Agents used for the management of symptoms in irritable bowel syndrome (IBS) include anticholinergics, antidiarrheals, tricyclic antidepressants, prokinetic agents, bulk-forming laxatives, serotonin receptor antagonists, chloride channel activators, and guanylate cyclase C (GC-C) agonists. (medscape.com)
1 ] Some experts consider imipramine one of the antidepressants of choice for nursing mothers. (nih.gov)
Following exposure te escapable shock, rats received a single injection of either tricyclic antidepressants (imipramine, desipramine), and atypical antidepressant (nomifensine), or saline. (fujita-hu.ac.jp)
Antidepressants are comprised of several different classes including: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs). (acc.org)
Although serotoninergic agents such as antidepressants have been shown to increase neurogenesis, the effects of MnRN lesions remain to be elucidated. (fapesp.br)
Imipramine treatment in depression might exert antidepressant action through BDNF production from astrocytes, and glial BDNF expression might be a target of developing novel antidepressants. (elsevierpure.com)
Controlled trials have found SAM-e to be more efficacious than placebo and equal in efficacy to the tricyclic antidepressants for treating major depressive disorder (MDD) when administered parenterally (either intravenously or intramuscularly). (psychiatrist.com)
Distribution of seven antidepressants (amitriptyline, nortriptyline, imipramine, desipramine, didesmethylimipramine, dothiepin, and citalopram) was measured in vitro in small volumes of blood or erythrocyte membrane suspension using radiolabeled drugs. (nel.edu)
Significantly higher ratios of RBCs to plasma concentrations were found for demethylated metabolites of tricyclic antidepressants and in the case of citalopram. (nel.edu)
Oral tricyclic antidepressants and traditional anticonvulsants are better for short term pain relief than newer generation anticonvulsants. (bmj.com)
Desipramine9
First, CYP2C19 converts imipramine into the active metabolite desipramine, which is then inactivated by CYP2D6. (nih.gov)
This retrospective single center study aimed to prove whether CYP2C19 and ample CYP2D6 genotyping (taking into consideration four null alleles and three decreased-activity alleles) could be used to predict imipramine and desipramine plasma concentrations in depressed patients, and whether genotype-based drug dose recommendations might assist in the early management of imipramine pharmacotherapy. (nih.gov)
In 181 subjects with major depressive disorder, drug doses were recorded, imipramine and desipramine plasma concentrations were monitored and CYP2C19 (*2) and CYP2D6 genotype (*3, *4, *5, *6, *9, *10, *41 and gene duplication) were obtained, yielding graded allele-specific CYP2D6 patient groups. (nih.gov)
Our protocol for CYP2D6 genotyping will thus importantly aid in the prediction of imipramine metabolism, allowing for the use of an adjusted starting dose and faster achievement of predefined imipramine+desipramine plasma levels in all genetic patient subgroups. (nih.gov)
Imipramine is metabolized to desipramine which has antidepressant activity equal to that of imipramine. (nih.gov)
Two women who were taking imipramine 50 mg daily for panic disorder had imipramine and desipramine breastmilk levels measured 1 month postpartum (time after dose not stated). (nih.gov)
Sixteen days after initiation, milk imipramine plus desipramine levels ranged from 21 to 59 mcg/L at various times while taking a dose of 200 mg daily. (nih.gov)
Milk imipramine plus desipramine levels ranged from 48 to 622 mcg/L, with little correlation to dosage. (nih.gov)
The inactivation and clearance of the tricyclic antidepressant imipramine is dependent on CYP2D6 activity. (nih.gov)
In addition, combination treatment of mice with risperidone and a monoamine reuptake inhibitor antidepressant imipramine or fluoxetine elicited larger increases in brain phospho-Ser-GSK3 than each agent alone. (researchgate.net)
Reuptake1
Imipraminoxide's pharmacology has not been well elucidated, but based on its very close relationship with imipramine, it likely acts as a serotonin and norepinephrine reuptake inhibitor and serotonin, adrenenaline, histamine, and muscarinic acetylcholine receptor antagonist, though with weaker antiadrenergic and anticholinergic actions. (wikipedia.org)
Metabolite2
Imipraminoxide is both an analogue and a metabolite of imipramine, and has similar effects. (wikipedia.org)
Milk levels of imipramine and its metabolite are low and have not been detected in the serum of breastfed infants. (nih.gov)
Serotonin1
Serotonin has been variously described as a central neurohumoral agent or chemical mediator, as a 'headache substance' acting directly or indirectly to lower pain threshold, as an intrinsic 'motor hormone' of the gastrointestinal tract, and as a 'hormone' involved in connective tissue reparative processes. (drugbank.com)
Possesses2
A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. (nih.gov)
Imipramine is a tricyclic antidepressant that possesses anti-inflammatory activity and has been reported to inhibit the progression of highly metastatic non-small cell lung cancer. (bvsalud.org)
Doses2
2 ] However, other agents may be preferred when large doses are required or while nursing a newborn or preterm infant. (nih.gov)
