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LeukemiaLeukemia, Myeloid, AcuteRadiation DosageRadiation, IonizingRadiation InjuriesLeukemia, Lymphocytic, Chronic, B-CellDose-Response Relationship, RadiationLeukemia, LymphoidLeukemia, ExperimentalRadiation ToleranceRadiationLeukemia, Myelogenous, Chronic, BCR-ABL PositiveRadiation ProtectionRadiation MonitoringLeukemia Virus, MurinePrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, T-CellLeukemia, Monocytic, AcuteLeukemia, Radiation-InducedRadiation OncologyMoloney murine leukemia virusLeukemia, Hairy CellLeukemia L1210Leukemia, B-CellLeukemia Virus, BovineCosmic RadiationLeukemia Virus, FelineRadiation Injuries, ExperimentalNeoplasms, Radiation-InducedRadiation PneumonitisGene Expression Regulation, LeukemicGamma RaysRadiotherapyBackground RadiationMyeloid-Lymphoid Leukemia ProteinCombined Modality TherapyLeukemia P388Leukemia, Biphenotypic, AcuteRadiotherapy DosageRadiometryAntineoplastic AgentsUltraviolet RaysFriend murine leukemia virusRadiation EffectsHL-60 CellsBone MarrowCytarabineLeukemia-Lymphoma, Adult T-CellRadiation-Sensitizing AgentsTumor Cells, CulturedRemission InductionLeukemia, Megakaryoblastic, AcuteAKR murine leukemia virusAcute DiseaseRadiation-Protective AgentsFusion Proteins, bcr-ablLeukemia, Myeloid, Chronic-PhaseTreatment OutcomeApoptosisPrecursor B-Cell Lymphoblastic Leukemia-LymphomaCell LineAcute Radiation SyndromeAntineoplastic Combined Chemotherapy ProtocolsCell Line, TumorTime FactorsKaryotypingRadioactive Hazard ReleaseDaunorubicinK562 CellsX-RaysMolecular Sequence DataPrognosisCell SurvivalLeukemia, Plasma CellLeukemia, Myeloid, Accelerated PhaseDNA DamageBase SequenceChromosome AberrationsLymphomaCobalt RadioisotopesNeoplasm ProteinsRadiobiologyRadiotherapy, ConformalRadiation Hybrid MappingWhole-Body IrradiationLeukemia, Prolymphocytic, T-CellDose FractionationHuman T-lymphotropic virus 1MutationLeukemia, ProlymphocyticNuclear WarfareSurvival AnalysisCore Binding Factor Alpha 2 SubunitRadiotherapy, Intensity-ModulatedBrachytherapyLeukemia, Myelomonocytic, JuvenileDisease-Free SurvivalFlow CytometryLeukemia, Basophilic, AcutePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma
AcuteCancersDosesDoseTumorsInstabilityApoptosisChromosomalNEOPLASMSProduced by exposureMalignantCancerSources of ionizingChemotherapyEpidemiologyCell cycle arrestForms of radiationMyelodysplasticDouble-strand breaksMyeloidGammaPhosphorylationChildhoodExposuresRisksOccupationsCells1999CellularCaused by exposure to radiation1986PathogenesisCause leukemiaLeukaemiaRadiotherapyHarmfulSurvivalDisruptWorkers Exposed to RadiationAssociation between radiationTreatmentKinaseDetectBystanderElectromagnetic radiationIncidenceEffectsDamageGeneticConsistentlyAssayStudyResearchersInjury
Acute18
  • In children, acute lymphoblastic leukemia and brain tumors are most common, except in Africa, where non-Hodgkin lymphoma occurs more often. (wikipedia.org)
  • The effect of potential risk factors for acute myeloid leukemia was evaluated in a case-referent study encompassing 59 cases and 354 referents, all of whom were alive. (nih.gov)
  • Therapy related leukemia is most commonly acute myeloid leukemia. (standardofcare.com)
  • Therapy related leukemia accounts for 10-20% of acute myelogenous leukemia cases. (standardofcare.com)
  • Several chemotherapy agents that include alkylating agents, topoisomerase inhibitors, and tax anew are associated with the development of acute myelogenous leukemia and myelodysplastic syndrome. (standardofcare.com)
  • Alkylating agents or radiation related and topoisomerase II inhibitor related acute myelogenous leukemia are often related to deletions of monosomies of chromosomes 5 and 7 amd a relatively long latency of 4-6 years. (standardofcare.com)
  • Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK[J]. Biomedical and Environmental Sciences, 2013, 26(11): 902-911. (besjournal.com)
  • Objective To explore the effects of resveratrol-induced apoptosis and autophagy in T-cell acute lymphoblastic leukemia (T-ALL) cells and potential molecular mechanisms. (besjournal.com)
  • The International Journal on Cancer, published in its January 2012 magazine a new study from France, establishing a very clear correlation between the frequency of acute childhood leukemia and proximity to nuclear power stations. (wiseinternational.org)
  • The most frequent rearrangement of the human MLL gene fuses MLL to AF4 resulting in high-risk infant B-cell acute lymphoblastic leukemia (B-ALL). (ibecbarcelona.eu)
  • MLL fusions are also hallmark oncogenic events in secondary acute myeloid leukemia. (ibecbarcelona.eu)
  • The Working Group was not aware of any good rodent models that simulate the occurrence of acute myeloid leukemia in humans. (who.int)
