Interferon beta. Medical search. Frequent questions

tell your doctor and pharmacist if you are allergic to interferon beta-1b injection, other interferon beta medications (Avonex, Plegridy, Rebif), any other medications, human albumin, mannitol, latex, or any of the other ingredients in interferon beta-1b injection. (medlineplus.gov)
Interferon beta-1a (Avonex) is a recombinant form of a physiologic human type I interferon important for antiviral, immunomodulatory and antiproliferative effects. (clinimmsoc.org)
Interferon beta products currently licensed in the UK are Avonex , Rebif (interferon beta-1a), Betaferon , Extavia (interferon beta-1b) and the new product Plegridy (peginterferon beta-1a). (mims.co.uk)
Interferons and Multiple Sclerosis: Lessons from 25 Years of Clinical and Real-World Experience with Intramuscular Interferon Beta-1a (Avonex). (physiciansweekly.com)
Before starting Interferon Beta-1A, Rebif/Avonex make sure your physician is aware of any allergies and medications you currently take, if you have cardiovascular disease, liver disease, a seizure disorder, or thyroid dysfunction. (advochealth.com)
Interferon Beta-1A, Rebif/Avonex use has been associated with rare but serious adverse events such as hypersensitivity reaction, autoimmune disorder, bone marrow suppression, flu like symptoms, hepatic effects, injection site reaction, neuropsychiatric disorder, and thrombotic microangiopathy. (advochealth.com)
Note this is not a complete list of side effects for Interferon Beta-1A, Rebif/Avonex, only common ones. (advochealth.com)

Skin reactions with interferon beta are more common with subcutaneous administration and vary greatly in their clinical presentation. (wikipedia.org)
In the present population-based study, we used routinely collected healthcare data in the Campania Region of Italy, from 2015 to 2017, to describe the use of different Interferon Beta formulations and to evaluate possible differences, assuming that dosing, frequency of administration, subcutaneous/intramuscular injection, and/or associated devices can affect persistence, adherence, healthcare resource utilisation and costs. (biomedcentral.com)
Pegylated Interferon Beta-1A is available as a prefilled pen device for injection, intended for subcutaneous administration. (mrmed.in)
In both studies, patients were randomized on a 1:1 ratio to receive either ocrelizumab or an already established treatment for relapsing MS: subcutaneous interferon-beta, injected three times weekly. (sciencedaily.com)
Subcutaneous interferon beta-1a in COVID-19: raking the ashes of an intervention trial" by Tom Wilkinson, 18 October 2021, The Lancet Respiratory Medicine . (scitechdaily.com)
Subcutaneous interferon beta-1a is a multiple sclerosis medication manufactured and marketed in the United States under the brand name Rebif by EMD Serono Inc., the biopharmaceutical business of Merck KGaA, Darmstadt, Germany. (scitechdaily.com)

Interferon Beta formulations presented with different prescription patterns, persistence, adherence, healthcare resource utilisation and costs, with Rebif® being used in younger patients and with less MS-related hospital admissions. (biomedcentral.com)

Side effects are often onerous enough that many patients ultimately discontinue taking interferons[citation needed] (or glatiramer acetate, a comparable disease-modifying therapy requiring regular injections). (wikipedia.org)
Immunomodulatory and cytotoxic agents that are used in adult MS in the event of suboptimal response to interferon-beta and/or glatiramer acetate have been used in a small number of pediatric patients. (medscape.com)
For patients with ON whose brain lesions on MRI indicate a high risk of developing clinically definite MS, treatment with immunomodulators (eg, interferon [INF] beta-1a, INF beta-1b, glatiramer acetate) may be considered. (medscape.com)

METHODS In this phase 3 trial, we randomly assigned patients 10 to 17 years of age with relapsing multiple sclerosis in a 1:1 ratio to receive oral fingolimod at a dose of 0.5 mg per day (0.25 mg per day for patients with a body weight of ≤40 kg) or intramuscular interferon beta-1a at a dose of 30 μg per week for up to 2 years. (elsevierpure.com)
A recent Cochrane systematic review demonstrated that intramuscular interferon beta 1a (IFN-ß-1a-IM) was inferior to the other beta interferons (IFN-ßs) for multiple sclerosis (MS). As a result, CONITEC commissioned an analysis to review possible disinvestment within SUS. (bvsalud.org)

