Interaction cell cycle. Medical search. Frequent questions

The last model integrates then all the genes of the cell and takes into account their interactions in the productions of different proteins through a common sharing of RNA-polymerases and ribosomes, available in limited quantities. (hal.science)
SL originally described a relationship between two genes, where alteration of either gene alone results in viable cells, but alteration (mutation, loss, or inhibition) of both genes simultaneously was lethal. (nature.com)
Because BRCA mutations are observed in fewer than 10% of cancer patients (cBioPortal: 6.7%) 11 , 12 , 13 the identification of additional genes that share synthetic lethal sensitivity relationships with mutated oncogenes or tumor suppressors would greatly enhance the implementation of tumor cell-specific synthetic lethal sensitivity to improve an anticancer therapeutic response. (nature.com)
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. (thebiogrid.org)
A total of 297 PR CNV regions overlapped with 437 Ensembl genes enriched in immunity and defense, like WC1 gene which uniquely expresses on gamma/delta T cells in cattle. (usda.gov)
Network analyses indicated that the PR specific genes were predominantly involved in gastrointestinal disease, immunological disease, inflammatory response, cell-to-cell signaling and interaction, lymphoid tissue development and cell death. (usda.gov)
By contrast, the 282 PS CNV regions contained 473 Ensembl genes which are overrepresented in environmental interactions. (usda.gov)
Network analyses indicated that the PS specific genes were particularly enriched for inflammatory response, immune cell trafficking, metabolic disease, cell cycle, and cellular organization and movement. (usda.gov)
C. elegans is a popular experimental model that combines transparency, reproducible anatomy, traceable cell lineage, sequenced genome and facile genetics, allowing to dissect animal development, physiology, and behaviour across scales of genes, cells and tissues. (embl.org)
The course lectures and practical modules develop in three axes of genes, cells, tissues. (embl.org)
It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. (cancerindex.org)
That is, enhanced tumor-initiating capacities could come down to interactions between stem cell genes and seemingly unrelated regulatory mechanisms. (genengnews.com)
The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
A recent paper from this study concerning apoptosis and cell cycle control genes identified caspase 8 as a possible susceptibility gene. (cdc.gov)

Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. (europa.eu)
The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. (mdpi.com)
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)
An MTT assay, flow cytometry and RT-PCR were performed to determine cell growth, apoptosis and IRE1α activity, respectively. (bvsalud.org)

While in G1 the cell synthesizes messenger RNA (mRNA) and proteins in preparation for subsequent steps of interphase leading to mitosis. (wikipedia.org)
Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. (ox.ac.uk)
In this project, I will employ biochemical, cell, systems biology and computational approaches to study the relevance of post-transcriptional regulators such as RNA-binding proteins and microRNAs in DDR. (europa.eu)
Quantitative proteomics will be applied to identify the differentially mRNA-bound proteins after the exposure of human cultured cells to ionizing radiation. (europa.eu)
b Cells were collected and heated in a narrow temperature range, with one sample incubated at 37 °C for expression measurements, protein aggregates were eliminated by ultracentrifugation and the soluble proteins were digested. (nature.com)
Whole cell extracts (15 µg protein) from NIH3T3 cells transfected with non-targeting control siRNA (siCON) or siRNA targeting Ahr (siAhr) were resolved on a 4-12% Bis-Tris gel, transferred to PVDF and probed with 1.0 µg/mL (1:500 dilution) of Purified anti-AHR Antibody, clone W16012A, overnight at 4°C. Proteins were visualized by chemiluminescence detection using HRP goat anti-rat IgG antibody (Cat. (biolegend.com)
Each configuration contains a contact zone, consisting of the set of amino acids from both interacting proteins that are with interaction distance, usually spanning from 3 to 5 Ångströms. (biomedcentral.com)
Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. (thebiogrid.org)
To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
Cancer cells tend to deemphasize these molecules because they can display abnormal proteins and attract the immune system's attention. (genengnews.com)
Although cell cycle control is an ancient, conserved, and essential process, some core animal and fungal cell cycle regulators share no more sequence identity than non-homologous proteins. (duke.edu)
Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

