Laboratory autoantibodies anemia hemolytic autoimmune. Medical search. Frequent questions

BACKGROUND: Warm-reactive autoantibodies (WAAs) are the most common cause of autoimmune hemolytic anemia (AIHA) and can also be present without clinically significant hemolysis. (ox.ac.uk)
Hemolytic Anemia (AIHA) is hemolysis or premature Premature Childbirth before 37 weeks of pregnancy (259 days from the first day of the mother's last menstrual period, or 245 days after fertilization). (lecturio.com)
Rare singular cases of autoimmune hemolytic anemia (AIHA) occurring months after alemtuzumab infusion are emerging. (ashpublications.org)
We show here that virtually all CD47-deficient nonobese diabetic (NOD) mice spontaneously develop severe lethal autoimmune hemolytic anemia (AIHA) at 180 to 280 days of age, whereas none of the control CD47 + NOD mice develop lethal AIHA at least during the first year of life. (ashpublications.org)
They found thrombocytopenia/autoimmune hemolytic anemia (AIHA), malar rash, proteinuria, anti-nuclear antibodies (ANA), immunological disorder and combined C3 and C4 hypocomplementemia were the strongest predictors against competing rheumatological diseases. (the-rheumatologist.org)
In primary IMHA, no inciting cause can be identified, hence the term idiopathic IMHA or autoimmune hemolytic anemia (AIHA). (vin.com)
In dogs idiopathic IMHA (AIHA) has been considered the most common cause of hemolytic anemias for decades, and many anemic dogs are presumptively managed for AIHA. (vin.com)
cold agglutinin hemolytic anemia ( cold AIHA ) and warm agglutinin hemolytic anemia ( warm AIHA ). (amboss.com)
Cold AIHA and warm AIHA share some characteristics, e.g., they can both present with clinical signs of anemia and laboratory signs of hemolysis , and produce symptomatic anemia severe enough to require blood transfusion . (amboss.com)
Careful clinical and diagnostic evaluation (including direct Coombs testing , antibody titers , and peripheral blood smear ) can help distinguish between the types, however, occasionally patients may have a mixed-type AIHA or unusual clinical presentations and laboratory findings. (amboss.com)

Although TMA lesions are often accompanied by clinical features of microangiopathic hemolytic anemia, thrombocytopenia, and ischemic end-organ injury, renal-limited forms of TMA are not infrequently encountered in clinical practice. (bvsalud.org)
TMA is characterised by thrombus formation in the microvasculature with laboratory findings of microangiopathic haemolytic anaemia (MAHA) and thrombocytopenia. (bvsalud.org)
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ ischemia. (bvsalud.org)
The initial presentation of the patient met the classical clinical triad of thrombotic microangiopathy (microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury) without preceding diarrheal illness. (chikd.org)
Hemolytic uremic syndrome (HUS) is a prototype of thrombotic microangiopathy (TMA) and is characterized by the clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI) [ 1 ]. (chikd.org)
Due to hemolytic anemia, thrombocytopenia, and schistocytosis, thrombotic thrombocytopenic purpura-hemolytic uremic syndrome was suspected and plasma exchange therapy was initiated immediately. (biomedcentral.com)
SLE: Normo-hypochromic anemia, leukopenia, thrombocytopenia, C-reactive protein and sedimentation rate elevated, anti-native-DNA (40-90%), anti-U1-RNP (40-60%), anti-SSA (Ro) (40-60%), anti-histone (70%), RF 30%, anti-cardiolipin antibodies (false positive syphilis serology). (cyberderm.net)
The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)
Thrombotic microangiopathy (TMA) is a well-known clinicopathologic entity characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ injury. (jrheum.org)
Most common signs include thrombocytopenia, microangiopathic hemolytic anemia, and organ ischemia, resulting from microvascular occlusion. (cablivi.com)

