• Evaluation of musculoskeletal adverse effects in patients on systemic isotretinoin treatment: A cross-sectional study. (iasp-pain.org)
  • This study aims to investigate the frequency of musculoskeletal adverse effects in acne vulgaris patients receiving systemic isotretinoin treatment. (iasp-pain.org)
  • Skeletal side effects of systemic isotretinoin treatment: do they depend on age, gender, treatment duration, daily -dose and isotretinoin-naiveness? (kent.edu.tr)
  • Propionibacterium acnes (P.acnes) has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity on keratinocytes by acting on TLR-2, leads to the development of comedones. (cosmeticsbusiness.com)
  • Increased sebum production under the inducing factors such as diet, living habits and androgens, abnormal keratinisation of keratinocytes, colonization by Propionibacterium acnes (P.acnes) and inflammation are thought to be the major pathogenic factors. (cosmeticsbusiness.com)
  • Anti-inflammatory effects of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils. (jomos.org)
  • However, understand that isotretinoin side effects will be a lot, way more severe. (page.tl)
  • alternative to oratane could actually cause cracking of the skin of the lips, nose bleeds, dry eyes, severe sunburn, acne flare-ups and some research have linked it to melancholy and suicidal pondering. (page.tl)
  • A randomized, placebo-controlled, study was carried out on patients with moderate to severe acne. (ac.ir)
  • This image displays severe cystic acne. (skinsight.com)
  • As displayed in this image, moderate and severe inflammatory acne can leave depressed scars. (skinsight.com)
  • Treatment of severe acne with isotretinoin in patients with inflammatory bowel disease. (globale-dermatologie.com)
  • Finally, within the context of a sensitivity analysis 3 that was not published with our article, we determined the risk of depression associated with the use of minocycline, a systemic antibiotic used to treat moderate-to-severe acne, and whose use was never associated with depression. (psychiatrist.com)
  • Isotretinoin is primarily indicated for patients with severe, recalcitrant acne who have not responded to conventional therapy. (psychiatrist.com)
  • While this may be a legitimate concern, it seems that patients whose treatments have failed are more likely to be diagnosed with depression at that point (ie, after treatment failure), rather than after initiating an isotretinoin treatment, with the latter being the most effective drug against severe acne currently on the market. (psychiatrist.com)
  • The Food and Drug Administration (FDA) reported a number of cases of severe allergic reactions to acne medicines containing benzoyl peroxide or salicylic acid. (poison.org)
  • The Food and Drug Administration (FDA) issued a warning about the possibility of severe allergic reactions to skin medicines containing two common drugs used to treat acne: benzoyl peroxide and salicylic acid. (poison.org)
  • Isotretinoin, a vitamin A product in pill form, is used for severe, persistent acne. (poison.org)
  • Patients with more severe acne, such as nodulocystic acne, will probably need systemic treatment, such as isotretinoin,' Dr. Perez-Maldonado says. (dermatologytimes.com)
  • Isotretinion was approved by United States Food and Drug Administration (US FDA) in 1982 for the treatment of severe recalcitrant nodulocystic acne. (ijord.com)
  • Objective of the study was to assess the efficacy and tolerability of 24 week of once daily micronized isotretinoin therapy in the treatment of moderate to severe acne vulgaris was conducted. (ijord.com)
  • Hence the micronized isotretinoin therapy had overall satisfactory outcome in the treatment of patients with moderate to severe acne vulgaris (grade 2, 3 and 4). (ijord.com)
  • A randomized trial of the efficacy of a new micronized formulation versus a standard formulation of isotretinoin in patients with severe recalcitrant nodular acne. (ijord.com)
  • Safety and efficacy of low-dose isotretinoin in the treatment of moderate to severe acne vulgaris. (ijord.com)
  • Cunliffe W, Meynadier J, Alirezai M, George SA, Coutts I, Roseeuw D, Hachem JP, Briantais P, Sidou F, Soto P. Is combined oral and topical therapy better than oral therapy alone in patients with moderate to moderately severe acne vulgaris? (jomos.org)
  • Relapses severe acne scars or treatment options. (myjuicecup.com)
