• Idiopathic orbital inflammatory syndrome, also known as orbital pseudotumor, was first described by Gleason in 1903 and by Busse and Hochheim. (wikipedia.org)
  • Its former name, orbital pseudotumor, is derived due to resemblance to a neoplasm. (wikipedia.org)
  • Several studies have described cases where onset of orbital pseudotumor was seen simultaneously or several weeks after upper respiratory infections. (wikipedia.org)
  • Orbital pseudotumor has also been observed in association with Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, myasthenia gravis, and ankylosing spondylitis all of which strengthen the basis of IOI being an immune-mediated disease. (wikipedia.org)
  • Trauma has also been seen to precede some cases of orbital pseudotumor. (wikipedia.org)
  • Inflammatory orbital disease, also called orbital pseudotumor, is inflammation that can affect any or all structures within the orbit. (msdmanuals.com)
  • Symptoms and signs of inflammatory orbital pseudotumor typically include a sudden onset of pain along with swelling and erythema of the eyelids. (msdmanuals.com)
  • but there is no history of trauma or adjacent focus of infection (eg, sinusitis) with inflammatory orbital pseudotumor. (msdmanuals.com)
  • Treatment for inflammatory orbital pseudotumor depends on the type of inflammatory response and may include oral corticosteroids, radiation therapy, and one of several immunomodulating drugs. (msdmanuals.com)
  • Orbital inflammatory disease (pseudotumor) usually is treated medically with systemic steroids. (medscape.com)
  • Examples include sarcoidosis, thyroid eye disease, and orbital pseudotumor. (web.app)
  • Orbital inflammatory pseudotumor (OIP) is a benign, non-specific inflammatory disorder that commonly occurs in middle-aged adults and is usually unilateral but can occur bilaterally. (bvsalud.org)
  • In the present report, we describe a case of sclerosing orbital pseudotumor in an 11-year-old castrated male American Shorthair cat. (bvsalud.org)
  • Previously, IMT was also described as inflammatory pseudotumor, plasma cell granuloma, and inflammatory myofibrohistiocytic proliferation. (hindawi.com)
  • The medical records of 13 patients diagnosed pathologically with IMT, inflammatory pseudotumor, or plasma cell granuloma of the paranasal sinus and nasopharynx in the Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital from 2006 to 2017 were reviewed. (hindawi.com)
  • Pathological involvement beyond the cavernous sinus, superior orbital fissure, or apex of the orbit occurs rarely, and the disorder is part of a continuum with idiopathic orbital pseudotumor, with which it shares histopathologic features. (medscape.com)
  • The superior orbital fissure connects directly to the cavernous sinus and the intracranial space. (medscape.com)
  • and the superior ophthalmic vein enter the cavernous sinus after exiting the orbit through the superior orbital fissure. (medscape.com)
  • An ophthalmoplegic syndrome, affecting all age groups, with characteristics of acute attacks (lasting a few days to a few weeks) of periorbital pain, ipsilateral ocular motor nerve palsies, ptosis, disordered eye movements and blurred vision usually caused by a non-specific inflammatory process in the cavernous sinus and superior orbital fissure. (nih.gov)
  • The term superior orbital fissure syndrome (SOFS) also called as Rochon-Duvigneaud syndrome is applied to lesions located immediately anterior to the orbital apex, including the structures exiting the annulus of Zinn and often those external to the annulus. (medicosnotes.com)
  • This disease also affects the region of the superior orbital fissure as well as the optic canal and leads to ophthalmoplegia. (healthncare.info)
  • The only difference between the orbital apex diseases such as OPS, CSS (Cavernous sinus syndrome), and SOFS (Superior orbital fissure syndrome) is the involvement of the optic nerve. (healthncare.info)
  • Tolosa-Hunt syndrome (THS) is a painful ophthalmoplegia caused by nonspecific inflammation of the cavernous sinus or superior orbital fissure. (medscape.com)
  • Nonspecific inflammation (noncaseating granulomatous or nongranulomatous) within the cavernous sinus or superior orbital fissure is the cause of the constant pain, which characterizes the onset of this disorder. (medscape.com)
  • They include inflammation of the extraocular muscles (myositis) with tendinous involvement, orbital fat stranding, lacrimal gland inflammation and enlargement (dacryoadenitis), involvement of the optic sheath complex, uvea, and sclera, a focal intraorbital mass or even diffuse orbital involvement. (wikipedia.org)