and regulation of cell cycle process. (nih.gov)
Regulation of attachment of equine spermatozoa to homologous oviduct epithelium was investigated by co-culture of spermatozoa with oviductal epithelial cell explants. (tamu.edu)
These data support the existence of a spermatozoal reservoir in the oviductal isthmus of the mare and suggest that there may be cycle stage-specific regulation of both motility and the number of spermatozoa attached to oviductal epithelium. (tamu.edu)
Involved in cell-cycle regulation. (biolegend.com)
The key interests lie within the field of genome integrity and variation, cell division, regulation of gene expression, protein turnover and signal transduction. (ki.se)
Furthermore, we used this assay to determine the effects of BRCA1 variants on cell cycle regulation, differentiation, and genomic stability. (jci.org)
This raises the possibility of phosphorylation-mediated control of Pin1-substrate interactions in cell cycle regulation. (rcsb.org)
Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. (kegg.jp)
Philipp was trained as a hard-core biochemist and in his own lab uses extensively genetically modified mice to study cell cycle regulation and human disease. (lu.se)

Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. (nature.com)
Understanding transitions from one cell type or state to another is in the focus of modern molecular biology. (nature.com)
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. (thebiogrid.org)
CMB is comprised of more than 30 independent research groups organized in three themes: Cell Biology, Developmental and Stem Cell Biology and Infection and Cancer. (ki.se)
The central aim of the research within the Cell Biology theme is to gain a deeper understanding of the biology of the eukaryotic cell. (ki.se)
Thus the theme encloses expertise within bioinformatics, biophysics, biochemistry, molecular cell biology and genetics. (ki.se)
The stem cell and developmental biology program at CMB is engaged in a broad range of basic research aimed at understanding the molecular mechanisms underlying diverse aspects of embryonic development and tissue regeneration. (ki.se)
Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes. (ki.se)
Gerlich joins the Academy's Cell and Developmental Biology Section, which has 226 members including 12 Nobel prize winners. (oeaw.ac.at)
Journal of Cell Biology. (ku.dk)
After being promoted to Senior Investigator, he moved to Singapore where he worked at the Institute of Molecular Cell Biology (IMCB/A*STAR/National University of Singapore). (lu.se)
The course is an optional second-cycle course for a degree of Bachelor or Master of Science in Biology. (lu.se)

The human rotamase or peptidyl-prolyl cis-trans isomerase Pin1 is a conserved mitotic regulator essential for the G2/M transition of the eukaryotic cell cycle. (rcsb.org)
Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. (kegg.jp)
As a biologically important example we have studied the complex formed by cyclins and cyclin-dependent kinases (CDKs), which play an essential role in the control of the eukaryotic cell cycle. (lu.se)

Here, we recover the temporal organisation of the cell cycle of budding yeast into phases and subphases, in an automated way. (biorxiv.org)

Chemical-genetic interactions-observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes-contain rich functional information linking compounds to their cellular modes of action. (nih.gov)
To systematically identify these interactions, an array of mutants is challenged with a compound and monitored for fitness defects, generating a chemical-genetic interaction profile that provides a quantitative, unbiased description of the cellular function(s) perturbed by the compound. (nih.gov)
Cellular processes like genome duplication and cell division stop. (wikipedia.org)
We detect alterations of protein properties in numerous cellular pathways and components including ribosome biogenesis and demonstrate that modulation of ribosome maturation through SBDS protein can be helpful for manipulating cell stemness in vitro. (nature.com)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
The Ahr is well known to be involved in a variety of cellular processes, such as the cell cycle, epithelial barrier function, cell migration, and immune function. (biolegend.com)
Both agents concomitantly induced a series of changes in the CBS cells that influence proliferation and differentiation, but cellular responses to the two agents were not identical. (aacrjournals.org)
However, isolated reports showed that user-tailoring could induce deleterious effects in exposed cells, from decrease in cellular proliferation, to changes in cellular adhesion, generation of reactive oxygen species or phenotypical variations, just to name a few. (cdc.gov)
By identifying changes in active hallmarks involved in cell-cell connections and maintaining epithelial layer integrity, we also determine the role that short-term exposure to SWCNTs plays in the overall cellular fate and cellular transformation. (cdc.gov)
The cell cycle and cellular differentiation in bacteria. (lu.se)

