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To report the clinical, histopathological and immunohistochemical findings of two novel mutations within the TGFBI gene. (bmj.com)
The two novel mutations within the TGFBI gene add another two phenotypes with atypical immunohistochemical and histopathological features to those so far reported. (bmj.com)
Shull's studies suggested that harmful, vigor-killing gene mutations that accumulate naturally in every generation are exposed by inbreeding, but hidden by crossbreeding. (eurekalert.org)
Identification and comparison of MDR TB using rapid molecular techniques (for rpob, gyrA, rrs and embB gene mutations) with reference to drug susceptibility test (DST) were the main objectives of this study. (nepjol.info)
Only two mutations were found in isoniazid resistance (INH R ) strain for Rv3919c (T to G in codon 341) and Rv1392 (G to A in codon 97) genes. (ac.ir)
Mutations in the BRAF gene are the most common cause of cardiofaciocutaneous syndrome. (medlineplus.gov)
Additional gene mutations in cells within the nevus after birth can lead to melanoma in people with giant congenital melanocytic nevus. (medlineplus.gov)
At least two mutations in the BRAF gene have been found to cause Noonan syndrome with multiple lentigines (formerly called LEOPARD syndrome). (medlineplus.gov)
The BRAF gene mutations change single amino acids in the BRAF protein: One mutation replaces the amino acid threonine with the amino acid proline at position 241 (written as Thr241Pro or T241P) and the other mutation replaces the amino acid leucine with the amino acid phenylalanine at position 245 (written as Leu245Phe or L245F). (medlineplus.gov)
Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

4 samples each) were identified using the R language, and were pooled using the Excel software program to select the common differentially expressed genes in the two datasets. (minervamedica.it)
RESULTS: Of the 255 concomitantly and differentially expressed genes identified after respective treatment with TNF-α and IL-1β, 141 were up-regulated and 114 were down-regulated. (minervamedica.it)
The gene ontology annotation analysis showed that these differentially expressed genes were primarily associated with cytokine activity, growth factor activity, the inflammatory reaction and the response to injury. (minervamedica.it)
The signaling pathway analysis showed that these differentially expressed genes were mainly related to the interactions of cytokines, apoptosis and NOD-like receptor signaling pathways. (minervamedica.it)
However, between malaria infected and coinfected children there were 240 differentially expressed genes with 180 genes upregulated and 60 downregulated in the coinfected group. (biomedcentral.com)

SLD-DST on 29 MDRTB strains by LPA showed 100%, 58.6%, 44.8% wild type for rrs , gyrA and emb B genes respectively. (nepjol.info)

Therefore, simultaneous targeting of multiple genes may be necessary. (ejbiotechnology.info)
These overlapping splicing events impacted multiple genes involved in phototransduction and neuronal function. (nsf.gov)

Gene M. Todd Jr. of Gloucester, born on July 13, 1955, went to be with the Lord on Monday, October 30, 2023. (gazettejournal.net)
The first gene therapy, delandistrogene moxeparvovec (Elevidys), gained accelerated FDA approval in June 2023 for the treatment of Duchenne MD in ambulant pediatric patients aged 4-5 years with a confirmed mutation in the DMD gene. (medscape.com)
This is a summary of the article "Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci" in the Journal Cell Geonomics on April 14, 2023. (medscape.com)
Cite this: Your Eventual Height May Be Determined by 145 Genes - Medscape - Jul 24, 2023. (medscape.com)

GSK3 inhibition in liver reduces expression of the gluconeogenic genes PEPCK (phosphoenolpyruvate carboxykinase), G6Pase (glucose-6-phosphatase), as well as IGFBP1 (insulin-like growth factor binding protein-1). (portlandpress.com)
The pckA gene, encoding the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK), was cloned by PCR amplification from the purple nonsulfur bacterium Rhodopseudomonas palustris No. 7. (asm.org)