  • The authors used various nomenclatures to describe conditions related to the presence of IgG4 until 2010 in Kanazawa, where it was unified as an "IgG4-related disease" with the consensus that it can affect various organs, including the thyroid and the eye with its adnexa and extraocular muscles [ 4 ]. (hindawi.com)
  • The subsequent cytokine activation and secretion of glycosaminoglycans by orbital fibroblasts leads to interstitial edema, ultimately resulting in volume expansion of extraocular muscles, retro-orbital fat, and connective tissue. (eyewiki.org)
  • Additionally, the edematous extraocular muscles lose compliance and can compress the optic nerve at the orbital apex, leading to compressive optic neuropathy. (eyewiki.org)
  • The syndrome is characterised by retro-orbital paralysis of extraocular muscles impairment of the branches of the 1st division of the trigeminal nerve and frequently extension to involve the optic nerve. (medicosnotes.com)
  • The extraocular muscles also originate through the orbital apex. (healthncare.info)
  • The MRI (magnetic resonance imaging) is utilized to scan the orbits to examine for enlargement or enhancement of extraocular muscles and orbital structures, or an orbital CT scan, which is likely a more widely available second-line alternative is used for the diagnosis. (healthncare.info)
  • A differential diagnosis includes lymphoproliferative lesions, thyroid ophthalmopathy, IgG4-related ophthalmic disease, sarcoidosis, granulomatosis with polyangiitis, orbital cellulitis and carotid-cavernous fistula. (wikipedia.org)
  • The most common etiology of noninfectious inflammatory orbital disease is thyroid eye disease (TED), also known as Graves ophthalmopathy. (msdmanuals.com)
  • The pathogenesis of TED is poorly understood but may result from immunoglobulins directed against the thyroid-stimulating hormone (TSH) receptors on orbital fibroblasts and fat, resulting in release of pro-inflammatory cytokines, inflammation, and accumulation of glycosaminoglycans. (msdmanuals.com)
  • In thyroid eye disease, tendon-sparing enlargement of the inferior rectus and medial rectus muscles is common. (msdmanuals.com)
  • He has special expertise in thyroid eye disease, and reconstructive surgery of the eyelids and upper face. (pennmedicine.org)
  • Dr. Woeller's current research interest is understanding the key molecular and cellular pathways involved in eye disease, with a particular focus on Thyroid Eye Disease (TED). (rochester.edu)
  • Recent studies have suggested that IgG4 plays a role in the pathophysiology of autoimmune thyroid diseases. (hindawi.com)
  • This ultimately led to the establishment of new clinical entities called IgG4-related thyroid disease and thyroid disease with an elevation of IgG4. (hindawi.com)
  • Thyroid eye disease (TED) is considered a chronic inflammatory and autoimmune condition. (eyewiki.org)
  • Almost all patients with thyroid eye disease have anti-thyrotropin-receptor antibodies that cause immunoreactivity against the thyrotropin receptor 4 . (eyewiki.org)
  • In a disease-free patient, synergistic activation of TSHR and IGF-1R (receptor for growth factor IGF-1) promotes DNA synthesis and thyroid cell proliferation. (eyewiki.org)
  • Thyroid eye disease (TED) is an autoimmune orbital inflammatory disease which ranges from mild to severe. (eyehospital.nl)
  • Traditional thyroid eye disease therapies with their sometime limited success are making way for new drugs with the potential to provide sustained benefits for patients, according to Erin Shriver, MD. (ophthalmologytimes.com)
  • The thyroid eye disease (TED) arena is finally beginning to evolve. (ophthalmologytimes.com)
  • The main clinical differential diagnoses would be thyroid orbitopathy, sarcoidosis, Sjögren syndrome, lymphoma, Rosai-Dorfman disease or periocular xanthogranulomas. (aad.org)
  • It can be a recurrence of childhood-onset strabismus or adult new-onset strabismus, which can be caused by orbital or head trauma, a stroke, brain tumor, orbital inflammatory disease, thyroid eye disease or other neurological or eye conditions. (usqeyecare.com)
  • Graves' ophthalmopathy is the most common extra-thyroid manifestation in patients with Graves' disease, based on inflammatory and autoimmune conditions in orbital tissue. (ui.ac.id)
  • She has a particular interest in aesthetic procedures around the eyes, endoscopic brow lifts, cosmetic injections of the face and under the eyes, eyelid and orbital reconstruction, pediatric ophthalmic plastic surgery, and complicated orbital inflammatory disorders, including thyroid eye disease. (oceanophthalmology.com)
  • She recently participated in an FDA multi-center study investigating a new treatment for thyroid eye disease and is a respected speaker for her expertise in the field. (oceanophthalmology.com)
