Isoforms human protein serine threonine kinases. Medical search. Frequent questions

The different isoforms differ mostly in the length and structure of their C-terminal non-catalytic region. (wikipedia.org)
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (antibodies-online.com)
Multiple transcript variants encoding different isoforms have been found for this gene. (abeomics.com)
Alternative splicing results in multiple transcripts encoding different isoforms. (utsouthwestern.edu)
It has 4 different isoforms with distinct expression patterns, indicating that isoform-specific interventions might be relatively tissue selective in mammalian cells [ 7 ]. (aging-us.com)
JNK is expressed as ten different isoforms due to differential mRNA splicing. (thermofisher.com)
Human tau exists as six different isoforms that result from alternative splicing of the single transcript derived from a gene located on chromosome 17. (biovendor.com)

It is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. (wikipedia.org)
In response to numerous tension stimuli, JNK turns into turned on via bis-phosphorylation by MAP kinase Hexanoyl Glycine supplier kinases (MKK4 and MKK7), and can subsequently phosphorylate many substrates(1, 3). (cgp60474.com)
In addition we aim to explore the ability of these isoforms to phosphorylate known mTOR targets such as 4E-BP1. (ucl.ac.uk)
The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets. (inamericawithgrace.com)
Ca2+ /CaM-dependent protein kinase kinases 1 and 2 (CaMKK1 and CaMKK2) phosphorylate and enhance the catalytic activity of downstream kinases CaMKI, CaMKIV, and protein kinase B. Accordingly, CaMKK1 and CaMKK2 regulate key physiological and pathological processes, such as tumorigenesis, neuronal morphogenesis, synaptic plasticity, transcription factor activation, and cellular energy homeostasis, and promote cell survival. (bvsalud.org)
GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. (umbc.edu)
PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. (utsouthwestern.edu)

JNK continues to be demonstrated to particularly phosphorylated Bcl-2 on serine and threonine residues including serine 70, which includes been shown to be always a required changes in apoptosis (4, 6, 17). (cgp60474.com)
The specificity of serine/threonine kinases is partly determined by interactions with a few residues near the phospho-acceptor residue, forming the so-called kinase-substrate motif. (inamericawithgrace.com)
In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. (utsouthwestern.edu)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)

