 binds p53 tumor suppressor protein less efficiently than that of HPV-16 and HPV-18 but, theoretically, could lead to accelerated degradation of the p53 protein. (medscape.com)

Two studies used genome sequencing independently to identify germline mutations in BAP1 in families with genetic predispositions to mesothelioma and melanocytic skin tumors The atypical melanocytic lesions resemble Spitz nevi and have been characterized as "atypical Spitz tumors" (ASTs), although they have a unique histology and exhibit both BRAF and BAP1 mutations. (wikipedia.org)
Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics. (amedeo.com)

abstract = "RGS proteins are GTPase-activating proteins for certain Gα subunits, accelerating the shutoff mechanism of G protein signaling, and also may interact with receptors and effectors to modulate G protein signaling. (elsevierpure.com)
abstract = "It is well established that the human subgroup C adenovirus type 5 (Ad5) E1B 55 kDa protein can regulate the activity and concentration of the cellular tumor suppressor, p53. (princeton.edu)

The mechanism by which MuSK signaling regulates the interaction of the AChR with scaffolding proteins that localize it in the postsynaptic membrane, however, remain unknown. (jneurosci.org)
The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF. (univ-paris5.fr)
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. (idrblab.net)

Mechanistically the N-terminus of BRCA1 also includes two nuclear export sequences (NES) that facilitate CRM1 (chromosome area maintenance proteins 1) -mediated export of BRCA1 in the nucleous (74-76). (healthy-nutrition-plan.com)
Recently the proteins exportin 1 (XPO1 also known as Chromosome Area Maintenance proteins 1 [CRM1]) continues to be validated being a focus on for therapeutic involvement in cancers. (tech-strategy.org)

For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)
However, changes in regulation that reduce the amount or function of the p27 protein in the nucleus are found in many types of cancer. (medlineplus.gov)
In addition, several BRCAl-interacting proteins have been isolated and they are preferentially located in the nucleus. (um.es)
During the interphase of early embryonic cell cycles, the OHO31 protein is present in the cytoplasm and massively accumulates in the nucleus at the onset of mitosis in late interphase and prophase. (rupress.org)
Moreover, the cell cycle-dependent accumulation of OHO31 in the nucleus indicates that this protein may be required for critical nuclear reactions occurring at the onset of mitosis. (rupress.org)
Cancer cells can utilize the transportins into and out of the nucleus to stimulate tumor growth and to effectively evade apoptotic mechanisms. (researchsquare.com)
These results indicate that the E1B protein fulfills an early function that correlates efficient entry into the late phase with the localization of E1B and p53 in the nucleus of Ad5-infected normal human cells. (princeton.edu)
XPO1 is among seven known nuclear export protein in charge of shuttling cargo in the nucleus towards the cytoplasm [17-19]. (tech-strategy.org)

In the case of multiple endocrine neoplasia type 2 (MEN 2), gain-of-function germline mutations clustered in specific codons of the RET proto-oncogene increase the risk of developing medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid tumors. (intechopen.com)
Multiple endocrine neoplasia typically involves the development of tumors in two or more of the body's hormone-producing glands, called endocrine glands. (medlineplus.gov)
Menin is a tumor suppressor that is mutated in patients with multiple endocrine neoplasia type I (MEN1), an inherited tumor-prone syndrome. (princeton.edu)

Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)
Both 5′- and 3′-splicing of two primary RGS12 transcripts occur to generate RGS12 mRNAs encoding proteins with four distinct N-terminal domains, three distinct C-terminal domains, and a common internal region where the semiconserved RGS domain is located. (elsevierpure.com)
Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)
Alternatively, a mutation may occur in the p53 protein, leading to clonal proliferation. (medscape.com)

This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. (caslab.com)
The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
Although menin interacts with a variety of nuclear proteins including transcription factors, it is unknown whether menin itself can directly bind DNA. (princeton.edu)
The E6 protein also inhibits p53 transcription. (medscape.com)

Using mice harboring a Brca1 CC (coiled coil) mutation that blocks the Brca1-Palb2 interaction, we uncovered an epistatic relationship between Rnf168 - and Brca1 CC alleles, which disrupted development, and reduced the efficiency of Palb2-Rad51 localization. (nih.gov)
Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. (cusabio.com)
Studies since id of both BRCA1 and BRCA2 possess provided solid PTZ-343 evidences because of their tumor suppressor actions specifically for breasts and ovarian cancers and this content aims to examine the current condition of knowledge about the BRCAs and linked cancers risk. (healthy-nutrition-plan.com)
23). These mutations have already been observed in breasts and ovarian malignancies and suggest the participation of BRCA1 C-terminus in tumor suppression (17 19 51 52 The BRCT area also reported to mediate DNA binding activity and relationship with other protein (53). (healthy-nutrition-plan.com)
Nevertheless several other research also stated BRCA1 localization generally in the nuclei of both regular and cancers cells (43 55 56 Furthermore research also indicated that BRCA1 was a 190 kDa secreted tumor suppressor instead of 220-230 kDa protein (57 58 These opposing observations general indicated the current presence of functionally different additionally spliced transcripts of BRCA1. (healthy-nutrition-plan.com)
BARD1 straight masks the NES indication from the BRCA1 and utilizes its NLS for effective import and nuclear localization of BRCA1. (healthy-nutrition-plan.com)

