Lipid atp binding cassette transporters. Medical search. Frequent questions

These kinds of changes emerging due to genetic alterations are classified as primary disorders of the lipid metabolism. (researchsquare.com)
More recently, studies in mice with targeted inactivation of ABCA1 ( 11 ) have demonstrated a critical role of ABCA1 in lipid metabolism and confirmed its role in the biogenesis of HDL. (jci.org)
The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. (nova.edu)
and Tew, Kenneth D, "The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. (nova.edu)
Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. (thno.org)
In vitro , we determined the major components of GLSP triterpenes by HPLC, and subsequently assessed the protective effects of these main active components on lipid metabolism, inflammation, and calcification in RAW264.7 and HASMC cells. (thno.org)
Public health relevance: Our findings demonstrate the genetic contribution of common and rare SCARB1 and ABCA1 variants to the regulation of lipoprotein-lipid levels in the general population, supporting the roles of SCARB1 and ABCA1 genes in lipid metabolism. (pitt.edu)
In PE, lipid metabolism is altered. (biomedcentral.com)
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. (reference.md)

These transporters promote unidirectional cholesterol efflux to lipid-poor apolipoprotein A-I (apoA-I), apoE, or HDL particles, respectively, and are under the transcriptional control of liver X receptors (LXRs), master intracellular sensors that are activated in response to cholesterol biosynthetic intermediates and oxysterols ( 11 , 12 ). (diabetesjournals.org)
The impairment of these pathways is partly dependent on cellular ATP-binding cassette transporter (ABC) A1-mediated efflux to lipid-poor apolipoprotein (apo) A-I in the extracellular space. (bvsalud.org)

Lipid-poor HDL precursors mature by obtaining cholesterol and phospholipids from cell membranes or triglyceride-rich lipoproteins. (jci.org)
All lipids are hydrophobic and mostly insoluble in blood, so they require transport within lipoproteins. (msdmanuals.com)
Lipoproteins containing apoA-I [highdensity lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins containing apoB) are involved in the lipid delivery pathway. (anatoljcardiol.com)

Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo. (medlineplus.gov)
The initial and rate-limiting step of cholesterol efflux is the transport of cellular free cholesterol to high-density lipoprotein (HDL) by cholesterol transporters, of which the best characterized are the ATP binding cassette transporter (ABC) A1, ABCG1 and scavenger receptor BI (SR-BI) [ 12 ]. (biomedcentral.com)

ATP-binding cassette transporters ABCA1 and ABCG1 primarily mediate the efflux of cholesterol from peripheral cells. (diabetesjournals.org)
LXRs also transcriptionally regulate the cholesterol efflux transporters ABCA1 and ABCG1, and deficiency of ABCA1 is associated with decreased body weight ( 18 ), while ABCG1 deficiency protects against diet-induced obesity ( 19 ). (diabetesjournals.org)
ABCA1 and ABCG1 transporters are suspected to play a function in CCA lipid homeostasis. (scholarsresearchlibrary.com)
Findings: ABCA1 and ABCG1 transporters had been expressed in HuCCA-1 cells. (scholarsresearchlibrary.com)

How does crowding affect mobility of proteins and lipids? (rug.nl)

The phenotypic alteration in surfactant lipid homeostasis resulted in an early macrophage predominant alveolitis which peaked at 8 weeks of age. (nih.gov)
Our results underline the autonomy of brain lipid homeostasis and indicate that peripheral supplementation of ether lipids is not sufficient to supply the brain with larger amounts of plasmalogens. (amsterdamumc.org)

nucleotide binding domains in red. (rug.nl)
The transmembrane domains (TMDs) and nucleotide-binding domains (NBDs) are indicated. (elifesciences.org)
Moreover, this family also presents two cytosolic nucleotide binding domains (NBD), and these bind and hydrolyze the ATP necessary for transporting substances across the membrane [ 13 , 14 ]. (biomedcentral.com)

The UIC2 monoclonal antibody specifically binds to an extracellular epitope of CD243, which is also known as ATP-binding cassette subfamily B member 1 (ABCB1), Multidrug resistance protein 1 (MDR1), or P-glycoprotein 1. (bdbiosciences.com)
Mutations in ABCA12 , a gene that encodes adenosine triphosphate (ATP)-binding cassette transporter (ABC), subfamily A, member 12, in chromosome region 2q35, underlie this disorder. (medscape.com)