Like other casein kinase 1 protein family members, casein kinase 1 epsilon recognizes the Ser(p)XXSer/Thr motif for phosphorylation. (wikipedia.org)
We also identify rabbit monoclonal antibodies displaying broad specificity (MJFF-pRAB8) that can be utilised to assess LRRK2-con-trolled phosphorylation of a range of endogenous Rab proteins, including Rab8A, Rab10 and Rab35. (dundee.ac.uk)
Activation of JNK via phosphorylation by upstream MAPK kinases (MAPKKs) (1) causes a little people of JNK to migrate to mitochondria. (cgp60474.com)
nevertheless, an identical peptide (TI-JIP), in the JNK-interacting proteins-1 (JIP1) JNK-binding domains, could totally inhibit JNK-mediated c-jun phosphorylation (15). (cgp60474.com)
Both CaMKKs are partly inhibited by phosphorylation, which in turn triggers adaptor and scaffolding protein 14-3-3 binding. (bvsalud.org)
The homopentameric α7-nAChR, abundantly expressed in the brain, is involved in the regulation of the neuronal plasticity and memory and undergoes phosphorylation by protein kinase A (PKA). (bvsalud.org)
In vitro assays indicate the protein lacks phosphorylation activity. (utsouthwestern.edu)
Tau phosphorylation regulates both normal and pathological functions of this protein. (biovendor.com)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
Using gene knockout, transgenic and molecular approaches we are investigating the signal mechanisms underlying regulation of protein phosphorylation and sperm function. (kent.edu)
Snow AJ, Puri P, Acker-Palmer A, Bouwmeester T, Vijayaraghavan S, Kline D. Phosphorylation-dependent interaction of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (YWHA) with PADI6 following oocyte maturation in mice.Biol Reprod. (kent.edu)
Protein phosphorylation is crucial for signaling transduction of this pathway. (biomedcentral.com)
In vitro kinase assay is applied to identify the kinase of PIK3CA/p110α tyrosine phosphorylation. (biomedcentral.com)
Tyrosine phosphorylation of RTKs, or adaptor proteins such as IRS-1 facilitate their binding with p85 regulatory subunits of PI3K, and then bring PI3K complex on membrane [ 2 ]. (biomedcentral.com)
PIP3 phosphatase PTEN is inactivated upon phosphorylation in its C-terminal region by several serine/threonine kinases [ 12 ]. (biomedcentral.com)
cSH2 domain S690 phosphorylation decreases p85 binding affinity to tyrosine-phosphorylated proteins resulting in less PI3K membrane localization [ 15 ]. (biomedcentral.com)
AGC kinases, like the 3 Akt (proteins kinase B) isoforms, proteins kinase A (PKA) and everything proteins kinase C (PKC) isoforms, require activation loop phosphorylation (threonine 308 in Akt1) aswell as phosphorylation of the C-terminal residue (serine 473 in Akt1) for catalytic activity and phosphorylation of downstream focuses on. (pkc-inhibitor.com)
In factor of the need for AGC proteins kinases in regulating cell 163222-33-1 destiny, the molecular systems that control the phosphorylation of the kinases have already been examined thoroughly. (pkc-inhibitor.com)
Akt Kinase Allosteric Conformations Regulate Akt Activation Loop Phosphorylation The majority of this prior work centered on molecular systems managing kinase activation. (pkc-inhibitor.com)
In lots of kinases, gain access to of ATP and substrate towards the energetic site cleft is certainly controlled with the activation loop, which, by method of phosphorylation, goes through marked conformational adjustments.5 In the unphosphorylated condition, the activation loop is normally disordered and acts to sterically impede gain access to of both nucleotide and substrate towards the catalytic cleft. (pkc-inhibitor.com)
Phosphorylation from the Akt/PKB activation loop is certainly additional constrained by close apposition from the N-terminal pleckstrin homology (PH) area concealing threonine 308.8,9 This constraint is relieved by membrane translocation and binding to PtdIns(3,4,5)P3 lipids which unmask the unphosphorylated activation loop (threonine 308 in Akt1). (pkc-inhibitor.com)
The phosphoinositide 3-kinase (PI3K)/RAC seine/threonine-protein kinase (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is a promising therapeutic target owing to its frequent dysregulation in HCC and the critical functions it has in regulating cell survival, proliferation, apoptosis, migration and angiogenesis through phosphorylation of distinct protein substrates ( 6 , 7 ). (spandidos-publications.com)

The c-Jun N-terminal Kinases (JNKs) are serine/threonine proteins kinases and associates from the mitogen-activated proteins kinase (MAPK) superfamily (1). (cgp60474.com)
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. (inamericawithgrace.com)
The kinases of this family that have been suggested to play a role in apoptosis are the mitogen-activated protein kinase (MAPK) family, specifically p42/44 ERK, p38 MAPK and c-Jun N-terminal kinase (JNK), cyclic AMP-dependent protein kinase (PKA), protein kinase B (PKB), or Akt and protein kinase C (PKC). (inamericawithgrace.com)
Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region. (creativebiomart.net)
It belongs to the MAPK superfamily of stress-activated protein kinases. (thermofisher.com)
p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. (umbc.edu)
The secretion of inflammatory factors as well as the marker proteins in the mitogen-activated protein kinase (MAPK) pathway were detected by Western blot. (frontiersin.org)

