ZidovudineDolutegravir and lamivudineEmtricitabineTabletsTenofovir DisoproxTabletNucleoside reverse tInfectionEfavirenzLAMIVIRMedicationAllergicRaltegravirEpivir HBVHepatitis B virYMDDInterferonReverse transcripCombinationTelbivudinePolymeraseDoravirineChronicSimplificationAntiretroviral agentsInhibitsAntiviralAIDSLeafletTreatmentSkipM184VAuthorisationDosesPatients
Zidovudine31
- Do not prescribe lamivudine/zidovudine, abacavir/lamivudine, or abacavir/lamivudine/zidovudine to patients taking emtricitabine. (wikipedia.org)
- These highlights do not include all the information needed to use LAMIVUDINE and ZIDOVUDINE TABLETS safely and effectively. (nih.gov)
- See full prescribing information for LAMIVUDINE and ZIDOVUDINE TABLETS. (nih.gov)
- Hematologic toxicity, including neutropenia and anemia, has been associated with the use of zidovudine, a component of lamivudine and zidovudine tablets. (nih.gov)
- Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues including lamivudine and zidovudine (components of lamivudine and zidovudine tablets). (nih.gov)
- Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with hepatitis B virus (HBV) and human immunodeficiency virus (HIV-1) and have discontinued lamivudine, a component of lamivudine and zidovudine tablet. (nih.gov)
- Lamivudine and zidovudine tablets, a combination of 2 nucleoside analogue reverse transcriptase inibitors, are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (nih.gov)
- Lamivudine and zidovudine tablets are contraindicated in patients with a previous hypersensitivity reaction to lamivudine or zidovudine. (nih.gov)
- Discontinue lamivudine and zidovudine tablet as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (nih.gov)
- Most commonly reported adverse reactions (incidence greater than or equal to 15%) in clinical trials of combination lamivudine and zidovudine were headache, nausea, malaise and fatigue, nasal signs and symptoms, diarrhea, and cough. (nih.gov)
- Lamivudine and zidovudine may decrease the number of certain cells in your blood, including red and white blood cells. (epnet.com)
- Lamivudine and zidovudine may cause muscle disorders, especially when used for a long period of time. (epnet.com)
- Lamivudine and zidovudine may cause life-threatening damage to the liver and a potentially life-threatening condition called lactic acidosis (buildup of lactic acid in the blood). (epnet.com)
- If you have liver disease your doctor will probably tell you not to take lamivudine and zidovudine. (epnet.com)
- Your doctor will order certain lab tests during and after your treatment to check your body's response to lamivudine and zidovudine. (epnet.com)
- The combination of lamivudine and zidovudine is used along with other medications to treat human immunodeficiency virus (HIV) infection. (epnet.com)
- Lamivudine and zidovudine are in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). (epnet.com)
- Lamivudine and zidovudine controls HIV infection but does not cure it. (epnet.com)
- Do not stop taking lamivudine and zidovudine without talking to your doctor. (epnet.com)
- When your supply of lamivudine and zidovudine starts to run low, get more from your doctor or pharmacist. (epnet.com)
- If you miss doses or stop taking lamivudine and zidovudine, your condition may become more difficult to treat. (epnet.com)
- or any of the ingredients in lamivudine and zidovudine tablets. (epnet.com)
- This randomized study evaluated the efficacy and tolerability of continued treatment with protease inhibitor plus nucleoside-analogue combination regimens (n = 79) or a change to the simplified regimen of abacavir-lamivudine-zidovudine (n = 84) in patients with suppressed human immunodeficiency virus type 1 (HIV-1) RNA for ⩾6 months who did not have the reverse transcriptase 215 mutation. (uzh.ch)
- The purpose of this study is to determine the safety of and immune response to CsA when given with abacavir sulfate (ABC), lamivudine (3TC), and zidovudine (AZT), (ABC/3TC/AZT) and lopinavir/ritonavir (LPV/r) to HIV infected adults in the early stages of infection. (drugpatentwatch.com)
- Lamivudine and zidovudine belong to a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). (rxhealthmed.ca)
- Lamivudine and zidovudine are used in combination to treat HIV infection by preventing reverse transcriptase from working properly. (rxhealthmed.ca)
- Each white to off-white, modified capsule-shaped, biconvex, film-coated tablets with deep breakline in between 'J' and '59' on one side and deep breakline on the other side, contains 150 mg of lamivudine and 300 mg of zidovudine. (rxhealthmed.ca)