When a person produces antibodies against their own red blood cells, as in cold agglutinin disease and other autoimmune conditions, the cells may agglutinate spontaneously. (wikipedia.org)
Depending on the reactivity to the temperature with which the antibodies bind to the red blood cells, it is possible to distinguish hemolytic anemia from hot autoantibodies (in which the antibodies are active at a temperature equal to or higher than 37° C), disease from cold antibodies (the reaction occurs at lower temperatures) and mixed forms. (healthrug.com)
Hughes Syndrome/Antiphospholipid syndrome (APS) is a systemic autoimmune, hypercoagulable, thrombo inflammatory, and thrombosis and/or pregnancy complications syndrome caused by the persistent presence of antiphospholipid antibodies (APL) in plasma of patients with vascular thrombosis and/or pregnancy morbidity along with persistent anti-phospholipid antibodies (APLA), including lupus anticoagulant (LA), anti-β2-glycoprotein I (anti-β2GPI) and/or anti-cardiolipin (ACL) antibodies. (endinglines.com)
Antiphospholipid syndrome is an acquired autoimmune disorder characterized by recurrent arterial or venous thrombosis and/or pregnancy losses, in the presence of persistently elevated levels of anticardiolipin antibodies and/or evidence of circulating lupus anticoagulant (these abnormalities are detected by blood tests). (endinglines.com)
Autoimmune disorders are caused when the body's natural defenses (antibodies, lymphocytes, etc.) against invading organisms attack perfectly healthy tissue. (endinglines.com)
The disease is generally categorized as warm or cold, depending on the thermal reactivity of the autoantibodies Autoantibodies Antibodies that react with self-antigens (autoantigens) of the organism that produced them. (lecturio.com)
Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)
Anti-LC1 antibodies occur alone in 30% of patients with autoimmune hepatitis type 2 (AIH-2). (medscape.com)
Of the multiple forms of ASMAs, antibodies against filamentous (F) actin may have the highest sensitivity for identifying patients with autoimmune hepatitis. (medscape.com)
To detect or confirm immunodeficiency, a special laboratory study of the immune status is necessary: determination of the number and morphology of lymphocytes, the content of immunoglobulins in the blood serum, the study of the complement system, the determination of specific antibodies, etc. (medic-journal.com)
Since many antibodies are not specific to a particular pathology, but are detected in a number of diseases of the immune system, laboratory diagnostics is always supplemented by instrumental methods (radiography, ultrasound, endoscopy, scintigraphy, biopsy, etc. (medic-journal.com)
The mechanism involves an immune response against the patient's own tissues by autoantibodies (antibodies to self), most commonly antinuclear antibodies (ANA). (scienceblogs.com)
These antibodies are called "autoantibodies. (allhealth.com.au)
Polyclonal B-cell activation with autoantibody formation: direct pathogenic antibodies (autoimmune haemolytic anaemia), circulating immune complexes (vasculitis, nephritis), antibody-mediated cytotoxicity (skin lesions). (cyberderm.net)
The 3 types of thyroid autoantigens that generate antibodies in autoimmune thyroid disease (Graves disease or Hashimoto thyroiditis) are thyroglobulin, thyroid microsomal antigen, and the thyrotropin receptor. (medscape.com)
Hence, most laboratories do not release results for thyroglobulin in the presence of antithyroglobulin antibodies. (medscape.com)
[ 2 , 3 ] Another cause of persistent thyroglobulin antibodies (even up to 20 years in some individuals without detectable differentiated thyroid cancer) is coexistent autoimmune thyroid disease. (medscape.com)
Hashimoto's thyroiditis is an autoimmune disorder in which the body's natural defenses against invading organisms (i.e., antibodies, lymphocytes etc.) suddenly begin to attack healthy tissue. (rarediseases.org)
While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the body's immune system mistakenly attacks normal organs and healthy tissue. (scienceblogs.com)
Systemic lupus erythematosus (SLE) is a chronic multi-systemic autoimmune disease, characterized by increased autoreactive cells and autoantibodies. (jrd.or.kr)
Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disorder, with a heterogeneous presentation. (lww.com)
This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. (lookformedical.com)
This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
As a prototypic autoimmune disease, systemic lupus erythematosus (SLE) has highly variable clinical and immunological manifestations. (archivesofrheumatology.org)
Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. (biomedcentral.com)
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can affect all organ systems due to alterations of both the innate and adaptive immune systems. (biomedcentral.com)

