IL13Mini Samples Mouse InterleukinCytokineELISAEosinophilsMonoclonal antibody that blocksDifferentiationReceptor complexCytokinesTransgenic miceEpithelialHigh affinityMast cellsInducesBinds2022AirwayInhibitorsChezExpressionHematopoieticAtopic DermatitisImmunoglobulin154.6ReceptorsPathwaysSerumAsthmaGenotypeCellsMacrophagesImmuneCollagenGeneBiologicalInflammationGenesHumanSubunitClinicalSignificantlyDiseasesDeficiencyConcentrationPatientsRoleLevelsDetermine
IL135
- Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. (wikipedia.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 13 (IL13) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (lscwarsaw.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 13 (IL13) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (lscwarsaw.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 13 (IL13) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (lscwarsaw.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 13 (IL13). (lscwarsaw.com)
Mini Samples Mouse Interleukin1
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 24 (IL24). (orbitalbiosciences.com)
Cytokine6
- IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. (wikipedia.org)
- IL-13 has effects on immune cells that are similar to those of the closely related cytokine IL-4. (wikipedia.org)
- Thus, rather than a lymphoid cytokine, IL-13 acts more prominently as a molecular bridge linking allergic inflammatory cell to the non-immune cells in contact with them, thereby altering physiological function. (wikipedia.org)
- Interleukin (IL)-13 is a key cytokine associated with the asthmatic phenotype. (soton.ac.uk)
- Interleukin (IL)-10, IL-4, IL-13, and transforming growth factor (TGF)-beta are usually considered to be the most important macrophage-deactivating factors, with inhibitory effects on cytokine production. (cornell.edu)
- IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. (rndsystems.com)
ELISA8
- In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
- Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
- Description: A sandwich ELISA kit for detection of Interleukin 18 from Guinea pig in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ibiomagazine.org)
- Low Endotoxin/Azide Free Anti-Human IL-13 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, ELISpot, and neutralization assays. (southernbiotech.com)
- Human IgG antibody Laboratories manufactures the quantikine human interleukin 6 elisa assay reagents distributed by Genprice. (genediag.com)
- The Quantikine Human Interleukin 6 Elisa Assay reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (genediag.com)
- Description: A competitive ELISA for quantitative measurement of Human Interleukin 6 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (genediag.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 Receptor Alpha (IL10Ra) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
Eosinophils2
- Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2 (17). (rndsystems.com)
- Although these diseases are idiopathic, recent investigations support the role of eosinophils, T helper 2 (Th2) cytokines (interleukin [IL]-3, IL-4, IL-5, and IL-13), and eotaxin as the critical factors in the pathogenesis of eosinophilic gastroenteritis. (medscape.com)
Monoclonal antibody that blocks1
- Dupilumab is a fully human monoclonal antibody that blocks a shared receptor component for interleukin-4 and interleukin-13, which are the key drivers for type 2 inflammation with EoE. (medscape.com)
Differentiation4
- Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium. (wikipedia.org)
- Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
- Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
- Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells. (ox.ac.uk)
Receptor complex2
- This receptor is a heterodimer receptor complex consisting of alpha IL-4 receptor (IL-4Rα) and alpha Interleukin-13 receptor (IL-13R1). (wikipedia.org)
- Andrews, Allison-Lynn , Holloway, John W. , Puddicombe, Sarah M. , Holgate, Stephen T. and Davies, Donna E. (2002) Kinetic analysis of the interleukin-13 receptor complex. (soton.ac.uk)
Cytokines5