In this investigation, the role of cholesterol transporters, ATP-binding cassette (ABC) A1 and ABCG1 are studied in HuCCA-1 cell line. (scholarsresearchlibrary.com)
ABCG1 transporter was down regulated the use of siRNA interference. (scholarsresearchlibrary.com)
ATP-binding cassette (ABC) A1 and ABCG1 are nicely characterized as cholesterol transporters in a range of cell types. (scholarsresearchlibrary.com)
Mice lacking the ATP-binding cassette transporter G1 (ABCG1) develop chronic inflammation in the lungs, which is associated with the lipid accumulation (cholesterol, cholesterol ester, and phospholipid) and cholesterol crystal deposition that are characteristic of atherosclerotic lesions and pulmonary alveolar proteinosis. (ulpgc.es)
In this article, we demonstrate that specific lipids, likely oxidized phospholipids and/or sterols, elicit a lung-specific immune response in Abcg1(-/-) mice. (ulpgc.es)
Collectively, these data demonstrate that the accumulation of lipids in Abcg1(-/-) mice induces the specific expansion and localization of B-1 B cells, which secrete NAbs that may help to protect against the development of atherosclerosis. (ulpgc.es)
Indeed, despite chronic lipid accumulation and inflammation, hyperlipidemic mice lacking ABCG1 develop smaller atherosclerotic lesions compared with controls. (ulpgc.es)

The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate. (wikipedia.org)

Based on the structure, we performed integrative analysis of the cellular trafficking, protein thermostability, ATP hydrolysis, and the transport activity of representative mutations. (elifesciences.org)
The structure and functional studies of disease-causing mutations are solid and will appeal to the transporter and medical genetics communities. (elifesciences.org)
Mutations in ABC transporter genes cause a variety of human pathologies and elicit drug resistance phenotypes in cancer cells. (nova.edu)
Although mutations in APP, PS1, or PS2 cause early-onset familial AD, ABCA7 encoding ATP-binding cassette transporter A7 is one of the susceptibility genes for late-onset AD (LOAD), in which its loss-of-function variants increase the disease risk. (elsevierpure.com)

Chambenoit O, Hamon Y, Marguet D, Rigneault H, Rosseneu M, Chimini G. Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter. (medlineplus.gov)

ABC transporters utilize the energy of ATP binding and hydrolysis to transport various substrates across cellular membranes. (wikipedia.org)
The membrane-spanning region of the ABC transporter protects hydrophilic substrates from the lipids of the membrane bilayer thus providing a pathway across the cell membrane. (wikipedia.org)
Substrates for transport include lipids, cholesterol and pharmacological agents. (nova.edu)

ABC transporters are considered to be an ABC superfamily based on the similarities of the sequence and organization of their ATP-binding cassette (ABC) domains, even though the integral membrane proteins appear to have evolved independently several times, and thus comprise different protein families. (wikipedia.org)
We have overcome this by using SMA to coimmunopurify membrane proteins and their native lipids from two regions of photoreceptor ROS disks. (nih.gov)
ATP-binding cassette (ABC) protein family encode for membrane proteins involved in the transport of various biomolecules through the cellular membrane. (biomedcentral.com)
Most of these ABC proteins are integral membrane proteins that use ATP to transport biomolecules through the plasma membrane [ 12 ]. (biomedcentral.com)
The major facilitator superfamily (MFS) of membrane proteins represents the largest family of secondary transporters with members from Archaea to Homo sapiens. (embl.de)

Probing lipid mobility of raft-exhibiting model membranes by Fluorescence Correlation Spectroscopy. (rug.nl)
The lipid bilayer of cell membranes is impermeable to large and polar molecules but permeable to water molecules and other small uncharged molecules like O 2 and CO 2 . (wikibooks.org)
ATP-binding cassette (ABC) transporters comprise a family of critical membrane bound proteins functioning in the translocation of molecules across cellular membranes. (nova.edu)

