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Estrogen Receptor alphaMolecular Sequence DataInterleukin-13 Receptor alpha1 SubunitPPAR alphaInterleukin-13 Receptor alpha2 SubunitBase SequenceReceptors, InterleukinProtein SubunitsAmino Acid SequenceRetinoid X Receptor alphaRNA, MessengerInterleukin-1Macromolecular SubstancesRecombinant ProteinsProtein BindingEstrogen Receptor betaInterleukin-2alpha 1-AntitrypsinThyroid Hormone Receptors alphaInterleukin-6Cells, CulturedGene Expression RegulationSignal TransductionMice, Inbred C57BLBinding SitesTransfectionCell LineTranscription FactorsReceptors, Retinoic AcidTranscription, GeneticCytokinesInterleukin-4 Receptor alpha SubunitReceptors, Cytoplasmic and NuclearKineticsHypoxia-Inducible Factor 1, alpha SubunitMice, KnockoutReceptors, Adrenergic, alphaTumor Necrosis Factor-alphaMutationGene ExpressionInterleukin-11 Receptor alpha SubunitCloning, MolecularPromoter Regions, GeneticInterleukin-4Interleukin-5 Receptor alpha SubunitReceptors, Interleukin-2Receptors, Interleukin-4Reverse Transcriptase Polymerase Chain ReactionT-LymphocytesPhosphorylationalpha7 Nicotinic Acetylcholine ReceptorBlotting, WesternTumor Cells, CulturedRecombinant Fusion ProteinsDNA-Binding ProteinsProtein Structure, TertiaryReceptors, EstrogenEstradiolReceptors, GABA-ALigandsReceptors, Interleukin-13Receptors, NicotinicDNA PrimersDose-Response Relationship, DrugSequence Homology, Amino AcidDNACell Line, TumorProtein ConformationInterleukinsInterleukin-8Interferon-gammaInterleukin-10Transcriptional ActivationMice, Inbred BALB CInterleukin-1alphaReceptors, Interleukin-5Electrophoresis, Polyacrylamide GelIntegrinsLiverIntegrin alpha6Cell DivisionEstrogensMutagenesis, Site-DirectedRetinoid X ReceptorsAntibodies, MonoclonalLymphocyte ActivationImmunohistochemistryModels, MolecularFolate Receptor 1Interleukin-13Time FactorsCell DifferentiationMolecular WeightInterleukin-15 Receptor alpha SubunitInterleukin 1 Receptor Antagonist ProteinEscherichia coliIntegrin alpha4Polymerase Chain ReactionMice, TransgenicUp-Regulation
AntigensHigh affinityKinaseIsoformsDimersSignaling pathwayCytokineActivatesLigandIL18ComplexesCatalyticSpecificityChainsGlycoproteinTissueAntagonistPhosphorylationMoleculeConsistProteinsInteractionAlphaBetaConcentrationGeneELISASignalsTypeCellCellsExpressionMassMousePeopleActivityChainShownEffectStudyResponseActivation
Antigens1
  • It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. (wakehealth.edu)
High affinity4
  • A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
  • This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. (wikipedia.org)
  • A "private" receptor system, binding specifically IL-13 with high affinity, seems to use different signalling pathways and is increasingly being studied for its potential as a novel prognostic factor, biomarker or therapeutic target in different types of cancer. (wikipedia.org)
  • Indeed, it has been shown that IL-13Rα2 blocks IL-13 driven STAT6 signalling by binding IL-13 with high affinity, however a partial block is also extending to IL-4 driven STAT6 signalling, presumably due to the cytoplasmic domain interfering with the assembling of IL-4/IL-4Rα with a secondary chain. (wikipedia.org)
Kinase5
  • Protein kinase CK2 (Casein kinase II) is an ubiquitous and highly conserved protein serine/threonine kinase that is typically found in tetrameric complexes consisting of two catalytic (alpha and/or alpha\') subunits and two regulatory beta subunits . (proteinkinase.biz)
  • Human recombinant casein kinase 2 holo enzyme (hCK2 holo) containing alpha (aa1-335) and beta subunits expressed separately in E. coli as non-fusion proteins, purified by several chromatography steps (HiTrapQ, Heparin agarose, Superdex200) and reconstituted to the CK2 alpha2beta2 holoenzyme in the course of purification. (proteinkinase.biz)
  • Bidwai AP, Reed JC, Glover CV (1993) "Phosphorylation of calmodulin by the catalytic subunit of casein kinase II is inhibited by the regulatory subunit" Arch. (proteinkinase.biz)
  • Battistutta R, Sarno S, De Moliner E, Marin O, Issinger OG, Zanotti G, Pinna LA (2000) "The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme" Eur. (proteinkinase.biz)
  • Benitez MJ, Cochet C, Jimenez JS (2001) "A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin" Mol. (proteinkinase.biz)
Isoforms1
Dimers1
  • The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers. (lookformedical.com)
Signaling pathway1
  • Stimulation of cAMP accumulation was not observed after pertussis toxin treatment of CHO cells expressing the human CB2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid CB1 receptor. (jneurosci.org)
Cytokine3
  • The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. (wikipedia.org)