- The epithelial cell-derived cytokines, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) have received attention for their role in allergic responses but not been studied during this critical window. (mirec-canada.ca)
- Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. (cornell.edu)
- Addition of IL-4 and IL-13 to peripheral blood mononuclear cell (PBMC) cultures inhibited production of IL-12, tumor necrosis factor (TNF)-alpha, IL-10, and IL-1 beta induced by lipopolysaccharide (LPS) or Staphylococcus aureus added simultaneously with the cytokines. (cornell.edu)
- On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. (rndsystems.com)
- Furthermore, lamina propria T cells from the duodenum of these patients proliferated in response to milk proteins and secreted Th2 cytokines (IL-13). (medscape.com)
Transgenic mice1
- Studies of IL-13 transgenic mice lungs with IL-13Rα2 null loci indicated that IL-13Rα2 deficiency significantly augmented IL-13 or ovalbumin-induced pulmonary inflammation and remodeling. (wikipedia.org)
Epithelial2
- 15-Lipoxygenase-1 (15LO1) which is an enzyme in the fatty acid metabolism and its metabolite, 15-HETE, are highly expressed in asthma (which lead to the overexpression of MUC5AC) and are induced by IL-13 in human airway epithelial cells. (wikipedia.org)
- Interleukin-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis. (nationaljewish.org)
High affinity4
- The high affinity of IL-13 to the IL-13R1 leads to their bond formation which further increase the probability of a heterodimer formation to IL-4R1 and the production of the type 2 IL-4 receptor. (wikipedia.org)
- In contrast, shIL-13R?2 produced a high affinity interaction with IL-13 (KD = 2.49 ± 0.94 nM n = 10). (soton.ac.uk)
- High-affinity mutant Interleukin - 13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma. (il-13.com)
- Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule (11-14). (rndsystems.com)
Mast cells3
- Ninety-four percent of the cells expressing IL-4 (3H4), 92% of those expressing IL-4 (4D9) and 100% expressing IL-13 in the airway smooth muscle were mast cells. (nih.gov)
- Fifty-five percent of the mast cells within the airway smooth muscle co-localized to IL-4 (3H4), 29% to IL-4 (4D9) and 17% to IL-13. (nih.gov)
- In asthma, IL-4+ and IL-13+ cells were present within the airway smooth muscle and were expressed predominantly by mast cells, suggesting that IL-4 and IL-13 may play an important role in mast cell-airway smooth muscle interactions. (nih.gov)
Induces2
- IL-13 induces a class of protein-degrading enzymes, known as matrix metalloproteinases (MMPs), in the airways. (wikipedia.org)
- Among other factors, IL-13 induces these MMPs as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. (wikipedia.org)
Binds4
- IL-13 also binds to another receptor known as IL-13Rα2. (wikipedia.org)
- The IL-13Rα2 subunit binds only to IL-13 and it exists in both membrane-bound and soluble forms in mice. (wikipedia.org)
- Detailed kinetic analyses of the binding properties of the heteromeric complexes suggested a sequential mechanism for the binding of IL-13 to its signaling receptor, in which IL-13 first binds to IL-13R?1 and this then recruits IL-4? (soton.ac.uk)
- IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha. (rndsystems.com)
20221
- Nature Communications 2022, 13: 3140. (yalemedicine.org)
Airway3
- Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. (wikipedia.org)
- Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. (wikipedia.org)
- In six subjects with asthma, IL-13 expression by cells within the airway smooth muscle was studied. (nih.gov)
Inhibitors3
- Expert perspectives on the interleukin pathway inhibitors, dupilumab and tralokinumab, and their role in managing atopic dermatitis. (consultantlive.com)
- Wang JH, Shih KS, Wu YW, Wang AW and Yang CR: Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fbroblast-like synoviocytes. (spandidos-publications.com)
- The aim of this study was to systemically review the efficacy and safety of inhibitors of interleukin 6 (IL-6): clazakizumab, IL-12/23: ustekinumab, and IL-17A: secukinumab, brodalumab, and ixekizumab in psoriatic arthritis (PsA). (medscape.com)
Chez1
