• Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism. (expasy.org)
  • inosine monophosphate dehydrogenase (IMPDH) inhibitor. (nih.gov)
  • MPA is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. (nih.gov)
  • Mycophenolic Acid exhibits a cytostatic effect on T- and B-lymphocytes by inhibiting inosine monophosphate dehydrogenase (IMPDH). (empr.com)
  • Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase , yielding xanthosine monophosphate , a key precursor in purine metabolism. (wikidoc.org)
  • Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of inosine monophosphate dehydrogenase. (wikidoc.org)
  • Potently inhibits inosine monophosphate dehydrogenase (IMPDH), thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. (tocris.com)
  • Added to this was 'another nucleotide that's often used to boost umami flavors, known as inosine monophosphate (IMP)', Medical Daily reports. (dailymail.co.uk)
  • This makes tuna a favorite for cats because it contains the nucleotide inosine monophosphate, which has a strong affinity for the umami binding sight. (livescience.com)
  • As we've just stated, inosine is an intermediate in several purine nucleotide pathways that affect muscle function. (tigerfitness.com)
  • Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. (wikipedia.org)
  • The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). (wikipedia.org)
  • The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP. (embl-heidelberg.de)
  • Katsuobushi is rich in inosine monophosphate, another amino acid. (norecipes.com)
  • Removing a phosphate group via nucleotidase to form adenosine followed by deamination (removal of a -NH2 amino group) to form inosine. (tigerfitness.com)
  • Inosine+monophosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural information available in the PDB for UniProt: P31939 (Human Bifunctional purine biosynthesis protein PURH (Inosine monophosphate synthase)) at the PDBe-KB. (wikipedia.org)
  • The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. (nih.gov)
  • Inosine Monophosphate/*analogs & derivatives. (reference.md)
  • Adenosine monophosphate (AMP) deaminase deficiency is a condition that can affect the muscles used for movement (skeletal muscles). (nih.gov)
  • Despite lack of clinical evidence that it improves muscle development, inosine remains an ingredient in some fitness supplements. (wikidoc.org)
  • Inosine is one such ingredient. (tigerfitness.com)
  • At one time, inosine was believed to be a potent performance-boosting compound, but after a chain of studies showed it had no effect on performance, inosine disappeared from the scene. (tigerfitness.com)
  • The first study into the potential ergogenic effects of inosine involved nine "highly trained" endurance runners in a double-blind, placebo-controlled, crossover study. (tigerfitness.com)
  • Lastly, inosine also results from the dephosphorylation of ATP -- the cellular currency of exercise. (tigerfitness.com)
  • Due to this, several fitness experts have claimed that supplementing with inosine can improve energy production and overall performance during exercise. (tigerfitness.com)
  • Inosine was initially considered as a means to boosting exercise performance by Eastern sports scientists in the 70s. (tigerfitness.com)
  • Suffice it to say, thought that there has been a severe lack of research regarding inosine and exercise performance, despite claims made by some in the fitness community that it helps improve performance. (tigerfitness.com)
  • Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs . (wikidoc.org)
  • However, inosine pairs preferentially with cytidine (C) and its introduction to RNA, e.g. by the action of ADARs, thereby destabilizes double stranded RNA by changing AU base-pairs to IU mismatches (Bass and Weintraub, Cell, 1988). (wikidoc.org)
  • In 2003, a study was initiated at the University of Pennsylvania MS Center to determine whether raising the levels of uric acid by the administration of inosine would slow the progression of MS. [5] The study was completed in 2006 but the results were not reported to NIH. (wikidoc.org)
  • The ability of ribavirin to inhibit inosine monophosphate dehydrogenase (IMPDH) is considered to be important in this clinical setting. (medscape.com)