2) HCMV dysregulates DNA repair in infected cells and 3) infection of neural progenitor cells by HCMV causes premature and abnormal differentiation of these important CNS cells. (uidaho.edu)
This research aims at characterizing molecules and signals involved in controlling the undifferentiated state and self-renewal capacity of stem cells, and to develop methods to direct the differentiation of stem cells into clinically relevant cell types. (ki.se)

To do so, we model the cell cycle as a partially temporal network of protein-protein interactions (PPIs) by combining a traditional static PPI network with protein concentration or RNA expression time series data. (biorxiv.org)
Studying the patterns of protein-protein interactions (PPIs) is fundamental for understanding the structure and function of protein complexes. (biomedcentral.com)
All complexes are composed of subunits, which constitute the complex via mutual protein-protein interactions (PPIs). (biomedcentral.com)
The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)

These areas are approached by investigations that span from structural characterization of single molecules, macromolecular interactions and supramolecular assemblies, over mapping of molecular pathways in different model organisms, to whole genome sequencing of human pathogens. (ki.se)
An elaborate network of signaling pathways orchestrates the communication between cancer cells and the surrounding stroma. (degruyter.com)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)

Therefore, we identified Lnk as a physiological negative regulator of JAK2 in stem cells and TPO/Mpl/JAK2/Lnk as a major regulatory pathway in controlling stem cell self-renewal and quiescence. (jci.org)
Therefore, compared to normal p53-proficient cells, p53-defective cells are more reliant on MK2 activity, which drives an alternative cell cycle checkpoint pathway that stabilizes the CKI inhibitors p27 Kip1 and Gadd45α in order to maintain G 1 /S and G 2 /M arrest after certain types of DNA damage 16 , 18 . (nature.com)
Furthermore, GSEA analysis of CDK1-hi tumor cells identified a pathway signature common in all three cancer types, including E2F, G2M, MYC, and spermatogenesis, confirming a stem-like nature of CDK1-hi tumor cells. (genengnews.com)
Here, we aimed to target the IRE1α/XBP1 pathway in order to sensitise CRC cells to the effects of chemotherapy. (bvsalud.org)
Exosomal release pathway and autophagy together maintain homeostasis and survival of cells under stressful conditions. (bvsalud.org)
Autophagy is a catabolic process through which cell entities, such as malformed biomacromolecules and damaged organelles, are degraded and recycled via the lysosomal-dependent pathway. (bvsalud.org)

We have previously reported a mouse model in which Brca1 exon 11 is eliminated in mammary epithelial cells through Cre-mediated excision. (nih.gov)
Equine spermatozoa attached by their rostral acrosomal region to both ciliated and nonciliated oviduct epithelial cells. (tamu.edu)
Our study provides a comprehensive analysis of the synergistic cyto- and genotoxic effects resulted from short-term exposure of human lung epithelial cells to pristine (as manufactured) and user-tailored SWCNTs, as a function of their physicochemical properties. (cdc.gov)

and syncytial blastoderm mitotic cell cycle. (nih.gov)
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. (kegg.jp)
Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. (lu.se)

Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
Although the immune defect primarily affects the T-cell system, mutations of RMRP result in more generalized hematopoietic impairments. (medscape.com)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)