this disease can occur spontaneously (idiopathic or primary) or in association with some pathologies (including lymphoma, chronic lymphocytic leukemia, SLE and other autoimmune diseases). (healthrug.com)
Me too' cold autoantibody anemia it can be idiopathic (primary) in nature or secondary to lymphoproliferative syndromes and infections (especially mycoplasma pneumonia or mononucleosis). (healthrug.com)
and/or 3) autoimmunity, including hemolytic anemia and idiopathic thrombocytopenic purpura. (nih.gov)
Since no clinical symptoms/laboratory findings indicated a malignant or specific autoimmune-mediated disorder, the diagnosis made was thrombotic thrombocytopenic purpura-hemolytic uremic syndrome due to idiopathic combined, autoantibody-mediated ADAMTS-13/factor H deficiency. (biomedcentral.com)
Here, we report a 17-year-old woman who presented with idiopathic combined autoantibody-mediated ADAMTS-13/factor H deficiency. (biomedcentral.com)
Immune-mediated hemolytic anemia (IMHA) is a common hematological disorder in dogs, may be primary (idiopathic, autoimmune) or occur secondarily to underlying diseases and is often associated with life-threatening complications. (vin.com)
Many dogs suspected to have idiopathic IMHA present with an acute history of vomiting, diarrhea, lethargy, or anorexia indicating a recent trigger rather than reflecting signs of hemolytic anemia. (vin.com)
AIHAs can be either idiopathic or secondary to another disease e.g., infectious, lymphoproliferative, or autoimmune diseases. (amboss.com)
In contrast to juvenile idiopathic arthritis and various other forms of autoimmune-mediated arthritis, including rheumatoid arthritis, there is no universally accepted maximum age up to which cSLE rather than aSLE is diagnosed. (biomedcentral.com)

Most of the literature was comprised of retrospective studies that often did not correlate laboratory results with clinical findings. (ox.ac.uk)
The diagnosis is based on clinical or laboratory evidence of hemolysis. (healthrug.com)
Chaplin H Jr: Clinical usefulness of specific antiglobulin reagents in autoimmune hemolytic anemias. (karger.com)
In many cases, diagnosis occurs because clinicians focus on the presence of a few high-yield clinical and immunologic symptoms, such as a malar rash in an individual with anti-DNA autoantibodies, that can be used in routine practice to clinically diagnose patients with SLE with high sensitivity and specificity. (the-rheumatologist.org)
Highly suspected of SLE based on clinical and laboratory findings, the patient was initially treated with corticosteroids. (jrd.or.kr)
The Department of Rheumatology and Clinical Immunology deals with the clinical correlation of autoimmune diseases and immune system disorders, i.e. with diagnostics and treatment of rheumatic diseases as well as primary and secondary immunodeficiency. (uniklinik-freiburg.de)
Associated with the Department of Rheumatology and Clinical Immunology is a special rheumatological-immunological laboratory, in which serological and cellular diagnostics for autoimmune and immunodeficiency diseases are carried out and further developed. (uniklinik-freiburg.de)
Demographic, clinical characteristics, and laboratory features were collected. (archivesofrheumatology.org)
IAH in SCD manifests as febrile haemolytic crisis with clinical and laboratory features of severe anaemia or pancytopenia. (bvsalud.org)