- Les taux d'IL-12 étaient nettement inférieurs chez les malades par rapport aux témoins (91,4 pg/ml contre 154,6 pg/ml), alors que les taux d'IL-13 étaient significativement plus élevés (42,5 pg/ml contre 5,7 pg/ml). (who.int)
Expression4
- 13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
- The present study evaluated cell viability, expression levels of collagen II (Col II) and matrix metalloproteinase‑13 (MMP‑13), and activity of the Wnt/β‑catenin and NF‑κB signaling pathways in treated SW1353 cells. (spandidos-publications.com)
- The present results suggested that IL‑1β could decrease Col II expression and increase MMP‑13 expression at both the mRNA and protein levels, and also activate the Wnt/β‑catenin and NF‑κB signaling pathways in SW1353 cells. (spandidos-publications.com)
- Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M and Zafarullah M: Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. (spandidos-publications.com)
Hematopoietic2
- IL-13 is known to induce changes in hematopoietic cells, but these effects are probably less important than that of IL-4. (wikipedia.org)
- In this study we investigated for the first time the potential role of IL-13 in the regulation of the growth of hematopoietic progenitor cells. (ox.ac.uk)
Atopic Dermatitis2
- Virus-Like Particle-Mediated Vaccination against Interleukin - 13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis. (il-13.com)
- While I think blocking IL-13 [pathways]…you see the data as very similar from [an] atopic dermatitis therapy standpoint. (consultantlive.com)
Immunoglobulin1
- Furthermore, IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells. (wikipedia.org)
154.62
- ووجدت الباحثات أن مستويات الإنترلوكين 12 أخفض بمقدار يُعْتَدُّ به إحصائياً لدى الحالات (91.4 بيكوغرام/ميلي لتر) مما هي عليه لدى الشواهد (154.6 بيكوغرام/ميلي لتر)، وأن مستويات الإنترلوكين 13 كانت أعلى بمقدار يُعْتَدُّ به إحصائياً لدى الحالات (42.5 بيكوغرام/ميلي لتر) مما هي عليه لدى الشواهد (5.7 بيكو غرام/ميلي لتر). (who.int)
- IL-12 levels were significantly lower among cases compared with controls (91.4 pg/mL versus 154.6 pg/mL), while IL-13 levels were significantly higher (42.5 pg/mL versus 5.7 pg/mL). (who.int)
Receptors2
- Interleukin-13 and its associated receptors with α subunit of the IL-4 receptor (IL-4Rα) allows for the downstream activation of STAT6. (wikipedia.org)
- Most normal cells, such as immune cells or endothelial cells, express very low or undetectable levels of IL-13 receptors. (wikipedia.org)
Pathways2
- I think being able to block both IL-4 and IL-13 pathways for atopic patients may be more attractive in certain situations, especially in these comorbid patients, which many of our patients are comorbid patients. (consultantlive.com)
- The IL-13 only pathway was looked at for asthma… even in inhaled anti-IL-13 [pathways] and didn't come to market because it wasn't successful from [an] asthma standpoint. (consultantlive.com)
Serum3
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 24 (IL24) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (orbitalbiosciences.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 24 (IL24) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
- The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
Asthma1
- Diisocyanate asthma and gene-environment interactions with IL4RA, CD-14, and IL-13 genes. (cdc.gov)
Genotype1
- Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds. (lu.se)
Cells4
- The median (range) of IL-13+cells was 2 (0.9-2.7). (nih.gov)
- IL-13 enhanced stem cell factor (SCF)-induced proliferation of Lin-Sca-1+ bone marrow progenitor cells more potently than IL-4. (ox.ac.uk)
- In contrast, IL-13 had no synergistic activity on SCF-induced proliferation of the more mature Lin-Sca-1- progenitor cells. (ox.ac.uk)
- IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. (rndsystems.com)
Macrophages1
- Finally, whereas stimulation of Lin-Sca-1+ progenitors by SCF + G-CSF resulted in the formation of 90% granulocytes, the addition of IL-13 resulted in the production of macrophages exclusively. (ox.ac.uk)
Immune1
- These results suggest an unexpected complexity in the regulatory role of IL-4 and IL-13 in immune responses. (cornell.edu)
Collagen1