  • Interleukin 13 (IL-13) is an effector cytokine partially sharing the signaling pathways with IL-4 due to the utilization of a common receptor system (IL-4 receptor type II). (wikipedia.org)
  • Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22 RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). (rndsystems.com)
Activates2
  • While the docking sites in IL-4R1 (and consequently IL-4) are able to efficiently activate both STAT6 and IRS2 signalling molecules, IL-4RII (and consequently IL-13) only activates effectively STAT6. (wikipedia.org)
  • The subunit alpha protein activates transcription of the subunit beta gene" J. Biol. (proteinkinase.biz)
Ligand1
  • Using the interaction of recombinant hCD40 ligand with HEK-Blue sensor cells expressing the CD40 receptor as example, we show that such an assay can be developed based on BCIP/NBT (5-bromo-4-chloro-3-indolyl phosphate/nitroblue tetrazolium chloride) as substrate. (envite.org)
IL183
Complexes2
  • It presents an extraordinary affinity to IL-13, but does not form complexes with any secondary chain. (wikipedia.org)
  • IL-10 R beta is also a component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29 (1, 2). (rndsystems.com)
Catalytic1
  • Isoform-specific differences in rates of assembly from catalytic and regulatory subunits" J. Biol. (proteinkinase.biz)
Specificity1
  • A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
Chains3
  • This different distribution of secondary chains accounts for the difference in distribution of completed receptors, with being IL-4RI prevalently expressed in lymphocyte, and IL-4RII prevalently in non-hematopoietic cells. (wikipedia.org)
  • events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
  • It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains. (lookformedical.com)
Glycoprotein1
Tissue6
  • It is constitutively expressed by DC but is down-regulated during local inflammation and in response to tissue damage (11-13). (rndsystems.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Calpain 1, Large Subunit (CAPN1) in samples from Tissue homogenates, cell lysates and other biological fluids. (clinical-trial-logistics.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Calpain 1, Large Subunit (CAPN1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (clinical-trial-logistics.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Calpain 1, Large Subunit (CAPN1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (clinical-trial-logistics.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Leptin Receptor (LEPR) in samples from serum, plasma, tissue homogenates or other biological fluids. (agctsequencing.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Leptin Receptor (LEPR) in serum, plasma, tissue homogenates and other biological fluids. (agctsequencing.com)
Antagonist1
  • This augmentation was blocked by the CB1 receptor antagonist SR141716A or the D2 antagonist sulpride. (jneurosci.org)
Phosphorylation1
Molecule1
  • It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. (lookformedical.com)
Consist2
  • Because of the apparent lack of signaling domain and the short tail, it has been initially thought not to have any signaling activity, and regarded as "decoy" receptor, that is its function would just consist in competing for IL-13 binding and neutralizing his effect. (wikipedia.org)
  • To increase stability of the holo complex hCK2 holo consist of shortened alpha subunits (aa1-335) and beta subunits. (proteinkinase.biz)
Proteins3
  • Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)
  • whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)
  • The targets of these candidate proteins included glutathione S-transferase, egg protein CP422 precursor, tubulin alpha-2/alpha-4 chain, actin-2, T-complex protein 1 subunit beta, histone H4, whey acidic protein core region, and molecular chaperone HtpG. (bvsalud.org)
Interaction2
  • These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. (wikipedia.org)
  • However, an interaction between D2 and CB1 receptors has not been established. (jneurosci.org)
Alpha7
  • Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
  • GDNF family receptor alpha 4 [Source. (gsea-msigdb.org)
  • Since CK2 alpha is unstable and prone to degradation, CK2 subunits alpha was shortened at the C-terminus to obtain a stable, crystallizable alpha subunit. (proteinkinase.biz)
  • A study with the complete set of subunits (alpha, alpha\' and beta), site-directed autophosphorylation mutants and a bicistronically expressed holoenzyme" Eur. (proteinkinase.biz)
  • The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
Beta1
  • IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. (rndsystems.com)
