In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)
Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
Repetitive apneic episodes disrupt the normal physiologic function and trigger sympathetic activation, vascular endothelial dysfunction, increased oxidative stress, inflammation, increased platelet aggregability, and metabolic dysregulation. (hindawi.com)
In particular, cocoa flavanols, a sub-group of flavonoids (also present in berries, grapes, apples and tea) have been shown to improve endothelial function in humans quite rapidly (within 1-2 h) by enhancing vasodilatory properties of peripheral arteries 5 , 6 . (nature.com)
Hence, hypercapnia represents a robust model to test whether flavanol-mediated increases in endothelial function (as assessed by gold-standard FMD) mediate benefits in cerebrovascular and cognitive function. (nature.com)
Diseases11
Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. (frontiersin.org)
We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. (frontiersin.org)
The abnormal morphology and dysfunction of mitochondria have been proven as the principal mechanisms in the pathogenesis of cardiovascular diseases, such as heart failure, myocardial infarction, atherosclerosis, and hypertension ( 4 - 6 ). (frontiersin.org)
So mitochondria-targeted therapy is suggested to be a potential treatment strategy for cardiovascular diseases. (frontiersin.org)
However, clinical trials of these agents for cardiovascular diseases were hardly approved to carry out, even less to evaluate their clinical effectiveness and safety. (frontiersin.org)
Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
There is a dichotomy in both developed and developing countries as their populations are experiencing the phenomenon of being 'over fed and under nourished', i.e., caloric/energy excess and lack of essential nutrients, leading to health deficiencies, skyrocketing global obesity rates, excess chronic diseases, and premature mortality. (springer.com)
Regardless of how "health" is defined by policy-makers, today's consumers want to be empowered to manage their own health, and the increased focus on self-care is often exacerbated by current public health challenges, including non-communicable diseases and/or pandemic. (springer.com)
Studies showed that pomegranate extracts are associated with the treatment and prevention of many diseases and disorders in men , such as cardiovascular diseases, infertility, and erectile dysfunction [ 13 , 14 , 15 ]. (bioactor.com)
The most important diseases and disorders for which the nurses would like to have shared operational guidelines were diabetes, cardiovascular diseases, pain, memory and psychiatric disorders. (helsinki.fi)
The susceptibility of strawberry fruit to postharvest diseases and decline of quality attributes increases after harvest and through extended storage, and as a consequence changes in physiological and biochemical parameters. (intechopen.com)
Disorders3
We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
The alarming degree to which OSA is clinically diagnosed in middle-aged men and women makes it a significant public health problem, and increasing evidence indicates that untreated OSA can lead to several comorbid disorders. (hindawi.com)
OSA is a risk factor for cardiovascular disorders including hypertension, congestive heart failure (CHF), myocardial ischemia, arrhythmias and infarction, and cerebrovascular conditions including stroke [ 3 ]. (hindawi.com)
Vascular1
There is a progressive decrease in sympathetic activity, blood pressure (BP), stroke volume, heart rate, cardiac output, and systemic vascular resistance, during deeper NREM sleep stages [ 4 ]. (hindawi.com)
Mortality1
Overall, 43% (3/7), 53% (10/19) and 74% (32/43) of the populations studied had decreasing trends in all-cause mortality rates in people with diabetes in 1970-1989, 1990-1999 and 2000-2016, respectively. (cdc.gov)
Fertility1
Zinc is a critical mineral for men's health as even a small deficiency can impact the immune system, cardiovascular health, reproductive function, and fertility [ 3 ]. (bioactor.com)
Populations1
CONCLUSIONS: Our results demonstrate the need to identify strategies to improve retention, especially among individuals who are younger or are members of racial/ethnic minority populations and among those who report less physical activity or less early weight loss. (cdc.gov)
Diabetes1
CONCLUSIONS: The prevalence of reported diabetes among adults with TB disease has increased. (cdc.gov)
Anaerobic threshold1
In humans, açai supplementation indicated positive results in increasing exhaustion time to 90% of VO and increasing intensity at the anaerobic threshold. (bvsalud.org)
Testosterone5
As men age, they experience a decrease in testosterone levels. (bioactor.com)
A study performed on 120 healthy men showed that a 12-week supplementation of fenugreek seed extract (600 mg/day) increased testosterone levels and improved sexual function, compared to placebo [ 1 ]. (bioactor.com)
Also, supplementation of fenugreek seed extract in healthy male athletes resulted in increased fat-free mass, lean body mass, and elevated testosterone levels compared to placebo [ 2 ]. (bioactor.com)
These findings suggest that fenugreek seed extract is a promising ingredient for men's health, especially in terms of increasing testosterone levels and improving sexual function. (bioactor.com)
Note - Research has shown testicular extracts contain nearly undetectable levels of testosterone that are insufficient to have a biological effect, so please do not consider seeking out or using testicular extracts to directly increase your T levels! (interplexus.com)
Immune1
It plays an important role in many physiological functions, such as supporting the immune system and healing damaged cells. (bioactor.com)