One such study found an apparent association between the level of expression of transformation related protein 53 ( TRP53 ) mRNA and the normality of embryo morphology [ 1 ]. (biomedcentral.com)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. (cancerindex.org)
Expression profiles following lilliputian and Suppressor of Triplolethal RNAi were nearly identical raising the possibility that they are obligatory co-factors. (sdbonline.org)
CK2 has enhanced expression or activity in numerous cancers, including GBM, and it has been demonstrated that inhibitors of CK2 regressed tumor growth in GBM xenograft mouse models. (stanford.edu)
In addition, intracranial injections of U87-MG cells with reduced GGT7 expression increased tumor growth in mice approximately 2-fold, and decreased mouse survival. (stanford.edu)
Expression of RGS12 proteins with long and intermediate C-terminal domains was not observed in COS-7 cells, suggesting that 3′-splicing of RGS12 transcripts may influence the expression or stability of the encoded proteins. (elsevierpure.com)
These results document extraordinary structural complexity in the RGS12 family and the role of alternative splicing and cell cycle-dependent mechanisms in expression and subnuclear targeting of RGS12 proteins. (elsevierpure.com)
To overcome these problems, profiling the expression levels of tumour related circulating miRNAs could increase the sensitivity and specificity of the CancerSEEK test, thus reducing the number of false positives and improving the detection rate of early stage cancers. (ysjournal.com)
Additionally, some studies have suggested that tumour derived (TD) exosomes also carry potential biomarkers like proteins and miRNAs whose expression levels differ from those found in the plasma or serum. (ysjournal.com)
Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)

Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. (weeksmd.com)

Herein we selected a Mendelian genetics form of familial cancer such as hereditary tumor syndromic endocrine neoplasias caused by highly penetrant germline mutations leading to pheochromocytoma-paraganglioma syndromes. (intechopen.com)

BAP1 encodes an 80.4 kDa nuclear-localizing protein with a ubiquitin carboxy-terminal hydrolase (UCH) domain that gives BAP1 its deubiquitinase activity. (wikipedia.org)
ALMS1 encodes a ~ 0.5 megadalton protein that localises to the base of centrioles. (springer.com)
STK11/LKB1 encodes a 433 amino acid ubiquitously expressed protein with a central catalytic domain and regulatory N- and C-terminal domains. (medscape.com)

These studies suggest that germline mutation of BAP1 results in a Tumor Predisposition Syndrome linking BAP1 to many more cancers. (wikipedia.org)
Although immunohistochemistry (IHC) for mismatch repair (MMR) proteins (MMR IHC) is used to identify DNA MMR status, universal screening of all patients with colorectal cancer (CRC) using a combination of both MMR IHC and genetic testing for the BRAFV600E mutation is limited in Japan. (bvsalud.org)
All dMMR tumors were additionally evaluated for BRAFV600 mutation status via Sanger sequencing. (bvsalud.org)
Patient clinical characteristics (age, sex, tumor location, size, and tumor pathology) were then classified using their dMMR and BRAFV600 mutation statuses. (bvsalud.org)

Given the function of XPO1 dysregulation in cancers there has been great desire for developing inhibitors of this protein. (tech-strategy.org)
The algorithm, named CancerSEEK, also faced the challenge of determining the location of the tumour out of the eight types of cancers chosen for the study. (ysjournal.com)

The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)

These mice provide evidence that the key functions of HDAC2, although not essential for survival of the organism, play a rate-limiting role for tumor development in vivo . (aacrjournals.org)
This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)
NK activation was evaluated, and its tumoricidal activity was assessed using in vitro and in vivo tumor models. (weeksmd.com)
In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)

A shortage of p27 has been associated with more aggressive tumors and a poorer prognosis. (medlineplus.gov)
It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)

