Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. (medlineplus.gov)
In Langerhans cell histiocytosis, excess immature Langerhans cells usually form tumors called granulomas. (medlineplus.gov)
Many researchers now consider Langerhans cell histiocytosis to be a form of cancer, but this classification remains controversial. (medlineplus.gov)
Other signs and symptoms that may occur in Langerhans cell histiocytosis, depending on which organs and tissues have Langerhans cell deposits, include swollen lymph nodes, abdominal pain, yellowing of the skin and whites of the eyes (jaundice), delayed puberty, protruding eyes, dizziness, irritability, and seizures. (medlineplus.gov)
Langerhans cell histiocytosis is often diagnosed in childhood, usually between ages 2 and 3, but can appear at any age. (medlineplus.gov)
The severity of Langerhans cell histiocytosis, and its signs and symptoms, vary widely among affected individuals. (medlineplus.gov)
Somatic mutations in the BRAF gene have been identified in the Langerhans cells of about half of individuals with Langerhans cell histiocytosis. (medlineplus.gov)
Pulmonary Langerhans Cell Histiocytosis (PLCH) is a relatively uncommon lung disease that generally, but not invariably, occurs in cigarette smokers. (nih.gov)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
Langerhans cell histiocytosis (LCH) is a rare disorder that occurs when a child has too many of a certain type of cell called Langerhans cells. (dana-farber.org)
Langerhans cell histiocytosis may occur at any age, but is most common in young children under 10. (dana-farber.org)
Single-system Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon type of Langerhans cell histiocytosis that affects only the lung. (histio.org)
Langerhans cell histiocytosis (LCH) is blood disease which is now recognized as a cancer and can affect virtually any organ system of the body. (histio.org)
The exact prevalence of single-system Pulmonary Langerhans cell histiocytosis (PLCH) is unknown. (histio.org)
Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. (scirp.org)
We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)
A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)
Findings on CT scan suggestive of Langerhans cell histiocytosis include multiple osteolytic lesions causing full thickness bone destruction. (wikidoc.org)
2013). "Skeletal involvement in Langerhans cell histiocytosis" . (wikidoc.org)
Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology, lacking an animal model, that cumulates symptoms that are found separately in various IL-17A-related diseases, such as aggressive chronic granuloma formation, bone resorption and soft tissue lesions with occasional neurodegeneration(11,12). (dtu.dk)
Clinical and microbiological evaluation of the oral cavity of patients with Langerhans Cell Histiocytosis. (authorea.com)
The Langerhans Cell Histiocytosis (LCH) is a disease characterized by the clonal proliferation of Langerhans cells. (authorea.com)
Sakata N, Toguchi N, Kimura M, Nakayama M, Kawa K, Takemura T. Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. (mayabouchenaki.com)
Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in langerhans cell histiocytosis of bone. (mayabouchenaki.com)
Erdem AP, Kasimoglu Y, Sepet E, Gencay K, Sahin S, Dervisoglu S. Oral manifestations may be the first sign of Langerhans cell histiocytosis. (mayabouchenaki.com)
Immunohistochemical staining of the specimen was positive for S100+ CD1a+ and negative for CD43 and myeloperoxidase, findings that confirmed a diagnosis of skin-limited congenital Langerhans-cell histiocytosis. (medizzy.com)
Langerhans cell histiocytosis (LCH) is a rare disease that involves the abnormal proliferation of Langerhans cells in the skin. (osmosis.org)
Langerhans cell histiocytosis: skeletal sites commonly involved, age and incidence ratio F:M. The femoral region has been circled, showing the object of our case [1]. (pacs.de)
Pulmonary Langerhans' cell histiocytosis (PLCH) remains an important diagnostic consideration in the differential diagnosis of diffuse infiltrative lung disease, particular among smokers. (elsevierpure.com)
Vassallo, R & Limper, AH 2002, ' Pulmonary Langerhans' cell histiocytosis ', Seminars in Respiratory and Critical Care Medicine , vol. 23, no. 2, pp. 93-101. (elsevierpure.com)
No consensus exists for the optimal therapy for Langerhans cell histiocytosis (LCH), particularly in the case of multisystem organ disease. (medscape.com)