Oldstone notes blockade of type I interferon receptor signaling corrected virus-induced disorganization of secondary lymphoid tissue, allowed migration of T cells in the lymphoid tissue and diminished molecules responsible for aborting virus-specific T cell activity -- all leading to restoration of T cell function and control of the viral infection. (sciencedaily.com)
Predicted to enable cytokine activity and type I interferon receptor binding activity. (nih.gov)

Binding of interferon beta-1a to its receptor leads to induction of many interferon inducible genes, including beta 2-microglobulin and neopterin, both of which can serve as biomarkers for interferon beta-1a administration. (clinimmsoc.org)
NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
NABs prevent IFN-beta binding to its receptor and inducing the response. (ms-selfie.blog)
In order to evaluate the kinetics of bioactivity loss in blood samples obtained every 6 months after therapy initiation, MxA and interferon receptor isoform/subunit mRNA were quantified by real-time PCR, anti-IFNβ binding antibodies were detected by radioimmunoprecipitation, and neutralizing antibodies by cytopathic effect inhibition assay. (ms-selfie.blog)
No interferon receptor isoform alterations that could explain these findings were found. (ms-selfie.blog)
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation. (cdc.gov)
Part of the receptor for interferon gamma. (lu.se)

Even though anti-interferon beta (IFNβ) antibodies are the main determinants of IFNβ bioactivity loss and Myxovirus-resistance protein A (MxA) is the most established marker of IFNβ biological activity in IFNβ-treated MSers, their usefulness in the routine clinical practice is still debated. (ms-selfie.blog)
Intervention1: Drug: PF-06823859 (anti-interferon beta therapy): Participants will receive PF-06823859 via intravenous infusion every 4 weeks. (who.int)

What is Betaferon®(Interferon beta-1b) and how does it work? (msaustralia.org.au)
The active ingredient of Betaferon® is interferon beta-1b. (msaustralia.org.au)
Clinical trials found that Betaferon® (interferon beta -1b) has a significant beneficial effect in people with relapsing-remitting MS by reducing the accumulation of permanent physical disability, exacerbation frequency and disease activity measured by active lesions on brain magnetic resonance images (MRI). (msaustralia.org.au)
How is Betaferon®(Interferon beta-1b) administered? (msaustralia.org.au)
What are the potential side effects of Betaferon®(Interferon beta-1b) treatment? (msaustralia.org.au)
Is Betaferon®(Interferon beta-1b) safe for pregnancy? (msaustralia.org.au)
How much does Betaferon®(Interferon beta-1b) cost? (msaustralia.org.au)
Betaferon belongs to a class of medicines known as interferons . (myvmc.com)
The active substance of Betaferon is interferon beta-1b, a recombinant human interferon beta produced from a strain of Escherichia coli . (myvmc.com)
Betaferon contains 0.25 mg of the active ingredient interferon beta-1b (rbe) per mL. (myvmc.com)

Commercially available interferons are human interferons manufactured using recombinant DNA technology. (medicinenet.com)
What are the available interferons? (medicinenet.com)
If I had my choice of the three available interferons it would be this one to start with. (drugs.com)

One of the factors related to non-respondance is the presence of high levels of interferon beta neutralizing antibodies. (wikipedia.org)
The levels of interferon beta-1b in breastmilk are minuscule. (msaustralia.org.au)

Yet, it is becoming clear that interferons don't simply boost the immune system. (sciencedaily.com)
Interferons are proteins produced naturally in the human body to help fight infections and regulate the immune system. (msaustralia.org.au)
Beta interferons have been shown to slow down activity and disease progression in MS. They do this by helping regulate the immune system, reducing attacks on myelin or nerves. (msaustralia.org.au)
Interferons are naturally occurring proteins produced by the body that help fight against attacks on the immune system such as viral infections. (myvmc.com)
Interferons are a family of naturally-occurring proteins that are made and secreted by cells of the immune system (for example, white blood cells, natural killer cells, fibroblasts, and epithelial cells). (medicinenet.com)
Interferons modulate the response of the immune system to viruses , bacteria, cancer , and other foreign substances that invade the body. (medicinenet.com)
Essentially, when confronted with a virus, each cell shoots an emergency flare of interferon to tell the immune system to marshall its defenses. (medicinenet.com)
The theory is, interferon may be able to make the immune system stronger by turning on dormant parts and directing them toward the defense against SARS -nCoV-2's assault. (medicinenet.com)
In other words if your own immune system is producing interferon-beta you are less likely to respond. (ms-selfie.blog)
Infected cells normally produce type 1 interferons to help the immune system fight pathogens, especially viruses. (scitechdaily.com)

