• We investigated effects on systemic inflammation, oxidative stress and DNA damage in humans who lived in a reconstructed Viking Age house, with indoor combustion of wood for heating and cooking. (ku.dk)
  • Different aspects of this relationship, such as genetic, environmental, and social risk factors, as well as pathogenic and pharmacological connections have been explored.One particularly compelling hypothesis is that systemic inflammation present in both psoriasis and CVD either leads to, or exacerbates, each disease. (cardiometabolichealth.org)
  • We assessed changes in the gut microbiota, intestinal permeability, gut peptides, intestinal epithelial tight-junction proteins ZO-1 and occludin (qPCR and immunohistochemistry), hepatic and systemic inflammation. (bmj.com)
  • We concluded that insulin can inhibit the production of inflammatory cytokines and the oxidative stress response, thereby improving brain tissue damage. (biomedcentral.com)
  • To followup these promising preliminary findings, we tested the efficacy of two doses of supplemental calcium (1.0 or 2.0 g/day) relative to placebo on modulating circulating biomarkers of inflammation [C-reactive protein (CRP) and 10 cytokines] and oxidative stress (F2-isoprostanes) over a 4-month treatment period among 193 patients with previous sporadic, colorectal adenoma in a randomized, double-blinded, placebo-controlled clinical trial. (umn.edu)
  • In this study, the levels of inflammatory cytokines in the intestinal mucosa, serum inflammatory indexes, oxidative stress indexes and immune-related indexes were detected, and their correlations with vitamin deficiency and clinical significance were discussed. (cellmolbiol.org)
  • Enzyme-linked immunosorbent assay (ELISA) was adopted to detect the serum level of 25-hydroxyvitamin D 3 , immunohistochemistry was applied to examine the expression of inflammatory cytokines in the intestinal mucosa, serum inflammatory indexes, oxidative stress indexes and immune-related indexes were measured, and their correlations were analyzed. (cellmolbiol.org)
  • Prebiotic-treated mice exhibited a lower plasma lipopolysaccharide (LPS) and cytokines, and a decreased hepatic expression of inflammatory and oxidative stress markers. (bmj.com)
  • This review presents scientific papers on the role of ROS and oxidative stress in the production of mediators of pulmonary inflammation and mechanisms of carcinogenesis from selected recent studies and reviews (most from high impact scientific publications) on the risks factors for developinmg cancer of the respiratory system. (chem-tox-ecotox.org)
  • CNT in biochemical models and in cells yielding the products engineered CNT represent a possible health risk due to their that did not cause pulmonary inflammation in mice [14]. (cdc.gov)
  • Associations were found between vitamin D status and biomarkers of oxidative stress and inflammation in adolescents and children. (liposomanutraceuticals.com)
  • Published observational or interventional studies were included with participants aged 2 to 19 years old, in which oxidative and/or inflammatory stress biomarkers were measured. (liposomanutraceuticals.com)
  • Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease. (bvsalud.org)
  • An abnormal increase in biomarkers of oxidative stress and inflammation are consistently linked with the development and even progression of metabolic diseases , including enhanced CVD risk . (bvsalud.org)
  • Coffee is considered one of the most consumed beverages in the world, while reviewed evidence regarding its capacity to modulate biomarkers of oxidative stress and inflammation remains limited. (bvsalud.org)
  • The current study made use of prominent electronic databases, including PubMed , Google Scholar, and Scopus to retrieve information from randomized controlled trials reporting on any association between coffee consumption and modulation of biomarkers of oxidative stress and inflammation in healthy individuals or those at increased risk of developing CVD. (bvsalud.org)
  • In fact, summarized evidence indicates that coffee consumption , mainly due to its abundant antioxidant properties, can reduce biomarkers of oxidative stress and inflammation , which can be essential in alleviating the CVD risk in healthy individuals. (bvsalud.org)
  • Overall, our results provide no evidence that calcium supplementation favorably modulates concentrations of circulating biomarkers of inflammation or oxidative stress over 4 months among patients with a previous colorectal adenoma. (umn.edu)
  • Cancer researchers have found that malondialdehyde, an endogenous product of oxidative stress, induces sequence-dependent frameshift mutations and base pair substitutions in bacteria and in mammalian cells and may play a role in the development of colorectal cancer in humans. (science-bbs.com)