Single-agent chemotherapy with cladribine (2-chlorodeoxyadenosine/2-CdA) may be a promising treatment for single-system pulmonary Langerhans cell histiocytosis. (medscape.com)
Symptoms of Langerhans' Cell Histiocytosis vary depending on the part of the body affected and the severity of the disease. (homeremedylifestyle.com)
Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age. (wikidoc.org)
Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age. (wikidoc.org)
2.0 2.1 2.2 2.3 2.4 Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version. (wikidoc.org)
Langerhans cell histiocytosis in the hypothalamic-pituitary region: a case report. (pacs.de)
Langerhans cell histiocytosis in a 6-year-old girl with headaches and diabetes insipidus. (pacs.de)
Axial T1 with contrast (below right) again shows the thick enhancing pituitary stalk and enhancing lesions in both sphenoid wings and in the left orbit.The diagnosis was Langerhans cell histiocytosis of the pituitary and Langerhans cell histiocytosis of the orbit. (pacs.de)
The central nervous system (CNS) is an uncommonly involved organ system in Langerhans cell histiocytosis (LCH) . (pacs.de)
For a general discussion of this disease please refer to the article on Langerhans cell histiocytosis (LCH) . (pacs.de)
Histiocytosis X was renamed Langerhans-cell histiocytosis , reflecting the concept that LCH cells represented dysfunctional epidermal Langerhans cells. (capsulehealth.one)
Available at: http://www.cancernetwork.com/oncology-journal/langerhans-cell-histiocytosis-emerging-insights-and-clinical-implications [Accessed 1 Jul. (capsulehealth.one)
Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
Pulmonary Langerhans Cell Histiocytosis Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
Langerhans cell histiocytosis (LCH) is a dendritic cell (antigen-presenting cell) disorder. (msdmanuals.com)
Symptoms and signs of Langerhans cell histiocytosis vary considerably depending on which organs are infiltrated. (msdmanuals.com)
Single-system pulmonary langerhans cell histiocytosis with only tracheobronchial involvement: a case report. (bvsalud.org)
Pulmonary Langerhans cell histiocytosis (PLCH) only with airway involvement manifested as diffuse thickening of the tracheobronchial walls is rare. (bvsalud.org)
Islets of Langerh16
Langerhans may refer to: Paul Langerhans (1847-1888), German pathologist and biologist Langerhans cells, dendritic cells abundant in the epidermis Islets of Langerhans, the area in which the endocrine cells of the pancreas are grouped Ryan Langerhans (born 1980), American baseball player This disambiguation page lists articles associated with the title Langerhans. (wikipedia.org)
The islets of Langerhans are small groups of cells in the pancreas that function as an endocrine gland . (daviddarling.info)
The islets of Langerhans are named after their discoverer, the German anatomist and microscopist Paul Langerhans (1847-1888). (daviddarling.info)
Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. (jci.org)
Contemporary research of beta cell biology in context of type-2 diabetes is based mainly on the long-standing technique for isolation of the pancreatic islets of Langerhans. (tu-dresden.de)
The islets of Langerhans, also called the islands of Langerhans, are the endocrine part of the pancreas. (keyence.com)
These clusters were named the "islets of Langerhans" after German pathologist Paul Langerhans, who discovered them. (keyence.com)
Insulin and other hormones secreted from the islets of Langerhans adjust blood glucose levels, and a weakening of this function is understood to cause diabetes. (keyence.com)
the islets of Langerhans are mostly distributed in the tail of the pancreas. (keyence.com)
Fluorescent immunostaining using anti-glucagon antibodies and anti-insulin antibodies allows for visualization of glucagon-positive cells as α cells and insulin-positive cells as β cells, clarifying each cell type's distribution in the islets of Langerhans. (keyence.com)
Normally, an objective lens with a magnification of 4x to 20x is required for such evaluations, but since the whole specimen does not fit in a single field of view, researchers observe and capture images with a focus on the parts with islets of Langerhans. (keyence.com)