  • It is a benign, nongranulomatous orbital inflammatory process characterized by extraocular orbital and adnexal inflammation with no known local or systemic cause. (wikipedia.org)
  • Idiopathic orbital inflammation has a varied clinical presentation depending on the involved tissue. (wikipedia.org)
  • It can range from a diffuse inflammatory process to a more localized inflammation of muscle, lacrimal gland or orbital fat. (wikipedia.org)
  • Pediatric IOI accounts for about 17% of cases idiopathic orbital inflammation. (wikipedia.org)
  • proposes that organisms resembling Mollicutes cause orbital inflammation by destroying the cytoplasmic organelles of parasitized cells. (wikipedia.org)
  • The histopathology of idiopathic orbital inflammation is described as nondiagnostic and diverse. (wikipedia.org)
  • Bisphosphonate-induced orbital inflammation is not a well recognised complication and there have been only a few published case reports of this. (nih.gov)
  • Inflammatory orbital disease is a benign space-occupying inflammation involving orbital tissues. (msdmanuals.com)
  • Inflammation of orbital tissues can be caused by infections. (msdmanuals.com)
  • Symptoms and signs of TED include those that are specific to the condition (ie, eyelid retraction) as well as the nonspecific symptoms seen in almost all orbital inflammation (ie, proptosis [exophthalmos], diplopia, periorbital edema, retrobulbar pain). (msdmanuals.com)
  • A useful imaging feature in distinguishing an infection from noninfectious inflammation is the presence of adjacent sinus involvement in orbital infection. (msdmanuals.com)
  • Histopathologic examination showed "idiopathic inflammation": infiltration of the lac-rimal gland by a mixed population of inflammatory cells consisting primarily of mature lymphocytes, as well as eo-sinophils, plasma cells, and neutrophils, without other histologic abnormality. (aao.org)
  • Inflammatory orbital disease, also called idiopathic orbital inflammatory syndrome and non-specific orbital inflammation, refers to eye disorders that involve the orbit. (orbit-eyecenter.com)
  • Computed tomography examination of the orbit revealed diffuse inflammation involving multiple orbital structures. (jhsmr.org)
  • This article describes a potential causal association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and orbital inflammation. (jhsmr.org)
  • Dinkin M, Feinberg E, Oliveira C, Tsai J. Orbital inflammation with optic perineuritis in association with COVID-19. (jhsmr.org)
  • Bilateral orbital inflammation in a 6-month old with SARS-CoV-2 infection. (jhsmr.org)
  • Idiopathic orbital inflammation: review of literature and new advances. (jhsmr.org)
  • Also provided is a pharmaceutical composition comprising laquinimod or a pharmaceutically acceptable salt thereof for use in treating a subject suffering from an OID, uveitis, bacterial conjunctivitis, viral conjunctivitis, an inflammation of the orbital tissue, the lacrimal apparatus, the eyelid, the cornea, the retina or the optic pathway. (justia.com)
  • This application also provides a method for treating a subject suffering from an autoimmune disease-associated ocular inflammation comprising periodic ocular administration to the subject a therapeutically effective amount of laquinimod or a pharmaceutically acceptable salt, and an ocular pharmaceutical composition comprising laquinimod or a pharmaceutically acceptable salt thereof for use in treating an autoimmune disease-associated ocular inflammation. (justia.com)
  • Ocular Inflammatory Disease ("OID") is a general term for describing inflammation affecting one or more parts of the eye or surrounding eye tissue. (justia.com)
  • PURPOSE: In humans, idiopathic orbital inflammation (IOI) is a diagnosis attributed to benign, inflammatory orbital conditions without identifiable local or systemic cause. (bvsalud.org)
  • Corticosteroids are efficient in reducing orbital inflammation, but the benefits cease after discontinuation. (karenlchapmanmd.com)
  • Radiotherapy is an alternative option to reduce acute orbital inflammation. (karenlchapmanmd.com)
  • A simple way of reducing inflammation is smoking cessation, as pro-inflammatory substances are found in cigarettes. (karenlchapmanmd.com)
  • Imaging with 18 F-fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) highlights the extent of disease, although it may not distinguish IgG4-RD from other causes of inflammation or malignancy (3). (aad.org)
  • Many inflammatory causes necessitate the use of systemic immunomodulatory drugs such as corticosteroids and steroid-sparing medicines to treat the main disease and reduce inflammation. (healthncare.info)
