The maximum Thyrogen Tg value was obtained 72 hours after the final Thyrogen injection, and this value was used in the analysis. (thyrogen.com)
Two prospective, randomized, phase clinical trials with a cross-over, nonblinded design, were conducted in patients with well differentiated thyroid cancer to compare 131-I WBS's obtained after Thyrogen injection to 131-I WBS's after THW. (thyrogen.com)
Genzyme Corp. recently announced that the US Food and Drug Administration (FDA) has approved a supplemental indication for thyrotropin alfa for injection (Thyrogen) to be used in combination with radioiodine to ablate, or destroy, the remaining thyroid tissue in patients who have had their cancerous thyroids removed. (cancernetwork.com)
Thyroid cancer1
Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. (pharmacycode.com)
20231
May 22, 2023 ยท Semaglutide injection ( Ozempic ) is also used to reduce the risk of a stroke, heart attack, or death in adults who have type 2 diabetes along with heart and blood. (gartenwerkstatt-leipzig.de)
Administration of recombinant2
To evaluate serum thyrotropin (TSH) concentrations after conventional (0.9 mg) or half-dose (0.45 mg) administration of recombinant human TSH (rhTSH) injections intramuscularly in patients with end-stage renal disease and differentiated thyroid cancer. (medscape.com)
The researchers therefore randomly assigned study participants in both dose groups to either withdrawal of the replacement thyroid hormones given after surgery (to allow the body's own thyrotropin level to rise) or administration of recombinant thyrotropin (thyrotropin alfa). (blogspot.com)
Interferon Alfa1
Several environmental factors including pregnancy (mainly postpartum), iodine excess, infections, emotional stress, smoking, and interferon alfa trigger immune responses on susceptible genes to eventually cause Graves' disease. (nih.gov)
Both trials also showed that either administering thyrotropin alfa or withdrawing thyroid hormones before administering radioactive iodine was effective for thyroid ablation at both radioactive iodine dose levels. (blogspot.com)
For radioactive iodine treatment to work, thyroid-stimulating hormone (thyrotropin) levels must be elevated. (blogspot.com)
Although thyrotropin alfa causes less discomfort than the withdrawal of replacement thyroid hormones, there was some concern that the drug might interfere with the effectiveness of radioactive iodine treatment. (blogspot.com)
Ablation1
In both trials, at both dose levels, rates of successful ablation did not differ significantly between patients receiving thyrotropin alfa or those undergoing replacement thyroid hormone withdrawal. (blogspot.com)
Intramuscularly1
A two-injection regimen is recommended: THYROGEN 0.9 mg is administered intramuscularly, followed by a second 0.9 mg intramuscular injection 24 hours later. (nih.gov)
Powder1
For injection: 0.9 mg of thyrotropin alfa as a lyophilized powder in a single-dose vial. (nih.gov)
Dose1
The typical dose is 0.24 mg/kg by injection once per week. (mdwiki.org)
Patients1
In 1 patient, we used 2 injections of 0.9-mg rhTSH, and in the other 2 patients, we administered 2 injections of 0.45-mg rhTSH. (medscape.com)
Hormone4
Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. (wikipedia.org)
Adequate uptake of radioiodine by remnant or remaining malignant thyroid tissue is dependent on an elevated level of thyrotropin (TSH) in the blood. (medscape.com)
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