Adults with bleeding disorders may present to their family physician with minor bleeding symptoms or hematologic laboratory abnormalities discovered during evaluation for surgery or another purpose. (medscape.com)
This article reviews the diagnostic approach to hematologic laboratory abnormalities and abnormal bleeding in adults, as well as basic preventive care and hemostatic management of adults with bleeding disorders. (medscape.com)
Adults with bleeding disorders may also initially present with abnormal coagulation laboratory studies or seek an initial consultation when a family member is diagnosed with an inherited bleeding disorder. (medscape.com)
2 , 3 Alemtuzumab is also FDA-approved for B-chronic lymphocytic leukemia (B-CLL) under the brand name Campath and used off-label for immune disorders such as graft-versus-host disease and aplastic anemia, and occasionally as a part of the conditioning regimen for solid organ and hematopoietic stem cell transplantations. (ashpublications.org)
5 , 6 The secondary autoimmune disorders tend to arise within the first 5 years of follow-up, with the peak incidence occurring in the first 3 years after the last dose. (ashpublications.org)
Autoimmune disorders constitute a special category of diseases of the immune system. (medic-journal.com)
Autoimmune hemolytic anemias (AIHAs) are a collection of disorders characterized by the destruction of RBCs through antibody-mediated hemolysis (extravascular and/or intravascular ). (amboss.com)
Older people are at risk for cobalamin (vitamin B12) deficiency because of a number of common disorders (e.g., autoimmune gastritis) and drugs (e.g., antacids) that may alter its absorption and utilization. (mjhid.org)
It requires a high degree of suspicion, due to heterogeneity and non-specificity of the signs and symptoms, ranging from macrocytosis (with or without anemia) to neuropsychiatric manifestations, that characterize several other aging-related disorders, like hematological malignancies, diabetes, hypothyroidism or vasculopathy. (mjhid.org)

If the anemia is severe or rapidly progressive, however, supportive care with transfusions of packed red blood cells may be warranted. (medscape.com)
Autoimmune hemolytic anemia can come on suddenly or develop gradually.Depending on the severity of hemolysis, high fever, severe asthenia, malaise, headache and severe pain in the lumbar region may occur. (healthrug.com)
the disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (icdlist.com)
It is related to severe deficiency in ADAMTS13, which is usually acquired via ADAMTS13 autoantibodies or inherited via mutations of the ADAMTS13 gene. (bvsalud.org)
Most autoimmune diseases have a steadily progressive course, and without appropriate treatment they can lead to severe disability. (medic-journal.com)
SCD patients with fever, severe anaemia or pancytopenia should be investigated for early diagnosis and prompt treatment of IAH, which is a life- threatening haematological emergency for which transfusion therapy alone may not suffice. (bvsalud.org)

DLHA, also known as paroxysmal cold hemoglobinuria, is an intravascular hemolytic anemia caused by a cold-reacting immunoglobulin (Ig). (medscape.com)

Atypical hemolytic uremic syndrome (aHUS), a rare form of thrombotic microangiopathy, is distinguished from the typical form by the absence of a preceding verotoxin-producing Escherichia coli infection. (chikd.org)
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome is a life-threatening condition with various etiopathogeneses. (biomedcentral.com)
7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)

Two forms of cold antibody autoimmune hemolytic anemias are generally recognized: Donath-Landsteiner hemolytic anemia (DLHA) and cold agglutinin disease. (medscape.com)
[ 1 , 2 , 3 ] (Whipple et al reported a case of autoimmune hemolytic anemia in which paroxysmal cold hemoglobinuria was caused by an IgA Donath-Landsteiner [D-L] antibody. (medscape.com)
In warm antibody hemolytic anemia, hemolysis occurs primarily in the spleen and is not due to direct lysis of RBCs. (msdmanuals.com)
Most of the autoantibodies in warm antibody hemolytic anemia are IgG. (msdmanuals.com)
DESMOGLEIN (DSG) 1 AND 3 ANTIBODY Bullous autoimmune dermatoses belong to the organ specific autoimmune diseases. (tersavictoria.com)
Pregnant women and family members of those with a history of autoimmune thyroiditis can also have positive thyroglobulin antibody. (medscape.com)

