Many controlled clinical trials and numerous systematic reviews of these studies have been published. (meridianhealthnc.com)
Effect1
Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in combination with other drugs, shows positive effect on steroidogenesis and spermatogenesis in men with T2DM and metabolic syndrome, thus MF treatment indicates prospective use for improvement of male reproductive functions and fertility in these disorders. (encyclopedia.pub)
Infertility11
Studies set in infertility clinics have the advantage of investigating obesity trends within infertile populations whereas populations of unselected healthy men across BMI categories enable evaluation of the association between obesity and fertility without a preconceived bias. (medscape.com)
Male obesity and infertility: observational studies of sperm parameters and BMI. (medscape.com)
Support relationship between obesity and male infertility? (medscape.com)
Secondary infertility refers to infertile couples who have been able to achieve pregnancy at least once before (with the same or different sexual partner). (uroweb.org)
In 50% of involuntarily childless couples, a male-infertility-associated factor is found, usually together with abnormal semen parameters [ 1749 ]. (uroweb.org)
In 30-40% of cases, no male-associated factor is found to explain the underlying impairment of sperm parameters and historically was referred to as idiopathic male infertility. (uroweb.org)
Unexplained male infertility is defined as infertility of unknown origin with normal sperm parameters and partner evaluation. (uroweb.org)
It is now believed that idiopathic male infertility may be associated with several previously unidentified pathological factors, which include but are not limited to endocrine disruption as a result of environmental pollution, generation of reactive oxygen species (ROS)/sperm DNA damage, or genetic and epigenetic abnormalities [ 1753 ]. (uroweb.org)
Advanced paternal age has emerged as one of the main risk factors associated with the progressive increase in the prevalence of male factor infertility [ 1754-1761 ]. (uroweb.org)
Table 52 summarises the main male-infertility-associated factors. (uroweb.org)
MATERIALS AND METHODS: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. (bvsalud.org)
Sperm2
Possible explanations why these population studies are not more consistent could include lack of sensitivity of BMI as a measurement of adiposity, presence of subfertility, which may manifest by more subtle changes in testicular/sperm physiology not captured by traditional semen assessments, and finally, heterogeneity within the overweight/obese populations. (medscape.com)
Of these 8, 7 men had increased sperm concentration to normozoospermic range at follow-up (median concentration, 22 million/mL [IQR, 17-25.5]), and 1 man remained oligospermic. (klinikfarmakoloji.com)
Fertility2
These men present with no previous history of diseases affecting fertility and have normal findings on physical examination and endocrine, genetic and biochemical laboratory testing, although semen analysis may reveal pathological findings (see Section 11.3.2). (uroweb.org)
The University of Miami institutional review board approved the study and written informed consent was obtained from all participants. (klinikfarmakoloji.com)
Male participants were about double the females and 60.9% were from Asian countries. (bvsalud.org)
Healthy1
This single-center prospective study at the University of Miami recruited healthy volunteers aged 18 to 50 years scheduled for mRNA COVID-19 vaccination through flyers posted throughout the university hospital and internal list-serve emails. (klinikfarmakoloji.com)
Evaluation1
For this reason, in all infertile couples the male should undergo medical evaluation by a urologist trained in male reproduction. (uroweb.org)
Design1
PURPOSE: This is the first study to design and assess a research capacity building (RCB) specifically tailored for clinical and non-clinical andrology practitioners worldwide. (bvsalud.org)
Figure1
The waterfall plot shows the within-participant change in TMSC from baseline (range, −22 million to 93 million) for each man ( Figure ). (klinikfarmakoloji.com)
Data1
Many population studies are limited by the small sample size of the obese study population, and tend to report overweight/obese data as a single group, which would be expected to reduce the strength of the associations measured. (medscape.com)