- The recommended dose for adults and adolescents 12 years of age and older, weighing at least 30 kg, is one tablet (150 mg of lamivudine and 300 mg of zidovudine) twice daily. (rxhealthmed.ca)
- For adults weighing less than 30 kg (70 pounds), children below 12 years of age, and people with reduced kidney function, it is recommended that lamivudine and zidovudine be taken separately so each medication dose can be adjusted as needed. (rxhealthmed.ca)
- Lamivudine - zidovudine may be taken with food or on an empty stomach. (rxhealthmed.ca)
- The effectiveness of the medication depends on the right amount of lamivudine and zidovudine in the bloodstream. (rxhealthmed.ca)
Dolutegravir and lamivudine6
- The safety results for dolutegravir and lamivudine seen in GEMINI 1 and 2 were consistent with the product labelling for dolutegravir and lamivudine. (gsk.com)
- Four patients (1%) in both the dolutegravir and lamivudine, and the dolutegravir and TDF/FTC, study arms experienced drug-related serious adverse events, and 15 patients (2%) in the dolutegravir and lamivudine arm and 16 patients (2%) in the dolutegravir and TDF/FTC arm had adverse events that led to discontinuation. (gsk.com)
- This treatment allows individuals to take a two-drug regimen in a single pill with dolutegravir at the core, building on the established potency and safety profiles of dolutegravir and lamivudine. (gsk.com)
- a bioequivalence study of the fixed-dose combination of abacavir, dolutegravir and lamivudine when taken as a single pill compared to the administration of dolutegravir and abacavir/lamivudine as separate pills. (hispanicprwire.com)
- Now, the HIV medication Dovato, made up of antiretrovirals (ART) dolutegravir and lamivudine, has been approved by the US Food and Drug Administrtion (FDA) in an expanded indication. (contagionlive.com)
- The safety results for those who switched to Dovato were consistent with the product labeling for dolutegravir and lamivudine. (contagionlive.com)
Emtricitabine2
- Assessment of the relative potency of emtricitabine and lamivudine. (cdc.gov)
- 50 copies/mL) in the dolutegravir and abacavir/lamivudine arm (the separate components of Triumeq) than in the Atripla ®+ (efavirenz, emtricitabine and tenofovir) arm, the most commonly used single-pill regimen. (hispanicprwire.com)
Tablets6
- tell your doctor and pharmacist if you are allergic to lamivudine, tenofovir, any other medications, or any of the ingredients in lamivudine and tenofovir tablets. (medlineplus.gov)
- The objective of this study was to design oral controlled release matrix tablets of lamivudine using hydroxypropyl methylcellulose (HPMC) as the retardant polymer and to study the effect of various formulation factors such as polymer proportion, polymer viscosity, and compression force on the in vitro release of drug. (unboundmedicine.com)
- The developed controlled release matrix tablets of lamivudine, with good initial release (20%-25% in first hour) and extension of release up to 16 to 20 hours, can overcome the disadvantages of conventional tablets of lamivudine. (unboundmedicine.com)
- Dovato (dolutegravir 50 mg/ lamivudine 300 mg tablets) was authorised by the US Food and Drug Administration in April 2019 [5] (please see US Prescribing Information including Box Warning), and further regulatory applications have been submitted worldwide. (gsk.com)
- Dovato (dolutegravir 50 mg/ lamivudine 300 mg tablets) is authorised in the EU for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine. (gsk.com)
- LONDON, Aug. 25, 2014 /PRNewswire-HISPANIC PR WIRE/ - On August 22, ViiV Healthcare announced that the US Food and Drug Administration (FDA) approved Triumeq ® (abacavir 600mg, dolutegravir 50mg and lamivudine 300mg) tablets for the treatment of HIV-1 infection. (hispanicprwire.com)
Tenofovir Disoprox2
- DRIVE-SHIFT trial evaluating a switch of medication to DELSTRIGO™, a once-daily fixed-dose combination tablet of doravirine (100 mg), lamivudine (3TC, 300 mg) and tenofovir disoproxil fumarate (TDF, 300 mg), in adults with HIV-1 infection who demonstrated virological suppression for at least six months on a stable antiretroviral treatment regimen. (merck.com)
- These agents are classified according to their chemical structures: the three nucleoside analogues include lamivudine, telbivudine and entecavir, whereas the two nucleotide analogues include adefovir dipivoxil, tenofovir disoproxil fumarate (TDF), [ 2 ] and the newly approved tenofovir alafenamide (TAF). (medscape.com)
Tablet6
- Lamivudine is taken by mouth as a liquid or tablet. (wikipedia.org)
- The combination of lamivudine and tenofovir comes as a tablet to take by mouth. (medlineplus.gov)
