Interaction repressor proteins. Medical search. Frequent questions

Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proceedings of the National Academy of Sciences of the United States of America. (wikipedia.org)
In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins. (kegg.jp)
Unlike immunofluorescence microscopy approaches, which provide correlative information about proteins sharing cellular space, co-IP can confirm direct often high-affinity physical interactions between two proteins or protein complexes of equal or better affinity. (aacrjournals.org)
Ultimately, this task is accomplished experimentally using techniques such as empirical deletion analysis, direct binding measurements, and co-precipitation of protein-DNA complexes. (biomedcentral.com)
It is assumed that the Id helix-loop-helix (HLH) proteins act by associating with ubiquitously expressed basic HLH (bHLH) transcription factors, such as E47 and E2-2, which prevents these factors from forming functional hetero- or homodimeric DNA binding complexes. (lu.se)
A novel protein call AnkA in A. phagocytophilum is translocated from the bacterium within a host vacuole into the host nucleus, where it forms complexes with heterochromatin and is largely responsible for many host transcriptional changes by directly binding to regulatory regions of the DNA. (cdc.gov)
Protein complexes, which are formed as a result of these interactions, consist of two or more components that associate along specific pathways - protein association pathways. (lu.se)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

Interaction with CTNNB1 results in transactivation of TCF1 target genes. (biolegend.com)
Binding of GA to its nuclear receptor GID1 enhances the GID1-DELLA interaction, which in turn leads to the rapid proteolysis of DELLA through the ubiquitin-proteasome pathway, and allows transcriptional reprogramming of GA-responsive genes. (duke.edu)
However, the existence of specific transcriptional repressors responsible for the silencing of lineage inappropriate genes remains elusive. (eur.nl)
Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
I want to have a network of the interactions between the proteins of these 100 genes. (stackexchange.com)
Each repressor targets a specific co-regulated group of genes by recognizing a specific sequence of DNA, called the operator in bacteria . (proteopedia.org)
Repressor proteins are coded for by regulatory genes. (proteopedia.org)
The lac repressor, and the group of genes it controls, which is called an operon , were the first such gene regulatory system to be discovered. (proteopedia.org)
The transcription rate of genes is dictated primarily by interactions between DNA-binding transcription factors. (biomedcentral.com)
Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)
Las redes funcionan para en última instancia especificar la expresión de conjuntos concretos de GENES para estados, momentos o lugares específicos. (bvsalud.org)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)

MDM2 is a multidomain protein that functions as an E3 ubiquitin ligase, transcription repressor, mRNA-binding protein, translation factor, and molecular chaperone. (ed.ac.uk)
In the inhibition of shoot branching, the α/β hydrolase D14-which metabolizes strigolactone-interacts with the F-box protein D3 to ubiquitinate and degrade the transcription repressor D53. (cam.ac.uk)

Lin F, Morrison JM, Wu W, Worman HJ: MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. (hmdb.ca)
When the lac repressor binds lactose, it changes to an inactive conformation that cannot repress the production of these enzymes. (proteopedia.org)
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a candidate vaccine antigen that binds angiotensin-converting enzyme 2(ACE2), leading to virus entry. (cdc.gov)

NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. (abcam.com)

Surprisingly, we recently found that DELLA directly interacts with multiple classes of key regulatory proteins in other signaling pathways. (duke.edu)
In S. cerevisiae , this interaction is at least in part provided by Spp1 that directly interacts with both methylated H3K4 near DSB sites and the axis-localized protein Mer2 (Acquaviva et al. (springer.com)
Pan D, Estevez-Salmeron LD, Stroschein SL, Zhu X, He J, Zhou S, Luo K: The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines. (hmdb.ca)
This led us to propose that wild-type Ataxin-1 might take on a conformation that resists clearance or interacts strongly with other proteins and that such conformation is favored by the expanded polyglutamine tract. (bcm.edu)

PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
Also, this region may contain nuclear localization signals and protein-protein interaction sites. (indigobiosciences.com)
SUMOylation influences Bonus's subnuclear localization, its association with chromatin and interaction with SetDB1. (elifesciences.org)