  • Dt, individuals are no idea is severe acne. (myjuicecup.com)
  • Efficacy of fixed low-dose isotretinoin (20 mg, alternate days) with topical clindamycin gel in moderately severe acne vulgaris. (dissectpodcast.com)
  • This study aimed to evaluate the efficacy of a combination of 5% dapsone gel plus oral isotretinoin in the treatment of acne vulgaris. (ac.ir)
  • Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris. (ac.ir)
  • Tanghetti E, Harper JC, Oefelein MG. The efficacy and tolerability of dapsone 5% gel in female vs male patients with facial acne vulgaris: Gender as a clinically relevant outcome variable. (ac.ir)
  • Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. (ac.ir)
  • A multicentre study was conducted to compare clinical safety and efficacy of adapalene 0.1% solution and tretinoin 0.025% gel, both topical treatments for acne, in a once-daily dosage regimen for 12 weeks. (researchgate.net)
  • Patients were assessed at baseline 6, 12 and 24 weeks and 12 weeks post treatment follow-up based on the assessment of severity of acne vulgaris using global acne grading system (GAGS), assessment of improvement in lesion counts, global assessment of overall efficacy by doctor (based on overall assessment) and by patients (based on overall relief in symptoms) and overall assessment of drug tolerability. (ijord.com)
  • Torok HM, Pillai R. Safety and Efficacy of Micronized Tretinoin Gel (0.05%) in Treating Adolescent Acne. (ijord.com)
  • This systematic review and meta-analysis aim to evaluate the clinical efficacy and safety of the antihistamines in the treatment of acne vulgaris. (ajosh.org)
  • Garner SE, Eady EA, Popescu C, Newton J, Li Wan Po A. Minocycline for acne vulgaris: efficacy and safety (Cochrane Review). (jomos.org)
  • July 8, 2009 - Accutane won't be sold any more, drug big Hoffmann-La Roche Inc. Isotretinoin, which is thirteen-cis-retinoic acid (Accutane), is most appropriately used for nodulocystic acne, acne conglobata, or scarring pimples that has been unresponsive to straightforward modes of remedy (e.g., oral and topical antibiotics, topical retinoids). (page.tl)
  • Many conventional acne (or acne vulgaris) treatments-antibiotics, oral steroids, hormonal birth control pills, and isotretinoin (sold with brand name Accutane)-have serious, sometimes downright scary, side effects. (marksdailyapple.com)
  • At our information on accutane isotretinoin roaccutane that. (myjuicecup.com)
  • After treatment of wind seems to help address the sun, including both courses of accutane, henry and isotretinoin. (myjuicecup.com)
  • This preceded the development of oral [[isotretinoin]] (sold as Accutane and Roaccutane) in 1980. (wikidoc.org)
  • He noted that while he is not privy to details of TMB-001's IPEG delivery system, "the way they have used polyethylene glycol to encapsulate the isotretinoin allows for greater barrier penetration and reduces a lot of the tolerability issues that are seen with other topical retinoids. (medscape.com)
  • Overview of the treatment of acne vulgaris with topical retinoids. (ac.ir)
  • The U.S. Food and Drug Administration (FDA) has received reports of premature epiphyseal closure in patients treated with isotretinoin retinoids, which are commonly prescribed by primary care providers as a treatment for acne. (degruyter.com)
  • Unfortunately, research into the skin microbiome, especially the white whale Acne vulgaris , has led to few actionable insights and innovations, with most standards of care being serendipitous discoveries, e.g., doxycycline and retinoids, or harsh broad-spectrum antimicrobials such as benzoyl peroxide, salicylic acid and antibiotics. (cosmeticsandtoiletries.com)
  • Topical antimicrobials, topical retinoids, oral antibiotics, and oral isotretinoin were used as a commonly therapy for acne, with a limited effect due to skin irradiation and antibiotic resistance [1-3]. (cosmeticsbusiness.com)
  • UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: implications for development of improved pharmaceutical formulations. (ijord.com)
  • Circulating plasma levels of both tretinoin and isotretinoin are only slightly elevated above those found in healthy normal controls. (nih.gov)
  • Our literature review was conducted between December 2020 and June 2021, utilizing PubMed with the following search terms: "isotretinoin" and "isotretinoin and premature epiphyseal closure. (degruyter.com)
