• A research team from Justus Liebig University Giessen and the Max Planck Institute for Heart and Lung Research in Bad Nauheim, led by Sven Reischauer from Justus Liebig University, has now been able to show that the suppression of scar formation in zebrafish is coupled to the signaling pathway mediated by the protein interleukin-11 receptor alpha. (mpg.de)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 10 Receptor Alpha (IL10Ra) in Tissue homogenates, cell lysates and other biological fluids. (tuberculosisdrugresearch.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 10 Receptor Alpha (IL10Ra) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (tuberculosisdrugresearch.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 Receptor Alpha (IL10Ra) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
  • This study was designed to investigate the expression of interleukin-2 receptor alpha chain CD25 in B-ALL and its biological significance, especially following the availability of specific CD25 targeting compounds. (ashpublications.org)
  • Our data suggest that ALL, and in particular Ph-positive ALL, aberrantly expresses the interleukin-2 receptor alpha chain, CD25. (ashpublications.org)
  • Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. (wikipedia.org)
  • It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. (wikipedia.org)
  • The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. (wikipedia.org)
  • In fibroblasts, IL-11 drives an ERK-dependent autocrine loop of fibrogenic protein synthesis that is at a nexus of fibrotic signalling and required for the pro-fibrotic activity of TGFB1, PDGF, endothelin1, angiotensin and many other pro-fibrotic factors. (wikipedia.org)
  • Recombinant IL-11 is a monomer protein consisting of 180 amino acid residue subunits, and migrates as an approximately 19 kDa protein under reducing conditions in SDS-PAGE. (reprokine.com)
  • The human IL-11 cDNA encodes a 199 amino acid residue precursor polypeptide with a 21 amino acid residue hydrophobic signal that is processed proteolytically to generate the 178 amino acid residue mature protein. (rndsystems.com)
  • Other cytokines that signal through receptors containing gp130 are Interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin M (OSM), Kaposi's sarcoma associated herpes virus interleukin 6 like protein (KSHV-IL6). (dadamo.com)
  • Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein. (curehunter.com)
  • An excessive extracellular presence of the proinflammatory cytokines interleukin 1 (IL1), tumour necrosis factor α (TNFα), and interleukin 6 (IL6), in particular, has been identified and intra-articular as well as systemic levels of these cytokines may to some extent reflect disease activity. (bmj.com)
  • More recently it has been discovered that over-expression of IL-11 is associated with a variety of cancers and may provide a link between inflammation and cancer. (wikipedia.org)
  • Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit a-1 (IL-11Ra1-deficient mice), a transmembrane receptor that is required conjointly with glycoprotein 130 to transduce IL-11 signaling. (cdc.gov)
  • Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. (dadamo.com)
  • IL-11 through its binding to its transmembrane IL-11Rα receptor and resultant activation of downstream signaling pathways has been thought to regulate adipogenesis, osteoclastogenesis, neurogenesis and platelet maturation. (wikipedia.org)
  • IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF). (rndsystems.com)
  • As IL-11 over expression is associated with a number of cancers, inhibition of its signaling pathway may have utility in treating cancer. (wikipedia.org)
  • Thus, the researchers found that zebrafish in which the interleukin-11 signaling pathway was knocked down using the CRISPR technique formed scars just like humans and other mammals. (mpg.de)
  • Native Mouse IL-11, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 19 kDa. (reprokine.com)
  • Recombinant mouse IL-11 was lyophilized from a 0.2 μm filtered PBS solution. (reprokine.com)
  • In direct ELISAs and Western blots, less than 25% cross-reactivity with recombinant mouse IL-11 is observed. (rndsystems.com)
  • Interleukin 11 is manufactured using recombinant DNA technology. (wikipedia.org)
  • Recombinant Mouse Interleukin-11 is produced by our Mammalian expression system and the target gene encoding Pro22-Leu199 is expressed with a Fc tag at the C-terminus. (bonopusbio.com)
  • 566. The Neutralization Dose (ND 50 ) is typically 10-20 µg/mL in the presence of 1 ng/mL Recombinant Human IL‑11. (rndsystems.com)
  • Recombinant Human IL-11 (Catalog # 218-IL ) stimulates proliferation in the T11 mouse plasmacytoma cell line in a dose-dependent manner (orange line). (rndsystems.com)
  • Proliferation elicited by Recombinant Human IL-11 (1 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-11 Polyclonal Antibody (Catalog # AB-218-NA). (rndsystems.com)
  • Consistent with the in vitro functions of IL‑11, in vivo administration of rhIL-11 in normal mice was found to enhance the generation of Ig producing cells and platelets, and to increase the cycling rates of bone marrow-derived CFU-GM, BFU-E, and CFU-GEMM progenitors. (rndsystems.com)
  • Immunity;54(11): 2611-2631.e8, 2021 11 09. (bvsalud.org)
  • IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130. (wikipedia.org)
  • Signal transduction is initiated upon binding of IL-11 to IL-11Ralpha and gp130, facilitating the formation of higher order structures involving dimers of gp130:Il-11:Il11RA complexes. (wikipedia.org)
