• Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazole group. (uchile.cl)
  • New derivatives of 1,2,3-triazole and pyrazole were obtained from the work that was conducted in this research. (derpharmachemica.com)
  • QSAR study using the (PC-ANN) methodology was conducted to predict the inhibition constants of 127 symmetrical and unsymmetrical cyclic urea and cyclic cyanoguanidine derivatives containing different substituent groups such as: benzyl, isopropyl, 4- hydroxybenzyl, ketone, oxime, pyrazole, imidazole, triazole and having anti-HIV-1 protease activities. (alquds.edu)
  • In this study, novel pyrazole, imidazole, pyrimidine derivatives bearing imidazo[4,5-b]indol moiety were successfully synthesized and their chemical structures were identified and confirmed by different spectral techniques. (ichem.md)
  • The hydrogen on the 1-bit nitrogen atom can be transferred to the 3-atom, therefore, imidazole derivatives with same substituent respectively on 4-bit and 5-bit are tautomers. (lookchem.com)
  • Imidazole derivatives are widely found in nature, such as histamine, histidine and benzimidazole, etc. (lookchem.com)
  • The chemistry of imidazole and its synthetic derivatives is reviewed in this article. (tsijournals.com)
  • As a result, the goal of this article is to examine published research on the introduction, chemistry, synthesis, properties, industrial, biological and medicinal applications with efficacy of imidazole derivatives in order to better understand and explore their various properties and pharmacological potentials. (tsijournals.com)
  • Subsequently, the product of the previous reaction was reacted with hydrazine derivatives (a-e) to give pyrazole derivatives (7a-e). (derpharmachemica.com)
  • For example, 1-acetyl imidazole is a stable acylating agent, after reaction with pyrrole, it becomes 1-acetyl pyrrole. (lookchem.com)
  • 3) The mass spectrometry of clusters of small biomolecules imidazole, pyrazole and pyrrole was investigated. (cuni.cz)
  • Alkaline of imidazole is slightly stronger than pyrazole and pyridine. (lookchem.com)
  • In this chapter, we will introduce the recent advances of the tetradentate cyclometalated platinum(II) complexes, including pyrazole, N-heterocyclic carbene, imidazole and pyridine-based complexes, molecular design, photophysical properties, and some of their device performances. (intechopen.com)
  • Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Biochemistry;Reagents for Oligosaccharide Synthesis;Highly Purified Reagents;Other Categories;Zone Refined Products;Buffer;ACS Grade Buffers;ACS Grade;Biological Buffers;Buffers A to Z;Building Blocks;C3 to C8;Chemical Synthesis;Essential Chemicals;Heterocyclic Building Blocks;Imidazoles;Inorganic Salts;Research Essentials;Solutions and Reagents;Intermediate for Propafenone hydrochloride. (lookchem.com)
  • R. Kenchappa, Y.D. Bodke, Synthesis, analgesic and anti-inflammatory activity of benzofuran pyrazole heterocycles. (dntb.gov.ua)
  • Imidazole is between the two nitrogen atoms of five membered heterocyclic compounds containing. (lookchem.com)
  • There are some interesting reagents in acyl imidazole compounds. (lookchem.com)
  • The relationship between imidazole and natural compounds is very close. (lookchem.com)
  • Imidazole is observed in a variety of key genetic compounds. (tsijournals.com)
  • Amongst the various heterocycles, pyrazole classes of compounds play an important role in medicinal chemistry. (ajptonline.com)
  • The literature contains reports of distorted octahedral geometries for Cadmium tetrafluoroborate complexes with nitrogen-containing ligands such as pyrazoles and imidazoles and porphyrins. (wikipedia.org)
  • To further clarify the influence of methyl substituents, we investigated a series of Cu( I ) complexes with (1-(2-pyridyl) pyrazole/imidazole and bis[2-(diphenylphosphino)phenyl]ether mixed ligands)[Cu(N^N)(P^P)] based on density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. (rsc.org)
  • M. Gaba, C. Mohan, Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions. (dntb.gov.ua)
  • The unshared electron pair of 1-bit nitrogen atom in imidazole ring participates in the cyclic conjugation, reduces the electron density of the nitrogen atom, and makes hydrogen of the nitrogen atom easily leave in the form of hydrogen. (lookchem.com)