  • Studies published in English between 1980 and 2020 were also included, as well as background sources relating to an isotretinoin profile with side effects and dosing. (degruyter.com)
  • Dall'Oglio F, Nasca MR, Fiorentini F, Micali G. Diet and acne: review of the evidence from 2009 to 2020. (legehandboka.no)
  • 12. My physician provided me information about the purpose and significance of offering information to the iPLEDGE Program should I change into pregnant whereas taking isotretinoin or within one month of the final dose. (page.tl)
  • It's essential to have a negative pregnancy check before you begin taking Claravis, earlier than each prescription is refilled, proper after you're taking your final dose of isotretinoin, and again 30 days later. (page.tl)
  • Additionally, premature epiphyseal closure and growth plate abnormalities occurred in nine patients with various durations and doses of isotretinoin ranging from the lowest dose of 0.5 mg/kg/day for a few months to 3.5 mg/kg/day for years. (degruyter.com)
  • Agarwal US, Besarwal RK, Bhola K. Oral isotretinoin in different dose regimens for acne vulgaris: A randomized comparative trial. (ijord.com)
  • A Delphi consensus study in which acne experts responded to a series of surveys found at least 70 percent consensus for checking alanine aminotransferase (ALT) and triglyceride levels within one month prior to isotretinoin therapy and after reaching the peak isotretinoin dose [ 1 ]. (uptodatefree.ir)
  • Early stages while taking isotretinoin dose course you know that can be dangerous for the scales, their liaison in april. (myjuicecup.com)
  • Genetic control of sebum excretion and acne - a twin study. (springer.com)
  • The prescription drug [[isotretinoin]] significantly reduces the amount of sebum produced by the sebaceous glands, and is used to treat acne. (wikidoc.org)
  • A recent study shows, for perhaps the first time, that the 1,450 nm diode laser's mechanism of action against acne vulgaris involves reducing sebum production, as clinicians have long suspected, the study's lead researcher says. (dermatologytimes.com)
  • Boston - A small study appears to confirm the 1,450 nm diode laser's suspected mechanism of action in treating acne: reducing sebum production. (dermatologytimes.com)
  • Papules and pustules occur when C. acnes colonizes the closed comedones, breaking down sebum into free fatty acids that irritate the follicular epithelium and eliciting an inflammatory response by neutrophils and then lymphocytes, which further disrupts the epithelium. (msdmanuals.com)
  • Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinisation, and the role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). (cosmeticsbusiness.com)
  • If acne in women is worsened by hormonal changes, hormone treatment may be used, too. (poison.org)
  • The search terms hormonal acne and sensitive skin have been trending upward on Google for at least the past five years (see Figure 1 ). (cosmeticsandtoiletries.com)
  • While systemic therapy includes oral antibiotics, hormonal therapy, and isotretinoin, depending upon the need of patients it has to be selected. (rjppd.org)
  • Thakrar and Robinson hypothesized that it is possible that patients who failed with conventional therapy initiated their isotretinoin treatment weeks or months later, making them less likely to be exposed in the control period. (psychiatrist.com)
  • Results from a long-term follow-up study indicate that although the response of hidradenitis suppurativa to isotretinoin is only moderate and is related to the severity of the disease, the promising effects of acitretin therapy described in this case series suggests the need for a randomized, controlled trial. (medscape.com)
  • We included the randomized controlled trials on acne vulgaris patients which compared any H1- antihistamine drug in combination with other medications to placebo, no treatment, or other medications, with acne lesion (non-inflammatory and inflammatory) counts, acne severity score, patient satisfaction, acne flare, or adverse events as an outcome of interest. (ajosh.org)
  • In one vehicle-controlled clinical trial, Tretinoin Cream 0.025%, applied once daily was more effective than vehicle in the treatment of facial acne vulgaris of mild to moderate severity. (nih.gov)