  • It's long been known that children with Down's syndrome have a much greater chance of developing acute leukemia -up to 20 times greater or even higher. (microwavenews.com)
  • Now, in the first study of its kind, a group of Mexican researchers have shown that Down's children exposed to magnetic fields of 6 mG (0.6 µT) or more had close to four times the risk of developing acute leukemia compared to other Down's children. (microwavenews.com)
  • Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
  • Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
  • However, recent studies clearly indicate that spontaneous translocations specific to acute lymphocytic leukemia (ALL) actually occur much more frequently than do leukemia cases with the same translocations. (bioone.org)
  • Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
Cancers14
  • Additionally, Part 2 addresses childhood cancers like leukemia and brain cancer and the fact that ultrasound can contribute to the development of cancer and other radiation-induced diseases. (birthofanewearthblog.com)
  • They are believed to repopulate cancers after chemotherapy and/or radiation treatment. (msdmanuals.com)
  • Because latency period for different nosological forms of radiation-induced malignant tumors varies widely, profound attention in further studies should be drawn not only to thyroid, breast cancers and leukemia, but also to malignancies with longer latent period: lung, stomach, colon, ovary, urinary bladder, kidney cancer and multiple myeloma. (org.ua)
  • Intensity-modulated radiation therapy, protons, and the risk of second cancers. (thejcdp.com)
  • Radiation-induced Cancers in DOE and Contractor Employees-Prospects for the Individual Ascertainment of Causation. (cdc.gov)
  • Response to Comments on "Assigned Shares in Compensation for Radiation-related Cancers. (cdc.gov)
  • Assigned Shares in Compensation for Radiation-related Cancers. (cdc.gov)
  • The lungs and heart are likely to receive a scattered amount of radiation during radiation therapy for breast cancers, since they are below the irradiated area. (pohjois-suomensyopayhdistys.org)
  • A study conducted in Australia on radiation exposure from CT scans in childhood and adolescence found that after an average of approximately 9 ½ years, people who underwent a CT scan had a 24% cancer risk because cancers caused by radiation take years to develop. (pohjois-suomensyopayhdistys.org)
  • Mutational signatures could be a diagnostic tool for both individual cases and groups of cancers, and could help us find out what types of cancer are caused by radiation. (pohjois-suomensyopayhdistys.org)
  • Numerous epidemiological and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung and skin cancers and leukemia ( 1 , 5 , 6 ). (jcancer.org)
  • BACKGROUND: The risk of solid cancers from low-level protracted ionizing radiation is not well characterized. (cdc.gov)
  • METHODS: We evaluated the association between penetrating ionizing radiation exposure and solid cancer mortality among a pooled cohort of nuclear workers in the USA, with extended follow-up to examine cancers with long latencies. (cdc.gov)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
Doses6
  • Induced leukemia-differences in the ages of patients and differences in the accumulative doses of alkylating agents explain the wide variations in risk from study to study. (standardofcare.com)
  • The risk of secondary leukemia is associated with the type of cytotoxic agents, cumulative dose, intensity of such agents and cumulative ionizing radiation doses. (standardofcare.com)
  • 1995). Effects of Low Doses and Low Dose Rates of External Ionizing Radiation: Cancer Mortality Among Nuclear Industry Workers in Three Countries. (cdc.gov)
  • We conclude that long-term exposure to low doses of [ionizing radiation] can induce formation of micronuclei in the PBL of interventional radiologists," the group wrote. (auntminnie.com)
  • We conclude that the other epidemiological data do not at present provide clear evidence of a risk of circulatory diseases at doses of ionizing radiation in the range 0-4 Sv, as suggested by the atomic bomb survivors. (bioone.org)
  • In conclusion, although radiation can cause cancer at high doses and high dose rates, public health data related to lower levels of exposure, below about 10 mSv (1000 mrem), are more difficult to interpret. (pohjois-suomensyopayhdistys.org)
Dose34
  • 1992. Radiation dose assessment from ingestion pathway in Saudi Arabia. (cdc.gov)
  • Induced leukemia-the risk is dose dependent and increases exponentially with age after the age of 40 years. (standardofcare.com)
