AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
DrosophilaDrosophila ProteinsDrosophila melanogasterQuality of LifeAnimals, Genetically ModifiedInsect ProteinsLarvaWingEmbryo, NonmammalianGene Expression Regulation, DevelopmentalMolecular Sequence DataMutationPhotoreceptor Cells, InvertebrateInsect HormonesAmino Acid SequencePupaBase SequenceTranscription FactorsGenome, InsectEyePhenotypeBody PatterningOogenesisSequence Homology, Amino AcidGenes, LethalCrosses, GeneticMorphogenesisDNA-Binding ProteinsWnt1 ProteinHomeodomain ProteinsSignal TransductionCloning, MolecularEcdysoneNuclear ProteinsMushroom BodiesBlastodermChromosomesSense OrgansChromosome MappingMetamorphosis, BiologicalLifeIn Situ HybridizationNervous SystemReceptors, NotchEvolution, MolecularFat BodyRNA InterferenceChromosomes, InsectDNA Transposable ElementsX ChromosomeGenes, HomeoboxTranscription, GeneticAllelesSpecies SpecificityLongevitySequence AlignmentRepressor ProteinsHemocytesDNAMembrane ProteinsTransgenesConserved SequenceArmadillo Domain ProteinsOptic Lobe, NonmammalianModels, GeneticPhylogenyCentral Nervous SystemModels, BiologicalRNA, MessengerSalivary GlandsBiological EvolutionMalpighian TubulesNerve Tissue ProteinsImaginal DiscsEye ProteinsCompound Eye, ArthropodFertilityCourtshipEcdysteroneDNA, ComplementaryEye ColorGerm CellsGene ExpressionSexual Behavior, AnimalHeterochromatinCell PolarityNeuronsOvaryNeuropeptidesFlight, AnimalJuvenile HormonesProtein BindingProtein Structure, TertiaryLife Cycle StagesSequence Homology, Nucleic AcidMultigene FamilyRecombinant Fusion ProteinsDNA PrimersSelection, GeneticMutagenesis
LarvalInbred Drosophila melanogasterGenesStudies using drosGeneticsEmbryoNeuromuscular junctionInsectsDevelopmental stagesMelanogaster strainsLarvaFliesEvoked synaptic transmissionModulatesWolbachiaFruit flyMetamorphosisTumoursMechanismsEmbryogenesisEpithelialBiologyGenomeStagesProteinSpecies groupMutantsStemBehaviorMorphologicalBehaviourInvestigationModelJuvenileExperimentalAdult lifePopulationsPathwayMutationsThermal preferenceMiceAnatomyIncreasesSensesExtensionResistanceFunction
Larval4
Inbred Drosophila melanogaster1
  • Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
Genes10
  • The ability of curcumin to mitigate the expression levels of age-associated genes in young flies suggests that the action of curcumin on these genes is a cause, rather than an effect, of its life span-extending effects. (escholarship.org)
  • Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. (nottingham.ac.uk)
  • Here, using the model species Drosophila melanogaster , we used a combination of Genome Wide Association mapping (GWAS) and transcriptomic profiling to characterize whether genes associated with thermal tolerance are primarily involved in dynamic stress responses or preparatory processes that influence physiological condition at the time of thermal stress. (frontiersin.org)
  • RNA-seq has been chosen to investigate Drosophila Malpighian (renal) tubules to identify novel genes following a three- way comparison between three popular transcriptome profiling methods. (gla.ac.uk)
  • Two types of novel gene have been found in Drosophila tubules, coding genes and noncoding genes. (gla.ac.uk)
  • Drosophila expression arrays and Drosophila tiling arrays all suffered from cross-hybridization, miss target detection and hybridization background noise, and also have low dynamic range for detecting lowly and highly expressed genes. (gla.ac.uk)
  • Poly(A) selected RNA-seq has been used as a discovery tool for searching novel genes in Drosophila Malpighian tubules in this thesis. (gla.ac.uk)
  • A TopHat and Cufflinks pipeline has been used as an analytical pipeline for novel gene discovery and differential gene expression analysis between Drosophila tubules and whole flies in order to find the tubule-enriched genes. (gla.ac.uk)
  • We investigated to what extent the cuticle inward barrier function depends on the genotype, comprising mitochondrial and nuclear genes in the fruit fly Drosophila melanogaster, and investigated the contribution of interactions between mitochondrial and nuclear genotypes (mito-nuclear interactions) on this function. (peerj.com)
  • Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)
Studies using dros1
  • Many studies using drosophila as a model system have focused on the understanding on how fly structures are formed (developmental biology), how they work (neurobiology), and how organs grow as the animal grows. (cherrybiotech.com)
Genetics5
  • Drosophila is a valuable experimental organism can be used as a reverse genetics model. (gla.ac.uk)
  • Reverse genetics has been applied to identify novel coding gene function in Drosophila tubules. (gla.ac.uk)
  • Reverse genetics has been applied to Drosophila to achieve a gene knockdown and overexpression by using the unique Gal4/UAS system to achieve the novel gene knockdown or overexpression in specific tissue and cell types. (gla.ac.uk)
  • Drosophila melanogaster are so popular when studying genetics because they have a short life cycle of 10-14 days, they are inexpensive to care for, and because they have numerous mutations that can be studied. (nmmra.org)
  • Using the powerful genetics of the vinegar fly (commonly called a fruit fly), Drosophila melanogaster , I examined how social space is affected by isolation and looked for a potential recovery after resocialization. (uwo.ca)