  • Scarring and hyperpigmenta- about the effect of diet and other factors tion are also found in addition to the typical on the severity of their acne and on their lesions of acne [ 3 ]. (who.int)
  • Ochsendorf F. Minocycline in acne vulgaris: benefits and risks. (jomos.org)
  • Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
  • Prevalence of facial acne in adults. (springer.com)
  • Psychiatric aspects of the treatment of mild to moderate facial acne. (globale-dermatologie.com)
  • Very recently, he had started taking isotretinoin for the treatment of facial acne. (medscape.com)
  • Kraft J, Freiman A. Management of acne. (ac.ir)
  • Harnessing the anti-inflammatory effects of topical dapsone for management of acne. (ac.ir)
  • Management of Acne Vulgaris: A Review. (legehandboka.no)
  • Management of acne: Canadian clinical practice guideline. (legehandboka.no)
  • Guidelines of care for the management of acne vulgaris. (legehandboka.no)
  • Successful management of acne needs careful selection of anti-acne agents according to clinical presentation and individual patient needs. (rjppd.org)
  • The most common locations for acne lesions include the face, neck, chest, and back, where the most sebaceous glands are located. (skinsight.com)
  • Most previous studies using the 1,450 nm diode laser (SmoothBeam, Candela) have focused on its effect on acne vulgaris and sebaceous glands,' says Adrian Perez-Maldonado, M.D., a Monterrey, Mexico, dermatologist in private practice who served as the study's lead author while at Boston University's dermatology department. (dermatologytimes.com)
  • Isotretinoin (Isobest) is a retinoid, prescribed for acne and other skin disorders. (medindia.net)
  • Oral isotretinoin, a systemic retinoid and a vitamin A derivative, has been widely utilized to treat acne in both adult and pediatric populations. (degruyter.com)
  • Growth plate abnormalities associated with retinoid derivatives other than isotretinoin were also excluded. (degruyter.com)
  • The Global Acne Assessment Score (GAAS), the number lesions and side-effects were documented at base line and weeks 4, 8 and 12. (ac.ir)
  • Dapsone gel was an effective medication for patients who received isotretinoin for acne vulgaris treatment resulting in a significant reduction of the number of lesions. (ac.ir)
  • A family history of acne is associated with earlier occurrence of the disease, increased number of retentional lesions, and therapeutic difficulties, especially a higher risk for a relapse after oral isotretinoin treatment [11]. (springer.com)
  • Whiteheads (closed comedones) are the earliest lesions of acne. (skinsight.com)
  • This image displays small, slightly elevated lesions and scars in an adult with chronic acne. (skinsight.com)
  • This image displays pus-filled lesions with whiteheads and blackheads (closed and open comedones) in an adult with moderate acne. (skinsight.com)
  • This image displays mild pus-filled lesions and bumps of acne on the chest. (skinsight.com)
  • This image displays pus-filled lesions and blackheads (open comedones), as well as darkened areas from previous acne lesions. (skinsight.com)
  • This image displays bumps, pus-filled lesions, and dark, flat pigmented marks from previous acne lesions. (skinsight.com)
  • This image displays small acne pus-filled lesions as well as darker marks from previous lesions on the forehead. (skinsight.com)
  • This image displays bumps, pus-filled lesions, whiteheads (closed comedones), and flat, brown marks from old lesions typical of acne. (skinsight.com)
  • Close-up of pustules and inflammatory skin lesions of acne. (skinsight.com)
  • This image displays small bumps, pus-filled lesions, and residual flat, red marks typical of acne. (skinsight.com)
  • This image displays numerous pink bumps and pus-filled lesions typical of acne. (skinsight.com)
  • This image displays moderate inflammatory acne lesions. (skinsight.com)
  • Acne results in a variety of skin lesions. (skinsight.com)
  • Closed comedones are the precursor lesions to inflammatory acne. (msdmanuals.com)
  • The gamma-linolenic acid in evening primrose oil may reduce non-inflammatory and inflammatory acne lesions ( 1 ). (stylecraze.com)
  • It is characterized by the formation of sex, age, age of acne onset, body weight comedones, non-inflammatory acne lesions and personal or family history of acne. (who.int)
  • Pediatric Acne: Clinical Patterns and Pearls. (legehandboka.no)
