These findings indicate that nonfunctional dihydrofolate reductase in human leukemia cells share an antigenic determinant(s) with a functional form of the enzyme from L1210 murine leukemia cells. (aku.edu)
Cells12
Antiserum raised in chickens to dihydrofolate reductase purified from L1210 leukemia cells by affinity chromatography inhibited the catalytic activity and the binding of methotrexate by the enzyme. (aku.edu)
Lysates of human chronic myelogenous leukemia cells, which had neither catalytic activity for dihydrofolate reductase nor binding of methotrexate, blocked the inhibiting effect of the antiserum on the function of the enzyme in L1210 cell lysates. (aku.edu)
Perwaiz Iqbal, M & Rothenberg, SP 1981, ' A nonfunctional protein in human leukemia cells reacts with antiserum to dihydrofolate reductase from L1210 leukemia cells ', Life Sciences , vol. 29, no. 7, pp. 689-696. (aku.edu)
Benzoyl peroxide increases UVA-induced plasma membrane damage and lipid oxidation in murine leukemia L1210 cells. (harvard.edu)
However, delta9-THC administered daily for 10 days significantly inhibited Friend leukemia virus-induced splenomegaly by 71% at 200 mg/kg as compared to 90.2% for actinomycin D. Experiments with bone marrow and isolated Lewis lung cells incubated in vitro with delta9-THC and delta8-THC showed a dose-dependent (10(-4)-10(-7)) inhibition (80-20%, respectively) of tritiated thymidine and 14C-uridine uptake into these cells. (erowid.org)
Previous studies from this laboratory established that the rapid but partial interconversion of tetrahydrofolate cofactors to dihydrofolate after exposure of L1210 leukemia cells to antifolates cannot be due to direct feedback inhibition of thymidylate synthase by dihydrofolate or any other endogenous folylpolyglutamates when dihydrofolate reductase activity is abolished by antifolates. (elsevierpure.com)
This paper explores the role of cell cycle phase in L1210 leukemia cells in logarithmic versus stationary phase growth as a factor in the rate and extent of tetrahydrofolate cofactor interconversion to dihydrofolate after exposure of cells to the dihydrofolate reductase inhibitor trimetrexate. (elsevierpure.com)
The S phase fraction was reduced by inoculating L1210 leukemia cells at high density to achieve a stationary state. (elsevierpure.com)
Effects of photo-activated porphyrins on membrane properties of leukemia l1210 cells. (jax.org)
Neopluramycin inhibits growth of Gram-positive bacteria, leukemia L-1210 in mice and Yoshida rat sarcoma cells in tissue culture. (ichacha.net)
"Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells" , Oncol Rep. 2003 Nov-Dec;10(6):2045-50. (sproutnet.com)
The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80, Mol Cancer Ther 2007 Jan;6(1):370-9. (wayne.edu)
Inhibition1
5-3 with inhibition activity against leukemia cell line L1210 at concentration 1.515 ppm. (univpancasila.ac.id)
Mice6
M5076 tumors in C57BL/6 mice and to prolong survival of DBA/2 mice with disseminated L1210 leukemia. (unboundmedicine.com)
Effects of ethylene glycol monomethyl (EGME) and monoethyl (EGEE) ethers on the immunocompetence of allogeneic and syngeneic mice bearing L1210 mouse leukemia. (cdc.gov)
Delta9-THC administered orally daily until death in doses of 50, 100, or 200 mg/kg did not increase the life-spans of (C57BL/6 times DBA/2)F1 (BDF1) mice hosting the L1210 murine leukemia. (erowid.org)
The in vivo antineoplastic activity of DAC administered as an i.v. infusion was evaluated in mice with murine L1210 leukemia by measurement of survival time, and in mice bearing murine EMT6 mammary tumor by excision of tumor after chemotherapy for an in vitro clonogenic assay. (biomedcentral.com)
In mice with L1210 leukemia and in mice bearing EMT6 tumors, the antineoplastic action of DAC also increased with the dose. (biomedcentral.com)
We also observed a correlation between in vitro and in vivo concentrations needed to produce optimal responses in mice with L1210 leukemia or with EMT6 tumor. (biomedcentral.com)
Tumor cell lines1
We have observed that DAC reduced the in vitro clonogenic potential in a dose-dependent manner of both human and murine leukemia and tumor cell lines. (biomedcentral.com)
Cytotoxicities1
The copper complex cleaves X174 supercoiled DNA efficiently and shows high cytotoxicities toward L1210 murine leukemia and A2780 human ovarian carcinoma cancer cell lines that are sensitive and resistant to cisplatin. (cobiss.net)
Antineoplastic1
2005) Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia. (jenabioscience.com)
Human1
In double immunodiffusion, these human leukemia cell lysates formed a single precipitin line against the antiserum. (aku.edu)
Activity1
19) While pure methyl 5-(2-chloroethylamino)-5-deoxy-2,3-O-isopropylidene-beta-D-ribofuranoside hydrochloride has no L-1210 leukemia activity, a decomposed sample was found to be very active. (comparewords.com)
Article1
For those who want to know about sprouts and leukemia, we have gathered a range of research materials in our article archive. (sproutnet.com)
It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
1 referred to leukemia dosages (≥ 3 mg/kg/day) of TG for the treatment of SARS-COV-2 and reasoned that due to the short time period the level of toxicity would be minimal. (xiahepublishing.com)
Range1
It has been used for a range of diseases in the past, such as leukemia and inflammatory bowel disease, and can be repurposed for other diseases, such as SARS-COV-2. (xiahepublishing.com)
Murine leukemia L1210 cells1
7. Resistance to cyclopentenylcytosine in murine leukemia L1210 cells. (nih.gov)
Tumor2
DMAB was active in the National Cancer Institute in vivo anticancer drug screen for tumor model L1210 leukemia in BDF1 mice. (nih.gov)
Esophageal cancer chemotherapy drug etoposide injection can cure more than half of L1210 leukemia in mice, on the S37, S180 tumor inhibition rate of 61% - 72%, so that the survival of mice suffering from leukemia P1534 compared with the control group increased by 83% - 110% of mice Lewis lung cancer lung metastasis was inhibited. (cancerlive.net)
P3881
The metallocene dihalides are a relatively new class of small, hydrophobic organometallic anticancer agents that exhibit antitumour properties against numerous cell lines including leukemias P388 and L1210, colon 38 and Lewis lung carcinomas, B16 melanoma, solid and fluid Ehrlich ascites tumours and several human colon and lung carcinomas transplanted into athymic mice. (eurekaselect.com)
Vivo1
Tissue culture cell line derived from L1210-5FU-R (TKG 0155, in vivo cell line). (tohoku.ac.jp)
Found1
83] shows of which potentiation can be found in a range of maintenance qualification with leukemia tissues. (immune-source.com)