Induction of aryl hydrocarbon hydroxylase, an enzyme that may produce carcinOgenic epaxide derivative of polycyclic hydrocarbons, has been shown to occur with THC and cannabis. (erowid.org)
Methylcholanthrene is a highly carcinogenic polycyclic aromatic hydrocarbon produced by burning organic compounds at very high temperatures[clarification needed]. (wikipedia.org)
This is likely because it is plausible that two polycyclic aromatic hydrocarbons are metabolized via the same pathway. (wikipedia.org)
The sexhormone is, like 3-MC, a polycyclic aromatic hydrocarbon. (wikipedia.org)
In addition, a variety of substances such as fuel, water, antifreeze, dust, and various combustion products such as polycyclic aromatic hydrocarbons (PAHs), metals, and metallic oxides accumulate in the oil. (cdc.gov)
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. (curehunter.com)
The aryl hydrocarbon receptor (AHR) is well known for mediating the toxic effects of TCDD and has been a subject of intense research for over 30 years. (oregonstate.edu)
A major participant in the process of the dioxin-toxicity is the dioxin receptor, namely the aryl hydrocarbon receptor (AhR). (biomedcentral.com)
Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 1 M). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties. (csnpharm.com)
Cytochrome3
2,3,7,8-Tetrachlorodibenzo- p Dioxin Induction of Aryl Hydrocarbon Hydroxylase in Female Rat Liver Evidence for de Novo Synthesis of Cytochrome P-448. (aspetjournals.org)
The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. (lookformedical.com)
The classic pathway is the predominant pathway, with the first and rate-limiting reaction catalyzed by a cytochrome P450 enzyme, cholesterol 7 α -hydroxylase (CYP7A1). (aspetjournals.org)
Receptors1
AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. (oregonstate.edu)
Enzyme1
Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. (drugbank.com)
CYP8B11
Subsequent enzymatic reactions catalyzed by sterol 12 α -hydroxylase (CYP8B1) and sterol 27-hyroxylase (CYP27A1), respectively, yield the primary BAs, cholic acid (CA) and chenodeoxycholic acid (CDCA). (aspetjournals.org)
Induces1
2 In addition, hypoxia induces genetic instability by the induction of fragile sites causing gene amplification. (bmj.com)
Osilodrostat is an inhibitor of 11β-hydroxylase (CYP11B1) and, to a lesser extent, aldosterone synthase (CYP11B2). (drugbank.com)
MRNA3
Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity. (academicinfluence.com)
The neurological properties of N2a-Rα based on AhR activation were evaluated by immunohistochemical analysis of cytoskeletal molecules and by RT-PCR analysis of mRNA expression of neurotransmitter-production related molecules, such as tyrosine hydroxylase (TH). (biomedcentral.com)
N2a-Rα cells expressed tyrosine hydroxylase (TH) mRNA as a functional marker of catecholaminergic neurotransmitter production. (biomedcentral.com)
Synthesis1
These results point towards inhibition of demethylase synthesis and/or induction of demetylase degradation. (wikipedia.org)
Hypoxia1
Induction of hypoxia in vitro boosts creation of VEGF-A in various cell lines in the retina. (researchensemble.com)
Cells1
Kenpaullone demonstrates a wide range of biological utility, extending from maintenance of pancreatic β cell survival and proliferation to the induction of apoptosis in cancer cells. (xcessbio.com)
Results1
These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps. (lookformedical.com)