• ligands
  • Indeed, the adhesion of some cancer cells to the extracellular matrix is mediated by interactions between LAMP1 and LAMP2 and E-selectin and galectins, with the LAMPs serving as ligands for the cell-adhesion molecules. (wikipedia.org)
  • cells
  • Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
  • They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
  • LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM. (wikipedia.org)
  • It has also been shown that the down-regulation of LAMP2 could both reduce the resistance of breast cancer cells to the paclitaxel and could inhibit cell proliferation in multiple myeloma cells. (wikipedia.org)
  • Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). (genecards.org)
  • F3 is a 135kDa glycoprotein expressed at the surface of cultured neuronal cells and released in soluble form in the culture medium. (go.jp)
  • Lysosomes of mammalian cells typically appear as small, spherical bodies with amorphous, electron-dense cores and a single limiting membrane. (beds.ac.uk)
  • This study showed that LAMP2 upregulation occurs in vitro and in vivo in neoplastic cells. (nih.gov)
  • mutation
  • In our study of the EOG in Danon disease, we show for the first time to our knowledge that a LAMP2 mutation may cause a primary retinal pigment epitheliopathy. (nih.gov)
  • Cardiomyopathy
  • Diseases associated with LAMP2 include Danon Disease and Cardiomyopathy . (genecards.org)
  • LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy. (sinobiological.com)
  • 2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. (sinobiological.com)
  • receptor
  • The data support a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits. (nih.gov)
  • molecular weight
  • Mature, functional LAMP2 is extensively glycosylated with a variety of different N linked and O linked oligosaccharides, with apparent molecular weight ranging from 45-130 kDa. (ptglab.com)
  • regulation
  • However, this makes the determining the precise function of LAMP1 difficult, because while the LAMP1 deficient phenotype is little different than the wild type due to LAMP2 up regulation, the LAMP1/LAMP2 double deficient phenotype leads to embryonic lethality. (wikipedia.org)
  • Up-regulation of LAMP2 is associated with carcinogenesis and progression of Salivary Adenoid Cystic Carcinoma. (nih.gov)
  • surface
  • however, due to the phenomenon of antigenic variation, intrinsic to the parasite's outer coat of variable surface glycoprotein, this has not yet been achieved. (oatd.org)