In a model with a changing volume that follows the cell cycle, we integrate successively the protein production mechanism (transcription and translation), the random segregation of compounds at divi- sion, and the gene replication. (hal.science)
Genetic engineering of cells with specific gene knockouts can also result in cells that arrest at different phases of the cell cycle. (wikipedia.org)
There was a statistically significant association between the expression of p27 and both cyclin D1 and the retinoblastoma gene product (pRb), corresponding to their close interactions in regulating the G1/S transition in the cell cycle. (ox.ac.uk)
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
In vitro studies and gene expression profiles showed that the transcriptional changes by the activated Ahr are ligand specific and are highly cell specific. (biolegend.com)
and interaction of RMRP and hTERT leads to an RNA-dependent RNA polymerase activity leading to siRNA altering gene expression. (medscape.com)
No single epidemiological study of brain tumors has adequate statistical power to evaluate most gene-environment or gene-gene interactions. (cdc.gov)

It is an artificial activation of naturally occurring cell cycle checkpoints, induced by exogenous stimuli controlled by an experimenter. (wikipedia.org)
These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of ASL as a generalized strategy to improve cancer treatment. (nature.com)

This thought may have occurred to scientists at the University of Colorado (CU) Cancer Center when they began looking at a population of cancer cells that, unlike most cancer cells, avoids downregulating MHC Class I molecules. (genengnews.com)
Cancer cells that carry a normal number or a surplus of MHC Class I molecules are conspicuously, well, inconspicuous. (genengnews.com)

Induced cell cycle arrest is the use of a chemical or genetic manipulation to artificially halt progression through the cell cycle. (wikipedia.org)
In an academic research context, cell cycle arrest is typically performed in model organisms and cell extracts, such as Saccharomyces cervisiae (yeast) or Xenopus oocytes (frog eggs). (wikipedia.org)
The cells can be induced to arrest as they arrive (at different time points) at a certain phase, so that when the arrest is lifted (for instance, rescuing cell cycle progression by introducing another chemical) all the cells resume cell cycle progression at the same time. (wikipedia.org)
Given that some of the mechanisms below of inducing cell cycle arrest involve damaging the DNA, this allows investigation into how the cell responds to damage of its genetic material. (wikipedia.org)
This natural process can be mimicked in a lab through the overexpression of p27Kip1, which results in induced cell cycle arrest in G1 phase. (wikipedia.org)
The use of serum deprivation - partially or completely removing the serum and its nutrients - has been shown to arrest and synchronize cell cycle progression in G0 phase, for example in neonatal mammalian astrocytes and human foreskin fibroblasts. (wikipedia.org)
is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)

Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. (nih.gov)
New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)

Although the scientists could suppress these stem-cell-like characteristics by inhibiting of CDK1 with pharmacological agents, they couldn't see how CDK1's role as a cell cycle regulator could be relevant. (genengnews.com)

Overexpression of CDK1, the CU Cancer Center scientists found, increased the spheroid forming ability, tumorigenic potential, and tumor-initiating capacity of the curious cell type. (genengnews.com)

Using our integrative proteomics approach and the web-based tool, we uncover a molecular basis for the uncoupling of robust transcription from parsimonious translation in stem cells and propose a method for maintaining pluripotency in vitro. (nature.com)
Ki-67 protein plays an essential role in ribosomal RNA transcription and cell proliferation. (biolegend.com)
Ultimately, the CU scientists conducted a proteomic analysis that revealed an interaction between CDK1 and the pluripotent stem cell transcription factor Sox2. (genengnews.com)
Sox2 is a transcription factor that helps embryonic and neural stem cells keep their stem-ness. (genengnews.com)

Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)

In human somatic cells, the cell cycle lasts about 18 hours, and the G1 phase makes up about 1/3 of that time. (wikipedia.org)

The MHC Class I-high cells also expressed high levels of CDK1, a "normal" molecule that regulates the cell cycle. (genengnews.com)
Hormonal interaction between the hypothalamus, anterior pituitary gland, and ovaries regulates the female reproductive system. (msdmanuals.com)
Puberty references Hormonal interaction between the hypothalamus, anterior pituitary gland, and ovaries regulates the female reproductive system. (msdmanuals.com)

During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)