An immunologically mediated erythrocyte lysis can also occur due to the intervention of alloantibodies in the hemolytic transfusion reaction (following a blood transfusion from an incompatible donor) and in hemolytic disease of the newborn . (healthrug.com)
Furthermore, alloimmune hemolytic anemias, such as hemolytic transfusion reactions are caused by specific anti-erythrocytic alloantibodies. (vin.com)

10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)

7.5 g/dL [70.5 g/L]). Autoantibodies in cold agglutinin disease are usually IgM. (msdmanuals.com)
Cold autoantibody anemia includes cold agglutinin disease and paroxysmal cold hemoglobinuria. (healthrug.com)
In cold autoantibody disease, other signs secondary to prolonged exposure to cold may be present, such as acrocyanosis, Raynaud's syndrome, or ischemic incidents associated with low temperatures. (healthrug.com)
From: Current Topics in … Herpetiform pemphigus is a unique form of pemphigus that clinically resembles dermatitis herpetiformis-an IgA-mediated disease-and immunologically has a feature of pemphigus-circulating and in vivo bound IgG autoantibodies against keratinocyte cell surfaces. (tersavictoria.com)
Mhashimoto TGreen KJShimizu NNishikawa T Absorption of pathogenic autoantibodies in pemphigus disease the blisters are formed whereas! (tersavictoria.com)
Cold agglutinin disease (CAD) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment for CAD patients. (nature.com)
However, the erythroid response in the bone marrow may be blunted by the immune process or the underlying disease, thereby leading to non-regenerative anemias. (vin.com)
Chronic inflammatory autoimmune disease with marked immunogenetic component which involves the skin and/or other organs. (cyberderm.net)
Hashimoto thyroiditis is an autoimmune disease in which the thyroid gland is attacked by autoantibodies. (medscape.com)
Any disease that results from such an aberrant immune response is termed an autoimmune disease . (wikidoc.org)
Thus, any autoimmune response was perceived to be abnormal and postulated to be connected with human disease. (wikidoc.org)
2002) demonstrated that self-MHC recognition (which, if too strong may contribute to autoimmune disease) maintains the responsiveness of CD4+ T cells when foreign antigens are absent. (wikidoc.org)
The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. (symptoma.ie)
BOTTOM LINE: Symptoms like fatigue, muscle aches, swelling , and redness could be signs of an autoimmune disease. (symptoma.ie)
See a doctor if you have symptoms of an autoimmune disease. (symptoma.ie)
This inhibits the formation of microthrombi while the underlying autoimmune disease is treated with immunosuppressive therapy. (cablivi.com)

Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by circulating autoantibodies (inhibitor) directed against coagulation factor VIII (FVIII). (journalmc.org)

Antiphospholipid syndrome is an autoimmune disorder of unknown cause. (endinglines.com)
While anaemia is present in 50%-86% of patients with Good's syndrome, only 41.9% of cases present pure red cell aplasia. (ecancer.org)
Doctors of various specialties are engaged in the diagnosis and treatment of this category of diseases: allergic pathology and immune insufficiency are in the field of view of allergologists-immunologists, autoimmune diseases (depending on the leading syndrome) are in the competence of specialists-rheumatologists, endocrinologists, neurologists, gastroenterologists, cardiologists, etc. (medic-journal.com)
HPV-B19 infections are mostly self-limited and occur rarely in adults, but if a patient presents lupus-like syndrome with transient autoantibody positivity, lupus mimickers including HPV-B19 should be considered. (jrd.or.kr)
Autoimmune polyendocrine syndrome type II, also known as Schmidt syndrome, is a rare autoimmune disorder in which there is a steep drop in production of several essential hormones by the glands that secrete these hormones. (rarediseases.org)

