• The Minimum Inhibitory Concentration (MIC) was defined as the lowest concentration required to inhibit ≥50% of M. tuberculosis growth. (utep.edu)
  • The actual minimum inhibitory concentration of AMB-NPs against Candida albicans was significantly lower than that of free AMB, and AMB-NPs were less toxic on blood cells. (dovepress.com)
  • The microdilution method was employed to determine the minimum inhibitory concentration (MIC). (altmetric.com)
  • Low-micromolar (4-8 μg/mL) minimum inhibitory concentration (MIC) values of PcephPT in ceftriaxone-resistant bacteria compared with median lethal dose (LD 50 ) values greater than 250 μM in mammalian cells suggests favorable selectivity. (aku.edu)
  • Extraction of EO-JC was performed by use of hydrodistillation using a Clevenger-type apparatus, and the EOs were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). Antifungal activity of EO-JC was evaluated by the use of solid-state diffusion (disc method) and microdilution to determine the minimum inhibitory concentration (MIC), against three strains of fungus, Aspergillus niger , Aspergillus flavus, and Fusarium oxysporum . (hindawi.com)
  • Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes. (nih.gov)
  • The median lethal dose (LD 50 ) of the MEHA after oral administration was approximately greater than 2000 mg/kg. (springeropen.com)
  • The values of LD50 (lethal dose 50%) calculated from experiments are different for each cell line . (lookformedical.com)
  • Actinomycin D was extremely potent with an inhibitory concentration IC 50 at 0.4 nM, whereas the lethal dose LD 50 was at 260 μM. (tmu.edu.tw)
  • It also was hypothesized that the three medicinal plants would have a cytotoxicity of ≤50% in human (U-937) cells. (utep.edu)
  • The second experiment evaluated the cytotoxicity of the plant extracts in human promonocyte U-937 cells, defined as the concentration killing 50% or more of the cells (LD50). (utep.edu)
  • The results of the cytotoxicity experiment revealed 0% of cytotoxicity at the lowest concentration for all plants used. (utep.edu)
  • In contrast, Gordolobo and A.adstringens showed significant cytotoxicity at concentrations as low as 12.5-25μg/ml and 25-50μg/ml, respectively. (utep.edu)
  • FE showed significant cytotoxicity against brine shrimp larvae with LD50 of 41.3 mu g/ml. (pkc-signal.com)
  • The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. (scialert.net)
  • Atrazine degrades rapidly, usually by way of hydrolysis, nitrogen dealkylation, and splitting of the triazine ring to less toxic compounds not normally inhibitory to plants and animals. (unl.edu)
  • The compounds showed inhibitory activity in a concentration dependant manner. (hindawi.com)
  • In recent studies, this linker modified analog of goniothalamin was shown to be cytotoxic against PC-3 (prostate cancer) and MCF-7 (human breast cancer) cell lines with half maximal inhibitory concentration values of 0.13 μM and 2.6 μM, respectively. (lookformedical.com)
  • The initial velocity decreased at enzyme concentrations higher than 0.13 mg protein per 2.0 ml of incubation mixture. (who.int)
  • Known acute oral lD-50 values for birds are >2,000 mg/kg body weight, and dietary lD-50s are >5,000 mg/kg ration. (unl.edu)
  • Acute toxicological investigations have shown that both E. indicum extracts have a high L.D. 50 value of 1533 mg/kg b.w for AE and 1567 mg/kg b.w for ME making them safe and non-toxic. (springeropen.com)
  • Phytotoxic studies of FC, FE and FW against Lemna minor showed 77.5-100% inhibitory effects at 1000 mu g/ml. (pkc-signal.com)
  • Residues have been detected at phytotoxic concentrations in groundwater, lakes, and streams as a result of runoff from treated fields. (unl.edu)
  • However, potentially harmful phytotoxic concentrations of atrazine, i.e., >10 ug/l for extended periods, have not been documented in the environment, and are probably unrealistic under current application and degradation rates. (unl.edu)
  • The lc50ld50 represent the concentration lc50 or dose ld50 at which. (web.app)
  • Along with each chemical structure is given the available rat oral LD50 (dose that kills 50% of a group of test animals), expressed in mg active ingredient/kg body weight. (umn.edu)
  • The concentrations of the plant extracts that were prepared for use in the experiments were 100μg/ml, 200 μg/ml, 400 μg/ml, 800 μg/ml, 1600 μg/ml, and 3200 μg/ml. (utep.edu)
  • The growth of bacterial colonies exposed to six concentrations of the three plant extracts were compared with the colony growth in control containing culture medium control. (utep.edu)