Members of this family have been shown to bind to KNOX and BELL- like TALE class homeodomain proteins. (utoronto.ca)

During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. (biolegend.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)
I have used STRING pretty heavily, and have compared it to various other databases of protein interactions and signaling pathways. (stackexchange.com)
In fact, biological outcomes are often due to physical interactions between proteins that are so highly selective that seemingly minor chemical modifications (i.e. methylation, acetylation or phosphorylation) can completely abolish biomolecular recognition processes and redirect signaling pathways. (mtu.edu)

Further analysis of two overlapping deficiency lines and mutant alleles led to identification of genetic interactions between the CDK8-CycC pair and the components of the Decapentaplegic (Dpp, the Drosophila homolog of TGFβ, or Transforming Growth Factor-β) signaling pathway. (sdbonline.org)

One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)
The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation. (embl.de)

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)
In vitro analysis revealed that a putative switch-protein kinase regulator, RsbW, is capable of interacting directly with σ 66 , as well as phosphorylating its own antagonist, RsbV1, rendering it inactive. (plos.org)
These tend to fall roughly into two categories: validation of putative or suspected interactions and identification of unknown associated proteins. (aacrjournals.org)

Compared to other vaccine formulations, immunization using CoPoP liposomes admixed with recombinant RBD induces multiple orders of magnitude higher levels of antibody titers in mice that neutralize pseudovirus cell entry, block RBD interaction with ACE2, and inhibit live virus replication. (cdc.gov)

DNA-binding proteins (DNA-BPs) and RNA-binding proteins (RNA-BPs) have critical roles in living cells in all kingdoms of life. (nature.com)
Motion, G.B., Howden, A.J.M., Huitema, E. & Jones, S. DNA-binding protein prediction using plant specific support vector machines: validation and application of a new genome annotation tool. (nature.com)
Collectively, these data highlight a biological role for SMRT in mediating DNA damage responses and suggest a model where p53 binding to the DAD limits HDAC3 interaction with this coregulator, thereby facilitating SMRT coactivation of p53-dependent gene expression. (nih.gov)
The analogous question of protein: DNA binding specificities has been answered through the use of DNase I footprinting. (caltech.edu)
Fe(II) footprinting has been compared with DNase I footprinting in their ability to determine the binding specificities of both small molecules and proteins. (caltech.edu)
Both methods provided similar information in the case of a sequence-specific DNA binding protein, lac repressor. (caltech.edu)
binding cooperativity of different small molecules) on the interactions of small molecules with native DNA. (caltech.edu)
The D-domain appears to allow for conformational changes in the protein structure following ligand binding. (indigobiosciences.com)
More than 95% of individuals with RTT have mutations in methyl-CpG-binding protein 2 (MECP2), whose protein product modulates gene transcription. (bmj.com)
This binding of Nutlin-3 has two consequences: (i) antagonistic effects through competitive disruption of the MDM2-p53 complex and (ii) agonist effects that allosterically stabilize MDM2 protein-protein interactions that increase p53 ubiquitination as well as nucleophosmin deoligomerization. (ed.ac.uk)
Pharmacologic inhibition of the retinol-induced interaction of retinol-binding protein 4 (RBP4) with transthyretin (TTR) in the serum may decrease the uptake of serum retinol to the retina and reduce formation of lipofuscin bisretinoids. (arvojournals.org)
RBP4 binding potency, ability to antagonize RBP4-TTR interaction, and compound specificity were analyzed for A1120 and for the prototypic RBP4 antagonist fenretinide. (arvojournals.org)
In comparison to fenretinide, A1120 did not act as a RARα agonist, while exhibiting superior in vitro potency in RBP4 binding and RBP4-TTR interaction assays. (arvojournals.org)
The functions currently known for members of the KRAB-containing protein family include transcriptional repression of RNA polymerase I, II and III promoters, binding and splicing of RNA, and control of nucleolus function. (embl.de)
The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. (embl.de)
KRAB (Kruppel-associated box) is an evolutionarily conserved protein domain found N-terminally with respect to the zinc finger repeats that encodes the DNA binding domain. (embl.de)
Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models. (ox.ac.uk)
Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. (ox.ac.uk)
Methyl-histone binding analysis of the yeast double chromodomain protein Chd1. (mtu.edu)
Specific sites within such regions are recognized by regulatory proteins (transcription factors), which act upon binding as transcriptional repressors or activators, controlling the rate of transcription. (biomedcentral.com)
It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. (nih.gov)
RS is related to various mutations on the MECP2 gene, which codes for methyl-CpG binding protein-2 (MECP2). (medscape.com)
However, the Id proteins did complex with HES-1, and increased levels of Id2 reduced the DNA binding activity of HES-1. (lu.se)