  • Results Resveratrol inhibited the proliferation and induced apoptosis and autophagy in T-ALL cells in a dose and time-dependent manner. (besjournal.com)
  • The cytokinesis-block micronucleus (CBMN) assay in cytogenetic biodosimetry uses micronucleus (MN) frequency scored in binucleated cells (BNCs) to estimate ionizing radiation dose exposed. (bvsalud.org)
  • 72 h (44 h at Cyt-B)]. Three donors (26-year-old female, 25-year-old male, 29-year-old male) were used for dose-response curve construction with radiation-induced MN/BNC. (bvsalud.org)
  • This is in line with a USA study by the National Academy Press, U.S., which argues that women and children are at significantly greater risk of suffering and dying from radiation-induced cancer than a man exposed to the same dose of ionizing radiation. (wiseinternational.org)
  • Part 8 -- Doctors and Sick People Stay Together * Part 9 -- People Live Long Enough to Die of Cancer * Part 10 -- "Ecologic" Studies Are Inherently Weak * Part 11 -- Natural Radiation Exceeds X-Rays in Dose * Part 12 -- Conclusion: Biologically Consistent Picture * Note 1 and References ------------------------------------------------------------------ Part 1 * What Are the Conclusions Under Review? (ratical.org)
  • Radiation from Medical Procedures in the Pathogenesis of Cancer and Ischemic Heart Disease" (Gofman 1999) is a massive dose-response study which began extensive circulation for peer-review among scientists in epidemiology, cancer etiology, IHD etiology, and health physics, immediately after its publication in November 1999. (ratical.org)
  • As a result of doing our earlier study of radiation-induced breast cancer (Gofman 1996), we learned that there is no way for anyone to make a reliable estimate of what the average per capita accumulated dose in the USA was --- or is today --- from pre-cancer medical x-rays. (ratical.org)
  • TFP or TMX alone did not induce apoptosis of resistant PANC-1 cells, while they dose-dependently enhanced TRA-8-induced apoptosis. (oncotarget.com)
  • The correlation of open circuit voltage with magnetic fields in the model combined with the dose estimates leads the authors to identify open circuit voltage as a factor potentially responsible for the association between residential magnetic fields and childhood leukemia. (electrahealth.com)
  • The correlation of Voc with magnetic fields in the model, combined with the dose estimates, lead us to conclude that Voc is a potentially important exposure with respect to childhood leukemia risks associated with residential magnetic fields. (electrahealth.com)
  • 1994). Relationship of Leukemia Risk to Radiation Dose Following Cancer of the Uterine Corpus. (cdc.gov)
  • Long-term exposure to low-dose radiation can cause DNA damage to lymphocyte cells in interventional radiologists - yet importantly, the doctors are likely not vulnerable to an increased risk of leukemia, according to researchers in Slovakia. (auntminnie.com)
  • However, they noted that such damage from low-dose radiation in other radiology workers has been associated with malignancies in previous research. (auntminnie.com)
  • Vieworks introduced three new radiation dose and image processing software technologies at RSNA 2023. (auntminnie.com)
  • Recent analyses of mortality among atomic bomb survivors have suggested a linear dose-response relationship between ionizing radiation and diseases of the circulatory system for exposures in the range 0-4 Sv. (bioone.org)
  • Among the remainder, one study found appreciable evidence that exposure to low-dose radiation was associated with circulatory diseases, but five others, all with appreciable power, did not. (bioone.org)
  • This amount of radiation was selected as a starting point to illustrate that when 700 joules of radiation are administered to a single 70 kg male, a lethal dose of 10 Gy is obtained. (pohjois-suomensyopayhdistys.org)
  • Unlike high-dose ionizing radiation, the cancer risk assessment of more frequent or prolonged radiation exposure is still under debate and uncertainty. (pohjois-suomensyopayhdistys.org)
  • Much debate rages concerning chronic low-dose radiation exposure. (seintl.com)
  • Certainly, the advantages of continued vigilance on chronic low-dose radiation exposure cannot be denied. (seintl.com)
  • A possible answer should be provided for the ongoing question of what, if any, causality is associated with low-dose radiation exposure so that radiation workers can have "peace of mind", and to settle any liability issues associated with low-dose radiation exposure. (seintl.com)
  • Also, the question arises whether or not strict adherence to radiation safety is necessary if no clinically measurable effects arc occurring in chronic low-dose occupationally exposed individuals. (seintl.com)