Treatment with interferons after an initial attack decreases the risk of developing clinical definite MS. Medications are modestly effective at decreasing the number of attacks in relapsing-remitting multiple sclerosis and in reducing the accumulation of brain lesions, which is measured using gadolinium-enhanced magnetic resonance imaging (MRI). (wikipedia.org)
Interferon therapy in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of the comparative trials. (clinimmsoc.org)
9. Einarson TR, Bereza BG, Machado M. Comparative effectiveness of interferons in relapsing-remitting multiple sclerosis: a meta-analysis of real-world studies. (clinimmsoc.org)
In the 12-month phase 3 TRANSFORMS study, fingolimod showed greater efficacy than intramuscular interferon beta (IFNβ)-1a in patients with relapsing-remitting multiple sclerosis (RRMS). (nih.gov)
LI, D. K. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. (bvsalud.org)

Recombinant interferon (IFN) β-1b was approved by the US Food and Drug Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in 1993. (physiciansweekly.com)
BACKGROUND: Whether combined treatment with recombinant interferon beta-1b and lopinavir-ritonavir reduces mortality among patients hospitalized with Middle East respiratory syndrome (MERS) is unclear. (wustl.edu)
Hospitalized adults with laboratory-confirmed MERS were randomly assigned to receive recombinant interferon beta-1b plus lopinavir-ritonavir (intervention) or placebo for 14 days. (wustl.edu)
CONCLUSIONS: A combination of recombinant interferon beta-1b and lopinavir-ritonavir led to lower mortality than placebo among patients who had been hospitalized with laboratory-confirmed MERS. (wustl.edu)

Background: Interferon beta (IFNB) is available in parenteral formulations for treatment of multiple sclerosis (MS). The purpose of this study was to evaluate safety, tolerability and effects on MRI lesions of three different doses of oral IFNB-1a compared with placebo over six months in relapsing-remitting (RR) MS patients. (amsterdamumc.org)

This is why interferon therapies for viral infections are typically a last resort -- the potential for dire side effects. (medicinenet.com)
Interferons are naturally occurring proteins that release in response to viral infections and pathogens. (mrmed.in)

In 2014, the FDA approved a new form of this medication Plegridy ("pegylated" form of interferon) for the approved treatment of relapsingâ€¨ MS. Plegridy can be administered subcutaneously every two weeks. (clinimmsoc.org)
Plegridy (peginterferon beta-1a) is the first pegylated. (mims.co.uk)

Do not take BETASERON ® (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or mannitol. (betaseron.com)

Researchers have long hypothesized that interferons evolved many different subtypes not just for the sake of redundancy, but because those subtypes have different biologic roles," said Oldstone. (sciencedaily.com)
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (nih.gov)

IInterferon beta-1b is in a class of medications called immunomodulators. (medlineplus.gov)
Pegylated Interferon Beta-1A Injection belongs to the class of immunomodulators. (mrmed.in)

8. Gerischer LM, Siebert E, Janke O, Jungehuelsing GJ, Ruprecht K. Favorable outcome of interferon-beta associated thrombotic microangiopathy following treatment with corticosteroids, plasma exchange and rituximab: A case report. (clinimmsoc.org)
The MHRA has reminded healthcare professionals to be vigilant for signs or symptoms of thrombotic microangiopathy and nephrotic syndrome in patients with multiple sclerosis receiving interferon beta. (mims.co.uk)
Both thrombotic microangiopathy and nephrotic syndrome may develop several weeks to several years after starting treatment with interferon beta. (mims.co.uk)