2006). TShiotani The pemphigus diseases are caused by pathogenic autoantibodies against desmoglein 1 and desmoglein 3, two adhesion proteins found in keratinocytes. (tersavictoria.com)

Accurate diagnosis depends on an ability to recognize the signs and symptoms that indicate an underlying bleeding disorder, followed by appropriate laboratory testing and interpretation of abnormal coagulation studies. (medscape.com)
The purpose of this article is to provide practical guidance for the family physician regarding the evaluation of bleeding symptoms and abnormal hematologic laboratory studies in adults. (medscape.com)

stimulate production of autoantibodies against Rh antigens ( methyldopa -type of autoimmune hemolytic anemia). (msdmanuals.com)
Diseases of the immune system are classified taking into account the activity of immune reactions: in the case of hyperreaction to external allergens, allergic diseases develop, with a perverted reaction to their own (endogenous) tissue antigens, autoimmune diseases. (medic-journal.com)
Now, it is accepted that autoimmune responses are vital to the development and functioning of vertebrate immune systems, and central to the development of immunological tolerance to self-antigens. (wikidoc.org)

Warm-reactive (immunoglobulin G) autoantibodies and laboratory testing best practices: review of the literature and survey of current practice. (ox.ac.uk)
An immunoglobulin G (IgG)-predominant polyclonal hypergammaglobulinemia is a common finding in patients with untreated autoimmune hepatitis. (medscape.com)
For example, with a deficiency of secretory immunoglobulin A, chronic infectious skin lesions may initially develop, further complicated by autoimmune diseases (dermatomyositis, rheumatoid arthritis, SLE and bronchial asthma. (medic-journal.com)

Notably, aHUS may be classified as a primary condition or may occur secondary to bone marrow transplantation, the use of specific drugs, pneumococcal or viral infections, and autoimmune diseases [ 1 ]. (chikd.org)

Worlledge SM, Blajchman MA: The autoimmune haemolytic anaemias. (karger.com)

In cases of asymptomatic hematologic laboratory abnormalities, the particular abnormality should narrow down the potentially affected hemostatic component(s), ideally streamlining subsequent investigation. (medscape.com)
a familial disorder characterized by anemia with multinuclear erythroblasts, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (erythroid precursor cells). (icdlist.com)

The 2019 American Association for the Study of Liver Diseases (AASLD) practice guideline states: "The diagnosis of autoimmune hepatitis cannot be made without liver biopsy and compatible histologic findings. (medscape.com)
Laboratory findings showed pancytopenia, increased creatinine level, proteinuria and hypocomplementemia. (jrd.or.kr)

We describe a patient with a history of this viral illness who later developed cold agglutinin anemia. (unisciencepub.com)
Our patient has an exceptional experience of persistent cold agglutinin anemia after the viral infection. (unisciencepub.com)

Blood typing should be performed on all patients even if anemia is mild. (medscape.com)
Two groups of patients with undiagnosed hemolytic anemia and negative conventional tube method-DAT (TM-DAT) were investigated using anti-IgA and anti-IgM sera, or column agglutination method-DAT (CM-DAT), respectively, in addition to radioimmunological quantitation of RBC-bound IgG. (karger.com)
We study patients with poorly characterized, inherited immunodeficiencies and autoimmune diseases, often lacking molecular diagnoses. (nih.gov)
In summary, transient autoimmune agglutinins have been reported in COVID-19 patients. (unisciencepub.com)
Autoimmune hepatitis is an unlikely diagnosis in patients who have acute hepatitis without hypergammaglobulinemia. (medscape.com)
Patients with aHUS may show the presence of anti-complement factor H (CFH) autoantibodies. (chikd.org)
In aTTP patients, however, ADAMTS13 is blocked by autoantibodies, thereby greatly increasing the amount of ultra large vWF in circulation. (cablivi.com)
That is, patients who even meet the classification criteria for a diagnosis of SLE are not necessarily SLE, and patients with non-rheumatic diseases or non-SLE autoimmune inflammatory rheumatic diseases (AIIRD) need to be excluded before the diagnosis of SLE is established. (archivesofrheumatology.org)

these immune cells bind to the membrane of red blood cells, reducing their survival and causing their premature destruction through hemolysis.This form of hemolytic anemia of immune origin has various causes. (healthrug.com)
a condition of inadequate circulating red blood cells (anemia) or insufficient hemoglobin due to premature destruction of red blood cells (erythrocytes). (icdlist.com)
Autoimmune hemolytic anemia Hemolytic Anemia Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). (lecturio.com)