  • This retrospective or prospective study would be one step in validating whether or not chronic low-dose radiation exposure is the etiological agent for an increase in morbidity and mortality at a younger age. (seintl.com)
  • and that is acknowledging radiation as a known carcinogen and killer at high dose levels. (seintl.com)
  • For the last one-hundred years many studies have reported the deleterious effects of high-dose radiation exposure. (seintl.com)
  • Radiation poisoning - Radiation poisoning, also called radiation sickness or a creeping dose , is a form of damage to organ tissue due to excessive exposure to ionizing radiation. (academic.ru)
  • OBJECTIVE: To evaluate the effect of protracted low dose, low dose rate exposure to ionising radiation on the risk of cancer. (cdc.gov)
  • MAIN OUTCOME MEASURES: Estimates of excess relative rate per gray (Gy) of radiation dose for mortality from cancer. (cdc.gov)
  • Restricting the analysis to the low cumulative dose range (0-100 mGy) approximately doubled the estimate of association (and increased the width of its confidence interval), as did restricting the analysis to workers hired in the more recent years of operations when estimates of occupational external penetrating radiation dose were recorded more accurately. (cdc.gov)
  • CONCLUSIONS: This major update to INWORKS provides a direct estimate of the association between protracted low dose exposure to ionising radiation and solid cancer mortality based on some of the world's most informative cohorts of radiation workers. (cdc.gov)
  • The summary estimate of excess relative rate solid cancer mortality per Gy is larger than estimates currently informing radiation protection, and some evidence suggests a steeper slope for the dose-response association in the low dose range than over the full dose range. (cdc.gov)
  • These results can help to strengthen radiation protection, especially for low dose exposures that are of primary interest in contemporary medical, occupational, and environmental settings. (cdc.gov)
Tumors4
Instability5
  • Furthermore, we analyzed the micronucleus (MN) frequency in survived cells after radiation exposure to investigate the effect of ELVs on radiation-induced genomic instability. (bvsalud.org)
  • In the last several years, heterozygosity leading to haploinsufficiency for proteins involved in DNA repair pathways was shown to play a role in genomic instability and carcinogenesis after DNA damage is induced. (aacrjournals.org)
  • Where genetic testing is unavailable, diagnosis can be supported by evidence of chromosomal instability (spontaneous and induced), increased cellular sensitivity to ionizing radiation in vitro , combined immunodeficiency, and complete absence of full-length nibrin. (orpha.net)
  • Fanconi Anemia is a recessive and rare genetic disorder, characterized by chromosomal instability that induces congenital alterations in individuals. (bvsalud.org)
  • This disease is characterized by the malfunctioning of the DNA repair mechanism, which present an increase in the rate of spontaneous damage, among these spontaneous chromosomal instability, and hypersensitivity of cells to the chromosomal breaking effect induced by clastogenic agents 2-3 . (bvsalud.org)
Apoptosis7
  • Methods The anti-proliferation effect of resveratrol-induced, apoptosis and autophagy on T-ALL cells were detected by using MTT test, immunofluorescence, electronic microscope, and flow cytometry, respectively. (besjournal.com)
  • When autophagy was suppressed by 3-MA, apoptosis in T-ALL cells induced by resveratrol was enhanced. (besjournal.com)
  • Conclusion Our findings have suggested that resveratrol induces cell cycle arrest, apoptosis, and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways. (besjournal.com)
  • Therefore, the reasonable inhibition of autophagy in T-ALL cells may serve as a promising strategy for resveratrol induced apoptosis and can be used as adjuvant chemotherapy for T-ALL. (besjournal.com)
  • We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic cancer cells, and underlying mechanisms. (oncotarget.com)
  • Consistently, caspase-8 inhibition blocked the effects of TFP/TMX on TRA-8-induced apoptosis. (oncotarget.com)
  • Altogether, we have demonstrated that CaM antagonists enhance TRA-8-induced apoptosis of TRA-8-resistant pancreatic cancer cells by increasing DR5 expression and enhancing recruitment of apoptotic signal while decreasing survival signals in DR5-associated DISC. (oncotarget.com)
Chromosomal1
NEOPLASMS1
  • Results of search for 'su:{Neoplasms, Radiation-induced. (who.int)
