• lipoprotein
  • For the present study, lead author Dr. Kasey Vickers from the NIH/NHLBI Lipoprotein Metabolism Section (presently at Vanderbilt University School of Medicine) and colleagues performed high-throughput small RNA sequencing of mouse liver and detected roughly 150 microRNAs. (bio-medicine.org)
  • FH patients, characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C), above 400mg/dL in heterozygotes and 600 mg/dL in homozygotes, are prone to recurrent migratory polyarthritis typically involving large joints such as knees, elbows, and ankles. (psychiatryadvisor.com)
  • The chylomicrons are ultimately taken up by liver hepatocytes via interaction between apolipoproteinE and the LDL receptor or Lipoprotein receptor-related proteins. (wikipedia.org)
  • The liver converts unburned food metabolites into very low density lipoproteins (VLDL) and secretes them into plasma where they are converted to intermediate density lipoproteins(IDL), which thereafter are converted to low-density lipoprotein (LDL) particles and non-esterified fatty acids, which can affect other body cells. (wikipedia.org)
  • High-density lipoprotein (HDL) particles transport cholesterol back to the liver for excretion, but vary considerably in their effectiveness for doing this[citation needed]. (wikipedia.org)
  • Tangier disease (also known as Familial alpha-lipoprotein deficiency) or hypoalphalipoproteinemia is a rare inherited disorder characterized by a severe reduction in the amount of high density lipoprotein (HDL), often referred to as "good cholesterol", in the bloodstream. (wikipedia.org)
  • deficiency
  • Nandrolone esters have also more recently been proposed for the treatment of androgen deficiency in men due to favorable properties including their high ratio of anabolic to androgenic effect and consequent much lower risk of prostate enlargement, prostate cancer, and scalp hair loss relative to testosterone. (wikipedia.org)
  • Kidney
  • However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving ritonavir. (drugs.com)
  • spleen
  • The cholesterol esters may also be found in lymph nodes, bone marrow, the liver and spleen. (wikipedia.org)
  • Hepatosplenomegaly (enlarged liver and spleen) is common. (wikipedia.org)
  • Other signs of this condition may include an enlarged spleen (splenomegaly), an enlarged liver (hepatomegaly), clouding of the cornea, and early-onset cardiovascular disease. (wikipedia.org)
  • After finding the same symptom in Teddy's sister and investigation revealing an extremely high number of foam cells in not only the tonsils but a wide range of tissues including the bone marrow and spleen, a second trip to the island was made and the discovery was made of very low HDL cholesterol in both the sister and parents of Teddy, evidence for a genetic basis of the disease. (wikipedia.org)
  • steatosis
  • Non-alcoholic fatty liver disease (NAFLD) is one of the types of fatty liver which occurs when fat is deposited (steatosis) in the liver due to causes other than excessive alcohol use. (wikipedia.org)
  • A liver can remain fatty without disturbing liver function, but by varying mechanisms and possible insults to the liver, it may also progress to become non-alcoholic steatohepatitis (NASH), a state in which steatosis is combined with inflammation and fibrosis (steatohepatitis). (wikipedia.org)
  • Non-invasive diagnostic tests have been developed, such as FibroTest, that estimates liver fibrosis, and SteatoTest, that estimates steatosis, however their use has not been widely adopted. (wikipedia.org)
  • The accumulation of fat in alcoholic or non-alcoholic steatosis may also be accompanied by a progressive inflammation of the liver (hepatitis), called steatohepatitis. (wikipedia.org)
  • The diagnosis of steatosis is made when fat in the liver exceeds 5-10% by weight. (wikipedia.org)
  • Liver disease with extensive inflammation and a high degree of steatosis often progresses to more severe forms of the disease. (wikipedia.org)
  • levels
  • Mice liver also exhibited increased proinflammatory cytokines' levels, decreased PGC-1α expression, and marked increase in p65 NFκB nuclear translocation. (springer.com)
  • Thus, physicians who treat patients with long-term HIV infection report seeing high levels of coronary plaque, and heart attacks and strokes are among the biggest health concerns for these patients over the past decade. (ajmc.com)
  • ACTH produced by the pars distalis is subject to negative feedback in a normal horse, so high cortisol levels reduce ACTH production by the pituitary, subsequently reducing cortisol levels. (wikipedia.org)
  • In a horse with PPID, ACTH levels are high as a result of pars intermedia production, but it is not subject to negative feedback regulation. (wikipedia.org)
  • Despite the high levels of ACTH, cortisol levels vary, and are sometimes lower than normal. (wikipedia.org)