Some mutations impair the protein's ability to interact with regulatory proteins, while others lead to the production of an unstable version of p27 that is quickly broken down. (medlineplus.gov)
Investigation of the subcellular distribution of cell cycle regulatory proteins, particularly p21(WAF1/CIP1), could provide valuable prognostic markers in breast cancer. (ox.ac.uk)
XPO1 may be the lone nuclear exporter of many main tumor suppressor and development regulatory proteins (TSPs and GRPs) including p53 p75 Rb p21 p27 STAT3 FOXO and IκB amongst others [21 22 There is currently significant data demonstrating that XPO1 is normally upregulated in both hematologic malignancies and solid tumors [17-19]. (tech-strategy.org)

BAP1 somatic mutations were identified in a small number of breast and lung cancer cell lines, but BAP1 was first shown to act as a tumor suppressor in cultured cells, where its deubiquitinase (UCH) domain and nuclear localization sequences were required for BAP1 to suppress cell growth. (wikipedia.org)

In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)

However, it remains unclear where these proteins bind on the AChR and how the interactions are regulated. (jneurosci.org)
However, the contribution(s) of these functions of the E1B protein to viral reproduction remains unclear. (princeton.edu)

This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)

The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. (intechopen.com)
Biochemical and genetic data suggest a role as a tumor suppressor. (cancerindex.org)
Some studies have suggested a role for this protein in maintaining centriole-nucleated sensory organelles termed primary cilia, and AS is now considered to belong to the growing class of human genetic disorders linked to ciliary dysfunction (ciliopathies). (springer.com)
Previously the Li lab has identified an interesting protein, known as casein kinase 2, which plays an integral role in adult brain tumor growth. (stanford.edu)
Our studies demonstrate that the CK2 subunit, CK2α, is overexpressed in and has an important role in regulating brain tumor-initiating cells (BTIC) in GBM. (stanford.edu)
May play a role in vesicle and/or protein transport. (lu.se)
Predictive Role of p53 Protein as a Single Marker or Associated to Ki67 Antigen in Oral Carcinogenesis. (bvsalud.org)

Based on this function, p27 is described as a tumor suppressor protein. (medlineplus.gov)
Histone deacetylases (HDAC) reverse the acetylation of histone and nonhistone proteins and thereby modulate chromatin structure and function of nonhistone proteins. (aacrjournals.org)
One of the first steps to investigate the function of BRCAl was to define its subcellular localization. (um.es)
As the density of neurotransmitter receptors is a key determinant of synaptic strength and function, the specific localization of receptors is critical for synapse formation, maintenance and plasticity. (jneurosci.org)
Thus, transcriptional profiles suggest that Lilliputian and Suppressor of Triplolethal are obligatory cofactors in the adult and that they can also function with Cyclin-dependent kinase 9 at a subset of loci. (sdbonline.org)
nevertheless, recent studies have got exposed a fresh potential function for CAPN3 being a structural proteins (23,24). (exposed-skin-care.net)
It really is plausible which the subcellular localization of CAPN3 determines its particular mobile function, which mutations make a difference some of those features straight or indirectly (1). (exposed-skin-care.net)
The biologic function of LKB1 includes the regulation of downstream kinases, including adenosine monophosphate-activated protein kinase (AMPK) and the related kinases (microtube affinity-regulating kinase [MARK] 1 through MARK4 and brain-specific kinase/synapses of the amphid-defective kinase [Brsk/SAD]), which are involved in cellular metabolic regulation-stress response and cellular polarity, the latter through tubulin stabilization, tight junction formation, and E-cadherin localization. (medscape.com)
May function as a tumor suppressor. (lu.se)

Ex is required for apical localization of Schip1 in imaginal discs . (sdbonline.org)
The localization of the apical components is unaffected in lgl or dlg mutants. (elsevierpure.com)

Furthermore, detailed mutagenesis studies indicate that positively charged residues in two nuclear localization signals mediate direct DNA binding as well as repression of cell proliferation. (princeton.edu)

a C-terminal domain: residues 598-729, which includes a UCH37-like domain (ULD) at residues 675-693 and two Nuclear localization sequences at residues 656-661 and 717-722. (wikipedia.org)
Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
CAPN3 provides some exclusive domains including its NH2-terminal domains I which has 20C30 additional proteins not within - and m-calpains and two exclusive insertion sequences' of 62 and 77 proteins on the COOH-terminal parts of domains II (known as Is normally1) and domains III (known as IS2). (exposed-skin-care.net)

Glioblastoma (GBM) is the most malignant primary brain tumor in adults, with a median survival time of one and a half years. (stanford.edu)
Canine oral malignant melanoma is a biologically aggressive tumor using a reported metastatic price as high as 90% [1]. (tech-strategy.org)