Embryo4
  • For more details on cleavage and gastrulation stages see [1] or go to Drosophila embryo live cell imaging. (cherrybiotech.com)
  • The syncytial Drosophila embryo as a mechanically excitable medium. (syr.edu)
  • Dive into the research topics of 'The syncytial Drosophila embryo as a mechanically excitable medium. (syr.edu)
  • Drosophila Embryo:dorsal-ventral specifiction. (osu.edu)
Neuromuscular junction1
Insects1
  • Research on this topic has been greatly facilitated by using powerful genetic model insects like Drosophila melanogaster, and more recently by advances in genome modification technology, notably CRISPR/Cas9. (ugent.be)
Developmental stages2
Melanogaster strains2
  • We evaluated the impact of curcumin on life span, fecundity, feeding rate, oxidative stress, locomotion, and gene expression in two different wild-type Drosophila melanogaster strains, Canton-S and Ives, under two different experimental conditions. (escholarship.org)
  • The observed positive effects of curcumin on life span and health span in two different D. melanogaster strains demonstrate a potential applicability of curcumin treatment in mammals. (escholarship.org)
Larva1
Flies4
  • Rapamycin could increase life span of weak insulin/Igf signaling (IIS) pathway mutants and of flies with life span maximized by dietary restriction, indicating additional mechanisms. (aston.ac.uk)
  • By employing highly controlled experiments, we investigated the impact of several environmental factors including humidity, food quality, light exposure, and experimental setup that may influence Tp measurements in adult Drosophila melanogaster flies. (geneconvenevi.org)
  • This research identified neuroligin3 and dopamine in the modulation of Drosophila social space after isolation and recovery, and that role could potentially be conserved, as other basic molecular mechanisms first discovered in flies. (uwo.ca)
  • In this project, we will manipulate stem cell capacity in Drosophila melanogaster flies by controlling their oxygen-sensing conditions (e.g., by keeping them under different oxygen concentrations or by using transgenic flies), and we will investigate whether and how fertility, longevity, and (potentially) tissue repair differ between flies with high or low stem cell capacity . (lu.se)
Evoked synaptic transmission1
  • In Drosophila RIM mutants, there is a large decrease in evoked synaptic transmission because of a significant reduction in both the clustering of Ca 2+ channels and the size of the readily releasable pool of synaptic vesicles at active zones. (jneurosci.org)
Modulates2
  • Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila . (sdbonline.org)
  • Cactin, a conserved protein that interacts with the Drosophila IkB proteinCactus and modulates its function. (osu.edu)
Wolbachia3
  • Several recent studies have demonstrated substantial effects of Wolbachia infections on host Tp in different Drosophila species. (geneconvenevi.org)
  • We find only subtle effects of Wolbachia on host Tp which are strongly affected by experimental variation in adult, but not during juvenile life stages. (geneconvenevi.org)
  • However, to the best of our knowledge, no study has yet investigated the effects of Wolbachia on Drosophila Tp at juvenile life stages. (solamonrenewableenergy.com)
Fruit fly3
  • Drosophila deflecta is a species of fruit fly in the Drosophila quinaria species group. (wikipedia.org)
  • In the fruit fly Drosophila, it has been suggested that nearly equal numbers of two subtypes of EEs (Allatostatin A: AstA and Diuretic hormone 31 : Dh31) are alternately produced from the intestinal stem cells in the posterior midgut. (bioone.org)
  • The authors support the claims in the paper through the use of gene knockdown, behavioral experiments, neuroanatomy, and optogenetic activation in the Drosophila fruit fly. (elifesciences.org)
Metamorphosis2
  • The life cycle of drosophila, from egg fertilization to adult life, takes about 10 days at 25°C. Drosophila is a model organism particularly used in developmental biology because it is a holometabolous insect, with major morphological differences occurring between larvae and adult animal (metamorphosis) [1]. (cherrybiotech.com)
  • This very uncommon life cycle could be considered as some sort of inverted metamorphosis. (researchgate.net)
Tumours1
  • This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)
Mechanisms3
  • We discuss this progress for a series of different insecticide targets, but also report a number of unsuccessful or inconclusive attempts that highlight some inherent limitations of using Drosophila to characterize resistance mechanisms identified in arthropod pests. (ugent.be)
  • Drosophila Malpighian (renal) tubules are important epithelial tissue in which to study transport mechanisms. (gla.ac.uk)
  • We also evidence that CIII neurons make use of atypical depolarizing chloride currents to encode cold, and that overexpression of ncc69 -a fly homologue of NKCC1 -results in phenotypes consistent with neuropathic sensitization, including behavioral sensitization and neuronal hyperexcitability, making Drosophila CIII neurons a candidate system for future studies of the basic mechanisms underlying neuropathic pain. (elifesciences.org)
Embryogenesis1
  • The activities of the two pathways depend on each other during Drosophila embryogenesis. (uzh.ch)
