The most notable dibenzopyrene isomer, dibenzo[a,l]pyrene is a constituent of tobacco smoke and is thought to be 30 to 100 times more potent as a carcinogen than benzo[a]pyrene. (wikipedia.org)
In 2017 the EPA published updated toxicity values for one type of prevalent petroleum contaminant, benzo[a]pyrene (BaP), in its IRIS database (Integrated Risk Information System). (nwtoxiccommunities.org)
To this end, soils under holm oak, black pine and beech were spiked with three PAHs (phenanthrene, pyrene, benzo[a]pyrene) characterized by different molecular weights and the effects on the tructural and functional stability were studied. (unisa.it)
The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes. (lookformedical.com)
Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions reveals the time-dependent formation of an intermediate(s) of which the visible spectra resemble those of several benzo(a)pyrene phenols. (lookformedical.com)
An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. (lookformedical.com)
The effect of inhibitors on the spectrophotometric assay correlates well with the results obtained from benzo(a)pyrene metabolite analysis using high-pressure liquid chromatography. (lookformedical.com)
Differences in benzo(a)pyrene metabolism between rodent liver microsomes and embryonic cells. (lookformedical.com)
Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. (lookformedical.com)
These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. (lookformedical.com)
These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps. (lookformedical.com)
Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA. (lookformedical.com)
The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. (lookformedical.com)
Nonenzymatic reduction of benzo(a)pyrene diol-epoxides to trihydroxypentahydrobenzo(a)pyrenes by reduced nicotinamide adenine dinucleotide phosphate. (lookformedical.com)
The diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a potent mutagen and possibly the ultimate carcinogenic form of benzo(a)pyrene. (lookformedical.com)
The predicted distributions of the 4-ring PAHs fluoranthene and pyrene and the 5-ring PAH benzo(a)pyrene are found to be sensitive to the combinations of factors with their synergistic effects being stronger than the direct effects of the individual factors. (copernicus.org)
It is found that the particulate mass fraction of the benzo(a)pyrene is well simulated, whereas those of other species are lower than observed. (copernicus.org)
Phenanthrene1
Ten monohydroxy-PAHs (OH-PAHs) were analyzed in urine samples, consisting in the principal metabolites of naphthalene (NAP), fluorene (FLU), phenanthrene (PHE), and pyrene (PYR). (polito.it)
Metabolites1
Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. (lookformedical.com)
Risk Information System2
This study uses diesel exhaust concentrations in the railroad work environment in conjunction with the USEPA's Integrated Risk Information System ("IRIS") risk assessment methodology to quantify the cancer risk posed to railroad workers due to occupational inhalation exposure to diesel exhaust. (springer.com)
NIOSH Bulletin 68 (2017) states that there is "no known safe level" of exposure to carcinogens and recommends an evaluation of the USEPA's IRIS guidance to evaluate quantitative risk assessment of human exposure to occupational carcinogens. (springer.com)
Effects1
Transcriptional responses and embryotoxic effects induced by pyrene and methylpyrene in Japanese medaka (Oryzias latipes) early life stages exposed to spiked sediments. (umr-sebio.fr)
Formation1
When 3-hydroxybenzo(a)pyrene was used as a standard for comparison of activity, the rates of formation of phenols were compared when measured by fluorometric, spectrophotometric, or high-pressure liquid chromatographic analytical techniques. (lookformedical.com)
Benzo10
Benzo[a]pyrene (BaP), the most widely-studied PAH lung carcinogen, is a class 1 known human carcinogen (IARC). (nih.gov)
The most notable dibenzopyrene isomer, dibenzo[a,l]pyrene is a constituent of tobacco smoke and is thought to be 30 to 100 times more potent as a carcinogen than benzo[a]pyrene. (wikipedia.org)
To evaluate the contribution of several microbial groups in soil anthracene and benzo[a]pyrene degradation, the analysis of phospholipid fatty acid (PLFA) profiles and machine learning techniques were employed. (fmach.it)
To this end, PLFAs and PAH concentrations were analysed, along 274 days of incubation in mesocosms, in soils artificially contaminated with anthracene and benzo[a]pyrene, subjected to different treatments: untreated soil and soils treated with biowaste compost or fungal consortium. (fmach.it)
Random forest models, figuring anthracene or benzo[a]pyrene concentrations as dependent variables and PLFAs as predictors, were then built to evaluate the contribution of each variable in PAH degradation. (fmach.it)
The former, together with fungi, are primarily responsible for anthracene and benzo[a]pyrene degradation in both treated soils, a process in which also metanotrophs and other Gramþ and Gram- bacteria participate. (fmach.it)
6. Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells. (nih.gov)
Paternal Benzo[a]pyrene Exposure Affects Gene Expression in the Early Developing Mouse Embryo. (oslomet.no)
Quartz silica and DQ12 potentiated the carcinogenicity of benzo[ a ]pyrene and thorotrast (an -radiation-emitting material). (nih.gov)
Mobilisation of polycyclic aromatic hydrocarbons (PAHs) such as pyrene or phenanthrene by organic acids (citric, oxalic, tartaric, lactic, or acetic) U0126 solubility is dependent on the type of organic acid, pH, and soil organic matter content [8, 57]. (hdac-assay.com)
For example, citric acid has been reported to be efficient in pyrene and phenanthrene extraction [8, 57]. (hdac-assay.com)
Adsorption1
Lower extractability of PAHs was found in soils of higher organic matter content, while adsorption of pyrene in the presence of organic acids decreased with increasing pH. (hdac-assay.com)