Role3
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. (frontiersin.org)
The physiological role of T in women also extends to direct impacts on follicular development. (interplexus.com)
Health4
Even compared to slow, relaxing music, silence resulted in greater decreases in these important measures of heart health. (healthline.com)
More research is needed to determine the long-term effects of silence on cardiovascular health, but these results are promising. (healthline.com)
Globally, there has been a marked increase in longevity, but it is also apparent that significant inequalities remain, especially the inequality related to insufficient 'health' to enjoy or at least survive those later years. (springer.com)
As the increasing expectations and pressures of our lives continue to evolve, it is important for men to develop a proactive approach to maintain their physical, mental, and sexual health. (bioactor.com)
Athletes2
In general, most coaches and athletes have assumed that increased training was the ultimate prescription for improvement. (lww.com)
However, there is a phenomenon that can take place with elite athletes, known as parasympathetic saturation , which the Kiviniemi research didn't account for. (whoop.com)
Decline1
Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults. (medlineplus.gov)
Humans2
Yet, the extent to which increases in circulatory levels of NO by flavanols can translate into benefits in the brain vasculature, and effectively influence cognitive performance in humans, is poorly understood. (nature.com)
CONCLUSION: This study demonstrated that the consumption of interesterified structured lipids EPA and MCTs improved endurance in humans. (bvsalud.org)
Greater2
If the recovery rate can be improved, greater training volumes would be possible without incurring the negative sequelae of overtraining. (lww.com)
Generally speaking, the Kiviniemi research suggested that training based on daily HRV measurements improves cardiovascular fitness at a greater rate than a traditional training method with a set schedule of workouts. (whoop.com)
Symptoms3
Objective: Most of the research on vasovagal reactions has focused on the contributions of cardiovascular activity to the development of symptoms. (researchgate.net)
Taking 30-500 mg of DHEA by mouth daily seems to improve symptoms of depression. (medlineplus.gov)
Taking DHEA by mouth does not improve symptoms of this condition. (medlineplus.gov)
Practices2
Modern lifestyles and trends that promote overconsumption and unhealthy practices have contributed to an increase in the annual incidence of diabetic AS worldwide, which has created a heavy burden on society. (wjgnet.com)
The training plan includes topics related to geriatric pharmacotherapy and improving collaborative practices and communication as identified by those involved in different stages of the study. (helsinki.fi)
Research3
Older 2003 research associated a chronically noisy environment with increases in heart rate and blood pressure. (healthline.com)
Research has advanced our knowledge of physiological, biomechanical, and the psychological aspects of physical training and performance. (lww.com)
The WHOOP Data Science team has expanded on the last decade of medical and academic HRV research to build a physiological monitoring platform capable of delivering athletic-performance optimizing analytics. (whoop.com)
Studies2
Studies also showed that it leads to a decrease in fatigue and tiredness [ 8 ]. (bioactor.com)
They further show the importance of studies combining physiological and graded cognitive challenges in young adults to investigate the actions of dietary flavanols on brain function. (nature.com)
Functions1
it projects to most key brain regions and modulates numerous physiological functions. (hindawi.com)
Adults2
Taking DHEA by mouth doesn't improve muscle strength in adults. (medlineplus.gov)
Taking DHEA by mouth doesn't improve physical performance in older adults. (medlineplus.gov)
Results1
It is well accepted that over-load is necessary for improvement, whereas overtraining results in a breakdown at some level, thus impairing, rather than improving, performance. (lww.com)
Bone2
They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels. (medlineplus.gov)
Levels1
Increased energy levels lead to improved stamina and sexual performance. (bioactor.com)
Systems1
Nucleus tractus solitarius (NTS) is the central integration hub for afferents from upper airway (somatosensory/gustatory), respiratory, gastrointestinal, cardiovascular (baroreceptor and chemoreceptor) and other systems. (hindawi.com)
Mental1
This mental phenomenon has a physiological basis. (healthline.com)
Risk1
Using higher doses or using it long-term can increase the risk of serious side effects including cancer. (medlineplus.gov)
Effects1
Purpose The goal of the present investigation was to examine the physiological effects of observing another experience a. (researchgate.net)
Normal1
In normal physiologic sleep, distinct sleep stage-related changes occur in cardiovascular regulation. (hindawi.com)
Elderly1
One way to improve the medication expertise of those various parties involved in caring elderly people is continuing education (CE). (helsinki.fi)
Body1
Training in its simplest form represents acute challenges to the body intended to optimize chronic improvements in physiological capabilities. (lww.com)
Years1
Taking DHEA by mouth or applying it to the skin might improve skin appearance after menopause and in people over the age of 60 years. (medlineplus.gov)
Performance1
Improved recovery may result in establishment of a performance plateau at a higher level. (lww.com)
Annual1
the annual proportion increased from 15% in 2010 to 22% in 2017. (cdc.gov)