Epithelial1
  • also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. (nih.gov)
Biology4
  • Our products aim to reduce the organ shortage and speed up drug development by providing accessible life science solutions that combine biology and technology, fundamentally shifting the global healthcare industry. (mattek.com)
  • Signalling networks that control the life or death of a cell are of central interest in modern biology. (sdbonline.org)
  • You will learn about life-history evolution and molecular cell biology. (lu.se)
  • Strong interests in life-history evolution and molecular cell biology. (lu.se)
Genome2
  • Douris V, Denecke S, Van Leeuwen T, Bass C, Nauen R, Vontas J. Using CRISPR/Cas9 genome modification to understand the genetic basis of insecticide resistance : Drosophila and beyond. (ugent.be)
  • Drosophila tiling microarrays also have a high false-positive detection rate, which may lead to overestimate the transcriptional activities of the genome. (gla.ac.uk)
Stages4
  • During these different stages in the fly life cycle, the structures and organs giving rise to the fly (adult) anatomy are formed. (cherrybiotech.com)
  • It, however, remains uncertain if such behavioral patterns are restricted to adults or are also found at juvenile life stages. (solamonrenewableenergy.com)
  • A morphological study of different stages during the reverted life cycle of Turritopsis nutricula led to the characterization of four different stages: healthy medusa, unhealthy medusa, four-leaf clover and cyst. (researchgate.net)
  • At least in experimental animals, genetical y modified strains, because on the differential effects of a wide greater susceptibility to chemical in these species the interval between variety of carcinogens in humans at carcinogens in utero and during birth and sexual maturity is only a different stages of life, including var early postnatal life is usual y man few weeks. (who.int)
Protein1
  • Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. (uzh.ch)
Species group1
  • nov. are members of the D. buzzatii cluster of the D. repleta species group of the genus Drosophila. (scielo.br)
Mutants1
  • We show here that feeding rapamycin to adult Drosophila produces the life span extension seen in some TOR mutants. (aston.ac.uk)
Stem2
  • The available experimental data support the hypothesis that the cap cells(CpCs) at the anterior tip of the germarium form an environmental niche for germline stem cells (GSCs) of the Drosophila ovary. (biologists.com)
  • However, the role of stem cell capacity in life-history trade-off has not been investigated. (lu.se)
Behavior1
Morphological1
  • We describe Drosophila antonietae (previously classified as D. serido type D by SILVA & SENE, 1991 and references thereafter) and Drosophila gouveai (previously classified as D.serido type B by SILVA & SENE, 1991 and references thereafter), in terms of morphological, genetic and ecological differences. (scielo.br)
Behaviour2
  • Measuring thermal behaviour in Drosophila is complex, and many environmental factors and experimental noise that potentially influence the Tp have to be accounted for. (solamonrenewableenergy.com)
  • Social behaviour is fundamental to the lives of humans and other organisms. (uwo.ca)
Investigation1
Model2
  • In a Drosophila disease model lacking Parkin (park(25) null mutant), we tested the effect of zinc supplementation. (uzh.ch)
  • Our IN model of insect rearing chambers is specifically designed for use in drosophila and mosquito studies, however they have also been useful to researchers in other fields. (darwinchambers.com)
Juvenile1
  • however, some species of Hydrozoa react to environmental stress by reverting their life cycle: i.e. an adult medusa goes back to the juvenile stage of polyp. (researchgate.net)
Experimental2
  • We also discuss an experimental framework that may circumvent current limitations while retaining the genetic versatility and robustness that Drosophila has to offer. (ugent.be)
  • Most experimental studies of the predominant results of earlylife do not develop in rats exposed to the carcinogenesis during prenatal life exposure are what would be expect same carcinogen during adult life and infancy have been conducted ed from a higher effective dose to the (Diwan and Rice, 1995 ). (who.int)
Adult life2
Populations1
  • Drosophila serido was described in 1977 by VILELA & SENE, and in the following years populations of this species from several regions were studied by means of several genetic markers. (scielo.br)
Pathway3
  • The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. (aston.ac.uk)
  • FAK suppressed RTKs signalling in Drosophila melanogaster epithelia by impairing MAPK pathway. (gla.ac.uk)
  • To identify novel regulators of JNK-dependent cell death, this study performed a dominant-modifier screen in Drosophila and found that the Toll pathway participates in JNK-mediated cell death. (sdbonline.org)
Mutations1
Thermal preference1
  • Manipulating thermal preference at this life stage of the host might thus be risky yet beneficial for the microbial symbiont, by "setting up" its thermal environment early in the host development. (solamonrenewableenergy.com)
Mice1
Anatomy2
Increases1
Senses1
Extension1
Resistance1
  • Increase in life span by rapamycin was associated with increased resistance to both starvation and paraquat. (aston.ac.uk)
Function4