Different dimer combinations act as transcriptional activators or repressors, respectively. (abcam.com)
In principle, development of small molecule inhibitors of interactions of specific transcriptional activators (or repressors) with DNA or with the basal transcription machinery could provide highly selective regulators of gene expression and thus highly selective therapeutic agents (e.g., antiviral agents based on disabling essential viral gene expression). (mtu.edu)

As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)
A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. (cshlpress.com)
Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. (cshlpress.com)
Solid evidence, leveraging both in vivo and in vitro studies, reveals the molecular requirements for Bonus' function as a transcriptional repressor, including a key role for sumoylation. (elifesciences.org)
SCRIPTS: ~~~~~~~~ present.tcl -- the master script, which sets up sets up the VMD presentation styles and colors, loads lac repressor + water, calls the other scripts (which create the Tk menus and load the PDB data for the elastic loop molecular sets), and resets the presentation to its initial state. (uiuc.edu)
Recognizing the importance of protein interactions for mediating SCA1 pathogenesis, and given that SCA1 shares clinical and pathological features with several other inherited ataxias, we proposed that understanding the interactions of Ataxin-1 as they relate to the interactions of proteins implicated in other ataxias might provide better insight about molecular mechanisms leading to Purkinje cell degeneration and ataxia. (bcm.edu)
I'm using cell and molecular biology techniques, biochemistry as well as microscopy to characterise the plant SUN proteins. (brookes.ac.uk)

Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (embl.de)

The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)

The formation of a complex then enables Lon to degrade free ribosomal proteins. (go.jp)

A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta, KRAB-A interacting protein and tripartite motif protein 28). (embl.de)

In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors. (wikipedia.org)
Functions as a transcriptional repressor that suppresses cell elongation. (utoronto.ca)
In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
We are interested in other related functions of EBNA3C through its interactions with a number of other cellular molecules. (pennmedicine.org)
Despite the fact that multiple modes of interaction between D14 and strigolactone have recently been determined, how the hydrolase functions with D3 to mediate hormone-dependent D53 ubiquitination remains unknown. (cam.ac.uk)
This includes finding out what other proteins the SUNs bind to and what functions they have during cell division. (brookes.ac.uk)
Protein performs its biological functions by interacting with other proteins. (lu.se)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1ß- and RNA-dependent co-activator of osteoclast gene expression. (bvsalud.org)

Proteins of interest (POI) are tagged with a GFP and transiently expressed in plant cells to serve as donor fluorophore. (nature.com)
To solve this dilemma, cells must use their own proteins as sources of amino acids in response to the nutritional downshift. (go.jp)
In particular, quinolone-like compound 91 (C91) at a non-toxic nanomolar concentration reduced mSIN3b nuclear entry and occupancy at the RE1/NRSE within the Bdnf locus, and restored brain-derived neurotrophic factor (BDNF) protein levels in HD cells. (ox.ac.uk)
Our analysis of SCA1 transgenic mice revealed that the mutant protein aggregates in the nuclei of cerebellar Purkinje cells and that these aggregates stain positively for ubiquitin, the proteasome, and some chaperones. (bcm.edu)
In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)
We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells in an undifferentiated state. (lu.se)
The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. (lu.se)