Using CRISPR genome-editing technology to look at 600 million mouse cartilage cells , researchers began eliminating genes that influence how the cells proliferate and mature to determine which would influence skeletal changes . (medscape.com)
Although CRISPR uses some of the same viral vectors as "gene therapy," which was pioneered in the 1990s , the cargo is more targeted. (medscape.com)
This precision is why CRISPR is called " gene editing " rather than "gene therapy. (medscape.com)

these effects are thought to involve alterations in gene expression. (jneurosci.org)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
these gene expression changes may be responsible for the alterations in striatal physiology. (jneurosci.org)
One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. (bmj.com)
Therefore inactivation of GSK3 is not a prerequisite for insulin repression of these genes, despite the previous finding that GSK3 activity is absolutely required for maintaining their expression. (portlandpress.com)
Key areas of interest are the design and production of vectors, delivery and targeting, gene expression and regulation, preclinical studies including animal models, developmental aspects and clinical trials. (genetherapynet.com)
It is an MGGP-based framework coupled with the gene expression programming acting as a pre-processing technique for input determination and the Pareto front serving as a post-processing measure for solution optimization. (iwaponline.com)
The ability to inhibit two or more genes simultaneously from one single expression vector further widens the application spectrum of RNAi, both in functional studies and therapeutic strategies. (ejbiotechnology.info)
BACKGROUND: To investigate the microarray data on the gene expression profiles of intervertebral disc degeneration related to cytokine exposure. (minervamedica.it)
CONCLUSIONS: We found that ICAM1 and other genes may play a role in the development of disc degeneration induced by inflammatory reactions using a bioinformatics analysis of the gene expression profiles of degenerative intervertebral disc cells stimulated with inflammatory factors, suggesting that bioinformatics methods can be used to identify potential target for intervertebral disc degeneration. (minervamedica.it)
Spatio-temporal expression dynamics differ between homologues of flowering time genes in the allopolyploid Brassica napus. (jic.ac.uk)
Here we investigate the retention and spatio-temporal expression dynamics of duplicated genes predicted to regulate the floral transition in Brassica napus (oilseed rape, OSR). (jic.ac.uk)
Furthermore, between 64% (leaf) and 74% (shoot apex) of the retained gene homologues show diverged expression patterns relative to each other across development, suggesting neo- or subfunctionalization. (jic.ac.uk)
Such differences in the expression dynamics of duplicated genes highlight the challenges involved in translating gene regulatory networks from diploid model systems to more complex polyploid crop species. (jic.ac.uk)
The 2 -ΔΔCt method was employed to calculate the relative expression levels of these genes. (ac.ir)
MicroRNAs (miRNAs) are small, single stranded RNAs that regulate gene expression by partial, complementary base pairing to specific messenger RNAs (mRNAs). (arvojournals.org)
Expression of miRNAs and mRNAs was investigated using Affymetrix GeneChip miRNA Array (6703 probe sets, Affymetrix, Santa Clara, CA) and Affymetrix GeneChip Human Gene 1.0 ST Array offering whole-transcript coverage (28869 genes), respectively. (arvojournals.org)
This study is the first to identify a combined miRNA and mRNA gene expression profile of human primary pterygium, which may contribute to the understanding of pterygium pathogenesis. (arvojournals.org)
Conclusions There sults suggest that aging is associated with more stringent retention of expression profiles for some genes and more abrupt changes in others, while more subtle but widespread changes in gene expression appear protective. (nsf.gov)
Our findings shed light in the mode of the transcriptional changes occurring in the brain during aging and suggest that strategies aiming to broader but more modest changes in gene expression may be preferrable to correct aging-associated deregulation in gene expression. (nsf.gov)
In flies, as in mammals, the aging eye undergoes changes in gene expression that correlate with declining visual function and increased risk of retinal degeneration. (nsf.gov)
However, we found no correlation with changes in differential gene expression. (nsf.gov)
There was also no difference in gene expression profile between healthy controls and coinfected children. (biomedcentral.com)
Pathway analysis revealed substantial modulation of gene expression in defence and immune responses and in particular modulation of genes in the Fcγ-receptor-mediated phagocytosis pathway. (biomedcentral.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. (lu.se)
To investigate the phenotype associated with estrogen receptor alpha (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast carcinomas discordant for ER status were determined using DNA microarray technology. (lu.se)
By reference to the serial analysis of gene expression database, we found that only a small proportion of the 100 most important ER discriminator genes were also regulated by estradiol in MCF-7 cells. (lu.se)
The results provide evidence that ER+ and ER- tumors display remarkably different gene-expression phenotypes not solely explained by differences in estrogen responsiveness. (lu.se)

To explore work on gene-environment interaction (GxE) at the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR), we examined the CDC-Authored Genomics and Precision Health Publications Database (CDC-Authored GPHPD) , which includes articles published by CDC/ATSDR authors since 2011. (cdc.gov)