  • patients experience unilateral onset of acute orbital pain and ophthalmoparesis, and the disorder may threaten sight if untreated inflammation extends beyond the cavernous sinus to affect the optic nerve. (medscape.com)
  • Preseptal and Orbital Cellulitis Preseptal cellulitis (periorbital cellulitis) is infection of the eyelid and surrounding skin anterior to the orbital septum. (msdmanuals.com)
  • Orbital cellulitis is infection of the orbital tissues posterior. (msdmanuals.com)
  • We report a case of acute, vectorborne Chagas disease, acquired locally in central Texas, USA, manifesting as Romaña's sign, which was initially mistaken for orbital cellulitis. (cdc.gov)
  • the infection was initially mistaken for orbital cellulitis. (cdc.gov)
  • Patient with acute Chagas disease manifesting as orbital cellulitis, Texas, USA, on the day he first accessed care. (cdc.gov)
  • The patient's eye symptoms worsened, and on day 5 of illness an ophthalmologist hospitalized him for orbital cellulitis. (cdc.gov)
  • A computed tomography scan demonstrated nonspecific preseptal and postseptal inflammatory changes, consistent with mild orbital cellulitis. (cdc.gov)
  • Preseptal (or periorbital) cellulitis, which is an inflammatory edema of the eyelids and periorbital skin with no involvement of the orbit, comprises the first group. (medscape.com)
  • At this point, our concern shifted from orbital cellulitis to dacryoadenitis, either infectious or inflammatory. (aao.org)
  • Conditions such as orbital cellulitis often are treated medically with various antimicrobial agents. (medscape.com)
  • This condition, called orbital cellulitis , is serious because of the possibility that the infection may spread into the cranial cavity via the pathways of the cranial nerves that reach the eye through the posterior orbit. (britannica.com)
  • She was initially diagnosed with probable orbital cellulitis secondary to sinusitis. (jhsmr.org)
  • The orbital apex syndrome can result from bacterial orbital cellulitis, viral infections, and fungal sinusitis. (healthncare.info)
  • type 1 autoimmune pancreatitis , interstitial nephritis , Riedel's thyroiditis , Mikulicz's disease , Küttner's tumor , inflammatory pseudotumors (in various sites of the body), mediastinal fibrosis and some cases of retroperitoneal fibrosis . (mdwiki.org)
  • proposed the term "IgG4-related autoimmune disease" as a systemic disease with multiorgan involvement [ 3 ]. (hindawi.com)
  • A 31-year-old woman with no history of systemic autoimmune disease developed bilateral pain, redness, periorbital edema, and proptosis while being hospitalized for mild coronavirus disease 2019 (COVID-19) pneumonia. (jhsmr.org)
  • Autoantibodies related to systemic autoimmune rheumatic diseases in severely ill patients with COVID-19. (jhsmr.org)
  • Not all cases of 'the bulge' result from of autoimmune disease, trauma or tumor. (reviewofoptometry.com)
  • Swelling of salivary and lacrimal glands, lymphadenopathy, and type 1 autoimmune pancreatitis are the most common manifestations of the disease. (aad.org)
  • The anterior border of the orbit is marked by the orbital septum, a fibrous band from the external bony orbit to both eyelids (specifically from the periosteum of the orbital rim to the levator aponeurosis in the upper eyelid and to the inferior border of the tarsal plate in the lower eyelid), which effectively separates the preseptal space from the orbital space. (medscape.com)
  • It forms in the depression of the orbicularis oculi muscle of the lower eyelid, which attaches to the inferior orbital rim. (eyewiki.org)
  • The area begins medially at the inferior orbital rim and increases in vertical distance laterally until it reaches a maximum vertical distance under the center of the globe, after which the vertical distance decreases till the lateral endpoint of the inferior orbital rim.The tear trough ends where the thin skin under the eyelid meets the thicker nasal and cheek skin below it. (eyewiki.org)
  • Chronic disease is treated with tear supplements, warm compresses, and occasionally oral antibiotics (eg, a tetracycline or azithromycin) for meibomian gland dysfunction or with eyelid hygiene and tear supplements for seborrheic blepharitis. (merckmanuals.com)
  • Eyelid disorders may be associated with facial and orbital abnormalities, specific breeds, and adjunct skin diseases, as well as with many systemic diseases. (merckvetmanual.com)
  • Orbital and eyelid granulomas are also common, as well as lacrimal gland infiltration. (aao.org)
  • Idiopathic orbital inflammatory (IOI) disease refers to a marginated mass-like enhancing soft tissue involving any area of the orbit. (wikipedia.org)