The effects of interleukin 1 (IL-1) on glucose-induced insulin secretion from isolated rat islets of Langerhans have been examined. (diabetesjournals.org)
These studies suggest that IL-1 may have a physiological role as a potent modulator of insulin secretion by islets of Langerhans. (diabetesjournals.org)
Experiments using isolated islets of Langerhans are hampered by lack of supply and the consuming isolation process. (ulster.ac.uk)
Conclusions: The current study found that MIN6 pseudoislets share many important functional and molecular features with islets of Langerhans. (ulster.ac.uk)
Scientists of the Paul Langerhans Institute Dresden developed a new approach to isolate islets from snap frozen surgical specimens donated by metabolically phenotyped pancreatectomized patients. (tu-dresden.de)
Our approach relies on the use of Laser Capture Microdissection (LCM), a technique that utilizes a laser beam to physically cut out the desired endocrine cells from the surrounding tissue" explains Marko Barovic, PhD student in the Solimena lab of the Paul Langerhans Institute Dresden and first author of the review. (tu-dresden.de)
Langerhans cells are named after Paul Langerhans , a bright, young medical student who worked with the new technique of gold colloid staining in the mid-19th century. (capsulehealth.one)
Epidermal11
Although the epidermal Langerhans cell has been presumed to be the cell of origin in LCH, recent studies have called this belief into question. (medscape.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
Murine epidermal Langerhans cells (LC) have been demonstrated to stimulate a vigorous T cell response to Leishmania major, a cause of human cutaneous leishmaniasis. (uni-wuerzburg.de)
Skin samples collected from these patients have reduced numbers of Langerhans cells (LCs), the major epidermal antigen presenting cells expressing Langerins. (eur.nl)
At this point, Birbeck granules were thought to be exclusive to epidermal Langerhans cells, skin-restricted cells of the mononuclear phagocyte system. (capsulehealth.one)
In 1868 , Langerhans described an epidermal cell population, accounting for approximately 1% of epidermal cells, with characteristic dendrites that he described as extracutaneous nerves. (capsulehealth.one)
We now know that epidermal Langerhans cells are not nerves but dendritic cells, a heterogeneous group of hematopoietic cells enriched in interface tissues and lymphoid organs. (capsulehealth.one)
Epidermal Langerhans cells are unique among dendritic cells in that they arise not from myeloid progenitor cells in bone marrow but rather from yolk-sac progenitors and fetal liver-derived monocytes that populate the skin before birth and are maintained locally under steady-state conditions. (capsulehealth.one)
Proliferation2
We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)
LCH is characterized by the proliferation of CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells (LCH cells) generating inflammatory granuloma. (mayabouchenaki.com)
CD1a3
Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
Der bekannteste Marker für Langerhans-Zellen ist CD1a, ein Oberflächenmarker, der an der Antigenpräsentation beteiligt ist. (antikoerper-online.de)
Immunohistochemistry: The Langerhans cells are positive for S100, CD68 and CD1a. (radiologycases.my)
Lesions3
Langerhans cell granulomatosis (LCG) is a clonal disorder characterized by lesions containing histiocyte-like cells, giant cells, and eosinophils. (medscape.com)
The pathologic hallmark of PLCH is the accumulation of Langerhans and other inflammatory cells in small airways, resulting in the formation of nodular inflammatory lesions. (nih.gov)
3) A relationship has been observed between lesions of the islands of Langerhans and the occurrence of diabetes mellitus. (rupress.org)
Cells are dendritic3
Langerhans cells are dendritic but unpigmented and are found nearer the skin surface than melanocytes. (mayabouchenaki.com)
[ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
Cell granulomatosis1
Cite this: Langerhans Cell Granulomatosis Manifested as Pigmented Villonodular Synovitis - Medscape - Dec 01, 2001. (medscape.com)
Form tumors1
In LCH, extra Langerhans cells spread through the blood and build up in certain parts of the body, where they can damage tissue or form tumors. (dana-farber.org)
Tissues2
They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