Produced by exposure1
Malignant1
  • The ionizing capability of X-rays can be utilized in cancer treatment to kill malignant cells using radiation therapy . (hpathy.com)
Cancer25
Sources of ionizing1
  • The health sector typically uses high-energy sources of ionizing radiation for medical treatments. (thincb2b.com)
Chemotherapy1
  • Chromosome changes of the same type in primary AML occur in most cases os of chemotherapy-induced myelodysplasia and AML. (standardofcare.com)
Epidemiology2
  • Only one new report from an original epidemiology study in relation to leukemia induction by formaldehyde has been published since the last review. (who.int)
  • Writing in the January 2007 issue of Epidemiology , Juan Mejia-Arangure and coworkers conclude that genetic susceptibility to leukemia may well modify the effects of EMFs. (microwavenews.com)
Cell cycle arrest2
  • It also induced cell cycle arrest at G0/G1 phase via up regulating cyclin-dependent kinase (CDK) inhibitors p21 and p27 and down regulating cyclin A and cyclin D1. (besjournal.com)
  • Treatment with etoposide consistently induced cell cycle arrest in S/G2/M independent of MA4/A4M expression, revealing a proper activation of the DNA damage checkpoints. (ibecbarcelona.eu)
Forms of radiation2
  • Gamma rays are often produced alongside other forms of radiation such as alpha or beta . (wikidoc.org)
  • But, to understand the risks, we first need to understand what forms of radiation are benign and which are potentially harmful. (thincb2b.com)
Myelodysplastic1
  • Examples of neoplastic disorders include myelodysplastic syndromes, leukemias, and sarcomas. (nih.gov)
Double-strand breaks1
Myeloid3
  • Therefore, on the basis of the data available at this time, it was not possible to identify a mechanism for the induction of myeloid leukemia in humans. (who.int)
  • The NCI group has published a recent update of one of their studies, with an additional 10 years of follow-up, and it continues to suggest a possible link between formaldehyde exposure and mortality due to lymphohematopoietic malignancies, particularly myeloid leukemia (Beane Freeman, Blair et al. (who.int)
  • Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
Gamma8
  • The possible effect of background radiation was evaluated by means of a gamma radiation index, which accounted for the differences between cases and referents in this respect, i.e., in time spent in concrete buildings both at home and at work places. (nih.gov)
  • Gamma rays (denoted as γ ) are a form of electromagnetic radiation or light emission of frequencies produced by sub-atomic particle interactions, such as electron-positron annihilation or radioactive decay . (wikidoc.org)
  • Gamma rays are generally characterized as electromagnetic radiation having the highest frequency and energy, and also the shortest wavelength (below about 10 picometer ), within the electromagnetic spectrum . (wikidoc.org)
  • In passing through matter, gamma radiation ionizes via three main processes: the photoelectric effect , Compton scattering , and pair production . (wikidoc.org)
  • For example, we are all exposed to low levels of gamma radiation from the sun, other stars, and the Earth's core over our lifetimes. (thincb2b.com)
  • One common practice is to distinguish between the two types of radiation based on their source: X-rays are emitted by electrons , while gamma rays are emitted by the atomic nucleus . (hpathy.com)
  • One common alternative is to distinguish X- and gamma radiation on the basis of wavelength (or, equivalently, frequency or photon energy), with radiation shorter than some arbitrary wavelength, such as 10 −11 m (0.1 Å ), defined as gamma radiation. (hpathy.com)
  • We evaluated different interventions with antioxidant or anti-inflammatory properties, including an antioxidant cocktail, dihydrolipoic acid, ibuprofen and dried plum, to determine their ability to prevent bone loss and to blunt the expression of genes in marrow cells that lead to the breakdown of bone after irradiation with either gamma rays or simulated space radiation. (sciencedaily.com)
Phosphorylation1
  • Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. (besjournal.com)
Childhood15
  • It could explain how power lines promote childhood leukemia. (microwavenews.com)
  • This paper presents data suggesting that contact current due to open circuit voltage is an exposure that may explain the reported associations of residential magnetic fields with childhood leukemia. (electrahealth.com)
  • The analysis was motivated by recent research suggesting that the physical location of power lines in the backyard, in contrast to the street, may be relevant to a relationship of power lines with childhood leukemia. (electrahealth.com)