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. (antibodies-online.com)
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. (genetex.com)
Introduction: CDKN1B gene, which encodes a cyclin-dependent kinase (Cdk) inhibitor, regulates the progression throughout G1 to S cell cycle progression. (endocrine-abstracts.org)
Background Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine proteins kinase, may play functions in lots of biological procedures. (techblessing.com)
Background Glycogen synthase kinase 3 (GSK3) encodes a multifunctional serine/threonine proteins kinase, which is usually ubiquitously indicated in organisms which range from yeasts to mammals [1-3]. (techblessing.com)
However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, poss Encodes a nuclear and cytoplasmically localized MAP kinase involved in mediating responses to pathogens. (creativebiomart.net)

Ca2+/calmodulin-dependent protein kinase II (CAMKII), multifunctional serine/threonine kinases, is a crucial mediator of translating intracellular Ca 2+ signals into cellular responses [ 6 ]. (aging-us.com)

The regulatory interactions of mTOR are mainly mediated by HEAT (Huntingtin, Elongation factor 3, protein phosphatase 2A, and TOR1) repeats and FAT (FRAP, ATM and TRRAP) domains. (ucl.ac.uk)
STP, serine/threonine protein phosphatase. (rupress.org)
PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. (signalchem.com)
We showed that a novel signal transduction system is centered around the sperm specific isoform, PP1g2, of the serine/threonine phosphatase. (kent.edu)
This protein phosphatase isoform, which is highly expressed in testis, is present only in mammalian spermatozoa. (kent.edu)
Dudiki T, Joudeh N, Sinha N, Goswami S, Eisa A, Kline D, Vijayaraghavan S. The protein phosphatase isoform PP1γ1 substitutes for PP1γ2 to support spermatogenesis but not normal sperm function and fertility. (kent.edu)
Chakrabarti R, Cheng L, Puri P, Soler D, Vijayaraghavan S. Protein phosphatase PP1 gamma 2 in sperm morphogenesis and epididymal initiation of sperm motility. (kent.edu)
Vijayaraghavan S, Chakrabarti R, Myers K. Regulation of sperm function by protein phosphatase PP1gamma2. (kent.edu)
Huang Z, Somanath PR, Chakrabarti R, Eddy EM, Vijayaraghavan S. Changes in intracellular distribution and activity of protein phosphatase PP1gamma2 and its regulating proteins in spermatozoa lacking AKAP4. (kent.edu)
Activation loop phosphorylations of Akt1, PKA and PKC take place at threonine 308, threonine 197 and threonine 403, respectively (Fig. 1B).6,7 Open up in another window Body 1 Evaluation of ATP-regulated phosphatase resistant set ups of AGC kinases. (pkc-inhibitor.com)

Protein kinase C (PKC) is a family of serine-threonine kinases that regulate many cellular processes including proliferation and survival. (endocrine-abstracts.org)
These findings suggest that identified novel isoforms have the potential to regulate the mTOR signalling pathway in a dominant-negative manner. (ucl.ac.uk)
p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. (umbc.edu)
Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. (utsouthwestern.edu)
p110s perform lipid kinase activity, and p85s stabilize and regulate p110s. (biomedcentral.com)

Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood. (inamericawithgrace.com)
Interferon-Î³ (IFN-Î³)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense by attacking intracellular pathogens and by inducing programmed cell death. (bvsalud.org)
Tau interacts with actin in the cytoskeleton and neuronal outgrowth, anchors enzymes such as protein kinases and phosphatases, and regulates intracellular vesicle transport. (biovendor.com)
intracellular degrees of cyclic AMP and cyclic GMP activate proteins kinase 163222-33-1 A (PKA) and proteins kinase G (PKG), respectively. (pkc-inhibitor.com)

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1. (umbc.edu)
Serine/Threonine Kinases (STKs), G protein-coupled Receptor Kinase (GRK) subfamily, GRK1 isoform, catalytic (c) domain. (umbc.edu)