Mani, S , Todd, M & Poo, WJ 1996, ' Recombinant beta-interferon in the treatment of patients with metastatic renal cell carcinoma ', American Journal of Clinical Oncology: Cancer Clinical Trials , vol. 19, no. 2, pp. 187-189. (elsevierpure.com)

Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). It is produced by mammalian cells, while interferon beta-1b is produced in modified E. coli. (wikipedia.org)
Interferon-beta is a cytokine (intracellular immune messenger) that binds to its receptors on cells to induce specific biological effects. (ms-selfie.blog)

Interferon therapy, and specially interferon beta 1b, induces the production of neutralizing antibodies, usually in the second 6 months of treatment, in 5 to 30% of treated patients. (wikipedia.org)

BETASERON is an interferon beta indicated for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. (nih.gov)
Cases of pulmonary arterial hypertension (PAH) have been reported in patients treated with interferon beta products, including BETASERON. (nih.gov)
To access the professional site for information about BETASERON ® (interferon beta-1b) please confirm that you are a healthcare professional. (betaseron.com)
Your healthcare provider will help you understand the benefits and the possible side effects of taking BETASERON ® (interferon beta-1b). (betaseron.com)
BETASERON ® (interferon beta-1b) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. (betaseron.com)
An MS-trained BETA Nurse is available 24/7 to answer your questions about BETASERON. (betaseron.com)

[7] [8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway , along with MAPK , PI3K , and Akt signaling pathways. (wikidoc.org)
Interferon Beta 1a, specifically, activates macrophages that engulf antigens and natural killer cells (NK cells), a type of immune T-Cell. (medicinenet.com)
Background: SARS-CoV-2 infection activates interferon-controlled signaling pathways and elicits a wide spectrum of immune responses and clinical manifestations in human patients. (gob.pe)

Interferon beta-1a and beta-1b are indicated for the treatment of remitting-relapsing multiple sclerosis (pictured). (mims.co.uk)

Interferons are widely used platform therapies as disease-modifying treatment of patients with multiple sclerosis. (uni-wuerzburg.de)
These systemic Interferons are widely used platform therapies as disease-modifying treatment of patients with multiple sclerosis. (uni-wuerzburg.de)

Although interferons are usually safe and well tolerated, they frequently cause dermatological side effects. (uni-wuerzburg.de)

ABSTRACT The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. (who.int)

There were no objective responders among the 15 patients treated with recombinant beta-interferon at an i.v. dose escalating from 90 x 10 6 to 720 x 10 6 U given three times a week until there was documented disease progression or complete response (CR). (elsevierpure.com)
MxA mRNA Quantification and Disability Progression in Interferon Beta-Treated Multiple SclerosisPatients. (ms-selfie.blog)
Pegylated Interferon Beta-1A directly binds to the receptors on the surface of cells and drastically reduces inflammation, thus slowing down the progression of disease and preventing its relapse. (mrmed.in)

We compared fingolimod with interferon beta-1a in this population. (elsevierpure.com)
RESULTS Of a total of 215 patients, 107 were assigned to fingolimod and 108 to interferon beta-1a. (elsevierpure.com)
Adverse events, excluding relapses of multiple sclerosis, occurred in 88.8% of patients who received fingolimod and 95.3% of those who received interferon beta-1a. (elsevierpure.com)
CONCLUSIONS Among pediatric patients with relapsing multiple sclerosis, fingolimod was associated with a lower rate of relapse and less accumulation of lesions on MRI over a 2-year period than interferon beta-1a but was associated with a higher rate of serious adverse events. (elsevierpure.com)
PARADIGMS Study Group 2018, ' Trial of fingolimod versus interferon beta-1a in pediatric multiple sclerosis ', New England Journal of Medicine , vol. 379, no. 11, pp. 1017-1027. (elsevierpure.com)