Four mothers who were taking imipramine in doses of 75 to 150 mg daily had milk samples taken 12 to 15 hours after their daily dose. (nih.gov)
Depression3
Imipraminoxide (brand names Imiprex, Elepsin), or imipramine N-oxide, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1960s for the treatment of depression. (wikipedia.org)
Scatchard analysis indicated normal binding affinity but a reduction in the number of imipramine binding sites in depression. (cambridge.org)
Serum2
One infant whose mother began imipramine 75 mg daily 2 weeks postpartum and was breastfed for 7 weeks had a serum level of 0.6 mcg/L. Another infant was breastfed for 17 weeks after his mother began imipramine 100 mg daily 8 weeks postpartum and later decreased to 75 mg daily. (nih.gov)
Iron, citalopram and imipramine or their combinations increased serum BDNF concentration, hippocampal neuronal count and dendritic spine densities. (bvsalud.org)
Inhibitors1
The imipramine-induced BDNF increase was suppressed with inhibitors for protein kinase A (PKA) or MEK/ERK. (elsevierpure.com)
Citalopram6
The present study evaluates the possible synergistic antidepressant effect of sub-therapeutic dose of iron co-administered with citalopram or imipramine in female Institute of Cancer Research mice. (bvsalud.org)
Mice (n = 8) received iron (0.8-7.2 mg/kg), citalopram (3-30 mg/kg), imipramine (3-30 mg/kg), desferrioxamine (50 mg/kg) or saline in the single treatment phase of each model and subsequently a sub-therapeutic dose of iron co-administered with citalopram or imipramine. (bvsalud.org)
Iron, citalopram and imipramine, unlike desferrioxamine, reduced immobility score in the TST, FST and OSST without affecting locomotor activity, suggesting antidepressant-like effect. (bvsalud.org)
Sub-therapeutic dose of iron in combination with citalopram or imipramine further enhanced the antidepressant-like effect, producing a more rapid effect when compared to the iron, citalopram or imipramine alone. (bvsalud.org)
Our study provides experimental evidence that iron has antidepressant-like effect and sub-therapeutic dose of iron combined with citalopram or imipramine produces more rapid antidepressant-like effect. (bvsalud.org)
We further show that iron alone or its combination with citalopram or imipramine attenuates the neuronal loss associated with depressive conditions, increases dendritic spines density and BDNF levels. (bvsalud.org)
Rats1
A possible role of Y1 receptor in anxiety-related behaviours was demonstrated by the observations that transgenic rats overexpressing NPY show less anxiety, and that NPY can mimic the effects of imipramine in the forced swim test. (jpn.ca)
Conclusion1
CONCLUSION: Imipramine effectively suppressed TNBC progression by inducing apoptosis and inhibiting metastasis. (bvsalud.org)
BDNF3
In the present study, we evaluated the effects of imipramine, a classic tricyclic antidepressant drug, on BDNF expression in cultured rat brain astrocytes. (elsevierpure.com)
Imipramine dose-dependently increased BDNF mRNA expression in astrocytes. (elsevierpure.com)
These results suggested that imipramine induced BDNF expression through CREB activation via PKA and/or ERK pathways. (elsevierpure.com)
Significantly1
The binding of tritiated imipramine was significantly reduced in the hippocampus and occipital cortex from a series of patients with depressive illness compared with age-matched patients with no psychiatric disorder. (cambridge.org)
Effectively1
The 2009 American College of Gastroenterologists (ACG) position statement on the management of irritable bowel syndrome noted that the antidiarrheal agent loperamide effectively reduced stool frequency and improved stool consistency, but it did not relieve pain, bloating, or other global irritable bowel syndrome symptoms. (medscape.com)
Effects4
Imipramine use during breastfeeding would usually not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. (nih.gov)
Follow-up for 1 to 3 years in 14 breastfed infants whose mothers were taking imipramine in an average dosage of 161 mg daily (range 125 to 225 mg daily) found no adverse effects on growth and development. (nih.gov)
So, the effects of MnRN lesion on hippocampal neurogenesis in animals chronically stressed and treated or not with Imipramine (a tricyclic antidepressant) will be investigated too. (fapesp.br)
Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. (bvsalud.org)
Treatment1
The treatment of MNE can be performed through behavioral therapy, use of alarms or medications such as desmopressin and imipramine. (bvsalud.org)
Results1
RESULTS: Imipramine induced caspase-mediated extrinsic and intrinsic apoptosis and was potentially associated with patient overall survival. (bvsalud.org)
Similar1
Antidepresivo tricíclico similar en acción y efectos colaterales a la IMIPRAMINA. (bvsalud.org)
Found1
In another study, 25 infants whose mothers took a tricyclic antidepressant during pregnancy and lactation were tested formally between 15 to 71 months and found to have normal growth and development. (nih.gov)
Expression1
Furthermore, imipramine suppressed the invasion and migration abilities and the expression of metastasis-associated proteins in TNBC cells. (bvsalud.org)
Study1
MATERIALS AND METHODS: This study used MTT assay, apoptosis markers flow cytometry analysis, open-source data analysis, NF-B reporter gene assay, and western blotting to elucidate the effect of imipramine on MDA-MB-231 and 4T1 cells. (bvsalud.org)