• Based on this notion and the observation that CD36 is found on the surface of cells, CD36 is thought to have a 'hairpin-like' structure with α-helices at the C- and N- termini projecting through the membrane and a larger extracellular loop (Fig. 1). (wikipedia.org)
  • This topology is supported by transfection experiments in cultured cells using deletion mutants of CD36. (wikipedia.org)
  • CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. (wikipedia.org)
  • Previously, we demonstrated that endothelial NO synthase (eNOS) was activated by high-density lipoprotein (HDL) via its scavenger receptor of the B class/human homologue of SR-BI, CD36 and LIMPII analogous-1(hSR-BI/CLA-1). (bvsalud.org)
  • The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. (wikipedia.org)
  • However exposure to the thrombospondin ligand causes CD36 to dimerize. (wikipedia.org)
  • Based on this notion and the observation that CD36 is found on the surface of cells, CD36 is thought to have a 'hairpin-like' structure with α-helices at the C- and N- termini projecting through the membrane and a larger extracellular loop (Fig. 1). (wikipedia.org)
  • Disulfide linkages between 4 of the 6 cysteine residues in the extracellular loop are required for efficient intracellular processing and transport of CD36 to the plasma membrane. (wikipedia.org)
  • The function of these lipid modifications is currently unknown but they likely promote the association of CD36 with the membrane and possibly lipid rafts which appear to be important for some CD36 functions. (wikipedia.org)
  • In the absence of ligand, membrane bound CD36 exists primarily in a monomeric state. (wikipedia.org)
  • Using Kyte-Doolittle analysis, the amino acid sequence of CD36 predicts a hydrophobic region near each end of the protein large enough to span cellular membranes. (wikipedia.org)
  • It is not clear what role these linkages play on the function of the mature CD36 protein on the cell surface. (wikipedia.org)
  • Immobilized human RSPO1 at 20 ug/ml (100 ul/well) can bind human LIMPII with a linear ranger of 32-800 ng/ml.2. (betalifesci.com)