Casein kinase I isoform epsilon or CK1ε, is an enzyme that is encoded by the CSNK1E gene in humans. (wikipedia.org)
therefore, this kinase is very similar to other members of the casein kinase 1 family, of which there are seven mammalian isoforms (α, β, γ1, γ2, γ3, δ and ε). (wikipedia.org)
It was officially identified as an isoform of the casein kinase 1 family. (wikipedia.org)
The protein encoded by the casein kinase 1 epsilon gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. (wikipedia.org)
The Casein kinase 1 epsilon protein is part of the mammalian oscillator, a group of proteins that keep cells on a roughly 24-hour schedule. (wikipedia.org)

MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. (thermofisher.com)
p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. (umbc.edu)
Mitogen-activated protein kinases (MAPKs) consist of a family of protein-serine/protein-threonine kinases followed by proline, prevalent in mammals (Pearson et al. (frontiersin.org)

2001 ), which can be activated by tyrosine kinase activity upstream through signal transduction (Oldenhof et al. (frontiersin.org)

p70 S6K (phospho Thr421/Ser424) antibody [HL5] detects p70 S6K (phospho Thr421/Ser424) protein at cytoplasm by immunohistochemical analysis in the presence of control peptide (left) or antigen-specific peptide (right). (genetex.com)
Immunohistochemical analysis of paraffin-embedded human oesophagus slide using 22988-1-AP (CDKAL1 Antibody) at dilution of 1:50. (ptglab.com)
Monoclonal antibody therapy has been developed over the past 30 years to target receptor tyrosine kinases (RTKs), which sit on the outer membrane of cancerous cells. (wisc.edu)

PIK3CA, encoding the catalytic subunit p110α of PI3K complex, is one of the most frequently mutated oncogenes in human cancers. (biomedcentral.com)

The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. (genetex.com)
mTOR (mammalian target of rapamycin) is a serine/threonine protein kinase which belongs to the family of phosphoinositide 3-kinase related kinases (PIKK), which also includes ATR, ATM, DNA-PK, SMG1 and TRRAP. (ucl.ac.uk)
mTOR contains several conserved protein-protein interaction modules at the N-terminus and a protein kinase domain at the C-terminus. (ucl.ac.uk)
mTOR is a key component of two distinct multi-protein complexes in mammalian cells, termed mTOR complex 1 (TORC1) and mTOR complex 2 (mTORC2). (ucl.ac.uk)
Dysregulation of mTOR signalling has been implicated in various human pathologies, including cancer, inflammation, neurodegenerative and metabolic disorders. (ucl.ac.uk)
There is only one mTOR gene in higher vertebrates, which is known to encode two splicing isoforms: mTORα and mTORβ. (ucl.ac.uk)
In contrast to the full length mTORα protein, mTORβ lacks most of its protein-protein interaction modules, HEAT and FAT, but retains domains responsible for FKBP12/rapamycin binding, protein kinase activity and regulation. (ucl.ac.uk)
Like other PIKK family members, there is increasing evidence of the presence of mTOR splicing isoforms. (ucl.ac.uk)
The main aim of this study was to identify new mTOR splicing isoforms and to determine their molecular characterization. (ucl.ac.uk)
Furthermore, we aim to study the role of the new isoforms in the mTOR-mediated cellular processes, such as cell proliferation, and the contribution of the identified isoforms in the oncogenic characteristics of cells. (ucl.ac.uk)
In this study, we have employed bioinformatics, biochemical, cell and molecular techniques to identify and characterize two novel mTOR splicing isoforms, denoted mTORδ and mTORγ. (ucl.ac.uk)
When compared to mTORα, the mTORδ splice variant contains only the N-terminal HEAT repeats and a unique C-terminal region, while the mTORγ isoform possesses a 12 amino acid deletion in the kinase domain. (ucl.ac.uk)
The existence of the mTORδ isoform was confirmed at mRNA and protein levels by identifying corresponding EST clones and detecting the splice variant with specific anti-mTORδ antibodies. (ucl.ac.uk)
In contrast to mTORα and the mTOR activated mutant S2215Y, the stably expressed mTORδ and mTORγ lack the kinase activity in vitro. (ucl.ac.uk)
The nutrient-sensing kinase mTOR (mammalian target of rapamycin) is a major determinant of ageing. (nih.gov)
mTOR promotes cell growth and controls central metabolic pathways including protein biosynthesis, autophagy and glucose and lipid homoeostasis. (nih.gov)
We specifically focus on distinct roles of isoforms and splice variants across the mTOR network. (nih.gov)