Genetic interactions, obtained from genome-wide double-mutant screens, provide a key for interpreting the functional information contained in chemical-genetic interaction profiles. (nih.gov)
Our approach successfully demonstrates the use of genetic interaction networks in the high-throughput functional annotation of compounds to biological processes. (nih.gov)
We found that Ca 2+ and/or 1,25(OH) 2 D 3 stimulated CaSR promoter activity and CaSR protein expression in the human colon carcinoma CBS cells, which possessed a functional CaSR. (aacrjournals.org)
however, even knowledge of the stoichiometry, affinity and lifetime of every protein-protein interaction would not reveal the functional relationships between and within such complexes. (thebiogrid.org)
Key areas of investigation are the identification and functional characterization of stem cell niches in developing tissues and adult organs. (ki.se)
In this study we developed a functional assay using mouse ES cells to study variants of BRCA1. (jci.org)
Our results demonstrate that this ES cell-based assay is a powerful and reliable method for analyzing the functional impact of BRCA1 variants, which we believe could be used to determine which patients may require preventative treatments. (jci.org)
Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
We propose that the BPTI decamer, with a heparin chain threading the decamer channel, plays a functional role in the mast cell. (lu.se)

3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)

Many tumor microenvironments, including lymphoma and carcinoma, are enriched in immune suppressive cells that contribute to immune exhaustion by means expression of inhibitory ligands, suppressive cytokines, and tumor-promoting factors. (researchgate.net)
Antitumor therapies targeted to reduce the induction, recruitment, or suppressive activities of the immune cells have been investigated. (researchgate.net)

To systematically study such transitions, we introduce a method that simultaneously measures protein expression and thermal stability changes in cells and provide the web-based visualization tool ProteoTracker. (nature.com)
Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization. (yeastgenome.org)

In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
It results in a single layer of arrested cells of arrested cells, and is a process that is notably missing in cancer cells. (wikipedia.org)
Cancer cells that are defective in p53 function are deficient in their ability to transcriptionally upregulate the CDK inhibitor p21 after genotoxic stress. (nature.com)
Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
Through detailed characterization of fundamental molecular mechanisms of normal and perturbed cells, the theme strives to unravel information that increases the understanding of various diseases such as cancer and neurodegenerative, cardiovascular and inflammatory disorders. (ki.se)
Access thousands of knockout cell lysates, generated from commonly used cancer cell lines. (abcam.com)
Autodock Vienna was exploited to investigate interaction of anti-cancer drugs, Actinomycin-D and Adriamycin. (degruyter.com)
Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
It is also a known marker of cancer stem cells, implicated in the development of more than 25 forms of the disease. (genengnews.com)
We can show Sox2 is very important for tumorigenesis, but it's difficult to have a Sox2 inhibitor," says Mayumi Fujita, M.D., Ph.D., an investigator at the CU Cancer Center and senior author of the current study, which found that CDK1 directly interacts with Sox2 to keep cancer cells "stemmy. (genengnews.com)
Importantly, this signature of MHC Class 1, CDK1, and Sox2 was common across melanoma, colon, and pancreatic cancers, implying that cancer stem cells across cancer types may share common features. (genengnews.com)

Pulmonary LAM is a disorder resulting from abnormal proliferation of smooth muscle cells within the lungs. (medscape.com)

Novel tumour-specific RNA-protein interacting partners may serve as candidates to selectively induce cell death in tumour cells. (europa.eu)

The proposed project aims to identify the dynamics of RNA-protein interactions during DNA damage response (DDR) using high-throughput "omics" approaches. (europa.eu)

A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. (cancerindex.org)
The unfolded protein response (UPR) is an adaptive response that is activated to sustain survival in the cells faced with the endoplasmic reticulum (ER) stress through a complex network that involves protein synthesis, exosomes secretion and autophagy. (bvsalud.org)

We apply our method to study differences between human pluripotent stem cells and several cell types including their parental cell line and differentiated progeny. (nature.com)

Temperature-Induced uncoupling of cell cycle regulators. (nih.gov)
The interest in p27 expression in mammary carcinoma lies in its behaviour when examined in combination with other G1 cell cycle regulators. (ox.ac.uk)

Downloaded from periodic thymic colonization by progenitor cells guarantees stage. (lu.se)

BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)

USB, Cleveland, OH, USA), and sequencing species, the virus serotype is determined by the specifi city was conducted by BigDye terminator cycle sequencing of interactions between VP2 and neutralizing antibodies chemistry (Applied Biosystems, Foster City, CA, USA) generated during infection of the mammalian host. (cdc.gov)

An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g. (yeastgenome.org)

We also present experimental validations of CG-TARGET-predicted tubulin polymerization and cell cycle progression inhibitors. (nih.gov)

This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. (cancerindex.org)
Current projects focus on the spatial organization and biophysical properties of chromosomes, and their interactions with cytoskeleton and membranes. (oeaw.ac.at)

In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. (intechopen.com)

Despite the utility of this approach, integrative analyses of genetic and chemical-genetic interaction networks have not been systematically evaluated. (nih.gov)
Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)

G1 phase is the first of the four phases of the cell cycle, and is part of interphase. (wikipedia.org)
CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. (kegg.jp)

The method employs light at different parts of spectrum (e.g., infrared) and from different sources (e.g., lasers) to obtain information about chemical composition of any type of material, including the fungal cells and their environment. (lu.se)

The tumor cell mass exerts mechanical pressure that can contribute to bone pain. (degruyter.com)

To get a new insight into pluripotency, we employed a plurifaceted experimental design combining expression proteomics with the proteome-wide integral solubility alteration (PISA) assay 7 to compare pluripotent cells with their isogenic progenies and parental cells as well as with allogeneic cells. (nature.com)

However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. (hindawi.com)
Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)

When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, resulting in a wide-range of immediate and/or delayed toxicological effects. (cdc.gov)
As a self-degradative mechanism, macroautophagy/autophagy has a role in the maintenance of energy homeostasis during critical periods in the development of cells. (bvsalud.org)

p27Kip1 protein levels are elevated in arresting cells. (wikipedia.org)

Mimosine is a plant amino acid that has been shown to reversibly inhibit progression beyond G1 phase in some human cells, including lymphoblastoid cells. (wikipedia.org)
Lee's work involves the study of host (human)/pathogen (cytomegalovirus or HCMV) interactions. (uidaho.edu)
We introduced BAC clones with human wild-type BRCA1 or variants into Brca1-null ES cells and confirmed that only wild-type and a known neutral variant rescued cell lethality. (jci.org)
In this issue of the JCI , Chang, Sharan, and colleagues describe a novel system to evaluate human BRCA1 alleles for in vivo function using BACs containing human BRCA1 vectors in mouse cells and embryos (see the related article beginning on page 3160). (jci.org)
Gerlich's research group studies how human chromosomes dynamically reorganize during the cell cycle. (oeaw.ac.at)
The human body has nearly 1013 cells. (cdc.gov)

An Epistatic MiniArray Profile (E-MAP) analysis was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. (thebiogrid.org)

Anatomy25

Organisms13

Diseases4

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes82

Disciplines and Occupations1

Information Science3

Health Care2

Genes16

Apoptosis11

Proteins14

Regulation9

Biology12

Eukaryotic3

Budding yeast1

Cellular10

Differentiation2

Protein-protein inte5

Pathways4

Pathway6

Epithelial cells3

Mitotic cell cycle3

Mutations9

Gene7

Checkpoints2

Molecules2

Arrest8

Proliferation and survival2

Regulator1

Overexpression1

Transcription4

Nucleus1

Somatic cells1

Regulates3

Progression through the cell cycle2

Functional9

Hematopoietic1

Immune2

Visualization2

Cancer13

Abnormal1

Tumour1

High-throughput1

Survival2

Stem1

Regulators2

Progenitor cells1

Chemotherapy1

Mammalian1

Annotation1

Inhibitors1

Cytoskeleton2

Ubiquitin1

Genetic interaction networks3

Phases of the cell cycle2

Fungal1

Tumor cell1

Pluripotent1

Mechanisms2

Homeostasis2

P27Kip11

Human6

Fitness defects1