Interferon beta-1a is available only in injectable forms, and can cause skin reactions at the injection site that may include cutaneous necrosis. (wikipedia.org)
Also over time, a visible dent at the injection site due to the local destruction of fat tissue, known as lipoatrophy, may develop, however, this rarely occurs with interferon treatment. (wikipedia.org)
Interferon beta-1b injection comes as a powder to be mixed with liquid and injected subcutaneously (just under the skin). (medlineplus.gov)
Inject interferon beta-1b injection at around the same time of day each time you inject it. (medlineplus.gov)
Use interferon beta-1b injection exactly as directed. (medlineplus.gov)
Your doctor will probably start you on a low dose of interferon beta-1b injection and gradually increase your dose. (medlineplus.gov)
Your doctor or nurse will show you or a caregiver how to prepare and inject a dose of interferon beta-1b injection at home. (medlineplus.gov)
Tissue damage at the site of injection occurs with all of the interferons but more commonly with interferon beta-1b and pegylated interferon alfa-2b. (medicinenet.com)
Pegylated Interferon Beta-1A Injection has been developed to treat adults with relapsing forms of multiple sclerosis like clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease. (mrmed.in)
During the Pegylated Interferon Beta-1A injection treatment, your doctor may periodically monitor your blood pressure, blood sugar, electrolytes, heart, liver and kidney parameters to prevent serious complications. (mrmed.in)
Do not use this injection if you are allergic to interferon beta, rubber or latex. (mrmed.in)
The common side effects that are likely to occur while you are on the treatment with Pegylated Interferon Beta-1A Injection are injection site reactions, chills, fever, headache, muscle pain, asthenia, pruritus, injection site pain, etc. (mrmed.in)
You can inject Pegylated Interferon Beta-1A Injection on your own after receiving proper training from your healthcare provider. (mrmed.in)
How to store Pegylated Interferon Beta-1A Injection? (mrmed.in)
Store Pegylated Interferon Beta-1A Injection in a refrigerator without freezing. (mrmed.in)
How is Pegylated Interferon Beta-1A Injection administered? (mrmed.in)
How do you manage side effects of Pegylated Interferon Beta 1A Injection? (mrmed.in)

Interferon beta differs from naturally occurring human protein by a single amino acid substitution and the lack of carbohydrate side chains which alters the expression and response to surface antigens and can enhance immune cell activities. (advochealth.com)
The study below shows that the greater average induction of this protein in MSers treated with interferon-beta predicts response to interferons. (ms-selfie.blog)
Aggregates play a major role in the immunogenicity of recombinant human interferon beta (rhIFNβ), a protein used to treat multiple sclerosis. (uu.nl)
Interferon beta-1a has the same amino acid sequence as a naturally occurring protein called interferon beta, which is in a class of proteins called type 1 interferons. (scitechdaily.com)

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with interferon beta-1b and each time you refill your prescription. (medlineplus.gov)

A review of the literature on the use of beta-interferon for metastatic RCC suggests that there may be some efficacy, but our experience with escalating i.v. doses ≤720 x 10 6 U given three times a week does not support it. (elsevierpure.com)
Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalized adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial" by Tom Wilkinson, 18 October 2021, The Lancet Respiratory Medicine . (scitechdaily.com)

Some research indicates that interferon injections may result in an 18-38% reduction in the rate of MS relapses. (wikipedia.org)
Interferons reduce relapses by approximately 30% and their safe profile make them the first-line treatments. (wikipedia.org)

The mechanism of action of interferon is complex and is not well understood. (medicinenet.com)

After that, you can inject interferon beta-1b yourself or have a friend or relative perform the injections. (medlineplus.gov)
You can inject interferon beta-1b anywhere on your abdomen, buttocks, the back of your upper arms, or your thighs, except the 2-inch (5-centimeter) area around your navel (belly button) and waistline. (medlineplus.gov)
Can you inject Pegylated Interferon Beta-1A on your own? (mrmed.in)

2023. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/109300/1/interferon_beta_1b. (unboundmedicine.com)
2023. https://im.unboundmedicine.com/medicine/view/Davis-Drug-Guide/109299/all/interferon_beta_1a. (unboundmedicine.com)