The availability of free energy is one of the factors that determine if a molecule will move across a membrane, the other being the permeability of the molecule in the lipid bilayer. (wikibooks.org)
Here, we report cryo-EM structures of multiple physiologically relevant states of lipid bilayer-embedded human MRP4, including complexes between MRP4 and two widely used chemotherapeutic agents and a complex between MRP4 and its native substrate. (rcsb.org)
Most outer membrane porins share a specific spatial structure called the ß-barrel that provides their structural integrity within the membrane lipid bilayer. (bvsalud.org)

ABCA7 is homologous to a major lipid transporter ABCA1 and is highly expressed in neurons and microglia in the brain. (elsevierpure.com)

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. (wikipedia.org)
This thesis focuses on outward transport of fluorescent (C6-NBD-) lipid analogs and endogenous lipids by the Multidrug Resistance 1 P-Glycoprotein (MDR1 Pgp), a member of the ATP binding cassette (ABC) transporter superfamily. (hu-berlin.de)
These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). (embl.de)

In this study we aimed to investigate the effects of ABCA 1 gene on lipid levels, and patient's clinical parameters under various polymorphic conditions in patients with primary hyperlipidemia. (researchsquare.com)
The role of PTPN11 gene on lipid profile has not been described in Chinese so far. (biomedcentral.com)

ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. (wikipedia.org)
Compared to other lipid ATP-binding cassette transporters, ALDP has two substrate binding cavities formed by the transmembrane domains. (elifesciences.org)
In eukaryotes, this family has a characteristic organization marked by two transmembrane domains (TMD) that are formed by five or six helixes which determine the specificity of the transporter [ 13 , 14 ]. (biomedcentral.com)
[ 6 ] ABCA12 encodes a transmembrane protein that mediates lipid transport. (medscape.com)

For instance, a potential lethal increase in osmotic strength is counterbalanced by activation of osmosensing ABC transporters that mediate uptake of solutes. (wikipedia.org)
Among the main mechanisms of this multidrug resistance is the overexpression of ATP-binding cassette (ABC) transporters that mediate drug efflux, and, specifically, ABCB1, ABCG2 and ABCC1 are known to cause cancer chemoresistance. (nature.com)

Heide van der T., and Poolman, B. (2002) ABC transporters: one, two or four extracytoplasmic substrate-binding sites? (rug.nl)

Here, we show that ABCA7 deficiency altered brain lipid profile and impaired memory in ABCA7 knock-out (Abca7 -/- ) mice. (elsevierpure.com)

One of the ABC transporters that is studied in detail is the osmoregulatory ABC transporter OpuA (class D). Osmotic control of OpuA involves gating by intracellular ionic strength and is mediated by lipid-protein interactions. (rug.nl)
The ABCA2 transporter: intracellular roles in trafficking and metaboli" by Jody T Mack, Danyelle M Townsend et al. (nova.edu)

Cholesterol mobilization involves adipose tissue ATP-binding cassette transporter A1 (ABCA1), which has recently been shown to contribute to HDL biogenesis in vivo ( 9 , 10 ). (diabetesjournals.org)

Besides MDR1 Pgp, the ABC half-size transporter Breast Cancer Resistance Protein (BCRP) is possibly also involved in transport of C6-NBD-PS and in increased exposure of endogenous PS, as found in a BCRP overexpressing EPG85-257 subline. (hu-berlin.de)

In gram-negative bacteria, exporters transport lipids and some polysaccharides from the cytoplasm to the periplasm. (wikipedia.org)

Im Mittelpunkt der vorliegenden Promotion steht der Auswärtstransport fluoreszierender (C6-NBD-) Lipid-Analoga und endogener Lipide durch das Multidrug Resistance 1 P-Glycoprotein (MDR1 Pgp), das der ATP Binding Cassette (ABC) Transporter Superfamilie angehört. (hu-berlin.de)
Multidrug resistance-associated protein 4 (MRP4) is an ATP-binding cassette (ABC) transporter expressed at multiple tissue barriers where it actively extrudes a wide variety of drug compounds. (rcsb.org)

