Leydig cell tumor. Medical search. Frequent questions

Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and (testicular) interstitial cell tumor (US spelling), is a member of the sex cord-stromal tumour group of ovarian and testicular cancers. (wikipedia.org)
These tumors can be pure or can be mixed with other sex cord-stromal or germ cell tumors. (medscape.com)
In the United States, Leydig cell testicular neoplasms are the most common sex cord-stromal tumors and comprise 1-3% of all testicular neoplasms. (medscape.com)
Sertoli-Lydig cell tumors (SLCTs), also known as androblastoma or arrhenoblastoma , are a type of sex cord-stromal tumor that originates in the ovaries. (knowcancer.com)
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. (medscape.com)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

[ 9 ] Leydig cells are located within the interstitium of the testis, between the seminiferous tubules, and produce testosterone in response to luteinizing hormone. (medscape.com)
Increased incidence of Leydig cell tumours of the testis in the era of improved imaging techniques. (medscape.com)
Augusto D, Leteurtre E, De La Taille A, Gosselin B, Leroy X. Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis. (medscape.com)
Al-Agha OM, Axiotis CA. An in-depth look at Leydig cell tumor of the testis. (medscape.com)
We report the clinical and hormonal findings in two boys with isosexual precocity secondary to Leydig cell tumor of the testis. (jamanetwork.com)
We present our experience in performing testis sparing surgery (TSS) to treat sequential bilateral testicular tumors. (canjurol.com)
Tumor formation generally start in cells in leydig cells in the testis that normally make male sex hormones. (planetayurveda.net)

Typical gross pathology of a Leydig cell tumor (in this case of the ovary): A well circumscribed, solid homogeneous mass with golden brown to brownish green cut surface. (wikipedia.org)
The final pathology showed a poorly differentiated Sertoli Leydig cell tumor at the right ovary and hilus cell hyperplasia at the left ovary. (aejog.com)
UTROSCT lacks FOXL2 and DICER1 mutations, which are found in granulosa cell tumors and Sertoli Leydig cell tumors of the ovary, respectively. (cedars-sinai.edu)
The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary. (cancercentrum.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)

The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 10% are malignant. (wikipedia.org)
Radical orchiectomy was once the primary treatment for Leydig cell tumors, and it remains in use for malignant cases. (medscape.com)
less than 5% of these tumors are malignant (cancerous). (knowcancer.com)
Malignant tumors may require further chemotherapy or radiation therapy following the operation. (knowcancer.com)
Bertram KA, Bratloff B, Hodges GF, Davidson H. Treatment of malignant Leydig cell tumor. (medscape.com)
DICER1 syndrome, also known as DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome, is a condition in which an individual is born with genetic changes that predispose him or her to develop benign and malignant tumors during childhood, through adolescence and, rarely, as an adult. (choa.org)
Red, scaly plaque, microscopically characterized by the spread of malignant cells within the epithelium, occasionally with invasion of underlying dermis. (brainscape.com)
Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)
A cancerous tumor is malignant, meaning it can grow, invade, and spread to other parts of the body. (cancer.net)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)

Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to undescended testes . (medlineplus.gov)