Gene mapping and medical genetics. (bmj.com)
This discovery has potential to have a significant impact on both the billion-dollar tomato industry, as well as agricultural practices designed to get the most yield from other flowering crops," says CSHL's Zach Lippman, Ph.D., one of the three authors on the study, which appears in the journal Nature Genetics online on March 28th. (eurekalert.org)

We show that flowering time genes are preferentially retained relative to other genes in the OSR genome. (jic.ac.uk)
In contrast to the apparently random dispersal of total undefined hnRNA synthesis through interdomain space, transcription and splicing for some genes occurs preferentially at specific sites, and a high degree of individual pre-mRNA metabolism is compartmentalized with discrete SC-35 domains. (rupress.org)

Sequencing of a 2.5-kb chromosomal Sma I- Pst I fragment containing the structural gene revealed an open reading frame encoding 537 amino acids, homologous to known pckA genes. (asm.org)
Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains. (rupress.org)

44 (3.7%) were found to be carriers of -thalassaemia, 14 (1.2%) of the sickle-cell gene and 1 (0.1%) of -thalassaemia. (who.int)

Six virulent and three avirulent isolates were characterized in terms of pathogenicity and molecular level using PCR technique with specific primers targeting three-virulence related genes located on the megaplasmid which was involved directly or indirectly in the disease process. (academicjournals.org)
The purpose of the study was to identify the key genes that were differentially expressed in these disc cells compared to cells without inflammatory cytokine treatment, using bioinformatics analyses, and to explore the related signaling pathways and interaction networks, providing clues to the molecular mechanisms of disc degeneration for future experimental studies. (minervamedica.it)
Recent advances in molecular biology have resulted in the identification of specific genes associated with lipid disorders. (nursingcenter.com)
Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N". The Journal of Biological Chemistry. (wikipedia.org)
American Journal of Respiratory Cell and Molecular Biology. (wikipedia.org)
Future ED therapies might consider the application of molecular technologies such as gene therapy . (bvsalud.org)
The goal of our search was to identify publications describing the role of specific genes, gene signatures, or molecular pathways and their effects in response to environmental exposures. (cdc.gov)

Abstract Background Genes that belong to the same network are frequently co-expressed, but collectively, how the coordination of the whole transcriptome is perturbed during aging remains unclear. (nsf.gov)

Journal Article Ozseyhan, Mehmet E. (osti.gov)
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. (aspetjournals.org)
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We suggest for the first time that although pharmacological inhibition of GSK3 reduces hepatic glucose production even in insulin-resistant states, feeding can repress the gluconeogenic genes without inhibiting GSK3. (portlandpress.com)

Gene Therapy covers both the research and clinical applications of novel therapeutic techniques based on a genetic component. (nature.com)
The journal is an Open Access online journal which publishes original research articles in all areas on experimental and clinical gene therapy research. (genetherapynet.com)
Clinical, histological and immunohistochemical characteristics of corneal opacification were reported and compared with the coding region changes in the TGFBI gene. (bmj.com)
While results from mouse cells may not mirror cellular processes in humans , it is believed that the 145 height genes could be used in clinical settings to help find treatments for patients with skeletal dysplasia and other skeletal disorders. (medscape.com)

They can also transduce resistance genes from Salmonella enterica serovar Typhimurium DT104 ( 1 ). (cdc.gov)
We evaluated genes that encode resistance to β-lactam agents within phage particles present in sewage samples. (cdc.gov)
The mutation in leptin receptor (LEPR) gene causes splicing abnormality that resulted in truncated receptor, aberrant signal transduction, leptin resistance, and obesity. (ajol.info)
16 smear+ve and 1 smear-ve), Gene Xpert MTB/RIF assay detected 100% M. tuberculosis and rifampicin resistance ( rpoB gene resistant) of which, 100% were culture positive by conventional Lowenstein-Jensen (LJ) method. (nepjol.info)
Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge. (janusinfo.se)