- This supported the hypothesis that IL-13Rα2 is a negative regulator of IL-13-induced response and illustrated significantly reduced production of TGF-β1 and deposition of collagen in the lungs of mice. (wikipedia.org)
Gene1
- The protein encoded by this gene is a subunit of the interleukin 13 receptor. (thermofisher.com)
Biological2
- Most of the biological effects of IL-13, like those of IL-4, are linked to a single transcription factor, signal transducer and activator of transcription 6 (STAT6). (wikipedia.org)
- The recently cloned interleukin 13 (IL-13) shares most investigated biological activities on B lymphocytes and monocytes with IL-4. (ox.ac.uk)
Inflammation1
- However, IL-13 is suspected to be the central mediator of the physiologic changes induced by allergic inflammation in many tissues. (wikipedia.org)
Genes2
- Objective: To determine if specific single nucleotide polymorphisms (SNPs) of interleukin 4 receptor alpha (IL4RA), IL-13, and CD14 promoter genes are associated with DA. (cdc.gov)
- Methods: Sixty-two workers with DA confirmed by specific inhalation challenge (SIC) and 75 diisocyanate -exposed, SIC-negative workers were analyzed for SNPs associated with IL4RA, IL-13, and CD14 promoter genes. (cdc.gov)
Human1
- Detects human IL-13 in direct ELISAs. (rndsystems.com)
Subunit1
- The signaling of IL-13 begins through a shared multi-subunit receptor with IL-4. (wikipedia.org)
Clinical1
- [ 13 ] These agents are either recently approved or being tested in clinical trials that have demonstrated encouraging results. (medscape.com)
Significantly1
- significantly increased the affinity of shIL-13R?1 for IL-13 but had no effect on the binding affinity of IL-13R?2. (soton.ac.uk)
Diseases1
- Interleukin-13 mucosal production in Helicobacter pylori-related gastric diseases. (southernbiotech.com)
Deficiency1
- Inherited interleukin 12 deficiency in a child with bacille Calmette-Gu rin and Salmonella enteritidis disseminated infection. (lu.se)
Concentration2
- Determine the concentration of interleukin-13 PE38QQR immunotoxin that produces histologic evidence of toxicity to tumor and the corresponding toxic effects of this drug when administered via continuous intratumoral infusion prior to second resection in patients with recurrent resectable supratentorial malignant glioma. (knowcancer.com)
- Cohorts of 3-6 patients receive escalating doses of pre-resection interleukin-13 PE38QQR immunotoxin until the histologically effective concentration (HEC) is reached or maximum tolerated dose (MTD) is determined. (knowcancer.com)
Patients5
- Unituxin is a GD2-binding monoclonal antibody indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. (nih.gov)
- Resection (all patients): Patients undergo maximal resection (en bloc, if feasible) followed by placement of 2-3 peritumoral catheters (4 days after completion of pre-resection infusion for the initial cohorts of patients and at study entry for subsequent cohorts of patients). (knowcancer.com)
- Post-resection therapy (all patients): Beginning on the second day after resection, patients receive interleukin-13 PE38QQR immunotoxin via continuous peritumoral infusion over 96 hours. (knowcancer.com)
- Cohorts of 3-6 patients receive escalating doses of interleukin-13 PE38QQR immunotoxin until the previously-defined HEC is reached or MTD is determined, whichever occurs first. (knowcancer.com)
- Beta-thalassaemia is the most IL-13 concentrations were investigated pernates were collected from each tube common type and has the highest in beta-thalassaemia patients and con- and stored at -20 °C to be assayed using frequency in the Mediterranean area. (who.int)
Role2
- Interleukin-13 has a critical role in goblet cell metaplasia. (wikipedia.org)
- Collectively, these findings indicate a novel role of IL-13 in early myelopoiesis, partially overlapping but also different from that of IL-4. (ox.ac.uk)
Levels3
Determine1
- To determine the binding contributions of the individual components of the IL-13 receptor to IL-13, we have employed surface plasmon resonance and equilibrium binding assays to investigate the ligand binding characteristics of shIL-13R?1, shIL-13R?2, and IL-4R? (soton.ac.uk)