While LXR-deficient mice are leaner than littermate controls and are protected against diet-induced obesity, the mechanisms that control fat loss in these mice are still a matter of debate and could involve either reduced lipogenesis, enhanced lipid oxidation and lipolysis, or reduced cholesterol efflux pathways ( 14 ). (diabetesjournals.org)
By crossbreeding Mdr1a-/-/Mdr1b-/-/Bcrp-/- and ether lipid-deficient Gnpat-/- mice as well as pharmacological inhibition with MK-571 to inactivate the major ABC transporters at the blood-brain barrier, we evaluated the potential of combined ABC transporter inhibition and oral batyl alcohol administration for the treatment of plasmalogen deficiency. (amsterdamumc.org)
A model of CAS in ApoE −/− mice fed with a rich-fat diet was established to analyze the regulatory effects of serum miR-26 on blood lipids in mice. (amegroups.org)
The therapeutic effect of ADSCs expressing miR-26 on model mice was evaluated by detecting the levels of inflammatory factors and blood lipids in the serum of the mice. (amegroups.org)

Recent studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) is highly regulated in macrophages and mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for HDL formation. (jci.org)

Despite cholesterol being delivered as cholesteryl ester in adipocytes, approximately 95% of cholesterol paradoxically exists as free cholesterol (FC) ( 7 ) and resides in the plasma membrane or the cytosolic interface of lipid droplets where it is readily available for mobilization ( 8 ). (diabetesjournals.org)
Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 National Heart, Lung, and Blood Institute Workshop. (skanestugan.se)

Recently, two ABC (ATP-binding cassette) transporters, ABCG5 and ABCG8, have been described as playing an important role in the absorption and excretion of sterols. (portlandpress.com)

Wie Experimente in einer BCRP überexprimierenden EPG85-257-Sublinie nahelegen, ist ausser MDR1 Pgp möglicherweise ebenfalls der ABC Halb-Transporter Breast Cancer Resistance Protein (BCRP) am Transport von C6-NBD-PS und an der verstärkten Exponierung von endogenem PS beteiligt. (hu-berlin.de)

In vitro studies have demonstrated normalization of lipid transport when the wild-type ABCA12 gene is transferred to keratinocytes of patients with harlequin ichthyosis. (medscape.com)

This transporter, along with other proteins that have a high degree of homology to ABCA2, including ABCA1 and ABCA7, are up-regulated in human macrophages during cholesterol import. (nova.edu)

The parental (F1) mouse line (mAbca3E292V) that retained an intronic pgk-Neo selection cassette (inserted in reverse orientation) (mAbca3E292V-rNeo) demonstrated an allele dependent extracellular surfactant phospholipid (PL) deficiency. (nih.gov)
For example, the deficiency in plasmalogens, the most abundant ether lipids in mammals, has detrimental effects on the brain, which is a major issue in inherited peroxisomal disorders but also contributes to more common disorders like Alzheimer's disease. (amsterdamumc.org)
Yet, the findings suggest that alkylglycerol treatment during pregnancy may pose a viable option to ameliorate some of the severe developmental defects of inborn ether lipid deficiency. (amsterdamumc.org)

Studies thus far implicate ABCA2 as a sterol transporter, the deregulation of which may affect a cellular phenotype conducive to the pathogenesis of a variety of human diseases including AD, atherosclerosis and cancer. (nova.edu)
Once advanced atherosclerotic plaques are established, the process by which they undergo a reduction in one or more standard parameters (size, lipid content, foam cell content, and macrophage inflammation) is termed atherosclerosis regression. (skanestugan.se)
They are intended to reduce the risk of atherosclerosis (a cardiovascular disease) by improving blood lipid levels.At least three medications within this class have failed to result in benefits however. (vondellhenderson.com)

Pathway defects in lipoprotein synthesis, processing, and clearance can lead to accumulation of atherogenic lipids in plasma and endothelium. (msdmanuals.com)

ABC uptake porters take up a large variety of nutrients, biosynthetic precursors, trace metals and vitamins, while exporters transport lipids, sterols, drugs, and a large variety of primary and secondary metabolites. (wikipedia.org)

Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important. (msdmanuals.com)

Normal extrusion of lipid from these granules into the extracellular space cannot occur, and lipid lamellae are not formed. (medscape.com)