Gene Therapy covers a range of subject areas, to read content across the scope of the journal view the journal's subjects page here . (nature.com)
Gene Therapy now provides its latest table of contents as an RSS web feed. (nature.com)
The Journal of Gene Medicine publishes high quality original articles and reviews on the science of gene transfer and its applications in gene and cell therapy. (genetherapynet.com)
Publication of The Open Gene Therapy Journal has been stopped as of September 2012. (genetherapynet.com)
The Open Gene Therapy Journal, a peer reviewed journal, aims to provide the most complete and reliable source of information on current developments in all areas of the field. (genetherapynet.com)
As a potential therapeutic tool, gene therapy might provide an effective and specific means for altering intracavernous pressure 'on demand' without affecting resting penile function. (bvsalud.org)
However, the safety of gene therapy remains a major hurdle to overcome before being accepted as a mainstream treatment for ED. Gene therapy aims to cure the underlying conditions in ED, including fibrosis . (bvsalud.org)
Furthermore, gene therapy might help prolong the efficacy of the PDE5 inhibitors by improving penile nitric oxide bioactivity. (bvsalud.org)
It is feasible to apply gene therapy to the penis because of its location and accessibility, low penile circulatory flow in the flaccid state and the presence of endothelial lined (lacunar) spaces. (bvsalud.org)
This review provides a brief insight of the current role of gene therapy in the management of ED. (bvsalud.org)

Gene Ontology analysis in both species, for the genes that exhibited inverse transcriptomic coordination during aging pointed to alterations in the perception of smell, a known impairment occurring during aging. (nsf.gov)

Gene Xpert, proportion method and Line Probe Assay (LPA) were used for first and second line drugs susceptibility testing (FLD-DST and SLD-DST). (nepjol.info)

Overexpression of GSK3 in cells antagonizes insulin regulation of these genes. (portlandpress.com)
In the present study we demonstrate that regulation of these three genes by feeding is normal in mice that express insulin-insensitive GSK3. (portlandpress.com)
This expands our understanding of how tumor cells may hijack androgen-regulated genes with neighboring genes and effectively alter its regulation. (eurekalert.org)

Targeting one single gene can lead to the development of escape mutants or may be insufficient to silence redundant pathways. (ejbiotechnology.info)

Entrez Gene: CPM carboxypeptidase M". Human CPM genome location and CPM gene details page in the UCSC Genome Browser. (wikipedia.org)
More than half (23 of 39) of the articles represent epidemiologic studies including candidate gene and genome-wide association studies (GWAS) examining genetic effect modification on disease risk. (cdc.gov)
The genes have now been precisely located in the human genome and could influence height more than other genetic factors do. (medscape.com)

ZNF558 evolved as a suppressor of LINE-1 transposons but has been co-opted to regulate a single target, the mitophagy gene SPATA18. (lu.se)

The editors particularly welcome articles dealing with the methodological aspects of gene transfer in vivo, notably in the context of human studies. (genetherapynet.com)

Results support a model reconciling light and electron microscopic observations which proposes that transcription of some specific genes occurs at the border of domains, which may also function in the assembly or distribution of RNA metabolic components. (rupress.org)
Geographic representativeness and or failed S -gene target amplification in certain multitarget median interval from specimen collection to result were cal- reverse transcription-polymerase chain reaction (RT-PCR) culated for both data sources. (cdc.gov)
Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)

The complex gene-environment interplay that contributes to interindividual variation in components of the lipid profile is also partially clarified. (nursingcenter.com)

Nepal Journals Online (NepJOL) is a service to provide online publication of Nepalese journals. (nepjol.info)

Unlike the gene fusions previously found in cancers, which arise when two chromosomes join together in an abnormal way, the new fusion occurs when the genes are being copied into RNA. (eurekalert.org)
The BRAF gene mutation that causes this condition is somatic, meaning that it occurs during a person's lifetime and is present only in certain cells. (medlineplus.gov)

This study aims to determine the association of LEPR gene polymorphisms, rs1137100 and rs1137101, on phenotype and leptin level between obese and control groups in Yogyakarta population. (ajol.info)

The genotype of 41 affected members of 16 families and nine sporadic cases was investigated by direct sequencing of the TGFBI gene. (bmj.com)

Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. (nature.com)
The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)

This study evaluated association between common and rare sequence variants in 10 nicotinic acetylcholine receptor subunit genes and the severity of nausea 21 days after initiating the standard, Food and Drug Administration-approved varenicline regimen for smoking cessation. (nature.com)
Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence. (nature.com)
Three alternatively spliced transcript variants encoding the same protein have been described for this gene. (wikipedia.org)
Do all gene variants affect health and development? (medlineplus.gov)
For example, some variants alter a gene's DNA sequence but do not change the function of the protein made from the gene. (medlineplus.gov)
Often, gene variants that could cause a genetic disorder are repaired by certain enzymes before the gene is expressed and an altered protein is produced. (medlineplus.gov)
Just because a gene is associated with a disease, does not mean that all variants in that gene are pathogenic. (medlineplus.gov)