  • As a noncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), MMF inhibits de novo purine synthesis. (skintherapyletter.com)
  • Mycophenolate mofetil selectively and noncompetitively inhibits inosine monophosphate dehydrogenase (IMPDH) in the de novo purine synthesis pathway. (skintherapyletter.com)
  • The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. (embl.de)
  • Mycophenolate blocks de novo purine synthesis via noncompetitive inhibition of inosine monophosphate dehydrogenase (IMPDH). (nih.gov)
  • inosine monophosphate dehydrogenase (IMPDH) inhibitor. (hipaaspace.com)
  • The enzyme inosine 5′-monophosphate dehydrogenase (IMPDH) changes IMP to XMP (System 1). (holyexperiment.org)
  • Mycophenolate inhibits inosine monophosphate dehydrogenase and is a standard treatment for LN. The mammalian or mechanistic target of rapamycin (mTOR) pathway is activated in LN. Rapamycin inhibits mTOR and is effective in preventing kidney transplant rejection, with the additional merits of reduced incidence of malignancies and viral infections. (portlandpress.com)
  • 9. Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase. (nih.gov)
  • The researchers found a substantially lower risk of developing Parkinson's disease among people who used either of two categories of immune-suppressing drugs: corticosteroids (about 20% lower) or inosine monophosphate dehydrogenase inhibitors (about 36% lower). (nih.gov)
  • ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide. (wikipedia.org)
  • The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). (wikipedia.org)
  • Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex. (expasy.org)
  • Inosine monophosphate (IMP) dehydrogenase had previously been determined to be a likely target enzyme for the sesquiterpene lactones, a class of potential anti-neoplastic drugs. (nih.gov)
  • gene provides instructions for producing an enzyme called adenosine monophosphate (AMP) deaminase. (nih.gov)
  • PNP is an enzyme in the purine salvage pathway that metabolizes inosine and guanosine to hypoxanthine. (medscape.com)
  • This enzyme facilitates the conversion of inosine monophosphate to xanthine monophosphate, an intermediate metabolite in the production of guanosine triphosphate. (skintherapyletter.com)
  • Specifically, during physical activity, this enzyme converts a molecule called adenosine monophosphate (AMP) to a molecule called inosine monophosphate (IMP) as part of a process called the purine nucleotide cycle. (medlineplus.gov)
  • The enzyme myoadenylate deaminase converts AMP to inosine and ammonia. (msdmanuals.com)
  • Unlike natural CDNs, whose constituent nucleosides are guanosine and/or adenine, cAIMP and its derivatives contain one adenine nucleoside and one inosine nucleoside. (invivogen.com)
  • Inosine is a natural purine nucleoside that commonly occurs in transfer RNAs in humans. (acs.org)
  • The researchers found that seawater temperature decreases induce the cephalopods to self-edit mRNA adenosine to inosine . (acs.org)
  • Inosine+monophosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural information available in the PDB for UniProt: P31939 (Human Bifunctional purine biosynthesis protein PURH (Inosine monophosphate synthase)) at the PDBe-KB. (wikipedia.org)
  • Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. (nih.gov)
  • But earlier this year, inosine turned up in an off-target result generated by a CRISPR-based gene editor. (acs.org)
  • In 2019, researchers found that a gene editor unexpectedly converted a small amount of adenosine in an RNA to inosine. (acs.org)
  • Ans3: Folate is involved in the synthesis inosine mono phosphate and this is the precursor for the synthesis of GMP and AMP. (assignmentexpert.com)
  • Design, synthesis, and biological evaluation of novel cyclic adenosine-inosine monophosphate (cAIMP) analogs that activate stimulator of interferon genes (STING). (invivogen.com)
  • Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. (embl.de)
  • 18. [Pathways of inosine monophosphate transformation in the chicken liver]. (nih.gov)
  • Since 2000, inosine has been tried as a treatment for medical conditions such as Parkinson's disease, multiple sclerosis, stroke, and spinal cord injuries. (acs.org)
  • Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure [3]. (embl.de)
  • 17. Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity. (nih.gov)