the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)
GSK3 and GSK3 are extremely homologous of their kinase domains [6]. (techblessing.com)
The Akt kinase family comprises three highly homologous isoforms: Akt1 (PKBα), Akt2 (PKBβ), and Akt3 (PKBγ) [4,14]. (inamericawithgrace.com)

Daily oscillations in protein and mRNA transcription have been observed in many cells, including the mammalian master clock known as the suprachiasmatic nucleus (SCN). (wikipedia.org)
Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types and, to date, the cloning of seven mammalian PKC genes encoding eight distinct isoforms has been reported. (bgu.ac.il)

You will find two carefully related GSK3 isoforms encoded by unique genes: GSK3 (51 kDa) and GSK3 (47 kDa) [5]. (techblessing.com)
In order to assess the importance of S/T kinases to Neurospora biology, we embarked on a global analysis of 86 S/T kinase genes in Neurospora. (inamericawithgrace.com)
We demonstrate our method in postmortem human brain using multiplex single-molecule fluorescent in situ hybridization and compare candidate TREGs against classic housekeeping genes. (biomedcentral.com)
This domain occurred 379 times on human genes ( 872 proteins). (umbc.edu)
Here we describe the molecular cloning and deduced primary structure of a cDNA encoding a novel PKC isoform, termed PKCθ, which was isolated in the course of attempts to identify PKC genes that are expressed selectively in hematopoietic cells. (bgu.ac.il)
Degenerate oligonucleotide primers corresponding to conserved sequence motifs, which distinguish the PKC family from other protein kinases, were employed in polymerase chain reactions (PCR) to amplify partial core sequences of putative PKC genes from a human peripheral blood lymphocyte-derived cDNA library. (bgu.ac.il)
Using bioinformatics analyses, we predicted HNK protein targets from several databases and retrieved the genes differentially expressed in mBCSCs from the GEO database. (hindawi.com)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
In contrast to the human genome that contains two genes, plant GSKs are encoded by a multigene family. (biomedcentral.com)

The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (nih.gov)

The role of PKC depends on the tissue and on the specific isoform, among the 11 identified so far. (endocrine-abstracts.org)

Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose to Parkinson's disease, suggesting that LRRK2 inhibitors might have therapeutic benefit. (dundee.ac.uk)
Nevertheless, these inhibitors aren't just inhibiting GSK3, but will also be influencing CDK kinase (2 and 5) and several other kinases. (techblessing.com)
Protein regulators of this enzyme include inhibitors I2 (PPP1R2) and I3 (PPP1R11), sds22 (PPP1R7), protein 14-3-3 and a protein kinase, glycogen synthase kinase 3 (GSK-3). (kent.edu)

The second messenger PIP3 recruits and activates 3-phosphoinositide dependent protein kinase-1 (PDK1) and AKT serine/threonine kinase on the membrane [ 2 ]. (biomedcentral.com)

Plant Glycogen Synthase Kinase 3/ SHAGGY-like kinases (GSKs) have been implicated in numerous biological processes ranging from embryonic, flower, stomata development to stress and wound responses. (biomedcentral.com)
Glycogen synthase kinase 3 (GSK-3) / SHAGGY kinase (SGG) are multifunctional non receptor serine/threonine kinases. (biomedcentral.com)

Alternatively spliced transcript variants encoding distinct isoforms have been reported. (utsouthwestern.edu)

