• eukaryotes
  • In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. (ebi.ac.uk)
  • The various aspects of the role of DNA methylation in prokaryotic restriction-modification systems and in a number of cellular processes in eukaryotes including gene regulation and differentiation is well documented. (wikipedia.org)
  • conformation
  • Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. (uniprot.org)
  • Bacillus
  • Recent studies showed that disruption of the purS gene in Bacillus subtilis resulted in a purine auxotrophic phenotype, due to defective FGAM synthetase activity. (ebi.ac.uk)
  • enzyme
  • it accounts for 60% of the carboxysomal protein, which amounts to approximately 300 molecules of enzyme per carboxysome. (ebi.ac.uk)
  • Azuma Y, Yamagishi M, Ishihama A. Subunits of the Schizosaccharomyces pombe RNA polymerase II: enzyme purification and structure of the subunit 3 gene. (ebi.ac.uk)
  • In archaeal and other bacterial systems, however, FGAM synthetase is encoded by separate genes, making it a multisubunit (rather than multidomain) enzyme. (ebi.ac.uk)
  • In enzymology, a protein-glutamate O-methyltransferase (EC 2.1.1.80) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + protein L-glutamate ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + protein L-glutamate methyl ester Thus, the two substrates of this enzyme are S-adenosyl methionine and protein L-glutamic acid, whereas its two products are S-adenosylhomocysteine and protein L-glutamate methyl ester. (wikipedia.org)
  • The systematic name of this enzyme class is S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase. (wikipedia.org)
  • This enzyme participates in bacterial chemotaxis - general and bacterial chemotaxis - organism-specific. (wikipedia.org)
  • encodes
  • UBIAD1 encodes a potential prenyltransferase, and is reported to interact physically with apolipoprotein E. UBIAD1 may play a direct role in intracellular cholesterol biochemistry, or may prenylate other proteins regulating cholesterol transport and storage. (biomedsearch.com)
  • A heat-shock gene which encodes the ATP-dependent protease La. (ebi.ac.uk)
  • putative
  • Sequencing of genes in our interval led to the identification of five putative causal mutations in gene UBIAD1, in our family as well as in four other small families of various geographic origins. (biomedsearch.com)
  • bacteria
  • This domain is found in a variety of polyhedral organelle shell proteins (CcmK), including CsoS1A, CsoS1B and CsoS1C of Thiobacillus neapolitanus (Halothiobacillus neapolitanus) and their orthologs from other bacteria. (ebi.ac.uk)
  • Bacterial ice-nucleation proteins is a family of proteins that enable Gram-negative bacteria to promote nucleation of ice at relatively high temperatures (above -5C). (wikipedia.org)
  • Inhibits
  • Maintenance of the prophage state requires the continuous expression of two repressors: (i) C1 is a protein which negatively regulates the expression of lytic genes including the C1 inactivator gene coi, and (ii) C4 is an antisense RNA which specifically inhibits the synthesis of an anti-repressor Ant. (ebi.ac.uk)
  • homologous
  • The lonD gene is homologous to the lon gene encoding an ATP-dependent protease and is essential for the development of Myxococcus xanthus. (ebi.ac.uk)
  • Wang N, Gottesman S, Willingham MC, Gottesman MM, Maurizi MR. A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. (ebi.ac.uk)
  • The protein is composed of the small form of PurL (smPurL), which is homologus to the ATPase domain of lgPurL, PurQ which is homologous to the glutamine-binding domain of of lgPurL, and PurS, whose function is not known. (ebi.ac.uk)
  • degradation
  • The propanediol utilization (pdu) operon of Salmonella enterica serovar Typhimurium LT2 includes genes necessary for formation of polyhedral organelles involved in coenzyme B(12)-dependent 1, 2-propanediol degradation. (ebi.ac.uk)
  • PduA is a shell protein of polyhedral organelles involved in coenzyme B(12)-dependent degradation of 1,2-propanediol in Salmonella enterica serovar typhimurium LT2. (ebi.ac.uk)
  • It catalyses the initial step of mitochondrial protein degradation. (ebi.ac.uk)
  • infection
  • Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. (genecards.org)
  • belongs
  • The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. (genecards.org)
  • mutations
  • Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy. (biomedsearch.com)
  • Although previous studies of the genetics of SCCD have localized the defective gene to a 1.58 Mbp interval on chromosome 1p, exhaustive sequencing of positional candidate genes has thus far failed to reveal causal mutations. (biomedsearch.com)
  • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. (ebi.ac.uk)
  • annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • terminus
  • Therefore, a DNA replication terminus site-binding protein binds to this site helping to block the DNA replication fork. (wikipedia.org)
  • function
  • This entry also contains related proteins of unknown function. (ebi.ac.uk)
  • Structure and function of bacterial sigma factors. (ebi.ac.uk)
  • Therefore, the PurS protein appears to be required for the function of the PurL and PurQ subunits of the FGAM synthetase, but the molecular mechanism for the functional role of PurS is currently not known. (ebi.ac.uk)
  • reveals
  • The structure reveals CheR to be a two-domain protein, with a smaller N-terminal helical domain linked via a single polypeptide connection to a larger C-terminal alpha/beta domain. (wikipedia.org)
  • different
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • catalytic
  • Haemophilus influenzae lon-B (HI1324), a protein which does not contain the ATP-binding domain, but possess a slightly divergent form of the catalytic domain. (ebi.ac.uk)
  • entry
  • This entry represents the C-terminal domain of the antirepressor protein (Ant) from Enterobacteria phage P1. (ebi.ac.uk)
  • Signatures from InterPro member databases are used to construct an entry. (ebi.ac.uk)
  • mutant
  • Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1. (ebi.ac.uk)
  • Maize contains a Lon protease gene that can partially complement a yeast pim1-deletion mutant. (ebi.ac.uk)
  • human
  • The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte. (ebi.ac.uk)