Interferons, a subclass of cytokines, are produced in the body during illnesses such as influenza in order to help fight the infection. (wikipedia.org)
You may be interested to know that interferon-beta was originally tried in MSers by Larry Jacobs as he thought MS was due to a viral infection. (ms-selfie.blog)
Serious adverse events occurred in 7 patients (6.5%) in the interferon beta-1a group and included infection (in 2 patients) and supraventricular tachycardia (in 1 patient). (elsevierpure.com)
In addition, previous studies of hospitalized patients with COVID-19 demonstrated reduced production of interferon in response to SARS-CoV-2 infection in many patients, and this was associated with more severe disease. (scitechdaily.com)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Simian Interferon Gamma (IFNg) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (maracpe.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Simian Interferon Gamma (IFNg) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (maracpe.org)
Description: A sandwich ELISA kit for detection of Interferon Gamma from Simian in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (maracpe.org)

Serious infections were not more frequent with ocrelizumab compared to the interferon (1.3 versus 2.9 per cent respectively). (sciencedaily.com)

Any suspected adverse reactions to interferon beta should continue to be reported via the Yellow Card scheme . (mims.co.uk)

A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia . (scitechdaily.com)
Interferon beta has both antiviral and anti-inflammatory properties. (scitechdaily.com)

Interferon beta-1a, currently in use to treat multiple sclerosis , and interferon alfa-2b are both under investigation as potential treatments for people with COVID-19 coronavirus disease, the deadly respiratory pandemic caused by the SARS -nCoV-2 virus. (medicinenet.com)

It is known that 30% of MS patients are non-responsive to Beta interferon. (wikipedia.org)
Moreover, a subset of RRMS patients with specially active MS, sometimes called "rapidly worsening MS" are normally non-responders to interferon beta 1a. (wikipedia.org)
Many patients report influenza-like symptoms hours after taking interferon beta that usually improve within 24 hours, being such symptoms related to the temporary increase of cytokines. (wikipedia.org)
Nevertheless, recommendation is that all patients should be monitored through laboratory blood analyses, including liver function tests, to ensure safe use of interferons. (wikipedia.org)
If the diagnosis is confirmed, patients should be treated immediately (with plasma exchange if necessary) and interferon beta therapy discontinued. (mims.co.uk)
Renal function should be monitored periodically in patients receiving interferon beta. (mims.co.uk)
It is possible there is a hesitance to use interferon in America because it was used in the late 1990s and early 2000s to treat Hepatitis C , and its side effects caused a lot of injury to U.S. patients. (medicinenet.com)
We report on the clinical course of 15 patients with metastatic renal cell carcinoma (RCC) who were treated with recombinant beta-interferon as part of a phase I-II study. (elsevierpure.com)
Thus, at our institution, in a cohort of 15 patients with metastatic RCC, recombinant beta-interferon when given i.v. at a dose ≤720 x 10 6 U three times per week, yielded no clinical antitumor activity. (elsevierpure.com)
This is why I tell patients in my care that are doing well on interferon-beta (NEDA) to stay on the drug. (ms-selfie.blog)
ADA data generated in Europe during the more than 10 years of ADA monitoring in MS patients treated with interferon beta (IFNβ) and natalizumab have been pooled and characterized through collaboration within a European consortium. (gencat.cat)
Methods: Here, we investigate the impact of prior vaccination on the innate immune response of hospitalized COVID-19 patients infected with the SARS-CoV-2 Beta variant through RNA sequencing of peripheral blood immune cells. (gob.pe)
We report on nine patients with multiple sclerosis who had received interferon beta-1a treatment for 6 months or more. (hkmj.org)
This study could not show whether or not the use of interferon beta-1a was beneficial to non-compliant patients, or patients with other types of multiple sclerosis. (hkmj.org)
Malignancies occurred in four ocrelizumab-treated patients and in two interferon-treated patients. (sciencedaily.com)
In addition, in a subgroup of patients who required high-flow oxygen, investigators found that interferon beta-1a was associated with more adverse events and worse outcomes. (scitechdaily.com)
However, most patients tolerate doses titrated following adult protocols or gradual titration to 30 µg once weekly for interferon-beta-1a IM and 22-44 µg SC 3 times/week for interferon-beta-1a. (medscape.com)

In conclusion, we think that neurologists should be aware of systemic cutaneous side effects and have a closer look on interferon-associated skin lesions. (uni-wuerzburg.de)