Here we describe how to detect nucleic acid-protein interactions in plant leaves by using a fluorescence resonance energy transfer (FRET) approach coupled to fluorescence lifetime imaging microscopy (FLIM). (nature.com)

Here I propose to call the polyP-Lon complex the "stringent protease," and I discuss new insights of protein degradation control in bacteria. (go.jp)

In collaboration with Harry Orr's group (University of Minnesota), we determined that the mutation responsible for SCA1 is an expansion of a CAG trinucleotide repeat encoding glutamine in the protein Ataxin-1. (bcm.edu)

Several tissue-specific bHLH proteins, including HASH-1, dHAND, and HES-1, are important for development of the nervous system. (lu.se)

This interaction may mediate relocalization of the TALE homeodomain from the nucleus to the cytoplasm. (utoronto.ca)

In addition, we identified proteins that interact with the KRAB domain of PRDM9 in yeast two-hybrid assay screens, particularly CXXC1, a member of the COMPASS complex. (springer.com)
This model predicts that most proteins that interact with wild-type Ataxin-1 should interact with the mutant protein and that modifications of Ataxin-1 that might alter its conformation are critical to pathogenesis. (bcm.edu)
We found that 14-3-3 proteins interact with Ataxin-1 in a S776-dependent manner and that 14-3-3 augments levels of Ataxin-1 when phosphorylated at S776 by Akt kinase. (bcm.edu)

To illustrate our approach, we provide experimental procedures to detect the interaction between plant DNA and two proteins (the AeCRN13 effector from the oomycete Aphanomyces euteiches and the AtWRKY22 defensive transcription factor from Arabidopsis ). (nature.com)

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. (wikipedia.org)
NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains. (wikipedia.org)
the other human protein that is a member of that family is Nuclear receptor co-repressor 1. (wikipedia.org)
We identified the nuclear transcriptional regulators DELLA proteins, which function as master growth repressors by inhibiting all aspects of GA responses. (duke.edu)
Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
EBNA3C is a large nuclear transcription factor involved in modulating transcription activated by a cellular repressor RBP-Jkappa and other transcription factors. (pennmedicine.org)
This suggested to us that the nuclear inclusions are probably protective by sequestering the glutamine-expanded protein and reducing its native interactions. (bcm.edu)

[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)

Hudson, W.H. & Ortlund, E.A. The structure, function and evolution of proteins that bind DNA and RNA. (nature.com)

The lactose ("lac") repressor controls the expression of bacterial enzymes involved in the metabolism of of the sugar lactose. (proteopedia.org)

A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein-DNA interactions. (cshlpress.com)

A general property of disordered proteins is their structural expansion that results in a high macromolecular flexibility. (lu.se)

This technique combines DNase I cleavage of protein protected DNA fragments and Maxam-Gilbert sequence determination methods, relying on the relatively low specificity of DNase I in a partial digestion and the ability of DNA-bound proteins to prevent phosphodiester bond hydrolysis between the base pairs they cover. (caltech.edu)

The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles and proteins, but it is also stimulated by environmental stress conditions, such as starvation, oxidative stress, and the accumulation of misfolded proteins. (mdpi.com)

In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
Encodes a member of the plant specific ovate protein family. (utoronto.ca)
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. (hmdb.ca)
Finally, we showed that Bonus SUMOylation is mediated by the SUMO E3-ligase Su(var)2-10, revealing that although SUMOylation of TIF1 proteins is conserved between insects and mammals, both the mechanism and specific site of modification is different in the two taxa. (elifesciences.org)
This involves purification of a specific protein from the pool of cellular proteins, followed by Western blotting of a suspected interacting protein ( 1 ). (aacrjournals.org)

Figure 8: GFP lifetime distribution of GFP:AeCRN13 and GFP:AeCRN13 AAA fusion proteins in plant nuclei. (nature.com)

In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. (cancerindex.org)
The current focus is copper-containing proteins and we use a multi-disciplinary approach to study the relationship between their structure and function. (ncl.ac.uk)
Significant insight into the function of proteins can be delineated by discovering and characterizing interacting proteins. (aacrjournals.org)
Glutamine-expanded Ataxin-1 causes disease by a gain-of-function mechanism given that mice lacking this protein do not reproduce SCA1 features. (bcm.edu)