  • Thus, even under the situation where cases were 'diagnosed' with acne in the risk and not the control period, these cases most likely had acne prior to their clinical diagnosis. (psychiatrist.com)
  • These results demonstrate the clinical feasibility of applying GMP for the treatment of acne. (cosmeticsbusiness.com)
  • Tan J, Desai SBK, Knezevic S. Oral isotretinoin: New developments relevant to clinical practice. (ijord.com)
  • Acne vulgaris is a chronic disease, that is frequently seen in clinical practice. (hacettepe.edu.tr)
  • Each patient was examined and the se- remain a clinical problem up to the age of 40 verity of their acne was graded based on the years or even older ages [ 4,5 ]. (who.int)
  • Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne. (ac.ir)
  • Neonatal, nodulocystic, and conglobate acne have proven genetic influences [2]. (springer.com)
  • Six studies contributing to 388 patients were included, involving two H1 antihistamines (i.e., levocetrizine and desloratadine), isotretinoin, azithromycin, and topical azelaic acid cream. (ajosh.org)
  • The desloratadine+isotretinoin retained the best balance in terms of non-inflammatory lesion count, inflammatory lesion count, acne flare, and mucocutaneous adverse events. (ajosh.org)
  • The desloratadine+isotretinoin and levocetirizine+isotretinoin were considered safe. (ajosh.org)
  • The role of inflammation in the pathology of acne. (ac.ir)
  • This image displays one raised acne lesion and several flat, dark spots from prior inflammation, which may take months to resolve due to the patient's darker skin. (skinsight.com)
  • In people with darker skin, redness and inflammation of acne can be difficult to see. (skinsight.com)
  • Acne vulgaris is the formation of comedones, papules, pustules, nodules, and/or cysts as a result of obstruction and inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). (msdmanuals.com)
  • It strongly suppressed P.acnes growth, and reduced inflammation by suppressing the TLR-2/NF- kB pathway in SZ-95 sebocytes and HaCaT keratinocytes. (cosmeticsbusiness.com)
  • Epigallocatechin-3-gallate (EGCG) suppressed the lipogenesis, inhibited the P.acnes and inflammation to against acne. (cosmeticsbusiness.com)
  • In this research, we verified the effect of GMP on treatment for acne, including P.acnes suppression, anti-inflammation on human SZ-95 sebocytes and HaCaT keratinocytes, as well as beneficial effects on follicular hyperkeratosis. (cosmeticsbusiness.com)
  • For the experiments related with inflammation, P. acnes cultures were heat-killed by subjecting to temperatures of 85℃ for 30 mins [5, 6]. (cosmeticsbusiness.com)
  • Skin inflammation medicines are likewise of the significant relic: : * Ancient Rome: Taking a hot bath, and frequently sulfurous, mineral water was one of only a handful few accessible skin acne medicines. (wikidoc.org)
  • Acne vulgaris, a common human skin condition, is an inflammatory disease characterized by comedones, papules, nodules and possibly scarring. (ac.ir)
  • Nodules and cysts are other manifestations of inflammatory acne. (msdmanuals.com)
  • 13-42 years attending dermatology clinics and assessed patients' perceptions of factors that have an effectontheiracnecondition.Familyhistoryofacnewaspositivein69.3%ofacnepatients.Emotional stress,hotweatherandsweatingwerebelievedtobeaggravatingfactorsbyacnepatientsofbothsexes, andpremenstrualfactorsandcosmeticswerefactorsamongwomen.Manyacnepatientsbelievedthat their acne was exacerbated by certain aspects of diet including nuts, chocolate, fatty food, fried food, eggs,cakesandbiscuits,spicesandcoffeeandtea. (who.int)
  • Steroid sulfatase activity in epidermis of acne-prone and non-acne-prone skin of patients with acne vulgaris. (globale-dermatologie.com)
  • Anxiety and Depression According to the Hospital Aanxiety Depression Scale in Patients with Acne Vulgaris at the Ho Chi Minh City Hospital of Dermato-Venerelogy, Vietnam. (google.com.ru)
  • There have been reported cases of premature epiphyseal closure in individuals receiving therapeutic doses of isotretinoin for acne treatment, which are much lower compared to the high doses utilized for neuroblastoma. (degruyter.com)
  • Acne: therapeutic perspectives with an emphasis on the role of isotretinoin. (globale-dermatologie.com)