  • The imidazole ring is a five-membered ring structure with 3C and 2N atoms, with N present in the first and third positions and containing a hydrogen attachment sphere and an electron contributor nitrogen system [ 1 ]. (tsijournals.com)
  • A review of the literature on several research papers and other publications that give thorough information on the chemistry of imidazole. (tsijournals.com)
  • The unshared electron pair of 3-bit nitrogen atom in imidazole ring doesn't participates in the cyclic conjugation, while it occupies the sp2 hybridized orbital, can accept protons, and form salt with strong acid. (lookchem.com)
  • substitution of the parazole with an imidazole group could reduce the ratio of 3 MLCT involved in emission transition. (rsc.org)
  • Imidazole is widely used as a pharmaceutical and agricultural intermediate, as well as a curing agent in epoxy systems. (chembuyersguide.com)
  • Pyrazole is a new class of pharmaceutical and pesticide intermediates that are widely used in pesticides, electronics, and pharmaceuticals. (chembuyersguide.com)
  • This review highlighted recent reports of antimicrobial, anticancer, ACE inhibitor, antiviral as well as anti-inflammatory activities of pyrazole. (ajptonline.com)
  • The most prevalent amino acid is 'histidine,' which has an imidazole on the side chain [ 3 ]. (tsijournals.com)
  • Imidazole is stable to acid, and has antioxidant activity. (lookchem.com)
  • Imidazole is amphiprotic, which means it may behave as an acid as well as a base. (tsijournals.com)
  • Imidazole is a component of theophylline, which is present in tea leaves and coffee beans and activates the central nervous system. (tsijournals.com)
  • Apart from its usage in pharmaceuticals, imidazole has a variety of industrial uses [ 4 ]. (tsijournals.com)
  • In the arena of five membered heterocyclic structures, the imidazole nucleus exhibits a range of properties. (tsijournals.com)
  • Heinrich Debus synthesised imidazole for the first time in 1858, but several imidazole products had been found as young as the 1840's. (tsijournals.com)
  • N -arylation of either aryl iodides or aryl bromides with common π-excessive nitrogen heterocycles (pyrroles, pyrazoles, indazoles, imidazoles, and triazoles) was successfully performed in good yield with catalysts derived from diamine ligands and CuI. (organic-chemistry.org)
  • The findings are compared with previous studies of pyrrole (C(4)N(1)H(5)) and imidazole (C(3)N(2)H(4)), providing a guide to H atom loss dynamics in simple N-containing heterocycles. (bris.ac.uk)
  • A photodissociation channel yielding H atoms with low kinetic energies is also clearly evident in both pyrazole and 2H-1,2,3-triazole. (bris.ac.uk)
  • 3. Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles as transforming growth factor-beta type 1 receptor kinase inhibitors. (nih.gov)
  • 10. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. (nih.gov)
  • 13. Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors. (nih.gov)
  • Pyrazole (Table 1, entry 1), imidazole (entry 2), and benzimidazole (entry 7) do not require analyses for regioselectivity [2a] . (wuxiapptec.com)
  • 8. Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor beta type 1 receptor (ALK5). (nih.gov)
  • Preincubation with the inhibitors 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1 H -imidazole (SB203580) and 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1 H -imidazole (SB202190) showed that phosphorylation of MAPK p38 was implicated in the signal transduction leading to apoptosis. (aspetjournals.org)
  • The H atom involved in the dimer N-H⋯N hydrogen bond is disordered over both symmetry-unique pyrazole mol-ecules with occupancies of 0.52 (5) and 0.48 (5). (iucr.org)
  • The H atom of the hydrogen bond is disordered over both pyrazole mol-ecules. (iucr.org)
  • Herein, we provide a short overview of recent developments in the classes of scorpionate ligands, derived from pyrazoles, triazoles, imidazoles, oxazolines, thioimidazoles and other similar systems, followed by an in-depth discussion of a new type of robust and tunable scorpionate ligand, tris(2-pyridyl)borates. (researchwithrutgers.com)
  • Pyrazole is very weak acid (pKa=14.21), introduction of electron withdrawing group (-I & -M effect) increase the acidity. (allclearmister.com)