  • Zebrafish with interleukin-11 signaling turned off respond at the cellular level basically like we humans do to injury and activate a fibrotic gene program. (mpg.de)
  • IL-11 has also been described in various aspects of tissue regeneration, predominantly in regenerative species like the zebrafish or the axolotl. (wikipedia.org)
  • Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. (mpg.de)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 24 (IL24) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (orbitalbiosciences.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 24 (IL24) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
  • Description: Quantitativesandwich ELISA kit for measuring Chicken Interleukin 6, IL-6 in samples from serum, plasma, tissue homogenates. (elisastrip.com)
  • Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. (wjgnet.com)
  • Here, activation of STAT3 by IL-11 is mandatory to allow regeneration and to prevent injury-induced fibrotic remodeling and scar formation. (wikipedia.org)
  • 2019 Sep 25;11(511):eaaw1237. (nih.gov)
  • Description: A sandwich ELISA kit for detection of Interleukin 18 from Guinea pig in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ibiomagazine.org)
  • Description: A sandwich ELISA kit for detection of Interleukin 24 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (orbitalbiosciences.com)
  • Description: Quantitative sandwich ELISA for measuring Chicken Interleukin 6 (IL-6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (elisastrip.com)
  • In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
  • Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
  • IL-11 exerts its biological activities through binding to a specific high-affinity receptor having an apparent molecular mass of 150 kDa. (rndsystems.com)
  • Interleukin 11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1 alpha -stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive murine plasmacytoma cell line T1165. (rndsystems.com)
  • Interleukin-23 ( IL-23 ) is a heterodimeric cytokine composed of an IL12B ( IL-12p40 ) subunit (that is shared with IL12 ) and the IL23A ( IL-23p19 ) subunit. (wikidoc.org)
  • Detects human IL‑11 in direct ELISAs and Western blots. (rndsystems.com)
  • Cell Proliferation Induced by IL‑11 and Neutralization by Human IL‑11 Antibody. (rndsystems.com)
  • Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis. (nih.gov)
  • Cowardin CA, Kuehne SA, Buonomo EL, Marie CS, Minton NP, Petri WA: Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. (msdmanuals.com)
  • In this article, the term "acute-phase serum" refers to antigens can also cause toxic shock (11). (cdc.gov)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
  • Many of the biological effects described for IL-11 overlap those for IL-6. (rndsystems.com)
  • Transforming growth factor β1 (TGFβ1) through up-regulation of IL-11, stimulates collagen production and is important in wound healing. (wikipedia.org)
  • sis factor alpha (TNF-), tumor necrosis factor beta (TNF- ), interleukin (IL)-1, and IL-2 (11-14). (cdc.gov)
  • OBJECTIVES Assessment of the numbers and spatial distribution of cells producing interleukin 1α (IL1α), interleukin 1β (IL1β), tumour necrosis factor α (TNFα), and interleukin 6 (IL6) in the synovial membranes of patients with rheumatoid arthritis (RA). (bmj.com)
  • Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling. (il-11.com)
  • Percent body fat, plasma inflammatory markers associated with obesity (interferon (IFN)-γ, interleukin (IL)-10, IL-12 p70, IL-1β, IL-6 and KC/GRO), plasma Cur metabolites and liver telomere length were measured. (springer.com)
  • IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation IL-11 causes bone-resorption. (wikipedia.org)
  • Measured by its ability to neutralize IL‑11-induced proliferation in the T11 mouse plasmacytoma cell line. (rndsystems.com)
  • 1. Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. (dadamo.com)
  • Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing and permeability in the colon of mice. (bmj.com)
  • In other instances, in stromal cells, IL-11 activates non-canonical MAPK/ERK-dependent signalling to initiate the post-transcriptional upregulation of specific subsets of transcripts in the absence of an effect on transcription. (wikipedia.org)
  • IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. (rndsystems.com)
  • IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell. (rndsystems.com)
  • According to researchers, interleukin 6 plays a critical role in how exercise helps to reduce body fat. (neurosciencenews.com)
  • This changes after the loss of the signal molecule interleukin-11 receptor (il11ra) (right figure). (mpg.de)
  • Journal Article] Associaction between type 11 diabetes and colon cancer among Japanese with reference to changes in food intake. (nii.ac.jp)
  • Parkinson's patients carrying mutations in PINK1 and Parkin genes have increased levels of circulating interleukin 6 and mitochondrial DNA. (neurosciencenews.com)
  • IL-11 is a cytokine that was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells. (wikipedia.org)
  • Effect of IL-11 on invasion of JEG-3 and HTR-8/SVneo cells. (reprokine.com)
  • Data is expressed as fold change in invasion following IL-11 (200 ng/ml) treatment as compared to untreated JEG-3 cells as control. (reprokine.com)
  • IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. (rndsystems.com)