  • Lupeol, a pentacyclic triterpene, identified as a therapeutic agent targeting multiple pathogenic factors of acne. (cosmeticsbusiness.com)
  • In recent years, due to better understanding of the pathogenesis of acne, new therapeutic modalities and various permutation and combinations have been designed. (rjppd.org)
  • To fill this information gap, Dr. Perez-Maldonado and his colleagues recruited four male and four female subjects, ages 25 to 42, with Fitzpatrick skin types II through IV and a history of mild-to-moderate acne vulgaris. (dermatologytimes.com)
  • As such, he says the laser provides a satisfactory alternative for patients with mild-to-moderate acne and those with adult-onset acne who can't take or haven't responded to systemic treatment. (dermatologytimes.com)
  • 1-6 The pathophysiology of inflammatory skin conditions from acne to rosacea to seborrheic dermatitis is commonly accepted as microbially mediated, while in autoimmune disorders, microbes may be more of a trigger than causative agent (e.g., chronic eczema). (cosmeticsandtoiletries.com)
  • First, acne is a slowly progressing, chronic condition. (psychiatrist.com)
  • Acne vulgaris is a chronic inflammatory skin disease which occurs in the follicle and the sebaceous gland unit. (cosmeticsbusiness.com)
  • This image displays darker color (pigment) in areas that had acne previously, which takes longer to heal in people with darker skin. (skinsight.com)
  • Acne, also known as acne vulgaris, is a common skin condition that affects people of all ages, but it is especially common in teens and young adults. (skinsight.com)
  • Acne can result in scarring, so minimizing breakouts and avoiding picking at the skin is important. (skinsight.com)
  • The good news is that as common as skin issues like acne are today, they are not an inevitable part of the human condition. (marksdailyapple.com)
  • Acne is the most common skin disease in the US and affects 80% of the population at some point in life. (msdmanuals.com)
  • Skin- effectiveness of isotretinion in acne-Cochrane data base. (ijord.com)
  • Approximately one-tenth of the global population suffer from acne vulgaris, which is a skin disease with considerable psychological impact. (ajosh.org)
  • AE}} {{HQ}} {{TAM}} ==Overview== ==Historical Perspective== The historical backdrop of skin acne compasses back to the beginning of written history. (wikidoc.org)
  • It is also used for acne, diabetes, cancer, osteoarthritis, aging skin, skin discoloration, and many other conditions, but there is no good scientific evidence to support most of these uses. (medlineplus.gov)
  • Applying a cream containing niacinamide seems to improve the appearance of skin in people with acne. (medlineplus.gov)
  • Acne Vulgaris is one of the most common skin disorders which dermatologists have to treat. (rjppd.org)
  • In this article, we discuss the benefits of evening primrose oil for skin, its effectiveness in managing acne, how to use it, and its potential side-effects. (stylecraze.com)
  • Isotretinoin does not affect the size of the apocrine gland, and etretinate or acitretin (25 mg bid) may be more useful, at least in some cases. (medscape.com)
  • The fact that some conditions do not respond to isotretinoin, yet do respond to etretinate and acitretin, suggests that the suppression of hyperkeratinization is more important than glandular shrinkage. (medscape.com)
  • TMB-001 is a proprietary, novel, topical isotretinoin formulation to treat CI that is being developed by Timber Pharmaceuticals. (medscape.com)
  • Scheinfeld N. Aczone, a topical gel formulation of the antibacterial, anti-inflammatory dapsone for the treatment of acne. (ac.ir)
  • From the network meta-analysis, levocetirizine+isotretinoin was better than the isotretinoin alone in the inflammatory lesion count, but not in the non-inflammatory lesion count. (ajosh.org)
  • Experience in the therapy of acne with topical administration of spironolactone as an antiandrogen]. (globale-dermatologie.com)
  • Hecht H. Heredity trends in acne vulgaris. (springer.com)
  • In addition, given the time span of our study (1983-2002), the case-crossover design was best suited to inherently adjust for trends in acne management over the years and guideline changes, as is discussed in length in our article. (psychiatrist.com)
  • Since various old and new topical and systemic agents are available to treat acne, it sometime confuse treating dermatologist. (rjppd.org)