Another common transient secondary effect with interferon-beta is a functional deterioration of already existing symptoms of the disease. (wikipedia.org)
interferon naturally occurring in the body is responsible for all flu-like symptoms to begin with, whether you have the coronavirus or a common cold . (medicinenet.com)
So, if someone is already on a ventilator and symptoms are about to overwhelm them, giving them an interferon-based medicine could be catastrophic. (medicinenet.com)
You can manage flu-like symptoms associated with the use of Pegylated Interferon Beta 1A by drinking sufficient water and taking over-the counter painkillers and fever medications. (mrmed.in)
For example, many children on interferon (35%-65%) report flulike symptoms. (medscape.com)

Case presentation: A 54-year-old female with past medical history of well-controlled multiple sclerosis on interferon-beta since 2013, presented with witnessed tonic colonic seizure. (lu.se)
The patient was started on seizure prophylxis and Interferon beta was discontinued. (lu.se)
Conclusions: A middle-aged female with multiple sclerosis who was on chronic IFN-beta presented to the emergency room with a witnessed tonic-clonic seizure, with MRI T2 FLAIR imaging consistent with PRES. (lu.se)

Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. (nih.gov)

a lack of induction or poor induction of MxA once you have been on IFN-beta for several months is predictive of NABs. (ms-selfie.blog)

This case illustrates that interferons not only cause local but also systemic adverse events of the skin. (uni-wuerzburg.de)
These changes were made after the study's Data and Safety Monitoring Board (DSMB) noted a greater rate of severe adverse events, particularly worsening of respiratory status, among participants requiring high-flow oxygen at enrollment who received interferon beta-1a compared to those who did not receive interferon beta-1a. (scitechdaily.com)

In addition, pulmonary expression of interferon alpha and beta and Irf7 specific pattern recognition receptors (PRR) and signaling molecules (Ddx58, Ifih1, Dhx58, ISGF3) were induced, an effect that showed specificity when compared to other inflammatory exposures. (cdc.gov)

Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster. (nih.gov)
Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (nih.gov)
The main difference between interferon 1A and 1B is that interferon-1A is more similar to the interferon naturally present in the human body. (mrmed.in)
this work, we studied the immunogenicity of recombinant human interferon beta-1a (rhIFNβ-1a) interacting with glass microparticles, stainless steel microparticles, and polystyrene nanoparticles. (uu.nl)
Incubation with stainless steel considerably enhanced the immunogenicity of rhIFNβ-1a in transgenic mice immune tolerant for human interferon beta. (uu.nl)

While more studies of the long-term effects of the drugs are needed, existing data on the effects of interferons indicate that early-initiated long-term therapy is safe and it is related to better outcomes. (wikipedia.org)
Beta interferon drugs help regulate the immune cells. (medicalnewstoday.com)

Participants were assigned at random in a 1-to-1 ratio to receive either interferon beta-1a plus remdesivir or a placebo plus remdesivir. (scitechdaily.com)

It is not known if Pegylated Interferon Beta-1A passes into the breastmilk. (mrmed.in)

Detection of psoriasiform lesions might indicate that interferons are probably not beneficial in the individual situation. (uni-wuerzburg.de)

Anatomy16

Organisms12

Diseases7

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes23

Technology, Industry, Agriculture1

Information Science3

Health Care1

Avonex7

Subcutaneous6

Rebif1

Glatiramer acetate3

Intramuscular Interferon Be2

Type I interferon receptor2

Receptor8

Anti-interferon beta2

Betaferon10

Available interferons3

Levels of interferon2

Immune system10

Relapsing-Remitting Multiple Sclerosis5

Recombinant interferon4

IFNB1

Viral infections2

Plegridy2

Albumin1

Subtypes2

Immunomodulators2

Thrombotic microangiopathy3

19961

Cytokine2

Antibodies1

BETASERON6

Activates3

Treatment of remitting-relapsin1

Therapies2

Safe and well tolerated1

Abstract1

Progression3

Fingolimod5

Injection17

Protein4

Medication1

Efficacy2

Relapses2

Mechanism of act1

Inject3

20232

Infection4

Gamma3

Versus1

Reactions1

Antiviral2

Treat multiple sclerosis1

Patients17

Cutaneous1

Symptoms5

Seizure3

Virus-induced1

Induction1

Adverse2

Receptors1

Human5

Drugs2

Placebo1

Breastmilk1

Lesions1