RNA interference (RNAi), mediated by short double-stranded RNAs, is a powerful mechanism for posttranscriptional gene silencing. (ejbiotechnology.info)

image: Hybrid offspring that have one functional and one defective copy of the SFT gene showed up to 60 percent increases in fruit yield as compared to their parents. (eurekalert.org)

To examine the morphological effects of catalase gene transfer in modulation of H 2 O 2 induced injury, transduced corneas were maintained in ex vivo culture and challenged with H 2 O 2 . (bmj.com)

Journal of Hydroinformatics (2021) 23 (5): 1000-1013. (iwaponline.com)

Detection anddigestion of the amplification PCR of the three genes by two restriction endonuclease enzymes EcoRI and DraI showed differences between the two forms of R. solanacearum , whereas digested egI gene by the DraI enzyme gave two bands with all virulent isolates, while it gave only one band with the avirulent isolates. (academicjournals.org)

Abnormal Blood Lipids: Is It Environment or Is It Genes? (nursingcenter.com)
SCD is the most prevalent genetic disease in the African Region.1 There are different subtypes of SCD in which the abnormal S gene (S) coexists with other abnormal haemoglobin genes. (who.int)

To examine the effect of catalase gene transfer on survival of corneal endothelial cells (EC) following challenge with hydrogen peroxide (H 2 O 2 ) in an ex vivo model of oxidative stress. (bmj.com)
Ex vivo catalase gene transfer can protect EC from death mediated by H 2 O 2 . (bmj.com)
This gene based approach to the protection of corneal endothelium from oxidative stress may have application in prevention of EC loss in pathological conditions in which H 2 O 2 is involved and in ex vivo donor corneal storage before transplantation. (bmj.com)

Specific genes of relevance to malaria infection, including CD8a, were significantly downregulated in malaria-infected compared to coinfected children. (biomedcentral.com)

The gene fusion biomarker is also a different type of fusion than researchers have found in cancer previously and may represent an entirely new mechanism that cancer cells use to outgrow their healthy neighbors. (eurekalert.org)
The SLC45A3-ELK4 gene fusion is detectable at high levels in the urine of some men at risk for prostate cancer. (eurekalert.org)
Dr. Rubin's team is already working with a company to develop a urine test for prostate cancer using a chromosome-based gene fusion called TMPRSS2-ERG that the team discovered previously while working with members of Dr. Arul Chinnaiyan's research group at the University of Michigan. (eurekalert.org)
The two genes, SLC45A3 and ELK4, reside next to one another on the chromosome in normal and prostate cancer cells. (eurekalert.org)
However, when the genes are copied into RNA in the prostate cancer cells, they frequently generate a single RNA message that fuses information from both genes. (eurekalert.org)
We think this type of gene fusion might be a common mechanism in cancer," Dr. Rubin says. (eurekalert.org)

Using a transcriptome time series in two tissues (leaf and shoot apex) across development we show that 67% of these retained flowering time genes are expressed. (jic.ac.uk)
To explore this, we calculated the correlation of each gene in the transcriptome with every other, in the brain of young and older outbred deer mice (P. leucopus and P. maniculatus). (nsf.gov)

An artificial microRNA (amiFATB) was created by replacing a microRNA sequence in the camelina Csa-miR159a gene with a FATB gene specific sequence. (osti.gov)
This work demonstrates a highly nonrandom distribution of specific genes relative to nuclear domains enriched in splicing factors and poly(A)+ RNA, and provides evidence for the direct involvement of these in pre-mRNA metabolism. (rupress.org)

We show that knock-down of each single gene from multiple target vectors is achieved at an efficiency comparable to that obtained after transduction using single target viral vectors. (ejbiotechnology.info)

In P. leucopus, alterations in genes related to cholesterol metabolism were also identified. (nsf.gov)

NEW YORK (April 9, 2009) -- A newly discovered gene fusion is highly expressed in a subset of prostate cancers, according to a study by researchers at Weill Cornell Medical College. (eurekalert.org)
The researchers are already planning to explore if genes related to florigen in other crops can cause heterosis and improve yield. (eurekalert.org)
Researchers identified 145 genes in mouse cartilage cells that were similar to those seen in certain skeletal disorders that affect the growth development of bones, joints, and cartilage in human babies . (medscape.com)

