• degradation
  • Although indicating the potential importance of this part in amyloidogenic processing, these fragments also have been proposed to be intermediates of the final degradation of APP in lysosomes ( Haass and Selkoe, 1993 ). (jneurosci.org)
  • tumors
  • They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
  • Cells
  • Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). (genecards.org)
  • Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
  • It has also been shown that the down-regulation of LAMP2 could both reduce the resistance of breast cancer cells to the paclitaxel and could inhibit cell proliferation in multiple myeloma cells. (wikipedia.org)
  • It is likely to be mediated by activated T cells, which early within the course of disease are present within the lesional skin in increased numbers ( 1 )( 2 ). (rupress.org)
  • Dendritic cells (DCs), an APC population uniquely capable of efficiently stimulating resting T cells ( 3 ), are also increased in psoriatic lesions ( 4 ) and possess an activated phenotype ( 2 )( 5 ). (rupress.org)
  • Caco-2 cells were fed or not fed for 3 days, with Neu5Gc, ManNGc or Neu5Ac, each at 3 mM final concentration. (patentsencyclopedia.com)
  • molecular
  • Mature, functional LAMP2 is extensively glycosylated with a variety of different N linked and O linked oligosaccharides, with apparent molecular weight ranging from 45-130 kDa. (ptglab.com)
  • In accordance with the invention, binding compounds derivatized with releasable molecular tags specifically bind to selected membrane-associated. (google.com)
  • In accordance with the invention, binding compounds derivatized with releasable molecular tags specifically bind to selected membrane-associated analytes, after which the molecular tags are released upon activation of cleavage moieties, or sensitizers, anchored in the same membrane as the membrane-associated analytes. (google.com)
  • separating and identifying the released molecular tags by the one or more physical characteristics to determine the one or more membrane-associated analytes in the sample. (google.com)
  • 2. The method of claim 1 wherein said step of separating includes electrophoretically separating said released molecular tags, and wherein each of said molecular tags has a molecular weight in the range of from 50 to 1500 daltons. (google.com)
  • absence
  • The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. (google.com)
  • highly
  • LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy. (sinobiological.com)
  • disease
  • Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis. (wikipedia.org)
  • cancer
  • Bladder Cancer 2:449-463 (2016). (abcam.com)
  • A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma Phillip Huyett 1 , Mark Gilbert 1 , Lijun Liu 2 , Robert L. Ferris 2 , Seungwon Kim 1 1 Department of Otolaryngology, University of Pittsburgh Medical Center, 2 University of Pittsburgh Cancer Institute, Hillman Cancer Center Perineural invasion (PNI) is a common feature of head and neck squamous cell carcinoma (HNSCC), conferring lower survival rates. (jove.com)