We identified Interferon regulating factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2) and S100 calcium binding protein A12 (S100A12) as the three proteins with the largest fold change between SLE patients and controls (SLE/Control = 1.4, 1.4, and 1.2 respectively). (nih.gov)
Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection. (umassmed.edu)
Genes7
Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. (wikipedia.org)
IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES. (umassmed.edu)
The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
By gene expression profiling, we have found that genes in the interferon (IFN) pathway were dysregulated during the spontaneous cellular immortalization of fibroblasts from Li-Fraumeni syndrome (LFS) patients with germ-line mutations in p53. (figshare.com)
We conclude that the epigenetic inactivation of the IFN pathway plays a critical role in cellular immortalization, and the reactivation of IFN-regulated genes by transcription factors IRF5 and/or IRF7 is sufficient to induce cellular senescence. (figshare.com)
Interferon tau (IFNtau) is the pregnancy recognition signal produced by the conceptus trophectoderm and acts in a paracine manner on the ovine endometrium to increase expression of IFN-stimulated genes primarily in the stroma and deep glandular epithelium, including IFN regulatory factor-1 (IRF-1). (tamu.edu)
This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. (nih.gov)
IRF56
IRF5 and SAM pointed domain containing ETS transcription factor (SPDEF). (nih.gov)
Unsupervised clustering of all investigated proteins identified three molecular subgroups among SLE patients, characterized by (1) high levels of rheumatoid factor-IgM, (2) low IRF5, and (3) high IRF5. (nih.gov)
IRF5 expressing microparticles were analyzed by flow cytometry in a subset of patients to confirm the presence of IRF5 in plasma and detection of extracellular IRF5 was further confirmed by immunoprecipitation-mass spectrometry (IP-MS). Interestingly IRF5, a known genetic risk factor for SLE, was detected extracellularly and suggested by unsupervised clustering analysis to differentiate between SLE subgroups. (nih.gov)
Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. (ox.ac.uk)
Bisulfite sequencing of the promoter regions of two IFN regulatory transcription factors (IRF5 and IRF7) revealed that IRF7, but not IRF5, was epigenetically silenced by methylation of CpG islands in immortal LFS cells. (figshare.com)
Betsy Jo Barnes, PhD, Professor at Northwell Health Feinstein Institutes for Medical Research in New York, studies the interferon regulatory factor 5 (IRF5) gene. (lupusresearch.org)
Within our dataset, Interferon regulatory factor 3 (IRF3) emerged as a leading candidate mediator of leptin-induced hunger-suppression. (biorxiv.org)
IRF72
Results: The novel finding was a dominant type I interferon signaling network with the transcription factor Irf7 as a central component maintained through 28 d. (cdc.gov)
In addition, pulmonary expression of interferon alpha and beta and Irf7 specific pattern recognition receptors (PRR) and signaling molecules (Ddx58, Ifih1, Dhx58, ISGF3) were induced, an effect that showed specificity when compared to other inflammatory exposures. (cdc.gov)
Pathway1
These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
IRF42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interferon Regulatory Factor 4 (IRF4) in Tissue homogenates, cell lysates and other biological fluids. (operatiebrp.nl)
Interferon regulatory issue 4 ( IRF4 ) is a transcription issue that regulates regular and malignant immune cell improvement and is implicated in a number of myeloma pathogenesis. (aetox.com)
Transcriptional7
The zinc finger protein ZNF224 can act as a transcriptional co-factor of WT1 and potentiate the cytotoxic response to the cytostatic drug cytarabine. (lu.se)
In this study, the role of the transcriptional activator IFN regulatory factor-1 (IRF-1) in murine NK cell activity was assessed. (silverchair.com)
Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages. (cornell.edu)
Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. (rcsb.org)
Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). (abcam.com)
Identifying the relevant transcriptional regulatory pathways in these neurons has been a priority, yet such attempts have been stymied due to their low abundance and the rich cellular diversity of the ARC. (biorxiv.org)
Cis-regulatory analysis of these integrated datasets enabled the identification of 28 putative hunger-promoting and 29 putative hunger-suppressing transcriptional regulators in AgRP neurons, 16 of which were predicted to be transcriptional effectors of leptin. (biorxiv.org)
These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. (rcsb.org)
Remarkably, these effects showed consistency across all tissues indicating a systemic type I interferon response that was complemented by changes in serum proteins (decreased MMP-9, CRP and increased VCAM1, oncostatin M, IP-10). (cdc.gov)
Inhibits type2
including vIRF1, which is a transforming oncoprotein that inhibits type 1 interferon activity. (wikipedia.org)
Human respiratory syncytial virus (RSV), a leading cause of respiratory tract infections in infants, inhibits type I interferon (IFN)-dependent signalling, as well as IFN synthesis. (microbiologyresearch.org)
IRF12
The results of the miRNA-prognostic DEPRG-TF regulatory network showed that GSDMC, IRF1, and PLCG1 were regulated by both specific and common miRNAs and TFs. (hindawi.com)
Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. (cedars-sinai.edu)
Macrophages1
Macrophages can kill specific tumor cells when activated by a combination of factors, including lymphokines (soluble factors produced by T cells) and interferon. (msdmanuals.com)
Hematopoietic1
The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein. (lu.se)
Post-Translational1
Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
Cells10
The activation of natural killer (NK) cells, cytotoxic lymphocytes capable of major histocompatibility complex (MHC)-unrestricted killing and early antiviral defense, is temporally related to the increased interferon (IFN)-alpha/beta production that is seen in the viral infection of mice. (silverchair.com)
Interferon regulatory factor 1 (IRF-1) is an important transcription factor in interferon gamma (IFNgamma)-mediated signaling in the development and function of NK cells and cytotoxic T lymphocytes. (cornell.edu)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
Under stress, microglial cells are induced into the M1 type, releasing inflammatory factors and causing neuroinflammatory responses. (frontiersin.org)
FoxP3 + regulatory T cells (Tregs) are wanted to suppress inflammatory ailments and keep immune homeostasis. (aetox.com)
Regulatory T cells (Tregs) are specifically reduced in adipose tissue of obese animals. (diabetesjournals.org)
In lab and animal studies, Dr. Barnes developed a nontoxic inhibitor molecule that penetrates the cell membrane and enters into a variety of immune cells, including those called plasmacytoid dendritic cells, a rare type of immune cell known to secrete large quantities of type 1 interferons, which are the main disease drivers in lupus. (lupusresearch.org)
Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
Gamma2
Decreased interferon-gamma may contribute to increased susceptibility to HSV infection in atopic skin. (medscape.com)
Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)
Type5
As the second messenger, cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. (frontiersin.org)
Description: A sandwich ELISA kit for detection of Interferon Regulatory Factor 4 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
A high total serum immunoglobulin E level has been identified as a risk factor for the development of KVE. (medscape.com)
Activation1
Activation and function of interferon regulatory factor 5. (ox.ac.uk)
Genetic3
Genetic risk factors play an important role in autoimmune disease susceptibility. (hindawi.com)
In particular, we are interested in papers describing novel genetic associations with autoimmune disease, genetic factors which predict disease outcome, or disease phenotype and papers which characterize the molecular or biological function of a known autoimmune disease risk variant. (hindawi.com)
host factors i.e., genetic differences in immune-signalling or senescence, and (iii. (smw.ch)
Expression2
The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. (lu.se)
Multivariate analysis showed that VGLL3 expression status was an independent risk factor for prognosis. (researchgate.net)
Response1
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. (microbiologyresearch.org)
Function2
For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein. (wikipedia.org)