The protein has a predicted molecular mass of 36.3 kDa after removal of the signal peptide.The apparent molecular mass of hFc-TGFBR1 is approximately 40-53 kDa due to glycosylation. (abeomics.com)
This updated gene model of Cdkl5 in rat provides a framework for studies into its protein products and provides a reference for the development of molecular therapies for testing in rat models of CDKL5 disorder. (nih.gov)
The molecular weight of the tau isoforms ranges from 48 kDa to 68 kDa. (biovendor.com)
The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 87-97 kDa. (kinexusproducts.ca)
My laboratory is focused on understanding mechanisms of resistance to molecular targeting agents directed against receptor tyrosine kinases. (wisc.edu)
We use molecular biology, proteomics, mouse modeling, including patient derived xenografts, and human tissues to understand how tumors that are initially responsive to therapy become resistant over time. (wisc.edu)
However, the action of individual AKT isoforms in different molecular subtypes of HCC has not been extensively evaluated. (spandidos-publications.com)

CDKL5 deficiency is a severe neurological disorder caused by mutations in the X-linked Cyclin-Dependent Kinase-Like 5 gene (CDKL5). (nih.gov)

The RAC serine/threonine-protein kinase (AKT) family of serine/threonine protein kinases, particularly the AKT1 isoform, has been identified abnormally expressed in hepatocellular carcinoma (HCC) cells, and is highly associated with cell behavior, including proliferation, survival, metabolism, and tumorigenesis. (spandidos-publications.com)

Human recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 produced in E.coli. (thermofisher.com)
The deduced primary structure contains consensus sequences characteristic of protein kinase catalytic domains and, based on its amino acid sequence and domain structure, is a member of the PKC family. (bgu.ac.il)
2011. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)

Serine/Threonine Kinases (STKs), p38 subfamily, catalytic (c) domain. (umbc.edu)

In vitro kinase assays showed that TaSK1 and TaSK2 possessed kinase activity. (biomedcentral.com)

These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. (antibodies-online.com)
p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. (umbc.edu)

Protein Kinase D (PKD) isoforms belong to the PKC/CAMK class of serine/threonine kinases and transmit diacylglycerol-regulated signals. (biomolecularsystems.com)

No immunoreactivity on protein dot blots with recombinant human Raf1. (kinexusproducts.ca)

Recent work has revealed that LRRK2 phosphorylates a subgroup of 14 Rab proteins, including Rab10, at a specific residue located at the centre of its effector-binding switch-II motif. (dundee.ac.uk)

Protein kinase C (PKC) is a key enzyme which regulates proliferation, apoptosis and differentiation, representing a pharmacological target for tumor therapy. (endocrine-abstracts.org)

Ser-9 in GSK3) catalyzed by either MAPKAP kinase-1/or p70S6K [11,12], whereas proteins kinase C phosphorylates and partly inhibits GSK3, however, not GSK3 [13]. (techblessing.com)

This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. (utsouthwestern.edu)

JNK may use Bcl-2 and various other BH3 family protein as substrates (4, 16, 17). (cgp60474.com)
B-Raf (RAFB1) is a protein-serine/threonine kinase of the TKL group and RAF family. (kinexusproducts.ca)
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. (utsouthwestern.edu)
The protein encoded by this gene is one of the PKC family members. (utsouthwestern.edu)
Some isoforms dominantly inhibit the activity of other estrogen receptor family members. (cancerindex.org)

Also, other proteins which involved in the same pathway with MAPK4 were listed below. (creativebiomart.net)
Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
PI3K/AKT signaling pathway plays important role in tumorigenesis of human cancer. (biomedcentral.com)

Certain kinase-related structural motifs were subsequently confirmed, such as a β-strand-turn-β-strand motif that anchors ATP, a DFG motif that orients ATP's phosphates, a catalytic loop that resembles that of PKA, and major substrate recognition sites in the C-terminal domain. (wikipedia.org)
The connections between JNK and Sab takes place through two kinase connections motifs (KIMs), dubbed KIM1 and KIM2. (cgp60474.com)