  • The U-397 cells suspended in RPMI-1640 with 10% heat-inactivated fetal calf serum were cultured in the presence of 5% CO2 at 37°C. Subsequently, plant extracts previously dissolved in saline or DMSO were added in concentration ranging from 12 to 400μg/ml in relation with the culture media. (utep.edu)
  • The results of the anti-mycobactericidal experiments revealed that all three plant extracts showed growth inhibition at low concentrations, however L. porteri (chuchupaste) inhibited more than 50% of the growth at the lowest used (5μg/ml). (utep.edu)
  • The total antibacterial activity (TAA) in ml/g and selectivity index (LC 50 /MIC) of the plant extracts were calculated. (biomedcentral.com)
  • The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. (pharmfair.com)
  • The oil's antiproliferative effects against three human tumor cell lines were also investigated using the MTT assay, and the toxic doses that yielded 50% reduction of cell viability (LD50) were reported. (altmetric.com)
  • Aquatic fauna are indirectly affected at atrazine concentrations of 20 ug/l and higher, partly through reduction of the food supply of herbivores, and partly through loss of macrophyte habitat. (unl.edu)
  • LD 50 =500 mg/kg (oral, rat), short-term side effects include high blood glucose levels and fluid retention. (pharmfair.com)
  • FE showed 65.60% antiglycation activity against the protein glycation while the other fractions showed less than 50% inhibitory potential. (pkc-signal.com)
  • HUVEC when comparing the IC50 (half maximal inhibitory concentration) values. (lookformedical.com)
  • 1998) Proc Natl Acad Sci USA, 95: 10443-10448) and show a noncovalently held dimer at high concentration required for crystallization (Ding et al. (justia.com)
  • H. malu, C. adhaesivum and E. quadricolor had a significant inhibitory effect on A431 cells. (scielo.br)
  • Furthermore, H. malu and C. adhaesivum had a significant inhibitory effect on T47D cell line at 40 µg/mL. (scielo.br)
  • This extract and some linear furanocoumarins exhibited carbohydrate metabolizing enzymes inhibitory effect. (hindawi.com)
  • Dosage in Adult and Pediatric Patients with Creatinine Clearance greater than or equal to 50 mL/minute (2.1. (nih.gov)
  • The LD 50 was found to be greater than 5000 mg/kg. (ijpsr.com)
  • Interestingly, the half maximal inhibitory concentration (IC50) of BLMs in different cancer cell lines varies from nM to μM ranges. (lookformedical.com)
  • Initial velocity was directly proportional to enzyme concentration, only in the low concentration ranges. (who.int)
  • Specifically L. porteri (chuchupaste) was not found to be toxic to human cells until a concentration of 50-100μg/ml. (utep.edu)
  • The enzyme was found to be inactivated by the metal chelating agent, ethylene diamine tetracetate (EDTA) at 5 X 10-3 and 5 X 10-4 M concentrations. (who.int)
  • Several exposures including inhalation and contact were used to determine lethality, as well as the repulsion test was conducted at concentrations of 4, 8, 16, and 32 μ L EO-JC. (hindawi.com)
  • In the test performed according to DIN 38412 part 27 (Bacteria Respiration test, preliminary draft) no inhibition of oxygen consumption of Pseudomonas putida was observed, therefore the EC 50 is higher than 10000 mg/L. (europa.eu)
  • Specific concentrations of each plant extract were then added and homogenized to the medium before solidification. (utep.edu)
  • Tsitsirika is an erect, smooth or slightly hairy, simple or slightly branched plant, 30 to 50 centimeters high. (stuartxchange.org)
  • FW remained in a uniform pattern of inhibitory effects in all three concentrations (10,100 and 1000 mu g/ml). (pkc-signal.com)
  • The results of this experiment are expressed as LD50. (utep.edu)
  • Sensitive species of aquatic plants experience temporary, but reversible, adverse effects at concentrations in the range of 1 to 5 ug atrazine/l. (unl.edu)
  • Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration. (pharmfair.com)
  • In the United States alone, more than 50 million kg (110 million pounds) are applied annually to more than 25 million ha (62 million acres), primarily to control weeds in corn and sorghum. (unl.edu)
  • The powder was extracted with water or ethanol-water (50-50: v/v). Dried powder was soaked in water and heated in bath water for 3 h (aqueous extract) or soaked in ethanol-water for 48 h (hydroalcoholic extract). (scialert.net)
  • Using the analysis tab in graphpad prism transform concentrations to log 10. (web.app)