A Sertoli-Leydig cell tumour is a combination of a Leydig cell tumour and a Sertoli cell tumour from Sertoli cells. (wikipedia.org)
Sertoli-Leydig cell tumor: a rare ovarian neoplasm. (wikipedia.org)
Sertoli-Lydig cell tumors are very rare. (knowcancer.com)
If the tumor is accompanied by high levels of testosterone, the tumor could be a Sertoli-Lydic cell tumor. (knowcancer.com)
Objective: To report the rare case of a patient with Complete Androgen Insensitivity Syndrome (CAIS) with Klinefelter Syndrome (KS) (47, XXY) presenting a Sertoli/Leydig cell tumor discovered during the gonadectomy. (remedypublications.com)
To synthesize the evidence on Sertoli-Leydig cell tumour (SLCT) relapses, and identify the clinicopathological characteristics and prognosis of patients with recurrent SLCT. (nih.gov)
We present a case report regarding a 71-year-old woman with postmenopausal virilization caused by ovarian hilus cell hyperplasia and Sertoli-Leydig cell tumor who was suffered from hair loss, clitoromegaly and hirsutism. (aejog.com)
Sertoli-Leydig cell tumors, which are relatively less common, are extremely rare to be seen in the postmenopausal period. (aejog.com)
What distinguishes this case from others is that Sertoli-Leydig cell tumor and hilus cell hyperplasia may cause virilization symptoms together, in addition to its prevalence in advanced age. (aejog.com)
Ertan B, Ozgozen E, Ilgen O, Bulbul G, Saatli B, Ulukus C. Ovarian Hilus Cell Hyperplasia and Sertoli-Leydig Cell Tumor in a Patient with Postmenopausal Virilization: a Rare Case Report. (aejog.com)
DICER1 syndrome is also associated with tumors in the ovaries known as Sertoli-Leydig cell tumors, which typically develop in affected women in their teens or twenties. (medlineplus.gov)
Sertoli-Leydig cell tumors usually do not metastasize. (medlineplus.gov)
There are two main types of testicular tumors known as Leydig cell tumors and Sertoli cell tumors. (home-remedies-for-you.com)
Common phenotypes of DICER1 syndrome include PPB, MNG, cystic nephroma and Sertoli-Leydig cell tumour. (bmj.com)
The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. (mountsinai.org)
The tumor consists of sex cord-like and mesenchymal differentiation with various possible components, including Sertoli-like tubules, nested granulosa-like architecture, retiform growth, lipidized cells, Leydig-like cells, stromal cells with infiltrative growth, and solid sheets of smooth muscle-like cells. (cedars-sinai.edu)
The patient aged 14 at time of partial thyroidectomy later manifested a Sertoli-Leydig Cell Tumor at age 15. (hypothes.is)
The normal sertoli cells generally support and nourish the sperm making germ cells and the same like leydig cells do not respond well to chemotherapy or radiation. (planetayurveda.net)

Since these tumors are typically benign and their growth is slow, outlook is generally very positive. (knowcancer.com)
The mutation increases the overall risk for affected children to develop cancer or a number of benign tumors, especially at younger ages. (choa.org)
A tumor can be cancerous or benign. (cancer.net)
A benign tumor means the tumor can grow but will not spread. (cancer.net)

Boys with estrogen-secreting tumors may present with feminizing symptoms such as gynecomastia , breast tenderness, and gonadogenital underdevelopment. (medscape.com)
In adults with estrogen-secreting tumors, symptoms such as loss of libido, erectile dysfunction , and infertility have been reported. (medscape.com)

This gene, often called a tumor suppressor gene, cannot protect cells from becoming cancerous when it isn't working properly. (choa.org)
More research is needed to determine when and why the cells that produce sperm can sometimes become a cancerous mass. (aia.com)

However, hormonal disturbances, in Leydig tumours, is present in only 2/3 of cases. (wikipedia.org)
Testicular Leydig cell tumours can be detected sonographically, ultrasound examinations may be ordered in the event of a palpable scrotal lump, however incidental identification of these lesions is also possible. (wikipedia.org)
Reinke crystals are classically found in these tumours and help confirm the diagnosis, although they are seen in less than half of all Leydig cell tumours. (wikipedia.org)
Immunohistochemical markers of Leydig cell tumours include inhibin-alpha, calretinin, and melan-A. The usual chemotherapy regimen has limited efficacy in tumours of this type, although imatinib has shown some promise. (wikipedia.org)

They increase the tumor marker protein called alpha fetoprotein as well as HCG. (planetayurveda.net)
This type also increases the alpha fetoprotein levels in tumors. (planetayurveda.net)

These differences indicate that a dexamethasone suppression test may be required to differentiate between Leydig cell tumors and congenital virilizing adrenal hyperplasia with adrenal rest tissue located within the testes. (jamanetwork.com)

citation needed] Due to excess testosterone secreted by the tumour, one-third of female patients present with a recent history of progressive masculinization. (wikipedia.org)
These are the cells in the testicles that release the male hormone, testosterone . (medlineplus.gov)
Although these tumors usually secrete testosterone, the production of estrogen, progesterone, and corticosteroids has also been described. (medscape.com)
Estrogen excess and feminizing syndromes may occur from the peripheral aromatization of testosterone or from the direct production of estradiol by the tumor itself. (medscape.com)
Purpose: Undercarboxylated-Osteocalcin (ucOCN), acting on its putative receptor GPRC6A, was shown to stimulate of testosterone (T) production by Leydig cells in rodents, in parallel with the hypothalamus-pituitary-gonadal axis (HPG) mediated by luteinizing hormone (LH). (endocrine-abstracts.org)
As men age, their testosterone tends to bind to a blood protein rendering the testosterone unavailable to cells throughout the body. (lifeextension.com)
In a study using testes cells from mice, they confirmed that pomegranate extract raised testosterone production. (lifeextension.com)

