TRPML1-mediated lysosomal calcium release can also dephosphorylate TFEB and promote its nuclear translocation and regulate lysosome biogenesis, autophagy, and lipid metabolism. (biomedcentral.com)
Lysosomal11
Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. (wikipedia.org)
It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. (wikipedia.org)
Residing primarily across lysosomal membranes, these glycoproteins consist of a large, highly glycosylated end with N-linked carbon chains on the luminal side of the membrane, and a short C-terminal tail exposed to the cytoplasm. (wikipedia.org)
poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. (wikipedia.org)
Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. (wikipedia.org)
Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. (wikipedia.org)
Structure of human lysosomal membrane glycoprotein 1. (wikipedia.org)
In the trans-Golgi network (TGN), phosphorylated lysosomal enzymes bind to M-6-P receptors, which direct the enzymes into clathrin-coated vesicles. (biomedcentral.com)
During this process, Rab7 promotes the assembly of HOPS, which mediates lysosomal tethering with endosomes by pairing an R-SNARE on a lysosome (VAMP7 or VAMP8) with three Q-SNAREs on an endosome (syntaxin-7, VTI1b, syntaxin-8). (biomedcentral.com)
Plasma membrane4
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)
2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
Intracellular5
Lysosomes were previously believed to be the sites of the degradation of intracellular and extracellular substances. (biomedcentral.com)
Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
Lysosomes play a crucial role in intracellular transport. (biomedcentral.com)
Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
Viability1
Moreover, EVs from VP patients reduced cell viability and mitochondrial membrane potential in HUVECs and increased oxidants and nitric oxide (NO) release. (bvsalud.org)
Cell3
The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. (wikipedia.org)
Indeed, the adhesion of some cancer cells to the extracellular matrix is mediated by interactions between LAMP1 and LAMP2 and E-selectin and galectins, with the LAMPs serving as ligands for the cell-adhesion molecules. (wikipedia.org)
Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
Potential1
This study briefly reviews the above information and explores the potential value of lysosomes in cancer therapy. (biomedcentral.com)
Selectins with carbohydrate ligands2
It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. (wikipedia.org)
This glycoprotein provides selectins with carbohydrate ligands. (antibodies-online.com)
Lysosomal membrane proteins1
poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. (wikipedia.org)
Proteins9
Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). (nih.gov)
It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN. (nih.gov)
HN - 2017 MH - ADAM12 Protein UI - D000072199 MN - D8.811.277.656.675.374.102.125 MN - D9.400.430.500.125 MN - D12.776.395.33.125 MS - A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS. (nih.gov)
HN - 2017 (1996) MH - ADAMTS Proteins UI - D000071096 MN - D8.811.277.656.675.374.102.500 MN - D9.400.430.500.500 MN - D12.776.395.33.500 MN - D12.776.860.300.85 MS - A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). (nih.gov)
In contrast to ADAM proteins, which reside on CELL MEMBRANES, ADAMTS proteases are secreted and function in the EXTRACELLULAR MATRIX. (nih.gov)
Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES . (lookformedical.com)
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS . (lookformedical.com)
The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (lookformedical.com)
Co-localization of conidia expressing green fluorescent protein with proteins present in the early endosomal (CD71) and lysosomal (CD63, LAMP-1) membrane was assessed using confocal microscopy. (silverchair.com)
Autophagy1
Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). (nih.gov)
LAMP23
The expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. (wikipedia.org)
Indeed, the adhesion of some cancer cells to the extracellular matrix is mediated by interactions between LAMP1 and LAMP2 and E-selectin and galectins, with the LAMPs serving as ligands for the cell-adhesion molecules. (wikipedia.org)
Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). (nih.gov)
Serum2
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES . (lookformedical.com)
The present findings suggest that the detection of immune complexes in unfractionated samples of late tumour-bearer serum using a C1q-binding assay is masked by the increasing production of tumour-specific antibodies and by a shift from complement fixing to non-complement-fixing tumour-specific antibodies. (nih.gov)
Gene2
Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. (wikipedia.org)
PMID- 214407 TI - Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. (nih.gov)
Cells5
Isolated fractions were examined for their capacity to bind [125I]C1q as a measure of immune complex levels, and for their ability to bind soluble tumour-specific antigen as well as to react with antigens expressed at the surface of viable hepatoma cells. (nih.gov)
In contrast, seropositive donor cultures seeded at the higher cell concentrations developed foci of proliferating EBNA-positive cells within the first 1--2 weeks but thereafter regressed completely and subcultures made after 4 weeks never gave rise to cell lines. (nih.gov)
In J774 cells, 75% of internalized conidia were found in phagosomes containing LAMP-1 120 minutes post-infection. (silverchair.com)
In A549 cells, 55% and 58% of internalized conidia were found to co-localize with LAMP-1 and CD63 by 24 hours. (silverchair.com)
Less than 1%of the initial inoculum survived in J774 cells by 12 hours post-infection. (silverchair.com)
The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. (wikipedia.org)
Human3
Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
Structure of human lysosomal membrane glycoprotein 1. (wikipedia.org)
Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. (wikipedia.org)
Specific1
It binds to a specific high affinity receptor ( RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR ). (lookformedical.com)
Normal1
AB - Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. (nih.gov)