  • The bony septa separating the orbit from the sinuses are thin and fenestrated, particularly in the medial orbital wall, where the lateral ethmoid bone, which also makes up the medial orbital wall, is particularly thin and porous and is named the lamina papyracea. (medscape.com)
  • The posterior wall of the orbit contains the optic canal and the superior and inferior orbital fissures. (medscape.com)
  • The smaller inferior ophthalmic vein exits the orbit through the inferior orbital fissure with the maxillary branch of the trigeminal nerve (CN V2) and connects with the temporal fossa. (medscape.com)
  • The first part deals with conditions affecting the orbit, lids, and external eye, and the second focuses on diseases of structures within the eyeball, or globe. (britannica.com)
  • Since the bone that separates the orbit from the nose and the nasal sinuses is rather thin, infection sometimes spreads from the nasal sinuses into the orbit, causing the orbital tissue to swell and the eye to protrude. (britannica.com)
  • The CT above shows the orbit on the left following orbital decompression. (karenlchapmanmd.com)
  • IgG4-related ophthalmic disease (IgG4-ROD), the preferred nomenclature for IgG4-RD affecting the ocular adnexa or orbit, is a common manifestation of IgG4-RD. A large IgG4-RD disease registry in North America found ophthalmic involvement in 23 % of all IgG4-RD cases. (aad.org)
  • Infection- Fungal infection of the orbit is an important though rare cause of an orbital apex syndrome and is usually secondary to sinus involvement. (medicosnotes.com)
  • The orbital apex is the point where the orbit connects with the skull at the craniofacial junction. (healthncare.info)
  • The imaging of the orbit is used to determine the diagnosis of orbital apex syndrome. (healthncare.info)
  • [ 3 , 4 ] Lymphoproliferative disease of the orbit usually presents later in life and causes symptoms due to gradually increasing mass effect. (medscape.com)
  • ICHD-II diagnostic criteria for Tolosa-Hunt syndrome in idiopathic inflammatory syndromes of the orbit and/or the cavernous sinus. (medscape.com)
  • Transcranial approaches can be used for tumors involving the orbital-cranial regions. (medscape.com)
  • Aouidad et al reported the case of a 51-year-old woman presenting with orbital "pseudotumors" (I do not understand why these are not just "tumors" - large swellings of any cause that may be benign or malignant) that histologically demonstrated eosinophilic angiocentric sclerosis related to IgG4. (aad.org)
  • Orbital Apex Syndrome is caused by various infections, inflammations, and tumors and the severity differs according to the origin of the disease. (healthncare.info)
  • Neuro-ophthalmic manifestations frequently are encountered in persons with multiple sclerosis (MS) and other central nervous system (CNS) inflammatory disorders, including neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). (medscape.com)
  • Optic neuritis is an inflammatory injury of the optic nerve that causes vision loss, which is common in MS and other CNS inflammatory disorders. (medscape.com)
  • Because patients with MS and other CNS inflammatory disorders who have visual symptoms often seek ophthalmic attention, eye care experts play a vital role in the localization and diagnosis of these conditions. (medscape.com)
  • eye disease , any of the diseases or disorders that affect the human eye . (britannica.com)
  • Later sections deal with injuries, ocular conditions associated with systemic disease , disorders of vision , methods of examining the eye, and devices for correcting visual defects. (britannica.com)
  • Chronic dacryoadenitis is usually due to noninfectious inflammatory disorders. (web.app)
  • For the recent 10 years, we summarized the experience of the rhinology unit of our department regarding orbital injury and complications of ESS for sinonasal inflammatory disorders. (scirp.org)
  • For the 10 years from 2003 to 2012, we summarized the experience of the rhinology unit of our department regarding orbital injury and complications of ESS for sinonasal inflammatory disorders. (scirp.org)
  • Inflammatory disorders, and vasculitic ischaemic diseases. (medicosnotes.com)
  • Some individuals with MS and other CNS inflammatory syndromes also may experience homonymous visual field defects caused by lesions in retrochiasmal or retrogeniculate (posterior) regions of the afferent visual pathway. (medscape.com)
  • Additional lab testing included antithyroperoxidase (TPO) antibody, angiotensin-converting enzyme (ACE) level, a myasthenia gravis panel, a de-myelinating disease panel, and a panel for anti-GQ1b syndromes. (aao.org)
  • This article briefly describes the more common diseases of the eye and its associated structures, the methods used in examination and diagnosis , and the factors that determine treatment and prognosis. (britannica.com)