  • There has long been widespread agreement that EMFs are linked to childhood leukemia. (microwavenews.com)
  • This is inexcusable given that the threshold for the childhood leukemia risk appears to be about 3-4 mG. (microwavenews.com)
  • Epidemiological studies linking childhood leukemia to EMFs are flawed and unreliable. (microwavenews.com)
  • Epidemiological studies carried out in the US and the UK don't show a link between EMF exposure and childhood leukemia. (microwavenews.com)
  • Despite a steady increase in electrification over the last century, there has been no parallel increase in the incidence of childhood leukemia. (microwavenews.com)
  • Air pollution from roadway traffic is a more important risk factor for childhood leukemia than EMFs. (microwavenews.com)
  • A virus is a more likely cause of childhood leukemia. (microwavenews.com)
  • And even if it were true that EMFs could lead to childhood leukemia, the risk is so small that it's not worth bothering about. (microwavenews.com)
  • This was brought home at the International Conference on Childhood Leukemia , held in London, September 6-10, sponsored by Children with Leukemia , a UK charity. (microwavenews.com)
  • The epidemiological evidence linking EMFs to childhood leukemia is "rather strong and consistent," said Anders Ahlbom in London. (microwavenews.com)
  • He has been studying EMFs and childhood leukemia for 20 years and is known to be cautious and not to overreach. (microwavenews.com)
  • In the early 1990s, Ahlbom and Maria Feychting put the skeptics on the run when they published their study of childhood leukemia and power lines in Sweden. (microwavenews.com)
Exposures3
  • Objective: Chronic lymphocytic leukemia (CLL) is generally considered to be non-radiogenic and is excluded from several programs that compensate workers for illnesses resulting from occupational exposures. (cdc.gov)
  • They don't even advocate some kind of ALARA policy (reducing exposures "as low as reasonably achievable"), an option which has been used to control ionizing radiation risks for generations. (microwavenews.com)
  • From this study, we can conclude that inclusion of dried plums in the diet may prevent the skeletal effects of radiation exposures either in space or here on Earth. (sciencedaily.com)
Risks2
  • Power analyses show that a pooled study might detect risk on the order of radiation induced non-CLL leukemia, but is unlikely to detect smaller risks. (cdc.gov)
  • Also there lire many more publications and journals that devote large sections to studies involving possible health risks associated with radiation. (seintl.com)
Occupations1
  • Bone loss caused by ionizing radiation is a potential health concern for those in occupations or in situations that expose them to radiation," she said. (sciencedaily.com)
Cells7
  • In this study, we collected ELVs from adipose tissue of an obese mouse (ob/ob) strain and control mouse (C57BL/6) strain, and checked whether adipose ELVs influence radiation-induced cell death on mouse fibroblast cells (m5S). (bvsalud.org)
  • Repair kinetics of etoposide- and ionizing radiation-induced DSBs was identical in WT, MA4- and A4M-expressing cells, as revealed by flow cytometry, by immunoblot for γH2AX and by comet assay. (ibecbarcelona.eu)
  • The results show that cells having low levels of both ATM and RAD9 proteins are more sensitive to transformation by radiation, have different DNA double-strand break repair dynamics and are less apoptotic when compared with wild-type controls or those cells haploinsufficient for only one of these proteins. (aacrjournals.org)
  • Another conclusion from most of the cases is that animals or cells haploinsufficient for the specified proteins have higher transformation rates after DNA damage is induced, but when their DNA is not significantly damaged by exogenous sources, tumor development rates are the same as for their wild-type counterparts. (aacrjournals.org)
  • Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
  • The origin of leukemia is often associated with the development of preleukemic fusion genes (PFGs), which trigger leukemogenesis , the process by which healthy white blood cells become cancerous, the researchers explained. (auntminnie.com)
  • Since radiation-induced DNA damage is generated essentially randomly in the genome, it does not seem likely that radiation could ever be responsible for the induction of identical translocations of relevance to ALL in multiple cells of an individual and hence be the primary cause of radiation-related leukemia. (bioone.org)
19991
Cellular3