The development of the disease is associated with microvascular inflammation and altered immune reaction due to strong infiltration of intima and sub-intima by oxidized lipids, oxidative stress, proliferative responses from cellular components of intima and media, accumulation of extracellular components with the shaping of atherosclerotic plaques, impaired vasomotion ability, endothelial dysfunction, and thrombosis, ultimately resulting in vascular remodeling and artery obstruction 11 , 12 . (bmrat.org)

Mutation occurring in ATP binding cassette transporter 1 (ABC1) which enables exit of cholesterol from the cell with resultant decrease in the levels of lipid-rich HDL-lipoprotein in the circulation decrease. (researchsquare.com)
The underlying genetic abnormality in harlequin ichthyosis is a mutation in the lipid-transporter gene ABCA12 on chromosome 2. (medscape.com)

High-resolution structures, biophysical and in silico studies have led to tremendous progress in understanding the mechanism of drug transport by these ABC transporters, and several promising therapies, including irradiation-based immune and thermal therapies, and nanomedicine have been used to overcome ABC transporter-mediated cancer chemoresistance. (nature.com)
Furthermore, genetic modification of ABC transporters by CRISPR-Cas9 and approaches to re-engineer amino acid sequences to change the direction of transport from efflux to import are briefly discussed. (nature.com)
Fig. 3: Substrate-binding pockets of ATP-binding cassette transporters and the drug transport cycle. (nature.com)
ABC (ATP binding cassette) transporters catalyze the transport of a wide variety of molecules across lipid bilayers into or out of cells and organelles. (rug.nl)
The adrenoleukodystrophy protein (ALDP) or ABCD1 is an ABC transporter that participates in the transport of free very long-chain fatty acids and their CoA esters across the peroxisomal membrane. (elifesciences.org)
In the past years, several proteins were suggested to transport lipids between the leaflets of a membrane, and to potentially influence transverse lipid asymmetry and related cell properties. (hu-berlin.de)
In addition, decreased accumulation of analogs of diacylglycerol and ceramide suggest MDR1 Pgp mediated transport of these lipid species. (hu-berlin.de)
It is possible to divide ABC transporters into the following two groups: those present only in prokaryotes and which require substrate-binding proteins for transport, and those found only in eukaryotes and that bind directly to the substrate from the interior of the cell [ 15 ]. (biomedcentral.com)
Scavenger receptor class B type 1 (SCARB1) and ATP-binding cassette transporter A1 (ABCA1) play important roles in the reverse cholesterol transport. (pitt.edu)
This protein plays a major role in the transport of lipids in the outermost layer of skin (epidermis). (igenomix.co.in)

CD243 acts as an ATP-dependent efflux pump for a large variety of lipophilic molecules and drugs. (bdbiosciences.com)

Most of the uptake systems also have an extracytoplasmic receptor, a solute binding protein. (wikipedia.org)
D. & E. Uptake systems with two or four covalently linked substrate-binding domains (SBDs). (rug.nl)

ADSC-exos expressing miR-26 has positive effects on correcting blood lipids and inflammatory factors in the mouse model of CAS. (amegroups.org)
The plaques contain lipids, inflammatory cells, smooth muscle. (msdmanuals.com)

24S-hydroxycholesterol is a known potent activator of LXR and as such serves as an activator of the expression of LXR target genes and thus, can effect regulation of overall cholesterol â ¦ accepts cholesterol from the tissues via the ATP-binding cassette transporter-1 (ABC-1). (vondellhenderson.com)

Oral administration of alkylglycerols like batyl alcohol, which carry a pre-formed ether bond, enables replenishment of ether lipids in various peripheral tissues. (amsterdamumc.org)

When the cholestasis occurred by the bile duct obstruction, this led to overexposure of cholangiocytes to bile lipid contents and toxic substances. (scholarsresearchlibrary.com)