- February 6, 2015 -- The United States Food and Drug Administration (FDA) has approved Dutrebis, a fixed dose combination tablet containing 150 mg of lamivudine and 300 mg of raltegravir. (drugs.com)
- One Dutrebis fixed dose combination table was shown to provide comparable lamivudine and raltegravir exposures to one Epivir 150 mg tablet plus on Isentress 400 mg tablet. (drugs.com)
- In the US the Food and Drug Administration (FDA) authorised Dovato, a complete, once-daily, single-tablet regimen of dolutegravir (DTG) 50 mg and lamivudine (3TC) 300 mg for the treatment of HIV-1 infection in adults with no antiretroviral (ARV) treatment history and with no known resistance to either DTG or 3TC. (gsk.com)
- Dovato is a complete, once-daily, single-tablet, two-drug regimen of dolutegravir (DTG) 50 mg and lamivudine (3TC) 300 mg, allows adults living with HIV the option to manage their virus without a third ARV. (contagionlive.com)
Nucleoside reverse t1
- Lamivudine is a nucleoside reverse transcriptase inhibitor and works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. (wikipedia.org)
Infection7
- Lamivudine (Epivir) is indicated in combination with other antiretroviral agents for the treatment of HIV‑1 infection. (wikipedia.org)
- Lamivudine (Epivir HBV) is indicated for the treatment of chronic hepatitis B virus infection associated with evidence of hepatitis B viral replication and active liver inflammation. (wikipedia.org)
- The combination of lamivudine and tenofovir is also sometimes used along with other medications to treat healthcare workers or other individuals exposed to HIV infection after accidental contact with HIV-contaminated blood, tissues, or other body fluids. (medlineplus.gov)
- Lamivudine Teva is used to treat adult patients who have chronic (long term) hepatitis B (a disease of the liver due to an infection by the hepatitis B virus). (europa.eu)
- Lamivudine is a prescription medicine approved by both the United States and European Union medical authorities for the treatment of HIV infection in adults and children. (scienceblog.com)
- The study enrolled 35 patients with controlled HIV infection (mean baseline HIV RNA serum level of 2.88 log(10) copies/mL by Roche Amplicor Monitor PCR) who were receiving lamivudine 150 mg twice daily as part of their combination anti-HIV treatment regimen for a median of 42.3 months prior to enrollment. (gilead.com)
- ViiV Healthcare, the global specialist HIV company, majority owned by GlaxoSmithKline, with Pfizer Inc. and Shionogi Limited as shareholders, today announced that the European Commission has granted Marketing Authorisation for Dovato (dolutegravir/lamivudine) for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine. (gsk.com)
Efavirenz1
- Tenofovir combined with lamivudine and efavirenz has proven excellent efficacy, but there is little experience when given with NVP. (uni-frankfurt.de)
LAMIVIR8
- What is Lamivir (Lamivudine) used for? (4nrx-uk.md)
- Lamivir (Lamivudine) is an oral antiviral medicine prescribed to treat patients with hepatitis B or who have HIV. (4nrx-uk.md)
- How should I use Lamivir (Lamivudine)? (4nrx-uk.md)
- Always use Lamivir (Lamivudine) strictly according to your doctor`s instructions to get the safest and most effective results from treatment. (4nrx-uk.md)
- What are the side effects of Lamivir (Lamivudine)? (4nrx-uk.md)
- Lamivir (Lamivudine) should not be taken by patents who are fructose intolerant, allergic to lamivudine, or who have had a bad reaction to similar treatments in the past. (4nrx-uk.md)
- Strictly use Lamivir (Lamivudine) as prescribed and follow all instructions provided by your doctor. (4nrx-uk.md)
- Lamivir (Lamivudine) may not be safe or suitable for all patients. (4nrx-uk.md)
Medication3
- Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. (wikipedia.org)
- HIV or HBV-infected women on lamivudine are warned to discontinue breastfeeding as this puts the baby at risk for HIV transmission and medication side effects. (wikipedia.org)
- Doravirine, lamivudine, and tenofovir may also be used for purposes not listed in this medication guide. (cigna.com)
Allergic1
- You should not use this medicine if you are allergic to doravirine, lamivudine, or tenofovir. (cigna.com)
Raltegravir3
- The indication of Dutrebis is based on efficacy and safety data demonstrated in clinical trials with lamivudine and with raltegravir. (drugs.com)
- www.drugguide.com/ddo/view/Davis-Drug-Guide/110367/all/lamivudine_raltegravir. (drugguide.com)
- Vallerand AHA, Sanoski CAC, Quiring CC. Lamivudine/raltegravir. (drugguide.com)
Epivir HBV1
- The generic ingredient in EPIVIR-HBV is lamivudine . (drugpatentwatch.com)