Concentration2
  • CD23 promoter in B cells, arginase1 enhancer in macrophages ) The binding affinity of IL-4 for IL-4Rα is much higher than IL-13 for the IL-13Rα1, hence IL-4 would out-compete IL-13 for receptor availability within IL4R2 at parity of concentration. (wikipedia.org)
  • The cannabinoid receptor-stimulated accumulation of cAMP was blocked in a concentration-dependent manner by SR141716A, suggesting that the response was regulated through the CB1 receptor. (jneurosci.org)
Gene1
  • citation needed] There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. (wikipedia.org)
ELISA3
  • Description: A sandwich ELISA kit for detection of Calpain 1, Large Subunit from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (clinical-trial-logistics.com)
  • Description: A competitive ELISA for quantitative measurement of Rat Leptin receptor(LEPR) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (agctsequencing.com)
  • Description: A sandwich ELISA kit for detection of Interleukin 18 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (agctsequencing.com)
Signals1
  • The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
Type9
  • IL-13 uses the IL-4 receptor type II (IL-4RII), a complex formed by an IL-4Rα chain and an IL-13Rα1 chain. (wikipedia.org)
  • The IL-4/IL-4Rα complex, however, can also bind to a different secondary chain, the IL-2Rγc, forming the IL-4 receptor type I (IL-4RI). (wikipedia.org)
  • Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in this website by year, and whether "Receptors, Tumor Necrosis Factor, Type I" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles. (childrensmercy.org)
  • Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a G s -type G-protein. (jneurosci.org)
  • SJMHE1 treatment improved clinical symptoms (rubbing and sneezing), suppressed infiltrates of inflammatory cells and eosinophils in nasal mucosa, modulated the production of type-2 (IL-4 and IL-13) and anti-inflammatory (IL-10) cytokines in the nasal lavage fluids (NLF), spleen, and serum. (bvsalud.org)
  • Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer. (lookformedical.com)
  • Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits. (lookformedical.com)
Cell1
Cells2
  • Consequently, only IL-4, through IL-4R1, is able to modulate the function of lymphocytes inducing Th2 polarisation and B cells IgG1/IgE class switching, while IL-13 is mainly acting on myeloid cells and non-hematopoietic cells, having strong effects on mucus production, smooth muscle contraction, epithelium permeabilisation (e.g. allergic asthma). (wikipedia.org)
  • Similar augmentation of cAMP accumulation after pertussis toxin treatment was observed in Chinese hamster ovary (CHO) cells transfected with, and stably expressing, the CB1 receptor. (jneurosci.org)
Expression2
  • According these studies, IL-13, through the over-expression (TNF-α induced) of IL-13Rα2 would be able to activate AP-1 signalling and production of TGF-β, driving pro-fibrotic effects. (wikipedia.org)
  • ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
Mass1
  • The download advanced mass spectrometry reticulum city receptors very explore the businesses in elongation at the phosphorylates of valine. (evakoch.com)
Mouse1
  • IL-13 signalling through IL-13Rα2 and AP1-driven TGF-β production has been initially reported in monocytes and then confirmed in mouse models. (wikipedia.org)
People1
  • Below are the most recent publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in Profiles. (rush.edu)
Activity1
  • Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)
Chain1
  • Besides IL-13Rα1 chain (which work in conjunction with the IL-4Rα, IL-13 can bind with much higher affinity to IL-13Rα2. (wikipedia.org)
Shown2
  • Within the striatum, CB1 receptors have been shown to be localized on the same neurons as G i -coupled dopamine D2 receptors. (jneurosci.org)
  • Previously, CB1 receptors have been shown to inhibit D1 receptor-mediated cAMP accumulation ( Bidaut-Russell and Howlett, 1991 ). (jneurosci.org)
Effect1
  • Pertussis toxin treatment of striatal neurons prevented the inhibition of cAMP accumulation by D2 receptors but unmasked a cannabinoid receptor-mediated stimulatory effect on cAMP accumulation. (jneurosci.org)
Study2
  • In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase. (jneurosci.org)
  • cutánea maligna de células T. Luego se realizó el frotis de médula ósea, en el que se identificaron células «cerebriformes» study conception, manuscript que confirmaron el diagnóstico de síndrome de Sézary. (bvsalud.org)
Response1
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
Activation1
  • Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)