This oscillator, or "circadian clock," is made up of a transcription-translation feedback loop (TTFL) in which several proteins work in tandem, each regulating the others' expression to generate a roughly 24-hour cycle of both mRNA and protein levels. (wikipedia.org)

MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. (thermofisher.com)

Puri P, Myers K, Kline D, Vijayaraghavan S. Proteomic amalysis of bovine sperm YWHA binding partners identify proteins involved in signaling and metabolism. (kent.edu)
They have already been implicated in influencing many areas of rate of metabolism and cell destiny and play important functions in the pathogenesis of human being illnesses, including metabolic disorders, degenerative illnesses and cancers. (pkc-inhibitor.com)

Only the delta and epsilon isoforms have been shown to play an important role in circadian rhythm regulation. (wikipedia.org)

The predominant human CDKL5 brain isoform is a 9.7kb transcript comprised of 18 exons with a large 6.6kb 3'-untranslated region (UTR). (nih.gov)
The predominant isoform in the brain, which we name rCdkl5_1, is orthologous to the human hCDKL5_1 and mouse mCdkl5_1 isoforms and is the most highly expressed isoform across all brain regions tested. (nih.gov)
PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. (nih.gov)

Included within this ~2.7-kilobase pair cDNA is an open reading frame of 2,118 nucleotides encoding a putative 82-kDa protein. (bgu.ac.il)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)

B-RAF is a known oncoprotein (OP). Cancer-related mutations in human tumours point to a gain of function of the protein kinase. (kinexusproducts.ca)
Gain-of-function mutations in B-Raf are estimated to be present in ~15-19% of all human cancers, and 66% of malignant melanomas have been identified with a B-Raf somatic missense mutation. (kinexusproducts.ca)
It has been reported to account for ~80% of the B-Raf mutations in human cancers. (kinexusproducts.ca)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Homologues of GSK3 isoforms from varieties as faraway from one another as flies, zebrafishes and human beings screen over 90% series similarity inside the kinase domain name [7,8]. (techblessing.com)
In human beings, only GSK3 is usually deactivated by insulin during physiological circumstances [14,15], whereas supraphysiological insulin shot in the rat prospects to deactivation of both GSK3 and GSK3 [15,16]. (techblessing.com)
Although differential rules by both isoforms of GSK3 had been proposed, the precise functions of GSK3 and GSK3 and endogenous focuses on of such rules remain to become investigated. (techblessing.com)

2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)

PKCθ displays the highest homology to PKCδ, lacks the Ca 2+ -binding C2 domain and, thus, belongs to the subfamily of Ca 2+ - independent PKC enzymes which also includes the δ, ε, ζ, and η isoforms. (bgu.ac.il)

It is a cytoplasmic kinase that participates in the RAS>RAF>MEK>ERK pathways, which is involved in the transduction of mitogenic signals from the cell membrane to the nucleus and promotion of cell division, differentiation, and cytokine secretion. (kinexusproducts.ca)

Anatomy18

Organisms10

Diseases2

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes57

Disciplines and Occupations2

Information Science4

Different isoforms7

Phosphorylate7

Residues5

Phosphorylation24

MAPK7

Encodes6

Multifunctional serine1

Phosphatase10

Regulate5

Intracellular4

Receptor Kinase2

Casein5

MAPKs3

Signal Transduction1

Antibody3

Subunit1

MTOR17

Homologous3

Mammalian2

Genes9

Superfamily2

Specific isoform1

Inhibitors3

Phosphoinositide1

Glycogen2

Transcript variants1

Molecular7

Cyclin-depend1

Akt11

Amino3

STKs1

Vitro kinase1

Targets2

CAMK1

Recombinant1

Residue1

Enzyme1

Phosphorylates1

Cellular1

Family5

Pathway3

Motifs2

MRNA and protein levels1

JNK11

Metabolism2

Epsilon1

Predominant3

Putative2

Mutations4

GSK33

Cell viability1

Subfamily1

Differentiation1