We conclude that there is now overwhelming evidence to support a nuclear localization for BRCAl, both in normal and cancer cells. (um.es)
The fact that XPO1 and other essential nucleo-cytoplasmatic transport proteins are over expressed in cancer, specifically in melanoma, offers the opportunity to treat cancer by modulating this transport system. (massgeneral.org)
We aimed to identify transportins that are overexpressed in Non-small cell lung cancer (NSCLC) and might be targeted to slow the tumor growth. (researchsquare.com)
Furthermore, we present the results of a promising neural network to boost the accuracy and efficiency of a liquid biopsy test for early cancer detection and localisation. (ysjournal.com)
Firstly, the cancer-related proteins used by the test are also present in people with inflammatory diseases such as arthritis. (ysjournal.com)
[6] These findings strongly suggest that adding key miRNAs to CancerSEEK could greatly increase its accuracy in early cancer diagnosis and tumour localisation. (ysjournal.com)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

These transcripts arise by both cis- and trans-splicing mechanisms, are expressed in a tissue-specific manner, and encode proteins ranging in size from 356 to 1447 amino acids. (elsevierpure.com)

Cells with a shortage of functional p27 can divide too quickly or in an uncontrolled way, forming a tumor. (medlineplus.gov)
studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division. (medlineplus.gov)
they are not inherited and are present only in tumor cells. (medlineplus.gov)
As a result, cells become more likely to divide abnormally and form a tumor. (medlineplus.gov)
Figure 1: Relationship between protein concentration of lysates from phosphatase-treated and H 2 O 2 -treated C2C12 cells and immediate light generation with chemiluminescent substrate is shown. (cellsignal.com)
Thus, Lgl and Dlg act in a common process that differentially mediates cortical protein targeting in mitotic neuroblasts, and that creates intrinsic differences between daughter cells. (elsevierpure.com)
Confocal microscopy and subcellular fractionation of COS-7 cells expressing RGS12 proteins with three different N termini (brain (B), peripheral (P), and trans-spliced (TS)) and a shared short (S) C-terminal domain demonstrated exclusive nuclear localization of these proteins and an influence of the N-terminal region on the pattern of intranuclear distribution. (elsevierpure.com)
Both native RGS12TS-S in HEK-293T cells and ectopically expressed RGS12TS-S localized to discrete nuclear foci (dots), a characteristic of various tumor suppressor proteins. (elsevierpure.com)
The steady-state concentrations of p53 were significantly higher in cells infected by the E1B 55 kDa null mutant Hr6 or three mutants carrying small insertions in the E1B 55 kDa protein coding sequence than in Ad5-infected cells. (princeton.edu)
The protein levels and activity are tightly regulated in cells. (umassmed.edu)
To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma todetermine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity. (bvsalud.org)
The localization of these p53 positive cells within the strata (i.e. basal/suprabasal, spinous and superficial layers) of epithelium between 3 groups, and also within each group according to histological grades was recorded. (bvsalud.org)
However the quantitative analysis of p53 positive cells and their localization in oral epithelium is of importance as a marker for oral squamous cell carcinoma. (bvsalud.org)

The main project of the Li lab is to elucidate the signaling pathways responsible for maintaining and initiating brain tumor growth. (stanford.edu)

Using chimeric proteins in which CD4 is fused to the large intracellular loop of each of the AChR subunits we found that agrin induced clustering of only chimeras containing the β subunit loop. (jneurosci.org)
Each subunit has a large intracellular loop between the third and fourth transmembrane domains that is the likely site for regulated interactions with postsynaptic scaffolding proteins. (jneurosci.org)

Schip1 is necessary for promoting membrane localization and phosphorylation of Hpo by recruiting the Hpo kinase Tao-1 . (sdbonline.org)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)

In this article, we propose and justify the potential use of circulating miRNAs and tumour derived exosomes to solve the problems announced above. (ysjournal.com)

Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics. (amedeo.com)

Anatomy16

Organisms9

Diseases27

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes74

Disciplines and Occupations1

Information Science3

Health Care1

Gene40

Apoptosis9

Functions as a tumor suppressor1

Cytoplasmic4

Adenomatous poly2

Oncogenic4

Tissues8

Recurrence2

Inhibition3

Metastasis3

Genes6

Brain tumors1

Drosophila4

Antibody2

Desmoid tumors15

Subcellular localisation3

Pathway9

Binds3

Atypical2

Abstract2

Regulates3

Chromosome area maintenance2

Nucleus8

Multiple endocrine3

Occur4

Transcription4

BRCA16

Expression13

Anti-tumor1

Germline mutations1

Encodes3

Mutation4

Cancers2

Epithelial cells1

Vivo4

Prognosis2

Regulatory3

Somatic1

Retinoblastoma1

Unclear2

Ovarian1

Role7

Function9

Apical2

Cell proliferation1

Sequences3

Malignant2

Cancer7

Amino acids1

Cells13

Pathways1

Intracellular2

Phosphorylation2

MiRNAs1

Differentiation1