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  • metabolism
  • LPL catalyzes the bulk reaction in lipoprotein metabolism, unloading plasma triglycerides in peripheral tissues. (ahajournals.org)
  • 1 2 Several studies have explored the relation between LPL activity and parameters of lipoprotein metabolism (for discussion, see References 3 and 4 3 4 ) by measuring LPL activity in plasma after heparin injection, which is assumed to reflect the LPL available at the endothelial surface, or by studies of LPL activity in tissue biopsies. (ahajournals.org)
  • Total cholesterol does not have a prognostic value in determining the possible risk of developing coronary heart disease and others, but he says the increased value of the need for a detailed study of lipoprotein metabolism. (healthtipsing.com)
  • causes
  • Hyperlipidemia can have several causes, the most common of which is a normal physiological response that occurs after a dog has eaten a meal containing moderate to high levels of fat. (petmd.com)
  • It causes high cholesterol and high blood triglycerides . (baptistjax.com)
  • The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). (wikipedia.org)
  • Nystagmus (usually affects the children) one of the first symptoms to occur which causes involuntary rapid eye movement. (wikipedia.org)
  • diseases
  • If hyperlipidemia persists despite fasting, my next step is to rule out other diseases that can cause fat levels in the blood to rise. (petmd.com)
  • Retesting a fasted serum sample and a thorough health work-up to rule out other diseases will eliminate most cases of hyperlipidemia … unless the dog in question in a schnauzer. (petmd.com)
  • lovastatin
  • In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from Aspergillus terreus, in very high-risk patients were undertaken, in which dramatic reductions in LDL cholesterol were observed, with very few adverse effects. (wikipedia.org)
  • Lovastatin is also naturally produced by certain higher fungi, such as Pleurotus ostreatus (oyster mushroom) and closely related Pleurotus spp. (wikipedia.org)
  • acute
  • Very high triglyceride levels also increase the risk of acute pancreatitis. (wikipedia.org)
  • Myocardial infarction and stroke prophylaxis in patients with type II diabetes There have been recent studies suggesting that high-dose statin therapy plays a plaque-stabilizing role in people suffering from acute coronary syndrome and thrombotic stroke. (wikipedia.org)
  • include
  • It can include several conditions, but usually refers to a high cholesterol and triglyceride level. (news-medical.net)
  • Other symptoms may include weight gain, feeling tired, and foamy urine. (wikipedia.org)
  • Other efforts include managing high blood pressure, high blood cholesterol, and infection risk. (wikipedia.org)
  • Symptoms of embolisation in an organ vary with the organ involved but commonly include: Pain in the involved body part Temporarily decreased organ function Later symptoms are closely related to infarction of the affected tissue. (wikipedia.org)
  • Symptoms of limb infarction include coldness, decreased or no pulse beyond the site of blockage, pain, muscle spasm, numbness and tingling, pallor and muscle weakness, possibly to the grade of paralysis in the affected limb. (wikipedia.org)
  • Some of the symptoms include: Heart failure (Dilated cardiomyopathy) in over 60% of cases, usually within the first few weeks after birth, but sometimes the onset is in adolescence or adulthood. (wikipedia.org)
  • Chronic
  • Chronic hyperlipidaemia leads to damage to the innermost layer (endothelium) of the arteries and subsequent formation of atheromatous plaques in the walls of the arteries, leading to their narrowing. (boloji.com)
  • drugs
  • PCSK9 inhibitors, such as alirocumab (Praluent) and evolocumab (Repatha) These represent a newer class of drugs to treat high cholesterol. (baptistjax.com)
  • However, at the moment, costs for these drugs are high and patients may have to undergo multiple injections. (springer.com)
  • While these drugs are useful for patients with hyperlipidemia, Tangier's disease patients do not benefit from these pharmaceutical interventions. (wikipedia.org)
  • atorvastatin
  • Geriatric: Plasma concentrations of atorvastatin in healthy elderly subjects are higher than those in young adults, and clinical data suggests a greater degree of LDL-lowering at any dose for patients in the population as compared to young adults. (wikipedia.org)
  • cause
  • Mitral stenosis poses a high risk of forming emboli which may travel to the brain and cause stroke. (wikipedia.org)
  • signs
  • Most of these symptoms are linked to one of the main signs and symptoms highlighted in the above section. (news-medical.net)
  • Some dogs with hyperlipidemia have no clinical signs while others become quite sick. (petmd.com)
  • These combined factors lead to the signs and symptoms of Tangier disease. (wikipedia.org)
  • This means both parents have to pass a copy of the ALMS1 gene in order for their child to have the syndrome even though the parents may not show signs or symptoms of the condition. (wikipedia.org)