  • http://www.buergerwelle.de /pdf/radiating_information .pdf RADIATING INFORMATION Radiation of cellular telephones is not danger free, as the cellular companies claim at present. (twoday.net)
  • Low-LET is characteristic of light charged particles such as electrons produced by x- and γ where the distance between ionizing events is large on the scale of a cellular nucleus. (seintl.com)
  • High-LET Is characteristic of heavy charged particles such as protons and α-particles where the distance between ionizing events is small on the scale side of a cellular nucleus. (seintl.com)
Caused by exposure to radiation1
  • The changes in remodeling activity caused by exposure to radiation can lead to impaired skeletal integrity and fragility both in animals and human radiotherapy patients," Turner said. (sciencedaily.com)
19861
  • International Conference on the Biological Effects of Ionizing Radiation (1986 : London, U.K. (who.int)
Pathogenesis1
  • Radiation-induced skin injury: pathogenesis, treatment, and management. (nih.gov)
Cause leukemia1
  • However, on p.276 of IARC Monograph 88 with regard to the ability of formaldehyde to cause leukemia it states: "In summary, there is strong but not sufficient evidence for a causal association between leukemia and occupational exposure to formaldehyde. (who.int)
Leukaemia1
  • Title : Risk of leukaemia mortality from exposure to ionising radiation in US nuclear workers: a pooled case-control study Personal Author(s) : Daniels, Robert D.;Bertke, Stephen;Waters, Kathleen M.;Schubauer-Berigan, Mary K. (cdc.gov)
Radiotherapy2
  • Therapy related leukemia this is complication of treatment that can develop months to years or even decades after exposure to cytotoxic agents or radiotherapy or both. (standardofcare.com)
  • Dried plums contain biologically active components that may provide effective interventions for loss of structural integrity caused by radiotherapy or unavoidable exposure to space radiation incurred over long-duration spaceflight," she said. (sciencedaily.com)
Harmful6
  • Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES. (bvsalud.org)
  • Ionizing radiation is the more complex and potentially more harmful form of radiation thanks to the potential to alter matter at the atomic level. (thincb2b.com)
  • We don't just find harmful levels of ionizing radiation in nuclear power stations. (thincb2b.com)
  • Hazards occur when personnel without appropriate protection enter an area with harmful levels of radiation or unsafe practices that produce dangerous levels outside of protected areas. (thincb2b.com)
  • Harmful levels of ionizing radiation can also naturally occur where a facility allows radioactive materials such as radon gas seeping from the ground to accumulate undetected in occupied spaces such as basements and other underground areas. (thincb2b.com)
  • This makes it a type of ionizing radiation , and therefore harmful to living tissue . (hpathy.com)
Survival2
  • LIF protects mice from Ionizing radiation: survival is measured in control group without treatment (WT) vs. those treated with LIF (WT + LIF). (testtechnologypublisher.com)
  • Analysis of TRA-8-induced death-inducing-signaling-complex (DISC) identified recruitment of survival signals, CaM/Src, into DR5-associated DISC, which was inhibited by TMX/TFP. (oncotarget.com)
Disrupt1
  • External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
Workers Exposed to Radiation2
  • Compensating Government Workers Exposed to Radiation. (cdc.gov)
  • In the future, the hospitals should continue to raise awareness of radiation protection principles, introduction of more frequent preventive examinations or stricter exposure limits among medicine workers exposed to radiation," the group concluded. (auntminnie.com)
Association between radiation1
  • Methods: A systematic review of radiation-exposed cohorts was conducted to investigate the association between radiation and CLL. (cdc.gov)
Treatment1
  • Invention Summary: Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury. (testtechnologypublisher.com)
Kinase1
  • Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C ( 4 ). (jcancer.org)
Detect1
  • In some, disease rates among those exposed at different levels may have differed for reasons unrelated to radiation exposure, while many had low power to detect effects of the relevant magnitude. (bioone.org)
Bystander1
  • Contribution of the immune system to bystander and non-targeted effects of ionizing radiation. (thejcdp.com)
Electromagnetic radiation3
Incidence2
  • This study again confirms an earlier German study (KiKK-Study Dec 2007) that the incidence of child leukemia more than doubles near nuclear power plants for children below the age 5 living within a 5 kilometer radius of nuclear power plants, compared to children living further then 20 kilometers from a nuclear power plant. (wiseinternational.org)