Interestingly, insulin injection of wild-type mice, which activates PKB (protein kinase B) and inhibits GSK3 to a greater degree than feeding (50% versus 25%), does not repress these genes. (portlandpress.com)
This hybrid, the team found, produced greater yields because there was one normal copy and one mutated copy of a single gene that produces a protein called florigen. (eurekalert.org)
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. (wikipedia.org)
When determining if a gene variant is associated with a genetic disorder, the variant is evaluated using scientific research to date, such as information on how the variant affects the function or production of the protein that is made from the gene and previous variant classification data. (medlineplus.gov)
Among the genes that exhibited the most pronounced inversion in their coordination profiles during aging was THBS4, that encodes for thrombospondin-4, a protein that was recently identified as rejuvenation factor in mice. (nsf.gov)
The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)

In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)

Since genes use RNA molecules to make proteins, these snippets effectively "silence" genes that carry the same sequence. (newscientist.com)

The two forms of the pathogen were containing the megaplasmid which carry three genes hrpB , egl and fliC . (academicjournals.org)

Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)

DMY is the second vertebrate sex-determining gene identified from the fish, Oryzias latipes. (amrita.edu)

Another theory for heterosis, supported by our discovery, postulates that improved vigor stems from only a single gene - an effect called "superdominance" or "overdominance. (eurekalert.org)
To find overdominant genes, the team developed a novel approach by turning to a vast tomato "mutant library" - a collection of 5,000 plants, each of which has a single mutation in a single gene that causes defects in various aspects of tomato growth, such as fruit size, leaf shape, etc. (eurekalert.org)
The concept that a mutation in only one copy of a single gene can improve yield has broad implications for plant breeding. (eurekalert.org)

Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. (nature.com)

Studies of a pckA-lacZ gene fusion indicated that when cells were grown in minimal media with various carbon sources, such as succinate, malate, pyruvate, lactate, or ethanol, under both anaerobic light and aerobic dark conditions, the pckA gene was induced in log phase, irrespective of the carbon source. (asm.org)
Using lentiviral constructs, stable gene silencing is established both in dividing and non-dividing cells. (ejbiotechnology.info)

Thus further study on another Indonesian ethnic population is required to investigate the variation in LEPR gene. (ajol.info)

Results showed the occurrence of phage particles carrying sequences of bla OXA-2 , bla PSE-1 or bla PSE-4 and bla PSE -type genes. (cdc.gov)
A mutation in one copy of the gene results in the exact dose of florigen required to cause heterosis. (eurekalert.org)
Chi square (χ2) for trend was used to analyze Gene Xpert, smear, FLD-DST and LPA results. (nepjol.info)
Results In about 25 % of the genes, coordination was inversed during aging. (nsf.gov)
Real-time RT-PCR cycle threshold (Ct) results average number of SGTF/SGTP and sequencing results were for three gene targets ( S , N , and ORF1ab ) were reported to U.S. (cdc.gov)

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology15

Phenomena and Processes1

Disciplines and Occupations61

Anthropology, Education, Sociology and Social Phenomena28

Technology, Industry, Agriculture4

Humanities22

Information Science85

Named Groups7

Health Care66

Publication Characteristics2

Geographicals12

Mutations11

Differentially expressed genes5

Strains1

Multiple genes2

20234

Phosphoenolpyruvate carboxykinase2

CRISPR3

Expression31

Centers for Diseas1

Genetics2

Preferentially2

Structural2

Sickle-cell gene1

Molecular7

Abstract1

Article3

Gluconeogenic1

Clinical4

Resistance5

Therapy10

Ontology1

Susceptibility1

Regulation3

Pathways1

Genome3

Regulate1

Aspects of gene1

Transcription3

Lipid1

Publication1

Occurs2

Aims1

TGFBI1

Neuronal2

Variants7

RNAi1

Functional1

Modulation1

20211

Amplification1

Abnormal2

Vivo3

Significantly1

Cancer6

Transcriptome2

Specific2

Viral1

Alterations1

Researchers3

Protein6

Cortex1

Effectively1

Pathogen1

Deletion1

Vertebrate1

Single gene3

Candidate gene1

Cells2

Variation1

Results5