Diseases of the immune system with an autoallergic mechanism are divided into organ-specific - in which autoantibodies are directed against a specific target organ (autoimmune gastritis, autoimmune thyroiditis, autoimmune hepatitis, etc.), non-organ-specific - in this case, autoantibodies can attack different organs and tissues (scleroderma, SLE, rheumatoid arthritis, etc.) and mixed. (medic-journal.com)

The most valuable methods of diagnosing autoimmune diseases are laboratory studies aimed at detecting autoantibodies to various tissues in the blood, circulating immune complexes, acute phase proteins, components of the complement system, genetic markers. (medic-journal.com)

The Donath-Landsteiner bithermic hemolytic test is a hemolytic assay in which the patient's serum is incubated with normal RBCs and complement at 0-4°C to allow the early components of complement to be fixed. (medscape.com)
acquired hemolytic anemia due to the presence of autoantibodies which agglutinate or lyse the patient's own red blood cells. (icdlist.com)

Archives of Pathology & Laboratory Medicine. (wikipedia.org)
At the same time, there is a close relationship in the occurrence of allergic, immunodeficiency and autoimmune pathology. (medic-journal.com)

Evidence of a hemolytic anemia is suggested clinically by icterus and a regenerative anemia with hyperbilirubinuria, and the presence of hemoglobinemia and hemoglobinuria refers to an intravascular process. (vin.com)

anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (mcv) and increased mean corpuscular hemoglobin (mch). (icdlist.com)
Immune-mediated hemolytic anemia (IMHA) arises when an immune response targets directly or indirectly erythrocytes and hemolytic anemia ensues. (vin.com)

Omine M, Kajii E, Kamesaki T, Karasawa M: A reference guide for diagnosis and treatment of autoimmunne hemolytic anemia. (karger.com)

any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. (icdlist.com)
Clinicians must consider the diagnosis of autoimmune hepatitis in any patient who presents with abnormal liver chemistries, acute hepatitis, or acute liver failure (defined by the new onset of coagulopathy and hepatic encephalopathy). (medscape.com)

Garratty G: Immune hemolytic anemia associated with negative routine serology. (karger.com)

hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. (icdlist.com)
This deficiency is due to formation of autoantibodies directed against ADAMTS13. (cablivi.com)

Plasma exchange removes vWF and autoantibodies and replenishes ADAMTS13. (cablivi.com)
Immunosuppressive therapies are intended to inhibit anti-ADAMTS13 autoantibody production. (cablivi.com)

A number of autoimmune diseases are caused by hereditary factors. (medic-journal.com)

anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. (icdlist.com)
She visited a local hospital in Vientiane, Laos PDR and underwent laboratory testing that showed the following results: hemoglobin 6.2 g/dL, platelet count 76,000 cells/mm 3 , serum potassium 6.9 mEq/L, blood urea nitrogen (BUN) 205 mg/dL, serum creatinine 5.5 mg/dL, serum albumin 2.9 g/dL, and serum cholesterol 289 mg/dL. (chikd.org)

Studies have shown that some people with APS have a faulty gene that plays a role in other autoimmune conditions, such as lupus. (endinglines.com)

An acquired form of aHUS that primarily affects children aged 9-13 years is observed in those who present with aHUS in association with anti-CFH autoantibodies (anti-CFHa-HUS) [ 4 - 6 ]. (chikd.org)

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