Previous studies have reported that different genotypes of PTPN11 gene (protein tyrosine phosphatase, non-receptor 11) were associated with different levels of serum lipids. (biomedcentral.com)
The aim of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) of PTPN11 and serum lipids in Northeast Chinese. (biomedcentral.com)
A total of 1003 subjects, 584 males and 419 females, were included in the study and their serum lipids were determined. (biomedcentral.com)
SNPs of PTPN11 may play a role in serum lipids in a sex-specific pattern. (biomedcentral.com)
Single nucleotide polymorphisms (SNPs) of protein tyrosine phosphatase, non-receptor 11 ( PTPN11 ) gene, which encodes SHP2, may be associated with serum lipid levels via changing the activity of SHP2 on lipometabolism. (biomedcentral.com)
The serum levels of miR-26 in patients were inversely correlated with the levels of blood lipids (TC, TG, and LDL-C), and positively correlated with HDL-C levels. (amegroups.org)

Further, we identify a niche-specific increase in natural Ab (NAb)-secreting B-1 B cells in response to this lipid accumulation that is paralleled by increased titers of IgM, IgA, and IgG against oxidation-specific epitopes, such as those on oxidized low-density lipoprotein and malondialdehyde-modified low-density lipoprotein. (ulpgc.es)

Surprisingly, batyl alcohol treatment of pregnant Gnpat+/- dams had beneficial effects on the plasmalogen levels of Gnpat-/- offspring with defective ether lipid biosynthesis, independently of ABC transporter status at the placental barrier. (amsterdamumc.org)
In harlequin ichthyosis, the ABCA12 -mediated transfer of lipid to lamellar granules is defective. (medscape.com)
This defective lipid "mortar" between corneocyte "bricks" results in aberrant skin permeability and lack of normal corneocyte desquamation. (medscape.com)

The present study gives a comprehensive transcriptome analysis of ABC proteins from C. rogercresseyi, providing relevant information about transporter roles during ontogeny and in relation to delousing drug responses in salmon lice. (biomedcentral.com)

High-resolution profiling of the ROS disk lipid composition gives new insights into how intricate membrane structure and protein activity are balanced within the ROS, and provides a model for future studies of other complex cellular structures. (nih.gov)
Our study provides key insights into the unusually broad substrate specificity of MRP4 and constitutes an important contribution toward a general understanding of multidrug transporters. (rcsb.org)

We suggest that current information regarding the structure, mechanism and regulation of ABC transporters should be used in clinical trials to improve the efficiency of chemotherapeutics for patients with cancer. (nature.com)

Background: Abnormal lipid-lipoprotein levels are associated with the risk of coronary heart disease (CHD), a major public health problem worldwide. (pitt.edu)

In eukaryotic cells, the lipid species are frequently distributed asymmetrically between the plasma membrane leaflets. (hu-berlin.de)

Each sample's copurified lipids were subjected to untargeted lipidomic and fatty acid analysis. (nih.gov)
We found that even in the absence of the most abundant ABC transporters, batyl alcohol supplementation did not restore plasmalogen levels in the brain, despite the presence of a wide spectrum of ether lipid subspecies in the plasma as demonstrated by lipidomic analysis. (amsterdamumc.org)

Anatomy7

Organisms5

Diseases3

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes35

Technology, Industry, Agriculture1

Information Science3

Metabolism9

Efflux to lipid-poor apolipoprotein2

Lipoproteins3

High density lip2

ABCA1 and ABCG14

Proteins and lipids1

Homeostasis2

Nucleotide binding3

Subfamily2

ABCG17

Adenosine triphosphate1

Mutations4

Apolipoprotein1

Substrates3

Membrane Proteins5

Membranes3

Bilayer3

Major lipid1

Superfamily3

Gene on lipid2

Transmembrane4

Mediate2

20021

Brain lipid1

Intracellular2

Adipose1

Endogenous1

Polysaccharides1

Multidrug resistance2

Mice4

Cholesterol and phospholipids1

Droplets2

ABCG51

BCRP1

Vitro1

Macrophages1

Deficiency3

Atherosclerosis3

Pathway1

Sterols1

Physiologically1

Extracellular space1

Inflammation1

Mutation2

Transport10

Molecules1

Uptake2

Inflammatory2

Genes1

Peripheral1

Substances1

Serum6

Accumulation1

Defective3

Roles1

Insights2

Mechanism1

Abnormal1

Plasma membrane1

Lipidomic2