• receptor
  • Interestingly, the hydrazide method isolated a number of other N-linked glycoproteins also known to be involved in breast cancer including, epidermal growth factor receptor (EGFR), CD44, and the breast cancer 1, and early onset isoform 1 (BRCA1) biomarker. (pubmedcentralcanada.ca)
  • The data support a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits. (nih.gov)
  • polypeptide
  • 35. The method of claim 34 wherein an agent that reduces the amount of the UNC93B or TLR polypeptide in endosomes/lysosomes/phagosomes is identified as an agent that inhibits a physical interaction between UNC93B and the TLR. (patentsencyclopedia.com)
  • 37. The method of claim 34, wherein an agent that increases the amount of the UNC93B or TLR polypeptide in endosomes/lysosomes/phagosomes is identified as an agent that enhances a physical interaction between UNC93B and the TLR. (patentsencyclopedia.com)
  • degradative
  • The lysosome's degradative machinery is potentially harmful to its limiting membrane, since it is capable of degrading intact lipid membranes. (beds.ac.uk)
  • By entering host cells and subsequently avoiding destruction within degradative lysosomes, bacteria can gain better access to scarce resources as well as protection from host defenses and antibiotics. (asmscience.org)
  • degradation
  • Although indicating the potential importance of this part in amyloidogenic processing, these fragments also have been proposed to be intermediates of the final degradation of APP in lysosomes ( Haass and Selkoe, 1993 ). (jneurosci.org)
  • metastatic
  • LAMP1 expression on the surface of tumor cells has been observed for a number of different cancer types, particularly in highly metastatic cancers such as pancreatic cancer, colon cancer and melanoma. (wikipedia.org)
  • They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
  • spike
  • Such underprocessed glycans form spatially distinct clusters, which shield the proteinous surface of the Lassa virus glycoprotein spike from the humoral immune response. (pnas.org)
  • cells
  • Accordingly, cell surface expression of LAMP1 is seen in cells with migratory or invasive functions, such as cytotoxic T cells, platelets and macrophages. (wikipedia.org)
  • Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
  • F3 is a 135kDa glycoprotein expressed at the surface of cultured neuronal cells and released in soluble form in the culture medium. (go.jp)
  • Lysosomes of mammalian cells typically appear as small, spherical bodies with amorphous, electron-dense cores and a single limiting membrane. (beds.ac.uk)
  • cancer
  • Analyzing the N-glycoproteins from membranes of breast cancer cell lines highlights the usefulness of the procedure for generating a practical set of potential biomarkers. (pubmedcentralcanada.ca)
  • Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes. (nih.gov)