  • Typical signs of GO accompanied by increased concentration of IgG4 include younger age at diagnosis, and more severe course of the disease with a higher Clinical Activity Score (CAS). (hindawi.com)
  • We strongly recommend considering the diagnosis of GO with elevated IgG4 in patients with an established diagnosis of GD, elevated serum IgG4 levels, and clinical features of ophthalmic disease overlapping with those of IgG4-related orbital disease. (hindawi.com)
  • The diagnosis of the disease becomes easy due to this feature of the orbital apex syndrome. (healthncare.info)
  • An understanding of this anatomic relationship (see the image below) is key to appreciating the pathophysiology of orbital infections. (medscape.com)
  • Orbital infections develop via direct inoculation, extension from adjacent structures, and hematogenous spread. (medscape.com)
  • More rarely, orbital infections develop from hematogenous seeding secondary to sepsis or bacterial endocarditis. (medscape.com)
  • Orbital infections are classified by a 5-tier system, as described by Smith and Spencer and modified by Chandler et al. (medscape.com)
  • The presence of protozoa in these infections of the corneospectacular space has been demonstrated repeatedly although their role in the disease is uncertain. (vin.com)
  • Cerebrospinal fluid (CSF) examination (infections, granulomatous disease, and malignancy) can be helpful. (medicosnotes.com)
  • Orbital infections are diseases that require special attention and care. (bvsalud.org)
  • The fungal infections that result in orbital apex syndrome are due to Mucormycosis or aspergillosis fungus. (healthncare.info)
  • Coronavirus disease 2019 (COVID-19) and dengue viral infections have similar presentations and laboratory findings, including fever and thrombocytopenia, and there have been reports of coinfection with SARS-CoV-2 and arthropod-borne virus. (who.int)
  • For medially located lesions, such as those encroaching on the nasal orbital apex, this approach is possible. (medscape.com)
  • Transnasal, transantral, and transethmoidal endoscopic approaches are being used more frequently to gain access to orbital lesions. (medscape.com)
  • It is a relapsing-remitting disease associated with a tendency to mass forming, tissue-destructive lesions in multiple sites, with a characteristic histopathological appearance in whichever site is involved. (mdwiki.org)
  • Its clinical manifestations have tremendous clinical heterogeneity and vary according to the site of infiltration and the degree of lesions, including orbital pain, swelling, diplopia, proptosis, restricted eye movement, and decreased visual acuity. (bvsalud.org)
  • Computed tomography and magnetic resonance imaging identified heterogeneous space-occupying, contrast-enhancing orbital lesions in all cases. (bvsalud.org)
  • The causes of these lesions are often identical to those responsible for inducing ophthalmic disease in mammals and birds. (vin.com)
  • At the most recent visit, she presented with new-onset binocular diplopia and orbital pain. (ophthalmologytimes.com)
  • Reports continue to emerge on further associations of COVID-19 with uveitic, retinovascular, and neuro-ophthalmic disease. (cov19longhaulfoundation.org)
  • A dermatologic riddle: How is IgG4-related ophthalmic disease parliamentary? (aad.org)
  • In cases of reactive lymphoid hyperplasia or IgG4-related orbital disease, there are typically few symptoms other than proptosis or swelling. (msdmanuals.com)
  • Ophthalmologists should be aware of this presentation when assessing patients with COVID-19 who present with orbital inflammatory symptoms. (jhsmr.org)
  • From the above-mentioned symptoms, the loss of vision is the most common complaint of patients with orbital apex syndrome. (healthncare.info)
  • Other commonly reported symptoms include myalgia, headache, retro-orbital pain and vomiting. (bvsalud.org)
  • The disease is usually mild with symptoms that last from several days to a week. (bvsalud.org)
  • It is the most common orbital complication of rhinosinusitis. (medscape.com)
  • In the setting of extensive sclerosis there may be restriction, compression, and destruction of orbital tissue. (wikipedia.org)
  • Infectious material can be inoculated directly into the orbital soft tissue secondary to trauma, surgery, or orbital foreign bodies. (medscape.com)
  • Woeller and his collaborators have already discovered and patented promising new therapies that may arrest this process and could be used in treating diseases that manifest with excessive scar formation and/or excessive fat tissue, like TED. (rochester.edu)