  • Statistically significant increase of leukemia incidence in CRW group was registered as well. (org.ua)
Effects6
  • I am just discovering the experience of the long term effects of the radiation, so please forgive me if my reply doesn't exactly fit your condition. (cancer.org)
  • Your condition is one of the long-term radiation effects. (cancer.org)
  • I have found that most doctors that I have dealt with thus far are unfamiliar with the long term effects of the radiation, and there is a serious lack of research on the topic. (cancer.org)
  • Abscopal effects of radiation therapy: a clinical review for the radiobiologist. (thejcdp.com)
  • Nuclear workers provide valuable information on the effects of ionizing radiation in contemporary exposure scenarios relevant to workers and the public. (cdc.gov)
  • Radiation and health : the biological effects of low-level exposure to ionizing radiation / edited by Robin Russell Jones and Richard Southwood. (who.int)
Damage4
  • Please understand that prenatal ultrasound is part of the radiation issue, and our developing babies are at great risk of being born with some form of genetic damage from exposure to this technology. (birthofanewearthblog.com)
  • Some additional studies were also performed: measurement of fullerenol nanoparticle size, zeta potential, and the influence of fullerenol on the ionizing radiation-induced damage to PMBCs. (biofullerene.com)
  • The study showed consuming dried plums can protect from ionizing radiation that increases oxidative damage in skeletal tissues and results in an imbalance in bone remodeling. (sciencedaily.com)
  • The team investigated interventions they hypothesized might prevent bone damage and oxidative stress-related factors leading to cancellous bone loss, also known as "spongy bone," from exposure to both low linear energy transfer and high linear energy transfer radiation. (sciencedaily.com)
Genetic3
  • I am not exaggerating when I say that entire genetic bloodlines are at risk of becoming extinct if we do not deal with the radiation issue now . (birthofanewearthblog.com)
  • Xiaoming Shen and coworkers at the Jiao Tong University School of Medicine in Shanghai have reported that children with this genetic variant -known as a polymorphism or snp (pronounced "snip") -and who lived within 100 meters of these sources of EMFs had over four times more leukemia than neighboring children with a fully functional version of the same gene. (microwavenews.com)
  • Using advanced genetic imaging techniques, the researchers analyzed blood samples from 12 interventional radiologists working in six various hospitals in Slovakia and 14 controls who worked in other hospital departments without radiation exposure. (auntminnie.com)
Consistently1
  • Increased risk for leukemia has consistently been observed in studies of professional workers and in two of three of the most relevant studies of industrial workers. (who.int)
Assay1
  • Despite the faster and simpler MN scoring, CBMN assay is not commonly recommended in radiation mass-casualty triage as human peripheral blood is typically cultured for 72 h. (bvsalud.org)
Study4
  • Nokia, the world's leading cellphone manufacturer, based in Finland, is working with the World Health Organization's International EMF project, to study the impact of electromagnetic field radiation (EMF) from cellphones. (sarshield.com)
  • The nation wide study includes 2753 child leukemia cases diagnosed between 2002 and 2007 and a control group of 30,000. (wiseinternational.org)
  • Dried plums are effective in protecting from bone loss due to iodized radiation, a new study shows. (sciencedaily.com)
  • Other institutions involved in the study were the Bone and Signaling Laboratory of NASA's Ames Research Center, the department of radiation oncology at the University of California-Irvine and the division of endocrinology at the University of California-San Francisco. (sciencedaily.com)
Researchers3
  • Chinese researchers have found that children who carry a defective version of a gene that would otherwise help repair damaged DNA are much more likely to develop leukemia if they also live near power lines or transformers. (microwavenews.com)
  • Dr. Nancy Turner, a Texas A&M AgriLife Research scientist in College Station, was one of a team of researchers who recently studied different interventions to protect from radiation-induced bone loss. (sciencedaily.com)
  • The researchers tested mice using the different interventions and exposing them to ionizing radiation. (sciencedaily.com)
Injury1
  • Radiation-Induced Lung Injury: Assessment and Management. (nih.gov)