  • TMAO treatment for either 24H or 48H induces reduced cell viability and enhanced oxidative stress. (nature.com)
  • This study demonstrates that TMAO induces distinct time-dependent molecular signatures involving inflammation and remodelling pathways, while pathways such as oxidative stress are also modulated, but in a non-time-dependent manner. (nature.com)
  • Vitamin C keeps skin healthy by protecting it from oxidative damage caused by the sun and exposure to pollutants like cigarette smoke or the ozone ( 12 , 13 ). (healthline.com)
  • However, a clear connection between exposure to oxidative stress and release of inflammatory mediators in brain neurons has not been shown. (biomedcentral.com)
  • In conclusion, even a high inhalation exposure to wood smoke was associated with limited systemic effects on markers of oxidative stress, DNA damage, inflammation, and monocyte activation. (ku.dk)
  • It acts as an anti-inflammatory supplement (exposure negative reviews) and an antioxidant to combat free radical damage and oxidative stresses. (ipsnews.net)
  • Besides the importance of this process, oxidation of LDL is not the sole initiator of inflammation, as the imbalance between oxidants and antioxidants is also important for the process of atherogenesis. (hindawi.com)
  • NAC can protect liver tissue against Cd by elevating antioxidants capacity, mitigating oxidative stress and inflammation, as well as down-regulating of apoptotic genes. (springer.com)
  • The current analysis of data highlights the importance of understanding how coffee consumption can be beneficial in strengthening intracellular antioxidants to alleviate pathological features of oxidative stress and inflammation to reduce CVD risk within the general population . (bvsalud.org)
  • A clearer appreciation of the potential therapeutic utility of antioxidants would emerge only when the complexity of their effects on mechanisms that interact to determine the extent of oxidative damage in vivo are more fully defined and understood. (unboundmedicine.com)
  • With its antioxidants, black garlic can help reduce inflammation in the body and prevent cognitive conditions such as Alzheimer's disease and Parkinson's disease . (webmd.com)
  • By reducing inflammation, the antioxidants in black garlic can help boost your immune system . (webmd.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • The objective of the present study was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effects of Nigella sativa L. supplementation on the circulating inflammatory and oxidative stress markers, including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), total antioxidant capacity (TAC) and malondialdehyde (MDA). (nih.gov)
  • The inflammation markers were measured in plasma using electrochemiluminescence detection-based immunoassays, and F2-isoprostanes were measured in plasma using gas chromatography-mass spectrometry. (umn.edu)
  • ROS and RNS can also indirectly contribute to tissue damage by activating a number of cellular pathways resulting in the expression of stress-sensitive genes and proteins to cause oxidative injury. (unboundmedicine.com)
  • The Dunaief lab has found that AMD retinas have iron overload, which can cause oxidative stress. (upenn.edu)
  • Pulmonary cancer mechanisms have been linked to a series of biochemical pathways of DNA and lipid membrane oxidative damage, macrophage stimulation, telomere shortening, modulation of gene expression and activation of transcription factors with important role in carcinogenesis. (chem-tox-ecotox.org)
  • According to the National Cancer Institute , inflammation can create DNA damage that may lead to cancer. (medicalnewstoday.com)
  • Here, we evaluated cardiac inflammation, oxidative stress, DNA damage, and coagulation events in mice with adenine (0.2% w/w in feed for 4 weeks)-induced CKD. (uaeu.ac.ae)
  • In conclusion, the administration of adenine in mice induced CKD-associated cardiac inflammation, oxidative stress, Nrf2 expression, and DNA damage. (uaeu.ac.ae)
  • Human lung tissues are exposed daily to air oxidants generated either endogenously or exogenously, but all aerobic organisms are protected against oxidative damage by evolutionary enzymatic and non-enzymatic antioxidant systems. (chem-tox-ecotox.org)
  • Moreover, oxidative stress also activates mechanisms that result in a glia-mediated inflammation that also causes secondary neuronal damage. (unboundmedicine.com)
  • Additionally, continual oxidative stress from CCl 3 causes DNA damage, protein malfunction, and disrupted calcium homeostasis. (cdc.gov)