Hepatitis B vir5
- Long-term use of lamivudine leads to emergence of a resistant hepatitis B virus (YMDD) mutant. (wikipedia.org)
- Long-term use of lamivudine can trigger a resistant hepatitis B virus (YMDD) mutant. (wikipedia.org)
- Because the hepatitis B virus can become resistant to Lamivudine Teva, the doctor should only consider prescribing Lamivudine Teva if other treatments that are less likely to lead to resistance cannot be used. (europa.eu)
- BOSTON, Oct 28, 2003 (BUSINESS WIRE) -- Gilead Sciences (Nasdaq:GILD) today announced that treatment with its once-daily, oral antiviral agent Hepsera(R) (adefovir dipivoxil 10 mg) was associated with sustained reductions in levels of hepatitis B virus (HBV) DNA through 144 weeks (approximately three years) among patients chronically infected with lamivudine-resistant HBV and co-infected with HIV. (gilead.com)
- 1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. (bioservuk.com)
YMDD3
- In hepatitis B, lamivudine resistance was first described in the YMDD (tyrosine-methionine-aspartate-aspartate) locus of the HBV reverse transcriptase gene. (wikipedia.org)
- Patients infected with a virus that has the 'YMDD mutation' (a change in the virus's DNA that is often found after treatment with lamivudine) should take Lamivudine Teva in combination with another medicine against hepatitis B. For more information, please see the summary of product characteristics (also part of the EPAR). (europa.eu)
- Lamivudine-resistant HBV (confirmed "YMDD" mutation) was detected in patients a median of 21.3 months prior to initiating treatment with Hepsera. (gilead.com)
Interferon6
- Patients who are infected with HIV and HCV and are on both interferon and lamivudine can experience liver damage. (wikipedia.org)
- Chronic hepatitis B treatment: the cost-effectiveness of interferon compared to lamivudine. (bvsalud.org)
- To perform a cost-effectiveness evaluation from the perspective of the Brazilian National Health System of alternatives strategies (i.e., conventional interferon , pegylated interferon , and lamivudine ) for the treatment of patients with chronic hepatitis B who present elevated aminotransferase levels and no evidence of cirrhosis at the beginning of treatment . (bvsalud.org)
- For HBeAg negative patients , it was observed that interferon (48 weeks) compared with long-term lamivudine presented an increase of 0.45 discounted life -years gained and ICER of US$15,766.90 per life -year gained. (bvsalud.org)
- Cost - effectiveness acceptability curve for HBeAg positive (pegylated interferon vs. conventional interferon ) and negative (conventional interferon vs. lamivudine ) showed that conventional interferon was cost -effective until three times the gross domestic product per capita. (bvsalud.org)
- For HBeAg negative patients , conventional interferon (48 weeks) compared to lamivudine provided more life -years gained at a favorable ICER. (bvsalud.org)
Reverse transcrip2
- We know that lamivudine, a reverse transcriptase inhibitor used against HIV, was shown in aged mice to decrease the activation of retrotransposons which could be linked to age-associated disorders. (scienceblog.com)
- Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. (bioservuk.com)
Combination6
- The combination of lamivudine and tenofovir is used along with other medications to treat HIV in adults and children. (medlineplus.gov)
- Doravirine, lamivudine, and tenofovir is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). (cigna.com)
- If you also take a medicine called rifabutin, you may need to take an extra dose of doravirine (Pifeltro) about 12 hours after you take the doravirine, lamivudine, and tenofovir combination (Delstrigo). (cigna.com)
- 1 Triumeq is ViiV Healthcare's first dolutegravir-based fixed-dose combination, offering many people living with HIV the option of a single-pill regimen that combines the integrase strand transfer inhibitor (INSTI) dolutegravir, with the nucleoside reverse transcriptase inhibitors (NRTIs) abacavir and lamivudine. (hispanicprwire.com)
- The deeply evaluated report on Tenofovir/Lamivudine/Atazanavir/Ritonavir Combination Drug market represents all the qualitative and quantitative aspects in the industry for the forecast period 2020 - 2025. (reportsinsights.com)
- Switching to the 2-drug regimen of dolutegravir/lamivudine (DTG/3TC) fixed-dose combination is noninferior to continuing a 3-drug regimen through 48 weeks in a randomized clinical trial (SALSA). (viivexchange.com)
Telbivudine1
- Lamivudine , telbivudine, or tenofovir are most commonly used. (msdmanuals.com)
Polymerase1