Idiopathic non-malignant disease characterized by idiopathic infiltration and accumulation of abnormal histiocytes (i.e. the Langerhans cells) within various tissues (bone marrow, skin, central nervous system, lung, liver, spleen, lymph nodes) causing focal or systemic effects. (capsulehealth.one)
Involvement1
Langerhans cell hystiocitosis - Head and neck involvement. (pacs.de)
CD2072
Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
Darüber hinaus ist Langerin (CD207) ein einzigartiger Marker, der von Langerhans-Zellen exprimiert wird und eine entscheidende Rolle für ihre Funktion spielt. (antikoerper-online.de)
Eosinophils1
It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
Birbeck1
The ultrastructural hallmark of the Langerhans cell, the Birbeck granule, was described a century later. (medscape.com)
Pathologic2
As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)
Over the next decades, reviews debated whether LCH was a disorder of transformed Langerhans cells or of normal Langerhans cells rendered pathologic by inappropriate stimuli. (capsulehealth.one)
Tissue2
It is believed that cigarette smoke attracts specific immune cells in the lungs (Langerhans cells) which leads to a cascade of inflammation and injury to the air passages and lung tissue over time. (histio.org)
Biopsy of pancreas tissue of diabetic and normal rats showed that the Langerhans islet beta cells of diabetic rats have been clearly degenerated. (scialert.net)
Histiocytic1
The tumour is composed of numerous histiocytic Langerhans cells displaying irregular nuclei with nuclear indentation and grooving, fine chromatin, inconspiciousto small nucleoli, and ample cytoplasm. (radiologycases.my)
Induces1
While the overwhelming majority of patients are smokers, mechanisms by which smoking induces this disease are not known, but likely involve a combination of events resulting in enhanced recruitment and activation of Langerhans cells in small airways. (nih.gov)
Inflammatory2
In the interlobular variety the inflammatory process is localized chiefly at the periphery of the lobule and implicates the islands of Langerhans only when the sclerotic process has reached a very advanced grade. (rupress.org)
The inflammatory change invades the islands of Langerhans. (rupress.org)
Transplantation1
Induction of experimental diabetes mellitus is indeed, the first step in the process of purification of pancreatic Langerhans islet cells of normal rats for transplantation under the testis subcutaneous of experimentally induced diabetic rats. (scialert.net)
Diabetes1
c ) In a fourth case of diabetes, hyaline deposit between the capillaries and the parenchymatous cells had so completely altered the islands of Langerhans that they were no longer recognizable. (rupress.org)
Islets21
Langerhans may refer to: Paul Langerhans (1847-1888), German pathologist and biologist Langerhans cells, dendritic cells abundant in the epidermis Islets of Langerhans, the area in which the endocrine cells of the pancreas are grouped Ryan Langerhans (born 1980), American baseball player This disambiguation page lists articles associated with the title Langerhans. (wikipedia.org)
The islets of Langerhans are small groups of cells in the pancreas that function as an endocrine gland . (daviddarling.info)
The islets of Langerhans are named after their discoverer, the German anatomist and microscopist Paul Langerhans (1847-1888). (daviddarling.info)
An Autonomous Cannabinoid System in Islets of Langerhans. (nih.gov)
Functional analysis of human islets of Langerhans maintained in culture. (nih.gov)
Futurist writer Harlan Ellison® has a web page dedicated to him called Islets of Langerhans - certainly meant to point out the sugar-coating the media placed on news items they wished to bury in the 1970s and even today. (hubpages.com)
Transplantation of the Islets of Langerhans is a simpler procedure, accomplished with a large-bore hypodermic needle. (hubpages.com)
Transplanting a large number of Islets of Langerhans from a donor pancreas can produce positive results and clinical trials are gathering additional research in order to perfect these techniques. (hubpages.com)
NIDDK reports that the Islets of Langerhans may be successfully transplanted. (hubpages.com)
Ultrastructural localization of synaptophysin to the secretory granules of normal glucagon and insulin cells in human islets of Langerhans. (nih.gov)
The effect of Ca 2+ and calmodulin has been studied on adenylate cyclase activity in homogenates of rat islets of Langerhans. (diabetesjournals.org)