  • Evidence suggests that cumulative oxidative damage contributes to AMD and aging in general. (upenn.edu)
  • Oxidative damage is believed to be one of the mechanisms behind aging and many diseases. (healthline.com)
  • Oxidative stress linked to vascular damage plays an important role in the pathogenesis of systemic sclerosis (SSc). (whiterose.ac.uk)
  • Our findings support the notion that the employment of PDE5i in the management of RP may be explored for its efficacy in modulating the oxidative stress-induced proinflammatory activation of dermal fibroblasts in vivo and may ultimately aid in the prevention of tissue damage caused by SSc. (whiterose.ac.uk)
  • It increases immunity, reduces oxidative stress and protects against free radical damage. (ipsnews.net)
  • The effect of curcumin supplementation on prooxidant/antioxidant balance, inflammation and exercise-induced muscle damage in physically active men. (who.int)
  • The purpose of this intervention is to evaluate the effects of 2 g curcumin supplementation on prooxidant/antioxidant balance, inflammation and exercise-induced muscle damage. (who.int)
  • Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
  • We then discuss how obesity leads to insulin resistance via a complex interplay among systemic fatty acid excess, microhypoxia in adipose tissue, ER stress, and inflammation. (jci.org)
  • In particular, we focus on the hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity. (jci.org)
  • Here, we hypothesised that prebiotic modulation of gut microbiota lowers intestinal permeability, by a mechanism involving glucagon-like peptide-2 (GLP-2) thereby improving inflammation and metabolic disorders during obesity and diabetes. (bmj.com)
  • Obesity is typically associated with a cluster of several metabolic disorders, characterised by a low-grade inflammation. (bmj.com)
  • Oxidative stress and inflammation in the vascular wall are essential mechanisms of atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic diseases, aging, hypertension, etc. (frontiersin.org)
  • This review article will summarize the most recent findings on the functional roles of arginases in vascular diseases and/or dysfunctions and the underlying mechanisms in relation to oxidative stress and inflammations. (frontiersin.org)
  • In the past decades, unambiguous evidence has been provided that heightened oxidative stress and vascular wall inflammation are the key mechanisms for initiation and progression of atherosclerosis and vascular diseases associated with the risk factors ( Hansson and Hermansson, 2011 ). (frontiersin.org)
  • Therefore, elucidation of mechanisms underlying oxidative stress and inflammations in the vascular wall will have important impact in understanding atherosclerosis and vascular diseases associated with cardiovascular risk factors and will eventually lead to novel and effective therapeutic modalities. (frontiersin.org)
  • Previous studies have demonstrated that inflammatory cytokine release and oxidative stress injury are major pathophysiological mechanisms of SAE in critically ill patients. (biomedcentral.com)
  • Biopersistence of carbon nanotubes (CNT) - resulting from their (neutrophils), - involved in the principal defense mechanisms of inherent durability [1,2] is one the major stumbling blocks on the innate immunity -was also effective in oxidative biodegradation of way of their broad biomedical applications. (cdc.gov)
  • Oxidative stress and neuroinflammation play important roles in the pathogenesis of AD. (nature.com)
  • Inflammation and oxidative stress play important roles in colorectal carcinogenesis. (umn.edu)
  • Previous in vitro and in vivo studies revealed that oxidative stress caused by the accumulation of Aβ contributed to the initiation of AD 8 . (nature.com)
  • Our results provide direct evidence for the participation of MPO - one of the key-orchestrators of inflammatory response - in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of nanomaterials through genetic or pharmacological manipulations. (cdc.gov)
  • Oxidative stress indexes such as superoxide dismutase (SOD) and malondialdehyde (MDA) in the vitamin deficiency group were significantly different from those in the normal vitamin group, but no difference was found in myeloperoxidase (MPO). (cellmolbiol.org)
  • Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
  • We previously reported that the gut microbiota is involved in high-fat diet-induced metabolic endotoxaemia, adipose tissue inflammation and metabolic disorders. (bmj.com)