  • IgG4-related disease ( IgG4-RD ), formerly known as IgG4-related systemic disease , is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4 -secreting plasma cells , various degrees of fibrosis (scarring) and a usually prompt response to oral steroids . (mdwiki.org)
  • Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory disorder associated with fibrosis and abundant tissue lymphoplasmacytic infiltrations. (hindawi.com)
  • Tissue remodeling, fibrosis and fat proliferation cause changes in the orbital tissues which can affect esthetics and visual function. (eyehospital.nl)
  • Orbital decompression involves removing some bone from the eye socket to open up one or more sinuses and so make space for the swollen tissue and allowing the eye to move back into normal position. (karenlchapmanmd.com)
  • It is the most common painful orbital mass in the adult population, and is associated with proptosis, cranial nerve palsy (Tolosa-Hunt syndrome), uveitis, and retinal detachment. (wikipedia.org)
  • Overall, radiographic features for idiopathic orbital inflammatory syndrome vary widely. (wikipedia.org)
  • Since December 2019, coronavirus disease 2019 (COVID-19) has become a global pandemic caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (cov19longhaulfoundation.org)
  • Some hypothesize that it is a clinical syndrome consisting of different diseases with different underlying etiologies. (aao.org)
  • Orbital apex syndrome is a condition in which the cranial and optic nerves are involved and they do not work properly. (healthncare.info)
  • The inclusion of ocular motor nerves in the anatomical zone of the orbital apex causes ophthalmoplegia and visual loss which leads to orbital apex syndrome. (healthncare.info)
  • Patients with orbital apex syndrome mostly complain about hypoesthesia of the forehead and afferent pupillary deficit. (healthncare.info)
  • Due to this, orbital apex syndrome is considered different from the other two diseases. (healthncare.info)
  • Thus, this feature of orbital apex syndrome is considered a distinguishing characteristic. (healthncare.info)
  • Bald Dacryoadenitis, dak-re-o-ad-en-i'- lis. (web.app)
  • Inflammatory myofibroblastic tumor (IMT), as a mesenchymal tumor, is common in the lung and abdomen but rare in the paranasal sinus and nasopharynx. (hindawi.com)
  • Inflammatory myofibroblastic tumor (IMT) is recognized as an intermediate mesenchymal tumor by the World Health Organization [ 1 ]. (hindawi.com)
  • It is also theorized that, with increasing age, the orbital septum becomes attenuated and fat herniates through the palpebral orbicularis to create the TTD 7 . (eyewiki.org)
  • The remodeling of scleral matrix is very important to investigate the pathogenesis and to develop therapeutic agents in various ocular diseases, including scleritis, orbital inflammatory diseases and vitreo-retinal diseases. (arvojournals.org)
  • She provides comprehensive eye care including both routine vision and medical eye exams, as well as optometric management of ocular diseases such as glaucoma, dry eye, macular degeneration and cataracts. (chesapeakeeyecare.com)
  • The incidence of lymphoproliferative ocular diseases, especially malignant lymphoma, has increased over the years. (medscape.com)
  • Given that Johnathan had not shown any improvement on IV antibiotics, had a reassuring MRI without abscess, and had no systemic signs of infection, we started him on IV steroids (1 mg/kg) for presumed idiopathic orbital inflam-mation (IOI). (aao.org)
  • Ophthalmic or endoscopic intervention may be required in the case of an orbital or subperiosteal abscess, depending on the severity of the infection. (healthncare.info)
  • As the disease progresses the mild orbital congestion and adnexal edema become more destructive. (healthncare.info)
  • Orbital and adnexal lymphoma is associated with systemic lymphoma in 30-35% of cases. (medscape.com)
  • The median age at presentation for orbital and adnexal lymphoma is older than 60 years. (medscape.com)
  • A complete systemic workup was performed to exclude other systemic inflammatory diseases. (jhsmr.org)
  • Sarcoidosis is a systemic inflammatory disease characterized by the formation of noncaseating granulomas in affected organs, most commonly the lungs, lymph nodes, skin, and eyes. (aao.org)
  • Sarcoid is a systemic inflammatory disease and can manifest itself in multiple ways. (aao.org)
  • We present a case of orbital inflammatory disease associated with zolendronate infusion. (nih.gov)
  • He remained febrile, and on day 15 he was transferred to a tertiary care center for evaluation by infectious diseases, oculoplastic surgery, and rheumatology specialists. (cdc.gov)