As a result, cells from the tumor must be biopsied (excised) and studied under a microscope for an accurate diagnosis. (knowcancer.com)
Not all individuals with a diagnosis of DICER1 syndrome will develop tumors or cancer. (choa.org)
The differential diagnosis includes endometrial stromal tumor with sex cord-like differentiation, endometrial carcinoma with sex cord-like differentiation, adenosarcoma with extensive sex cord-like differentiation, and mesonephric adenocarcinoma. (cedars-sinai.edu)

Unlike germ cell testicular tumors, Leydig cell neoplasms are not associated with cryptorchidism . (medscape.com)
Leydig cell tumors are rare ovarian steroid cell neoplasms. (scite.ai)

Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)

Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)

They represent less than 0.2% of all ovarian tumors . (knowcancer.com)
Ovarian tumors are diagnosed by a physician during a pelvic exam or other physical examination. (knowcancer.com)
Virilizing ovarian tumors (VOT) and ovarian stromal hyperthecosis (OH) are the most common hyperandrogenism etiologies in the postmenopausal women. (usp.br)

most individuals with genetic changes associated with this condition never develop tumors. (medlineplus.gov)
People with DICER1 syndrome who develop tumors most commonly develop pleuropulmonary blastoma, which is characterized by tumors that grow in lung tissue or in the outer covering of the lungs (the pleura). (medlineplus.gov)

Prognosis of SLCT depends on the stage and degree of differentiation of the tumor. (knowcancer.com)

Leydig cell tumors (see the image below) are rare testicular tumors of the gonadal interstitium that may be hormonally active and lead to feminizing or virilizing syndromes. (medscape.com)
Paraneoplastic syndromes due to tumor-mediated factors lead to various presentations. (medscape.com)

A stromal tumor is a rare type of testicular tumor. (mountsinai.org)

As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers. (medlineplus.gov)
These cancers grow from germ cells, the cells that make sperm. (mountsinai.org)
Most of the testicular cancers arise from germinal cell tumors and spread rapidly. (planetayurveda.net)
Greater than 95%of testicular cancers start with germ cells. (planetayurveda.net)
These Are the less developed cancers with cells that appear like embryos in their early stages. (planetayurveda.net)

Testicular cancer needs to be caught early to prevent cancer cells from spreading. (aia.com)
Tumors around the testicular area are considered to be one of the most promising signs of being affected by testicular cancer. (home-remedies-for-you.com)
The tumors that form in almost 90 percent of testicular cancer cases will be painless, but some patients may experience a heavy sensation in the scrotum area. (home-remedies-for-you.com)
Once cancer is found, the first step is to determine the type of cancer cell by examining it under a microscope. (mountsinai.org)
Testicular cancer is a condition in which the unusual cell grows out of control in the tissue of one or both of the testes. (planetayurveda.net)
These types of cancer begin when healthy cells in these areas change and grow out of control, forming a mass called a tumor. (cancer.net)
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)

Pathologic evaluation of the removed tumors revealed immature teratoma and Leydig cell tumor. (canjurol.com)

Other symptoms depend on age and the type of tumour. (wikipedia.org)

PDE8 is responsible of cAMP hydrolysis and its expression has been characterized in all steroidogenic cell types in rodents including adrenal and Leydig cells in rodents however scarce data are currently available in humans. (uniroma1.it)

Presence of an ovarian tumour plus hormonal disturbances suggests a Leydig cell tumour, granulosa cell tumour or thecoma. (wikipedia.org)
Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome. (cancercentrum.se)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
Bjorkholm E, Silfversward C. Granulosa- and theca-cell tumors. (cancercentrum.se)

Treatment for SLCT depends upon the age of the patient, the degree of differentiation of the tumor, and whether or not the tumor has ruptured. (knowcancer.com)
Taken together our findings suggest that 1) a specific pool(s) of cAMP is/are regulated by PDE8A during spermiogenesis pointing out a possible new role of this PDE8 isoform in key events governing the differentiation and maturation of human sperm and 2) PDE8B can be involved in Leydig cell transformation. (uniroma1.it)
Through this role in regulating the activity (expression) of genes, the Dicer protein is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation). (medlineplus.gov)
Therefore, the MAPK family governs almost all the physiological functions and processes such as cell adaptation, proliferation, differentiation, survival, and programmed cell death. (spandidos-publications.com)

As the abnormal growth of cells in the brain leads of brain tumor, similarly, the uncharacteristic d. (home-remedies-for-you.com)

Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)
Inflammatory cytokines in the testes and serum, including interleukin-1 β (IL-1 β ), IL-6, IL-10, and tumor necrosis factor- α (TNF- α ), were measured using ELISA and RT-qPCR. (hindawi.com)
Increasing evidences indicate that the imbalance among these pro- and anti-inflammatory molecules, such as interleukin-1 β (IL-1 β ), IL-6, tumor necrosis factor- α (TNF- α ), and IL-10, in testicular cells can result in orchitis [ 3 , 4 ]. (hindawi.com)

and in type III, the growth is a solid tumor that can fill a large portion of the chest. (medlineplus.gov)
Light will not transmit through a solid tumor, while a hydrocele will glow a soft red color. (aafp.org)

This can be done because the tumour is typically unifocal, not associated with precancerous lesions, and is unlikely to recur. (wikipedia.org)

Through their hormonal balance, these cells play an important role in the development of secondary male characteristics and spermatogenesis. (medscape.com)
The hormonal profile at the initial evaluation was quite different in the two cases suggesting differences in steroid biosynthesis by the tumors. (jamanetwork.com)

Enucleation for prepubertal leydig cell tumor. (medscape.com)

Mosaicism is a phenomenon where two genetically distinct populations of cells arise following postzygotic acquisition in one cell of a de novo mutation. (bmj.com)

While the tumour can occur at any age, it occurs most often in young adults. (wikipedia.org)
These tumors occur in infants and young children and are rare in adults. (medlineplus.gov)
Stromal tumors usually occur during childhood. (mountsinai.org)

It has many synonyms like endodermal sinus tumor, infantile embryonal carcinoma and orchid blastoma. (planetayurveda.net)

Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)

The rate of living theory is closely related to the "wear and tear" theory of aging, that our bodies are (except for our germ cells) made up of "post-mitotic cells," unable to continue dividing once growth is complete, and so must die when those cells are "worn out. (doctorsaredangerous.com)
By the middle of the 20th century, those ideas had been disproved in many ways, but in the 1960s Leonard Hayflick renewed for a time the doctrine of aging as the wearing out of unrenewable cells, with his doctrine that somatic cells (non-germ cells) have an absolute limit of 50 replications. (doctorsaredangerous.com)
They contain eggs, also called germ cells. (cancer.net)

The patients were diagnosed with secondary testicular tumors in the contralateral testes on follow up. (canjurol.com)
Secondary tumors are uncommon. (cytojournal.com)

Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor. (medscape.com)
Radiation therapy using high-dose x-rays or other high-energy rays may be used after surgery to prevent the tumor from returning. (mountsinai.org)

If it is secreting androgens the tumour is usually asymptomatic, but can cause precocious puberty in pre-pubertal boys. (wikipedia.org)
Adults with androgen-secreting tumors are generally asymptomatic. (medscape.com)

This approach involves an inguinal or scrotal incision and ultrasound guidance if the tumour is non-palpable. (wikipedia.org)
Magnetic resonance imaging: Can reveal small nonpalpable Leydig cell tumors that are not visible on ultrasound. (medscape.com)
If tumour markers for hCG and AFP are normal and findings on a physical exam or ultrasound are inconclusive, the best advice is to repeat the ultrasound in six to eight weeks. (aia.com)

People with DICER1 syndrome are also at risk of multinodular goiter, which is enlargement of the thyroid gland caused by the growth of multiple fluid-filled or solid tumors (both referred to as nodules). (medlineplus.gov)

On gross exam 5.0 x 3.0 x 2.5 cm tumor was found in the left side of the uterine corpus and did not involve the cervix. (cedars-sinai.edu)
Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)

Anatomy3

Diseases13

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Disciplines and Occupations1

Cord-stromal8

Testis7

Ovary12

Malignant11

Undescended testes1

Sertoli18

Benign4

Estrogen-secret2

Cancerous2

Tumours4

Alpha-fetoprotein2

Hyperplasia1

Testosterone7

Diagnosis3

Neoplasms2

Ovaries1

Primary tumors2

Epithelial tumors2

Ovarian tumors3

Develop tumors2

Prognosis1

Syndromes2

Stromal tumor1

Cancers5

Cancer8

Teratoma1

Symptoms1

Adrenal1

Granulosa5

Differentiation4

Brain tumor1

Necrosis3

Solid tumor2

Lesions1

Hormonal2

Prepubertal1

Mutation1

Occur3

Embryonal1

Mesenchymal1

Germ cells3

Secondary2

Surgery2

Asymptomatic2

Ultrasound3

Thyroid1

Cervix2