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • Evidence has been provided that activation of the vascular endothelial cells in the presence of the risk factors promotes oxidative stress and vascular inflammatory responses, leading to acceleration of atherosclerotic vascular disease. (frontiersin.org)
  • The differentially expressed oxidative stress genes (DEOSGs) were analyzed by intersection of DEGs and oxidative stress-related genes. (nature.com)
  • Our study identified 9 key genes associated with oxidative stress and immune reaction in AD pathogenesis. (nature.com)
  • Insulin has important immunomodulatory effects and protective effects against oxidative stress injury in the peripheral organs of septic patients. (biomedcentral.com)
  • Therefore, in this study, we aimed to explore whether insulin therapy can inhibit cytokine production (IL-1, IL-6, and TNF-a) and oxidative stress injury of the brain tissue in septic rats. (biomedcentral.com)
  • After 6 hours of insulin therapy, we found that the cytokine concentrations notably decreased and oxidative stress injuries in the cortex, hypothalamus, and hippocampus were alleviated in septic rats. (biomedcentral.com)
  • These data show that acetaminophen has anti-oxidant and anti-inflammatory effects on neurons and suggest a heretofore unappreciated therapeutic potential for this drug in neurodegenerative diseases such as AD that are characterized by oxidant and inflammatory stress. (biomedcentral.com)
  • [ 1 ] This approach tries to alleviate pain by modifying the afferent sensory nerves in the celiac plexus, using agents that anesthetize, reduce inflammation, or destroy the nerve fibers. (medscape.com)
  • The primary such as hs-CRP, total homocysteine, as well enzymatic defences are intracellular, but as oxidative stress, have been proposed other antioxidant defences are largely ex- as risk factors for the development and tracellular, including antioxidative sub- progression of atherosclerosis and athero- strates such as uric acid and unconjugated thrombotic cardiovascular disease [10-13]. (who.int)
  • suggests that bilirubin is a potent physiolog- ical antioxidant that may provide important protection against atherosclerosis, CAD and inflammation. (who.int)
  • Recent research provides emerging evidence supporting an essential role of increased activity of arginases including arginase-I and arginase-II in causing eNOS-uncoupling, which results in vascular oxidative stress and inflammatory responses, and ultimately leading to vascular diseases. (frontiersin.org)
  • There is strong evidence that calcium reduces risk for colorectal neoplasms, possibly through its ability to bind bile acids and prevent their colonic toxicity (which occurs via an oxidative mechanism and results in an inflammatory response). (umn.edu)
  • The purpose of this review is to summarize the current evidence in support of this critical role played by oxidative stress of neuronal and glial origin in neurodegenerative diseases. (unboundmedicine.com)
  • STZ has been shown to generate an imbalance between oxidative and antioxidant systems by decreasing the secretion of peroxidase in submandibular glands. (naturalnews.com)
  • Immune cells mistakenly identify the joints and surrounding areas as invaders and release inflammatory factors and oxidative molecules as an ill-informed defense mechanism. (medicalnewstoday.com)
  • Curcumin can suppress many molecules known to play major roles in inflammation, but its bioavailability needs to be enhanced. (healthline.com)
  • Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. (mdpi.com)
  • Vitamins are also related to oxidative stresses to some extent but have little effect on immune-related indexes. (cellmolbiol.org)
  • Nigella sativa supplementation is associated with improved inflammation and oxidative status. (nih.gov)
  • Here, we investigated the effects of the phosphodiesterase type 5 inhibitor (PDE5i) sildenafil, currently used in the management of RP, in modulating the proinflammatory response of dermal fibroblasts to oxidative stress in vitro. (whiterose.ac.uk)
  • Unhealthy diets, lack of physical activity, and stress are key factors contributing to hypertension.2. (thailand-business-news.com)
  • As such, they concluded that the aqueous extract could be used as a local or systemic preventive agent against oral diseases caused by oxidative stress in diabetic subjects. (naturalnews.com)
  • Studies in China and foreign countries have shown that vitamins have anti-inflammation and immunoregulation functions in patients with UC, but the specific mechanism is not yet clear. (cellmolbiol.org)
  • With that in mind, a group of researchers conducted a study on whether an aqueous extract can be used to treat oxidative stress in the submandibular glands of diabetic rats. (naturalnews.com)