  • Very high levels that would increase the risk of pancreatitis is treated with a drug from the fibrate class. (wikipedia.org)
  • tissue
  • A liver biopsy (tissue examination) is the only test widely accepted as definitively distinguishing NASH from other forms of liver disease and can be used to assess the severity of the inflammation and resultant fibrosis. (wikipedia.org)
  • inflammation
  • After euthanasia, liver morphology was examined by HE staining and inflammation was determined by IL-6, TNF-α, and IL-1β quantification. (springer.com)
  • A new study finds that children born with HIV may be at higher risk for cardiovascular (CV) disease by adolescence, due to the accumulated effects of chronic inflammation and other risk factors. (ajmc.com)
  • tissues
  • In the present review, the characteristics of SRs will be discussed, with a specific emphasis on their role in the liver compared with their role in other tissues. (ahajournals.org)
  • Table 1 ⇓ summarizes the cellular expression of the various SRs within the liver and in extrahepatic tissues. (ahajournals.org)
  • infection
  • The same mechanisms that cause those with long-term HIV infection to suffer higher rates of heart attacks or strokes put children born with disease at early risk of cardiovascular disease, according to a new study. (ajmc.com)
  • 140/90 mmHg), or arteriosclerosis Liver pathologies Infection (Hepatitis C) Hemochromatosis Gastroparesis Polycystic ovary syndrome (PCOS) Hypercortisolism (e.g. (wikipedia.org)
  • As a result of high prices and the spread of HIV infection, the government of Thailand issued a compulsory license on 29 January 2007, to produce and/or import generic versions of lopinavir and ritonavir. (wikipedia.org)
  • disease
  • Study details published in the February issue of Hepatology , a journal of the American Association for the Study of Liver Diseases (AASLD), describe a new in silico approach to identify the significance of microRNAs in regulating disease-related gene pathways. (bio-medicine.org)
  • If you have high cholesterol, talk to your doctor about maintaining a healthy lifestyle to help reduce your risk of heart disease. (bidmc.org)
  • The CVI's Lipid and Cardiovascular Disease Prevention Clinic helps patients with high cholesterol assess and reduce their risk of cardiovascular disease. (bidmc.org)
  • Liver disease-Use with caution. (mayoclinic.org)
  • Those in the HIV group also had higher mean and maximum measures for carotid intima-media thickness, a measure of the inner 2 layers of the carotid artery that can serve as an early warning of heart disease before patients experience symptoms. (ajmc.com)
  • Native American men have a high prevalence of non-alcoholic fatty liver disease. (wikipedia.org)
  • Prevalence of non-alcoholic fatty liver disease was 38% in carriers, 0% wild (normal). (wikipedia.org)
  • Hence, bile acid sequestrants may be used for the prevention of pruritus in patients with chronic liver disease. (wikipedia.org)
  • It results from a slow, progressive destruction of the small bile ducts of the liver, with the intralobular ducts and the Canals of Hering (intrahepatic ductules) being affected early in the disease. (wikipedia.org)
  • It is difficult to distinguish alcoholic FLD, which is part of alcoholic liver disease, from nonalcoholic FLD (NAFLD), and both show microvesicular and macrovesicular fatty changes at different stages. (wikipedia.org)
  • Acute fatty liver of pregnancy and Reye's syndrome are examples of severe liver disease caused by microvesicular fatty change. (wikipedia.org)
  • While these drugs are useful for patients with hyperlipidemia, Tangier's disease patients do not benefit from these pharmaceutical interventions. (wikipedia.org)
  • human liver
  • Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed, in contrast to the parallel domain arrangement of other NRs that bind an AGGTCA direct repeat spaced by 1 nt. (wikipedia.org)
  • NAFLD
  • NAFLD is the most common liver disorder in developed countries. (wikipedia.org)
  • Soft drinks have been linked to NAFLD due to high concentrations of fructose, which may be present either in high-fructose corn syrup or, in similar quantities, as a metabolite of sucrose. (wikipedia.org)
  • receptors
  • The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. (wikipedia.org)
  • Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. (wikipedia.org)
  • The liver X receptors are classified into subfamily 1 (thyroid hormone receptor-like) of the nuclear receptor superfamily, and are given the nuclear receptor nomenclature symbols NR1H3 (LXRα) and NR1H2 (LXRβ) respectively. (wikipedia.org)
  • Zotepine has a high affinity for the D1 and D2 receptors. (wikipedia.org)
  • Cholestasis
  • It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis. (wikipedia.org)