In contrast, the addition of Ca 2+ together with calmodulin is stimulatory and demonstrates the existence of a Ca 2+ -dependent adenylate cyclase in islets of Langerhans. (diabetesjournals.org)
Previous studies have applied this technique to visualize the architecture of pancreatic islets of Langerhans in wild-type mice. (nih.gov)
Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Islets of Langerhans" by people in Profiles. (childrensmercy.org)
Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: A 4-year study. (humanxenotransplant.org)
Glucagon, secreted from pancreatic α-cells integrated within the islets of Langerhans, is involved in the regulation of glucose metabolism by enhancing the synthesis and mobilization of glucose in the liver. (nih.gov)
Cells28
People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. (nih.gov)
The cause of this disease is unknown, although most data suggest that it is characterized by a growth of immature Langerhans cells that appear to have genetic changes of the BRAF gene in about half the cases. (nih.gov)
Histologically, the lesions were composed of focal aggregates of Langerhans cells in a polymorphous background of mature eosinophils, lymphocytes, and giant cells. (medscape.com)
Higher magnification of these histiocytes showed classical Langerhans-type cells (Fig 7). (medscape.com)
Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. (medscape.com)
The tissue will be looked at under the microscope to see if there is an abundance of Langerhans cells. (clevelandclinic.org)
Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (merckmanuals.com)
The role of the Langerhans cells (LC) during HSV-1 infection in murine skin was examined. (tau.ac.il)
Sprecher, E & Becker, Y 1986, ' SkinLangerhans cells play an essential role in the defense against HSV-1 infection ', Archives of Virology , vol. 91, no. 3-4, pp. 341-349. (tau.ac.il)
Langerhans cells (LC) are immunocompetent antigen presenting cells (APC) which are involved with many infections including those caused by herpes simplex virus (HSV). (umaryland.edu)
However, in 11 of 12 cases studied, a subpopulation of cells with features of Langerhans' histiocytes (LH) was also identified. (mssm.edu)
Mouse anti Guinea Pig lymphocytes and Langerhans cells antibody, clone MsGp2 ( MCA560 ) used for the detection of infiltrating lymphocytes in guinea pig skin following intradermal Mantoux injection and subsequent electroporation by immunofluorescence. (bio-rad-antibodies.com)
Guinea pig skin sections were immunohistochemically stained with an antibody recognizing lymphocytes and Langerhans cells (Tetramethylrhodamine isothiocyanate (TRITC) secondary) after ID GFP plasmid administration followed by EP with SEP. (bio-rad-antibodies.com)
Langerhans cells stained the positive for CD1a, CD207 (langerin) and S100 ( Fig. 3 a-3b). (actasdermo.org)
LCH lesions are granulomatous lesions consisting of pathologic "Langerhans cells" (LCs), lymphocytes (primarily T-cells), eosinophils, and macrophages. (ijhcr.com)
Confocal microscopy confirmed this and additionally revealed an increased number of epidermal CD83 + Langerhans cells in FLG -null subjects. (dundee.ac.uk)
We show that subjects with FLG -null mutations have more mature Langerhans cells in nonlesional skin irrespective of whether they have AD. (dundee.ac.uk)
Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction. (bvsalud.org)
We tested the contribution of mucosal Langerhans cells (LCs) to alveolar bone homeostasis in mice following oral colonization with a well-characterized human periodontal pathogen, Porphyromonas gingivalis We found that oral mucosal LCs did not protect from or exacerbate crestal alveolar bone destruction but were responsible for promoting differentiation of Th17 cells specific to P. gingivalis. (bvsalud.org)
Novel concepts: Langerhans cells in the tumour microenvironment. (otago.ac.nz)
Langerhans cells suppress CD49a+ NK cell-mediated skin inflammation. (nih.gov)
Pancreas1
In a public elementary school, my classmates and I were incorrectly taught that the "Isles of Langerhans" were 2 sizable glands that sit on the underside of the pancreas.Today, we are shocked by that misinformation. (hubpages.com)
Ultrastructural1
The ultrastructural hallmark of the Langerhans cell, the Birbeck granule, was described a century later. (medscape.com)