What percentage of time this DNA sequence spends in a kinked state, in the absence of bound lac repressor protein, is not known, but it may be a significant percentage (see next section below). (proteopedia.org)
dnademos.tar.gz (5MB) AUTHOR: Alexander Balaeff [email protected] From the README file included with the demos GOAL: ~~~~~ The scripts set up a menu to present the protein-DNA complex of the lac repressor, solvated in a water bath, with different elastic rod loops attached to the protein-bound DNA segments. (uiuc.edu)
On top of the elastic rods, one shows fitted all-atom DNA structures, electric field profiles, forces of protein-DNA interaction, and the CAP protein bound within the short loops. (uiuc.edu)
The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. (brookes.ac.uk)
To demonstrate the flexibility and modular nature of the liposome system, 10 recombinant surface antigens representing distinct influenza virus strains were bound simultaneously to generate a highly multivalent protein particle that with 5 ng individual antigen dosing induced antibodies in mice that specifically recognized the constituent immunogens and conferred protection against heterologous H5N1 influenza virus challenge. (cdc.gov)
In QENS experiments of protein solutions hydrogens act as reporters for the motions of methyl groups or amino acids to which they are bound. (lu.se)

The Dl and Twist proteins appear to make synergistic contact with the basal transcription complex, so that snail is activated throughout the presumptive mesoderm in response to both peak and high levels of the Dl gradient. (sdbonline.org)
Yeast two-hybrid ), those that also find proteins that are in the same complex even if there is no direct interaction between them (e.g. (stackexchange.com)
17-mer used in this work and for the crystal structure of the 2:1 trp repressor/operator complex by Lawson & Carey (1993). (lu.se)
1988) for the d-(ACT)Ád-(AGT) halfsites contacting the repressor in the 1:1 complex. (lu.se)
Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation. (lu.se)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

Alternative translocations include EWS-ERG t(21;22), EWS-ETV t(7;22), and EWS-FEV t(2;22), all of which involve the ETS family protein. (medscape.com)

Mid-SUN proteins are a neglected family of conserved type III membrane proteins of ancient origin with representatives in plants, animals and fungi. (brookes.ac.uk)

Various experimental approaches exist for the study of nucleic acid-protein interactions in vitro and in vivo , but the detection of such interactions at the subcellular level remains challenging. (nature.com)

who also correctly proposed the general mechanism of regulation by the lac repressor. (proteopedia.org)

NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. (abcam.com)
The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. (embl.de)

The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. (kegg.jp)

I do feel like it has a lot of quality interaction annotations, but you have to sift through a lot of noise to get to them. (stackexchange.com)

PRDM9 is a member of the PRDM family of transcription regulators, but unlike other family members, it contains a Krüppel-associated box (KRAB)-related domain that is predicted to be a potential protein interaction domain. (springer.com)
There are 50777 KRAB domains in 49028 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing KRAB domain. (embl.de)
The complete taxonomic breakdown of all proteins with KRAB domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing KRAB domain in the selected taxonomic class. (embl.de)

Anatomy7

Organisms8

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes61

Information Science3

Complexes8

Genes13

Transcription repressor2

Binds3

Domain-containi1

Interacts4

Localization3

Homeodomain proteins1

Coactivator1

Pathways3

Genetic1

Chromatin3

Putative3

Inhibit1

Binding23

Activators2

Molecular8

Zinc finger p1

Transcriptional Activation1

Degrade1

Intermediary Factor1

Functions8

HDAC31

Cells7

Microscopy1

Bacteria1

Mutation1

BHLH1

Mediate1

Interact3

Arabidopsis1

Nuclear7

Tumor1

Bind1

Metabolism1

Insights1

Structural1

Specificity1

Cytoplasmic1

Specific5

Nuclei1

Function4

Bound6

Complex6

Family protein1

Membrane1

Vitro1

Mechanism1

Corepressors2

Species1

Annotations1

KRAB5