  • Author of more than 150 publications on retinal diseases and surgery, Dr. Elman is an Assistant Professor of Ophthalmology at the Johns Hopkins University School of Medicine. (medstarhealth.org)
  • He received fellowship training in Retinal Vascular Diseases at the Wilmer Eye Institute of the Johns Hopkins University and fellowship training in Diseases and Surgery of the Retina and Vitreous at Barnes Hospital/Retina Consultants, Ltd. of Washington University. (medstarhealth.org)
  • This discussion is not meant to be a comprehensive tome on orbital surgery but merely an overview of commonly described orbitotomies. (medscape.com)
  • Orbital injury and complications are commonly encountered in endoscopic sinus surgery (ESS) despite advances in techniques and instrumentation. (scirp.org)
  • This paper presents and discusses the management of six patients admitted with orbital infection by service Oral and Maxillofacial Surgery General Hospital Roberto Santos in Salvador, Bahia. (bvsalud.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • I'm Loretta Jackson Brown and I'm representing the Clinician Outreach and Communication Activity - COCA - with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • Dr. Dana Meaney-Delman is a senior medical advisor in the National Center for Emerging and Zoonotic Infectious Diseases at the Centers for Disease Control and Prevention. (cdc.gov)
  • Dr. Cynthia Moore is a director of the Division of Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention. (cdc.gov)
  • The clinical manifestations of bandlike in character) and retro-orbital pain, general- dengue may include high-grade fever, headache, retro- ized body ache, myalgia and arthralgia. (who.int)
  • Secondary osteoporosis and metabolic bone disease in patients 50 years and older with osteoporosis or with a recent clinical fracture: a clinical perspective. (myeloma.org.uk)
  • respiratory compromise secondary to cerebrovascular accident, respiration failure secondary to neurological diseases (i.e. (reviewofoptometry.com)
  • IgG4-related disease (IgG4-RD) is a chronic fibro-inflammatory disorder that potentially affects virtually every organ system. (aad.org)
  • A Harvard-trained specialist in retinal and macular diseases and board-certified ophthalmologist, Dr. Diala joined the practice in 2012. (chesapeakeeyecare.com)
  • Removal of exposed orbital fat using powered instruments was performed in 3 patients, two of whom transiently showed periorbital edema postoperatively. (scirp.org)
  • The aim of this paper is to describe the pathophysiological, histopathological, and clinical features of Graves' Disease (GD) and Graves' Orbitopathy (GO) with elevated IgG4 levels. (hindawi.com)
  • The aim of this paper is to summarize current knowledge on the role of IgG4 as a biomarker of Graves' Disease and Graves' Orbitopathy. (hindawi.com)
  • For example, some companies stipulate that in order to be covered, patients cannot have Graves disease for 9 months. (ophthalmologytimes.com)
  • Lacrimal gland swelling may rarely be a sign of childhood Sjögren's disease. (web.app)
  • In her career at CDC, she has focused on the development of evidence-based clinical guidelines for infectious diseases. (cdc.gov)
  • On histopathology, this fibroinflammatory disease is characterized with specific findings such as lymphoplasmacytic infiltration of IgG4-positive plasma cells, obliterative phlebitis, and storiform fibrosis, in most cases accompanied by increased levels of serum IgG4 [ 10 ]. (hindawi.com)
  • Histopathology revealed mixed inflammatory infiltrates of lymphocytes, plasma cells, and histiocytes. (bvsalud.org)
  • TED is the most common orbital disease in North America. (eyewiki.org)
  • Whereas Hodgkin lymphoma rarely causes ocular disease, non-Hodgkin lymphoma (NHL) is the most common type of ocular lymphoma. (medscape.com)
  • A history of pulmonary disease in an individual with granulomatous uveitis should raise the suspicion of sarcoidosis. (aao.org)
  • The inflammatory response can be nonspecific, granulomatous, or vasculitic or due to reactive lymphoid hyperplasia. (msdmanuals.com)
  • Disclosed is a method for treating an ocular inflammatory disease (OID), e.g., uveitis or conjunctivitis, comprising periodic administration of a therapeutically effective amount of laquinimod or a pharmaceutically acceptable salt thereof. (justia.com)
  • Coronaviruses can cause severe ocular disease in animals, including anterior uveitis, retinitis, vasculitis, and optic neuritis in feline and murine species. (cov19longhaulfoundation.org)
  • It was not until 1909 that a Danish ophthalmologist, Heerfordt Christian Frederik [2] , described uveitis as part of the disease process. (aao.org)
  • Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease. (myeloma.org.uk)