- Lamivudine interferes with the action of a viral enzyme, DNA polymerase, which is involved in the formation of viral DNA. (europa.eu)
Doravirine6
- What is the most important information I should know about doravirine, lamivudine, and tenofovir? (cigna.com)
- Doravirine, lamivudine, and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body. (cigna.com)
- What should I discuss with my healthcare provider before taking doravirine, lamivudine, and tenofovir? (cigna.com)
- Some drugs should not be used together with doravirine, lamivudine, and tenofovir. (cigna.com)
- You may be more likely to have a broken bone while using doravirine, lamivudine, and tenofovir. (cigna.com)
- How should I take doravirine, lamivudine, and tenofovir? (cigna.com)
Chronic4
- Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV/AIDS. (wikipedia.org)
- Treatment with Lamivudine Teva should be initiated by a doctor who has experience in the management of chronic hepatitis B. The recommended dose of Lamivudine Teva is 100 mg once a day. (europa.eu)
- The development of resistance - which emerges in up to 90 percent of immunocompromised HBV-infected patients after four years of therapy with lamivudine - can lead to progression of chronic hepatitis B," said Dr. Benhamou. (gilead.com)
- Study 460i is a single-center, open-label study of Hepsera in chronic hepatitis B patients with lamivudine-resistant HBV and co-infected with HIV. (gilead.com)
Simplification1
- Simplification to Abacavir/Lamivudine + Atazanavir Maintains Viral Suppression and Improves Bone and Renal Biomarkers in ASSURE, a Randomized, Open Label, Non-Inferiority Trial. (aidshealth.org)
Antiretroviral agents1
- Missing doses makes Lamivudine less effective and may also make the virus resistant to Lamivudine and other possible antiretroviral agents. (singhealth.com.sg)
Inhibits2
- 2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. (bioservuk.com)
- Lamivudine- After intracellular conversion to its active form (lamivudine-5-triphosphate), inhibits viral DNA synthesis by inhibiting the enzyme reverse transcriptase. (unboundmedicine.com)
Antiviral1
- The active substance in Lamivudine Teva, lamivudine, is an antiviral agent belonging to the class of the nucleoside analogues. (europa.eu)
AIDS2
- Although lamivudine and tenofovir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. (medlineplus.gov)
- Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) and the IrsiCaixa AIDS Research Institute, a centre jointly promoted by the "la Caixa" Foundation and the Department of Health of the Generalitat de Catalunya. (scienceblog.com)
Leaflet1
- For more information about treatment with Lamivudine Teva, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist. (europa.eu)
Treatment4
- The COLATE study has suggested that there is no benefit to continuing lamivudine treatment in patients with lamivudine resistance. (wikipedia.org)
- Your doctor may test you to see if you have HBV before you begin your treatment with lamivudine and tenofovir. (medlineplus.gov)
- Though clinical studies are necessary to confirm that the drug elicits a similar effect in humans, the initial research highlights the potential of using pharmacological interventions such as lamivudine - or other drugs capable of blocking the same therapeutic target - as a treatment for ameliorating cognitive impairment of people with Down syndrome. (scienceblog.com)
- Akima T, Tamano M, Yamagishi H, Kubota K, Fujimori T, Hiraishi H. Surgical treatment of HCC in a patient with lamivudine-resistant hepatitis B cirrhosis with adefovir dipivoxil. (wjgnet.com)
Skip1
- If you stop taking lamivudine and tenofovir even for a short time, or if you skip doses, the virus may become resistant to medications and may be harder to treat. (medlineplus.gov)
M184V1
- A better explanation of the data is that lamivudine continues to have a partial anti-viral effect even in the presence of the M184V mutation. (wikipedia.org)
Authorisation3
- It explains how the Committee for Medicinal Products for Human Use ( CHMP ) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Lamivudine Teva. (europa.eu)
- The Committee recommended that Lamivudine Teva be given marketing authorisation . (europa.eu)
- The European Commission granted a marketing authorisation valid throughout the European Union for Lamivudine Teva on 23 October 2009. (europa.eu)
Doses1
- Lamivudine Teva is not suitable for patients who require doses below 100 mg. (europa.eu)
Patients1
- Because Lamivudine Teva is a generic medicine , studies in patients have been limited to tests to determine that it is bioequivalent to the reference medicine, Zeffix. (europa.eu)